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P49708

- IFNG_CHICK

UniProt

P49708 - IFNG_CHICK

Protein

Interferon gamma

Gene

IFNG

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: AgBase
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: RefGenome
    13. negative regulation of cytolysis Source: AgBase
    14. negative regulation of growth of symbiont in host Source: Ensembl
    15. negative regulation of interleukin-17 production Source: Ensembl
    16. negative regulation of myelination Source: Ensembl
    17. negative regulation of smooth muscle cell proliferation Source: Ensembl
    18. neutrophil apoptotic process Source: Ensembl
    19. neutrophil chemotaxis Source: Ensembl
    20. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    21. positive regulation of chemokine biosynthetic process Source: Ensembl
    22. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    23. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    24. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    25. positive regulation of interleukin-12 production Source: Ensembl
    26. positive regulation of interleukin-1 beta secretion Source: Ensembl
    27. positive regulation of interleukin-23 production Source: Ensembl
    28. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    29. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    30. positive regulation of killing of cells of other organism Source: Ensembl
    31. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    32. positive regulation of MHC class II biosynthetic process Source: Ensembl
    33. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    34. positive regulation of osteoclast differentiation Source: Ensembl
    35. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    36. positive regulation of reactive oxygen species metabolic process Source: AgBase
    37. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    38. positive regulation of T cell proliferation Source: Ensembl
    39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    41. positive regulation of tumor necrosis factor production Source: Ensembl
    42. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    43. positive regulation of vitamin D biosynthetic process Source: Ensembl
    44. protein import into nucleus, translocation Source: Ensembl
    45. regulation of insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Enzyme and pathway databases

    ReactomeiREACT_197538. Regulation of IFNG signaling.
    REACT_197548. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    IFN-gamma
    Gene namesi
    Name:IFNG
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 164145Interferon gammaPRO_0000016463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP49708.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49708.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiP49708.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    PhylomeDBiP49708.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD    50
    GGPIIVEKLK NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL 100
    YTLKNNLPDG VKKVKDIMDL AKLPMNDLRI QRKAANELFS ILQKLVDPPS 150
    FKRKRSQSQR RCNC 164
    Length:164
    Mass (Da):18,953
    Last modified:October 1, 1996 - v1
    Checksum:i18D9B0BCA415B600
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27465 mRNA. Translation: AAC59723.1.
    X99774 mRNA. Translation: CAA68118.1.
    Y07922 Genomic DNA. Translation: CAA69227.1.
    U96875
    , U96872, U96873, U96874 Genomic DNA. Translation: AAG27918.1.
    AF424744 mRNA. Translation: AAL17845.1.
    AY501004 mRNA. Translation: AAR98863.1.
    PIRiJC6536.
    RefSeqiNP_990480.1. NM_205149.1.
    UniGeneiGga.916.

    Genome annotation databases

    EnsembliENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
    GeneIDi396054.
    KEGGigga:396054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27465 mRNA. Translation: AAC59723.1 .
    X99774 mRNA. Translation: CAA68118.1 .
    Y07922 Genomic DNA. Translation: CAA69227.1 .
    U96875
    , U96872 , U96873 , U96874 Genomic DNA. Translation: AAG27918.1 .
    AF424744 mRNA. Translation: AAL17845.1 .
    AY501004 mRNA. Translation: AAR98863.1 .
    PIRi JC6536.
    RefSeqi NP_990480.1. NM_205149.1.
    UniGenei Gga.916.

    3D structure databases

    ProteinModelPortali P49708.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P49708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000016105 ; ENSGALP00000016086 ; ENSGALG00000009903 .
    GeneIDi 396054.
    KEGGi gga:396054.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi P49708.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    PhylomeDBi P49708.
    TreeFami TF336308.

    Enzyme and pathway databases

    Reactomei REACT_197538. Regulation of IFNG signaling.
    REACT_197548. Interferon gamma signaling.

    Miscellaneous databases

    NextBioi 20816114.
    PROi P49708.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the chicken interferon-gamma gene."
      Digby M.R., Lowenthal J.W.
      J. Interferon Cytokine Res. 15:939-945(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Biological properties of recombinant chicken interferon-gamma."
      Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.
      Eur. J. Immunol. 26:2440-2447(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure of the chicken interferon-gamma gene, and comparison to mammalian homologues."
      Kaiser P., Wain H.M., Rothwell L.
      Gene 207:25-32(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: N LINE.
    4. "Molecular genetic analysis of chicken interferon gamma gene."
      Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: White leghorn.
      Tissue: Spleen.
    5. "Chicken interferon-gamma."
      Lv Y.Z., Cao Y.C., Bi Y.Z.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    6. "Cloning and expression of the chicken interferon-gamma gene."
      Bao M., Zhong D., Xu F., Yu W.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiIFNG_CHICK
    AccessioniPrimary (citable) accession number: P49708
    Secondary accession number(s): Q53YS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3