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Protein

Putative alpha-L-fucosidase

Gene

W03G11.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei276 – 2761May be important for catalysisPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.51. 1045.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
ORF Names:W03G11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiW03G11.3; CE37417; WBGene00012225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 482466Putative alpha-L-fucosidasePRO_0000010316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49713.
PRIDEiP49713.

Interactioni

Protein-protein interaction databases

STRINGi6239.W03G11.3.

Structurei

3D structure databases

ProteinModelPortaliP49713.
SMRiP49713. Positions 18-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
InParanoidiP49713.
KOiK01206.
OMAiMWPSATS.
OrthoDBiEOG7DC249.
PhylomeDBiP49713.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFLIFSILF LHLANCDYTP DWESLDNRPL PSWYDDSKFG IFCHWGLYSV
60 70 80 90 100
PAFRSEWMWW YWKGTQPDKD VVNFVDKNYK PGTTYADFAK DFTAEYFNAN
110 120 130 140 150
QFAETVKTSG ARYFVFTSKH HEGFTMWPSR TSWNWNSMDI GPKRDIVGEL
160 170 180 190 200
RDAFKKTDVH FGLYFSQFEW FHPMFLDDGK FNTTFYPEQV SYPQMIDIVT
210 220 230 240 250
KYNPEVVWSD GEWDKSDDYW KAKEFLAWLY NSSPVKDQVV VNDRWGTGTM
260 270 280 290 300
GKHGGFMTYS DHYDPGKLLE KKWENCMTLD KHSWGNRRDM KASEVNTAYE
310 320 330 340 350
IIEQLARTIA CNGNLLLNVG PNMHGQIPAI FEDRLEEIGR FVNITSEAIF
360 370 380 390 400
GTRPWIHQND TSASNVWYTS KYSSGKKPLK NLYQNVYNFQ LEEHTIVYAW
410 420 430 440 450
ILDTSHEQFE LKSVKTTKNT TATILGTDVV LTGFEESDSM IILSSKIDWK
460 470 480
KLPRRDIIVL KIEKAASYLR NPLMSTNEHH VQ
Length:482
Mass (Da):56,460
Last modified:June 21, 2005 - v2
Checksum:i8818D452AD261A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67738 Genomic DNA. Translation: CAA91546.2.
PIRiT26127.
RefSeqiNP_510020.2. NM_077619.3.
UniGeneiCel.24951.

Genome annotation databases

EnsemblMetazoaiW03G11.3; W03G11.3; WBGene00012225.
GeneIDi189173.
KEGGicel:CELE_W03G11.3.
UCSCiW03G11.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67738 Genomic DNA. Translation: CAA91546.2.
PIRiT26127.
RefSeqiNP_510020.2. NM_077619.3.
UniGeneiCel.24951.

3D structure databases

ProteinModelPortaliP49713.
SMRiP49713. Positions 18-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W03G11.3.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PaxDbiP49713.
PRIDEiP49713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW03G11.3; W03G11.3; WBGene00012225.
GeneIDi189173.
KEGGicel:CELE_W03G11.3.
UCSCiW03G11.3. c. elegans.

Organism-specific databases

CTDi189173.
WormBaseiW03G11.3; CE37417; WBGene00012225.

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000029598.
InParanoidiP49713.
KOiK01206.
OMAiMWPSATS.
OrthoDBiEOG7DC249.
PhylomeDBiP49713.

Enzyme and pathway databases

BRENDAi3.2.1.51. 1045.

Miscellaneous databases

NextBioi941460.
PROiP49713.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiFUCO_CAEEL
AccessioniPrimary (citable) accession number: P49713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 21, 2005
Last modified: July 22, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.