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P49713

- FUCO_CAEEL

UniProt

P49713 - FUCO_CAEEL

Protein

Putative alpha-L-fucosidase

Gene

W03G11.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei276 – 2761May be important for catalysisPROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: RefGenome
    2. fucose binding Source: RefGenome

    GO - Biological processi

    1. fucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.51. 1045.

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase
    Gene namesi
    ORF Names:W03G11.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiW03G11.3; CE37417; WBGene00012225.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 482466Putative alpha-L-fucosidasePRO_0000010316Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP49713.
    PRIDEiP49713.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.W03G11.3.

    Structurei

    3D structure databases

    ProteinModelPortaliP49713.
    SMRiP49713. Positions 18-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    GeneTreeiENSGT00440000035378.
    HOGENOMiHOG000029598.
    InParanoidiP49713.
    KOiK01206.
    OMAiVGSICKH.
    OrthoDBiEOG7DC249.
    PhylomeDBiP49713.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49713-1 [UniParc]FASTAAdd to Basket

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    MIFLIFSILF LHLANCDYTP DWESLDNRPL PSWYDDSKFG IFCHWGLYSV    50
    PAFRSEWMWW YWKGTQPDKD VVNFVDKNYK PGTTYADFAK DFTAEYFNAN 100
    QFAETVKTSG ARYFVFTSKH HEGFTMWPSR TSWNWNSMDI GPKRDIVGEL 150
    RDAFKKTDVH FGLYFSQFEW FHPMFLDDGK FNTTFYPEQV SYPQMIDIVT 200
    KYNPEVVWSD GEWDKSDDYW KAKEFLAWLY NSSPVKDQVV VNDRWGTGTM 250
    GKHGGFMTYS DHYDPGKLLE KKWENCMTLD KHSWGNRRDM KASEVNTAYE 300
    IIEQLARTIA CNGNLLLNVG PNMHGQIPAI FEDRLEEIGR FVNITSEAIF 350
    GTRPWIHQND TSASNVWYTS KYSSGKKPLK NLYQNVYNFQ LEEHTIVYAW 400
    ILDTSHEQFE LKSVKTTKNT TATILGTDVV LTGFEESDSM IILSSKIDWK 450
    KLPRRDIIVL KIEKAASYLR NPLMSTNEHH VQ 482
    Length:482
    Mass (Da):56,460
    Last modified:June 21, 2005 - v2
    Checksum:i8818D452AD261A5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67738 Genomic DNA. Translation: CAA91546.2.
    PIRiT26127.
    RefSeqiNP_510020.2. NM_077619.3.
    UniGeneiCel.24951.

    Genome annotation databases

    EnsemblMetazoaiW03G11.3; W03G11.3; WBGene00012225.
    GeneIDi189173.
    KEGGicel:CELE_W03G11.3.
    UCSCiW03G11.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67738 Genomic DNA. Translation: CAA91546.2 .
    PIRi T26127.
    RefSeqi NP_510020.2. NM_077619.3.
    UniGenei Cel.24951.

    3D structure databases

    ProteinModelPortali P49713.
    SMRi P49713. Positions 18-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.W03G11.3.

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Proteomic databases

    PaxDbi P49713.
    PRIDEi P49713.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W03G11.3 ; W03G11.3 ; WBGene00012225 .
    GeneIDi 189173.
    KEGGi cel:CELE_W03G11.3.
    UCSCi W03G11.3. c. elegans.

    Organism-specific databases

    CTDi 189173.
    WormBasei W03G11.3 ; CE37417 ; WBGene00012225 .

    Phylogenomic databases

    eggNOGi COG3669.
    GeneTreei ENSGT00440000035378.
    HOGENOMi HOG000029598.
    InParanoidi P49713.
    KOi K01206.
    OMAi VGSICKH.
    OrthoDBi EOG7DC249.
    PhylomeDBi P49713.

    Enzyme and pathway databases

    BRENDAi 3.2.1.51. 1045.

    Miscellaneous databases

    NextBioi 941460.
    PROi P49713.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiFUCO_CAEEL
    AccessioniPrimary (citable) accession number: P49713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3