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P49716 (CEBPD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCAAT/enhancer-binding protein delta

Short name=C/EBP delta
Alternative name(s):
Nuclear factor NF-IL6-beta
Short name=NF-IL6-beta
Gene names
Name:CEBPD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts with PRDM16 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
   PTMAcetylation
Isopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription from RNA polymerase II promoter

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 269268CCAAT/enhancer-binding protein delta
PRO_0000076621

Regions

Domain191 – 25464bZIP
Region195 – 22228Basic motif By similarity
Region226 – 25429Leucine-zipper By similarity

Amino acid modifications

Modified residue21N-acetylserine Ref.6
Cross-link120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.5

Natural variations

Natural variant2481R → W.
Corresponds to variant rs34948549 [ dbSNP | Ensembl ].
VAR_037087

Experimental info

Mutagenesis1201K → A: Loss of sumoylation. Ref.5
Sequence conflict21S → T in AAA59927. Ref.1
Sequence conflict131R → G in AAA59927. Ref.1
Sequence conflict140 – 1412AA → GP in AAA59927. Ref.1
Sequence conflict140 – 1412AA → GP in AAB27293. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P49716 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: AFDE9E2244BDF84A

FASTA26928,467
        10         20         30         40         50         60 
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP AMYDDESAID 

        70         80         90        100        110        120 
FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL LPGGPARPLG PGPAAPRLLK 

       130        140        150        160        170        180 
REPDWGDGDA PGSLLPAQVA ACAQTVVSLA AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK 

       190        200        210        220        230        240 
SAGKRGPDRG SPEYRQRRER NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL 

       250        260 
TRDLAGLRQF FKQLPSPPFL PAAGTADCR 

« Hide

References

« Hide 'large scale' references
[1]"A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6."
Kinoshita S., Akira S., Kishimoto T.
Proc. Natl. Acad. Sci. U.S.A. 89:1473-1476(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization."
Cleutjens C.B., van Eekelen C.C., van Dekken H., Smit E.M., Hagemeijer A., Wagner M.J., Wells D.E., Trapman J.
Genomics 16:520-523(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[5]"Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene."
Wang J.-M., Ko C.-Y., Chen L.-C., Wang W.-L., Chang W.-C.
Nucleic Acids Res. 34:217-231(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION AT LYS-120, MUTAGENESIS OF LYS-120.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83667 mRNA. Translation: AAA59927.1.
S63168 Genomic DNA. Translation: AAB27293.1.
CH471068 Genomic DNA. Translation: EAW86679.1.
BC105109 mRNA. Translation: AAI05110.1.
CCDSCCDS6142.1.
PIRA47008.
RefSeqNP_005186.2. NM_005195.3.
UniGeneHs.440829.

3D structure databases

ProteinModelPortalP49716.
SMRP49716. Positions 193-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107481. 23 interactions.
DIPDIP-146N.
IntActP49716. 1 interaction.
MINTMINT-6609320.
STRING9606.ENSP00000386165.

PTM databases

PhosphoSiteP49716.

Polymorphism databases

DMDM160332350.

Proteomic databases

MaxQBP49716.
PaxDbP49716.
PRIDEP49716.

Protocols and materials databases

DNASU1052.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408965; ENSP00000386165; ENSG00000221869.
GeneID1052.
KEGGhsa:1052.
UCSCuc003xqh.1. human.

Organism-specific databases

CTD1052.
GeneCardsGC08M048649.
HGNCHGNC:1835. CEBPD.
MIM116898. gene.
neXtProtNX_P49716.
PharmGKBPA26378.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279313.
HOGENOMHOG000013112.
HOVERGENHBG050879.
InParanoidP49716.
KOK10050.
OMAVPNLELC.
OrthoDBEOG7R56TQ.
PhylomeDBP49716.
TreeFamTF105008.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
SignaLinkP49716.

Gene expression databases

BgeeP49716.
CleanExHS_CEBPD.
GenevestigatorP49716.

Family and domain databases

InterProIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCEBPD.
GenomeRNAi1052.
NextBio4405.
PROP49716.
SOURCESearch...

Entry information

Entry nameCEBPD_HUMAN
AccessionPrimary (citable) accession number: P49716
Secondary accession number(s): Q14937, Q2M2X9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM