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Protein

Interferon gamma

Gene

IFNG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_298551. Interferon gamma signaling.
REACT_340124. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 164145Interferon gammaPRO_0000016463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49708.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP49708.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP49708.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD
60 70 80 90 100
GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL
110 120 130 140 150
YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS
160
FKRKRSQSQR RCNC
Length:164
Mass (Da):18,953
Last modified:October 1, 1996 - v1
Checksum:i18D9B0BCA415B600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27465 mRNA. Translation: AAC59723.1.
X99774 mRNA. Translation: CAA68118.1.
Y07922 Genomic DNA. Translation: CAA69227.1.
U96875
, U96872, U96873, U96874 Genomic DNA. Translation: AAG27918.1.
AF424744 mRNA. Translation: AAL17845.1.
AY501004 mRNA. Translation: AAR98863.1.
FJ788637 mRNA. Translation: ACY72343.1.
PIRiJC6536.
RefSeqiNP_990480.1. NM_205149.1.
UniGeneiGga.916.

Genome annotation databases

EnsembliENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
GeneIDi396054.
KEGGigga:396054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27465 mRNA. Translation: AAC59723.1.
X99774 mRNA. Translation: CAA68118.1.
Y07922 Genomic DNA. Translation: CAA69227.1.
U96875
, U96872, U96873, U96874 Genomic DNA. Translation: AAG27918.1.
AF424744 mRNA. Translation: AAL17845.1.
AY501004 mRNA. Translation: AAR98863.1.
FJ788637 mRNA. Translation: ACY72343.1.
PIRiJC6536.
RefSeqiNP_990480.1. NM_205149.1.
UniGeneiGga.916.

3D structure databases

ProteinModelPortaliP49708.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP49708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
GeneIDi396054.
KEGGigga:396054.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP49708.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP49708.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiREACT_298551. Interferon gamma signaling.
REACT_340124. Regulation of IFNG signaling.

Miscellaneous databases

NextBioi20816114.
PROiP49708.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the chicken interferon-gamma gene."
    Digby M.R., Lowenthal J.W.
    J. Interferon Cytokine Res. 15:939-945(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Biological properties of recombinant chicken interferon-gamma."
    Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.
    Eur. J. Immunol. 26:2440-2447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues."
    Kaiser P., Wain H.M., Rothwell L.
    Gene 207:25-32(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: N LINE.
  4. "Molecular genetic analysis of chicken interferon gamma gene."
    Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
    Tissue: Spleen.
  5. "Chicken interferon-gamma."
    Lv Y.Z., Cao Y.C., Bi Y.Z.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  6. "Cloning and expression of the chicken interferon-gamma gene."
    Bao M., Zhong D., Xu F., Yu W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  7. "Cloning and sequence analysis of interferon gamma of China Lushi chicken."
    Zhang X., Zhang C., Li Y., Cheng X., Wu T.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood lymphocyte.

Entry informationi

Entry nameiIFNG_CHICK
AccessioniPrimary (citable) accession number: P49708
Secondary accession number(s): D3GGX1, Q53YS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.