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P49708

- IFNG_CHICK

UniProt

P49708 - IFNG_CHICK

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Protein

Interferon gamma

Gene

IFNG

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: AgBase
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: RefGenome
  13. negative regulation of cytolysis Source: AgBase
  14. negative regulation of growth of symbiont in host Source: Ensembl
  15. negative regulation of interleukin-17 production Source: Ensembl
  16. negative regulation of myelination Source: Ensembl
  17. negative regulation of smooth muscle cell proliferation Source: Ensembl
  18. neutrophil apoptotic process Source: Ensembl
  19. neutrophil chemotaxis Source: Ensembl
  20. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  21. positive regulation of chemokine biosynthetic process Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  23. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  24. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  25. positive regulation of interleukin-12 production Source: Ensembl
  26. positive regulation of interleukin-1 beta secretion Source: Ensembl
  27. positive regulation of interleukin-23 production Source: Ensembl
  28. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  29. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  30. positive regulation of killing of cells of other organism Source: Ensembl
  31. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  32. positive regulation of MHC class II biosynthetic process Source: Ensembl
  33. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  34. positive regulation of osteoclast differentiation Source: Ensembl
  35. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  36. positive regulation of reactive oxygen species metabolic process Source: AgBase
  37. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  38. positive regulation of T cell proliferation Source: Ensembl
  39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  40. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  41. positive regulation of tumor necrosis factor production Source: Ensembl
  42. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  43. positive regulation of vitamin D biosynthetic process Source: Ensembl
  44. protein import into nucleus, translocation Source: Ensembl
  45. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_197538. Regulation of IFNG signaling.
REACT_197548. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 164145Interferon gammaPRO_0000016463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49708.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP49708.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP49708.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49708-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD
60 70 80 90 100
GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL
110 120 130 140 150
YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS
160
FKRKRSQSQR RCNC
Length:164
Mass (Da):18,953
Last modified:October 1, 1996 - v1
Checksum:i18D9B0BCA415B600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27465 mRNA. Translation: AAC59723.1.
X99774 mRNA. Translation: CAA68118.1.
Y07922 Genomic DNA. Translation: CAA69227.1.
U96875
, U96872, U96873, U96874 Genomic DNA. Translation: AAG27918.1.
AF424744 mRNA. Translation: AAL17845.1.
AY501004 mRNA. Translation: AAR98863.1.
PIRiJC6536.
RefSeqiNP_990480.1. NM_205149.1.
UniGeneiGga.916.

Genome annotation databases

EnsembliENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
GeneIDi396054.
KEGGigga:396054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27465 mRNA. Translation: AAC59723.1 .
X99774 mRNA. Translation: CAA68118.1 .
Y07922 Genomic DNA. Translation: CAA69227.1 .
U96875
, U96872 , U96873 , U96874 Genomic DNA. Translation: AAG27918.1 .
AF424744 mRNA. Translation: AAL17845.1 .
AY501004 mRNA. Translation: AAR98863.1 .
PIRi JC6536.
RefSeqi NP_990480.1. NM_205149.1.
UniGenei Gga.916.

3D structure databases

ProteinModelPortali P49708.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P49708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000016105 ; ENSGALP00000016086 ; ENSGALG00000009903 .
GeneIDi 396054.
KEGGi gga:396054.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

eggNOGi NOG45353.
GeneTreei ENSGT00390000007831.
HOGENOMi HOG000254784.
HOVERGENi HBG056912.
InParanoidi P49708.
KOi K04687.
OMAi KEYFNAS.
OrthoDBi EOG7VHSZM.
PhylomeDBi P49708.
TreeFami TF336308.

Enzyme and pathway databases

Reactomei REACT_197538. Regulation of IFNG signaling.
REACT_197548. Interferon gamma signaling.

Miscellaneous databases

NextBioi 20816114.
PROi P49708.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the chicken interferon-gamma gene."
    Digby M.R., Lowenthal J.W.
    J. Interferon Cytokine Res. 15:939-945(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Biological properties of recombinant chicken interferon-gamma."
    Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.
    Eur. J. Immunol. 26:2440-2447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues."
    Kaiser P., Wain H.M., Rothwell L.
    Gene 207:25-32(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: N LINE.
  4. "Molecular genetic analysis of chicken interferon gamma gene."
    Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
    Tissue: Spleen.
  5. "Chicken interferon-gamma."
    Lv Y.Z., Cao Y.C., Bi Y.Z.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  6. "Cloning and expression of the chicken interferon-gamma gene."
    Bao M., Zhong D., Xu F., Yu W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiIFNG_CHICK
AccessioniPrimary (citable) accession number: P49708
Secondary accession number(s): Q53YS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3