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Protein

CCAAT/enhancer-binding protein delta

Gene

CEBPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.

GO - Molecular functioni

GO - Biological processi

  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP49716.

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
Nuclear factor NF-IL6-beta
Short name:
NF-IL6-beta
Gene namesi
Name:CEBPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:1835. CEBPD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi120 – 1201K → A: Loss of sumoylation. 1 Publication

Organism-specific databases

PharmGKBiPA26378.

Polymorphism and mutation databases

BioMutaiCEBPD.
DMDMi160332350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 269268CCAAT/enhancer-binding protein deltaPRO_0000076621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Cross-linki120 – 120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP49716.
PaxDbiP49716.
PRIDEiP49716.

PTM databases

PhosphoSiteiP49716.

Expressioni

Gene expression databases

BgeeiP49716.
CleanExiHS_CEBPD.
GenevisibleiP49716. HS.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts with PRDM16 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107481. 26 interactions.
DIPiDIP-146N.
IntActiP49716. 1 interaction.
MINTiMINT-6609320.
STRINGi9606.ENSP00000386165.

Structurei

3D structure databases

ProteinModelPortaliP49716.
SMRiP49716. Positions 193-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni195 – 22228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni226 – 25429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG279313.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP49716.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG7R56TQ.
PhylomeDBiP49716.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. C/EBP_chordates.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL
110 120 130 140 150
LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA
160 170 180 190 200
AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF
260
FKQLPSPPFL PAAGTADCR
Length:269
Mass (Da):28,467
Last modified:November 13, 2007 - v2
Checksum:iAFDE9E2244BDF84A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → T in AAA59927 (PubMed:1741402).Curated
Sequence conflicti13 – 131R → G in AAA59927 (PubMed:1741402).Curated
Sequence conflicti140 – 1412AA → GP in AAA59927 (PubMed:1741402).Curated
Sequence conflicti140 – 1412AA → GP in AAB27293 (PubMed:8314590).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti248 – 2481R → W.
Corresponds to variant rs34948549 [ dbSNP | Ensembl ].
VAR_037087

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83667 mRNA. Translation: AAA59927.1.
S63168 Genomic DNA. Translation: AAB27293.1.
CH471068 Genomic DNA. Translation: EAW86679.1.
BC105109 mRNA. Translation: AAI05110.1.
CCDSiCCDS6142.1.
PIRiA47008.
RefSeqiNP_005186.2. NM_005195.3.
UniGeneiHs.440829.

Genome annotation databases

EnsembliENST00000408965; ENSP00000386165; ENSG00000221869.
GeneIDi1052.
KEGGihsa:1052.
UCSCiuc003xqh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83667 mRNA. Translation: AAA59927.1.
S63168 Genomic DNA. Translation: AAB27293.1.
CH471068 Genomic DNA. Translation: EAW86679.1.
BC105109 mRNA. Translation: AAI05110.1.
CCDSiCCDS6142.1.
PIRiA47008.
RefSeqiNP_005186.2. NM_005195.3.
UniGeneiHs.440829.

3D structure databases

ProteinModelPortaliP49716.
SMRiP49716. Positions 193-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107481. 26 interactions.
DIPiDIP-146N.
IntActiP49716. 1 interaction.
MINTiMINT-6609320.
STRINGi9606.ENSP00000386165.

PTM databases

PhosphoSiteiP49716.

Polymorphism and mutation databases

BioMutaiCEBPD.
DMDMi160332350.

Proteomic databases

MaxQBiP49716.
PaxDbiP49716.
PRIDEiP49716.

Protocols and materials databases

DNASUi1052.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408965; ENSP00000386165; ENSG00000221869.
GeneIDi1052.
KEGGihsa:1052.
UCSCiuc003xqh.1. human.

Organism-specific databases

CTDi1052.
GeneCardsiGC08M048649.
HGNCiHGNC:1835. CEBPD.
MIMi116898. gene.
neXtProtiNX_P49716.
PharmGKBiPA26378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279313.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP49716.
KOiK10050.
OMAiVPNLELC.
OrthoDBiEOG7R56TQ.
PhylomeDBiP49716.
TreeFamiTF105008.

Enzyme and pathway databases

ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP49716.

Miscellaneous databases

GeneWikiiCEBPD.
GenomeRNAii1052.
NextBioi4405.
PROiP49716.
SOURCEiSearch...

Gene expression databases

BgeeiP49716.
CleanExiHS_CEBPD.
GenevisibleiP49716. HS.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. C/EBP_chordates.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6."
    Kinoshita S., Akira S., Kishimoto T.
    Proc. Natl. Acad. Sci. U.S.A. 89:1473-1476(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization."
    Cleutjens C.B., van Eekelen C.C., van Dekken H., Smit E.M., Hagemeijer A., Wagner M.J., Wells D.E., Trapman J.
    Genomics 16:520-523(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene."
    Wang J.-M., Ko C.-Y., Chen L.-C., Wang W.-L., Chang W.-C.
    Nucleic Acids Res. 34:217-231(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-120, MUTAGENESIS OF LYS-120.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCEBPD_HUMAN
AccessioniPrimary (citable) accession number: P49716
Secondary accession number(s): Q14937, Q2M2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 13, 2007
Last modified: June 24, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.