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Protein

CCAAT/enhancer-binding protein delta

Gene

CEBPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30873-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP49716.
SIGNORiP49716.

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
Nuclear factor NF-IL6-beta1 Publication
Short name:
NF-IL6-beta1 Publication
Gene namesi
Name:CEBPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:1835. CEBPD.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120K → A: Loss of sumoylation. 1 Publication1

Organism-specific databases

DisGeNETi1052.
OpenTargetsiENSG00000221869.
PharmGKBiPA26378.

Polymorphism and mutation databases

BioMutaiCEBPD.
DMDMi160332350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000766212 – 269CCAAT/enhancer-binding protein deltaAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP49716.
MaxQBiP49716.
PaxDbiP49716.
PeptideAtlasiP49716.
PRIDEiP49716.

PTM databases

iPTMnetiP49716.
PhosphoSitePlusiP49716.

Expressioni

Gene expression databases

BgeeiENSG00000221869.
CleanExiHS_CEBPD.
GenevisibleiP49716. HS.

Organism-specific databases

HPAiHPA067581.

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF4P188482EBI-7962058,EBI-492498
CEBPAP497152EBI-7962058,EBI-1172054
CEBPGP535672EBI-7962058,EBI-740209
DDIT3P356382EBI-7962058,EBI-742651

Protein-protein interaction databases

BioGridi107481. 24 interactors.
DIPiDIP-146N.
IntActiP49716. 8 interactors.
MINTiMINT-6609320.
STRINGi9606.ENSP00000386165.

Structurei

3D structure databases

ProteinModelPortaliP49716.
SMRiP49716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 254bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 222Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni226 – 254Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISXU. Eukaryota.
ENOG4111S4B. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP49716.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG091G11FC.
PhylomeDBiP49716.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL
110 120 130 140 150
LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA
160 170 180 190 200
AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF
260
FKQLPSPPFL PAAGTADCR
Length:269
Mass (Da):28,467
Last modified:November 13, 2007 - v2
Checksum:iAFDE9E2244BDF84A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → T in AAA59927 (PubMed:1741402).Curated1
Sequence conflicti13R → G in AAA59927 (PubMed:1741402).Curated1
Sequence conflicti140 – 141AA → GP in AAA59927 (PubMed:1741402).Curated2
Sequence conflicti140 – 141AA → GP in AAB27293 (PubMed:8314590).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037087248R → W.Corresponds to variant rs34948549dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83667 mRNA. Translation: AAA59927.1.
S63168 Genomic DNA. Translation: AAB27293.1.
CH471068 Genomic DNA. Translation: EAW86679.1.
BC105109 mRNA. Translation: AAI05110.1.
CCDSiCCDS6142.1.
PIRiA47008.
RefSeqiNP_005186.2. NM_005195.3.
UniGeneiHs.440829.

Genome annotation databases

EnsembliENST00000408965; ENSP00000386165; ENSG00000221869.
GeneIDi1052.
KEGGihsa:1052.
UCSCiuc003xqh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83667 mRNA. Translation: AAA59927.1.
S63168 Genomic DNA. Translation: AAB27293.1.
CH471068 Genomic DNA. Translation: EAW86679.1.
BC105109 mRNA. Translation: AAI05110.1.
CCDSiCCDS6142.1.
PIRiA47008.
RefSeqiNP_005186.2. NM_005195.3.
UniGeneiHs.440829.

3D structure databases

ProteinModelPortaliP49716.
SMRiP49716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107481. 24 interactors.
DIPiDIP-146N.
IntActiP49716. 8 interactors.
MINTiMINT-6609320.
STRINGi9606.ENSP00000386165.

PTM databases

iPTMnetiP49716.
PhosphoSitePlusiP49716.

Polymorphism and mutation databases

BioMutaiCEBPD.
DMDMi160332350.

Proteomic databases

EPDiP49716.
MaxQBiP49716.
PaxDbiP49716.
PeptideAtlasiP49716.
PRIDEiP49716.

Protocols and materials databases

DNASUi1052.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408965; ENSP00000386165; ENSG00000221869.
GeneIDi1052.
KEGGihsa:1052.
UCSCiuc003xqh.2. human.

Organism-specific databases

CTDi1052.
DisGeNETi1052.
GeneCardsiCEBPD.
HGNCiHGNC:1835. CEBPD.
HPAiHPA067581.
MIMi116898. gene.
neXtProtiNX_P49716.
OpenTargetsiENSG00000221869.
PharmGKBiPA26378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISXU. Eukaryota.
ENOG4111S4B. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP49716.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG091G11FC.
PhylomeDBiP49716.
TreeFamiTF105008.

Enzyme and pathway databases

BioCyciZFISH:G66-30873-MONOMER.
ReactomeiR-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP49716.
SIGNORiP49716.

Miscellaneous databases

GeneWikiiCEBPD.
GenomeRNAii1052.
PROiP49716.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221869.
CleanExiHS_CEBPD.
GenevisibleiP49716. HS.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPD_HUMAN
AccessioniPrimary (citable) accession number: P49716
Secondary accession number(s): Q14937, Q2M2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.