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P49708 (IFNG_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon gamma

Short name=IFN-gamma
Gene names
Name:IFNG
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the type II (or gamma) interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
Growth regulation
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD8-positive, alpha-beta T cell differentiation involved in immune response

Inferred from electronic annotation. Source: Ensembl

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-18

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum unfolded protein response

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of myelination

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

neutrophil apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of MHC class II biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-23 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of killing of cells of other organism

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of vitamin D biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 164145Interferon gamma
PRO_0000016463

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P49708 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 18D9B0BCA415B600

FASTA16418,953
        10         20         30         40         50         60 
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD GGPIIVEKLK 

        70         80         90        100        110        120 
NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL YTLKNNLPDG VKKVKDIMDL 

       130        140        150        160 
AKLPMNDLRI QRKAANELFS ILQKLVDPPS FKRKRSQSQR RCNC 

« Hide

References

[1]"Cloning and expression of the chicken interferon-gamma gene."
Digby M.R., Lowenthal J.W.
J. Interferon Cytokine Res. 15:939-945(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Biological properties of recombinant chicken interferon-gamma."
Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.
Eur. J. Immunol. 26:2440-2447(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues."
Kaiser P., Wain H.M., Rothwell L.
Gene 207:25-32(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: N LINE.
[4]"Molecular genetic analysis of chicken interferon gamma gene."
Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White leghorn.
Tissue: Spleen.
[5]"Chicken interferon-gamma."
Lv Y.Z., Cao Y.C., Bi Y.Z.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[6]"Cloning and expression of the chicken interferon-gamma gene."
Bao M., Zhong D., Xu F., Yu W.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27465 mRNA. Translation: AAC59723.1.
X99774 mRNA. Translation: CAA68118.1.
Y07922 Genomic DNA. Translation: CAA69227.1.
U96875 expand/collapse EMBL AC list , U96872, U96873, U96874 Genomic DNA. Translation: AAG27918.1.
AF424744 mRNA. Translation: AAL17845.1.
AY501004 mRNA. Translation: AAR98863.1.
PIRJC6536.
RefSeqNP_990480.1. NM_205149.1.
UniGeneGga.916.

3D structure databases

ProteinModelPortalP49708.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP49708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
GeneID396054.
KEGGgga:396054.

Organism-specific databases

CTD3458.

Phylogenomic databases

eggNOGNOG45353.
GeneTreeENSGT00390000007831.
HOGENOMHOG000254784.
HOVERGENHBG056912.
InParanoidP49708.
KOK04687.
OMAKEYFNAS.
OrthoDBEOG7VHSZM.
PhylomeDBP49708.
TreeFamTF336308.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERPTHR11419. PTHR11419. 1 hit.
PfamPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001936. IFN-gamma. 1 hit.
ProDomPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio20816114.
PROP49708.

Entry information

Entry nameIFNG_CHICK
AccessionPrimary (citable) accession number: P49708
Secondary accession number(s): Q53YS2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families