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Reviewed, UniProtKB/Swiss-Prot P49715 (CEBPA_HUMAN)

Last modified June 16, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CCAAT/enhancer-binding protein alpha
      Short name=C/EBP alpha
Gene names
Name: CEBPA
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X. Ref.5 Ref.6

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PARP1P098741EBI-1172054,EBI-355676

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358CCAAT/enhancer-binding protein alpha
PRO_0000076613

Regions

Domain317 – 34529Leucine-zipper
DNA binding286 – 30621Basic motif
Compositional bias99 – 1046Poly-Gly
Compositional bias183 – 1897Poly-Pro

Experimental info

Sequence conflict40 – 412AQ → PK in AAC50235. Ref.1
Sequence conflict95 – 984VGPT → WAH in CAA72289. Ref.2
Sequence conflict2411L → V in CAA72289. Ref.2
Sequence conflict248 – 2503GPG → ALA in CAA72289. Ref.2
Sequence conflict2691S → T in AAC50235. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49715-1 [UniParc].

Last modified February 5, 2008. Version 3.
Checksum: 574C0A049E25BCAC

FASTA35837,561
        10         20         30         40         50         60 
MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPA QPPAPPAAPE PLGGICEHET 

        70         80         90        100        110        120 
SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAVGPTGG GGGGDFDYPG APAGPGGAVM 

       130        140        150        160        170        180 
PGGAHGPPPG YGCAAAGYLD GRLEPLYERV GAPALRPLVI KQEPREEDEA KQLALAGLFP 

       190        200        210        220        230        240 
YQPPPPPPPS HPHPHPPPAH LAAPHLQFQI AHCGQTTMHL QPGHPTPPPT PVPSPHPAPA 

       250        260        270        280        290        300 
LGAAGLPGPG SALKGLGAAH PDLRASGGSG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR 

       310        320        330        340        350 
DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)."
Antonson P., Xanthopoulos K.G.
Biochem. Biophys. Res. Commun. 215:106-113(1995) [PubMed: 7575576] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Umbilical cord.
[2]"Transcription factor C/EBP-alpha: novel sites of expression and cloning of the human gene."
Swart G.W.M., van Groningen J.J.M., van Ruissen F., Bergers M., Schalwijk J.
Biol. Chem. Hoppe-Seyler 378:373-379(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]SeattleSNPs variation discovery resource
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133.
Tissue: Pancreas.
[5]"Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter."
Choi B.H., Park G.T., Rho H.M.
J. Biol. Chem. 274:2858-2865(1999) [PubMed: 9915821] [Abstract]
Cited for: INTERACTION WITH HBV PROTEIN X.
[6]"Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors."
Aho S., Buisson M., Pajunen T., Ryoo Y.W., Giot J.-F., Gruffat H., Sergeant A., Uitto J.
J. Cell Biol. 148:1165-1176(2000) [PubMed: 10725330] [Abstract]
Cited for: INTERACTION WITH UBN1.
+Additional computationally mapped references.

Cross-references

Sequence databases

U34070 Genomic DNA. Translation: AAC50235.1.
Y11525 mRNA. Translation: CAA72289.1.
EU048234 Genomic DNA. Translation: ABS82765.1.
BC027902 mRNA. Translation: AAH27902.1.
IPIIPI00292025.
PIRJC4311.
RefSeqNP_004355.2.
UniGeneHs.699463

3D structure databases

HSSPHSSP built from PDB template 1NWQ based on UniProtKB P05554.
SMRP49715. Positions 281-340.
ModBaseSearch...

Protein-protein interaction databases

IntActP49715. 4 interactions.

PTM databases

PhosphoSiteP49715.

Genome annotation databases

EnsemblENSG00000184771. Homo sapiens. [Contig view]
GeneID1050.
KEGGhsa:1050.

Organism-specific databases

GeneCardsGC19M038482.
HGNCHGNC:1833. CEBPA.
MIM116897. gene.
PharmGKBPA26376.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP49715.
OMAP49715. MHLQPGH.

Enzyme and pathway databases

Pathway_Interaction_DBhnf3bpathway. FOXA2 and FOXA3 transcription factor networks.
ar_tf_pathway. Regulation of Androgen receptor activity.

Gene expression databases

CleanExHS_CEBPA.

Family and domain databases

InterProIPR011700. bZIP_2.
IPR016468. CCAAT/enhancer-binding.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4397.
SOURCESearch...

Entry information

Entry nameCEBPA_HUMAN
AccessionPrimary (citable) accession number: P49715
Secondary accession number(s): A7LNP2, P78319, Q05CA4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 5, 2008
Last modified: June 16, 2009
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents