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Protein

G1/S-specific cyclin-D2

Gene

CCND2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-GGA-69231 Cyclin D associated events in G1
R-GGA-8934593 Regulation of RUNX1 Expression and Activity

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D2
Gene namesi
Name:CCND2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804401 – 291G1/S-specific cyclin-D2Add BLAST291

Proteomic databases

PaxDbiP49706

Expressioni

Gene expression databases

BgeeiENSGALG00000017283

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036477

Structurei

3D structure databases

ProteinModelPortaliP49706
SMRiP49706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
GeneTreeiENSGT00910000144111
HOGENOMiHOG000008182
HOVERGENiHBG050837
InParanoidiP49706
KOiK10151
OMAiVVPTKKC
OrthoDBiEOG091G0URX
PhylomeDBiP49706

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF66 PTHR10177:SF66, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P49706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEVDP MRRALPDPNL LYDDRVLHNL LTIEERYLPQ CSYFKCVQKD
60 70 80 90 100
IQPFMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAV VPTRKCHLQL
110 120 130 140 150
LGAVCMFLAS KLKETIPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN
160 170 180 190 200
LAAVTPHDFI EHILRKLPLP KDKLVLIRKH AQTFIALCAT DFNFAMYPPS
210 220 230 240 250
MIATGSVGAA ICGLQLDDGD RSLSGDSLTD FLAKITSTDV DCLKACQEQI
260 270 280 290
ESVLVSNLRQ VRQQQQQSNP SKTIEELDQA STPTDVRDIN L
Length:291
Mass (Da):33,164
Last modified:October 1, 1996 - v1
Checksum:i43A7E646AEAF3109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28980 Genomic DNA Translation: AAA96955.1
PIRiJC4579
RefSeqiNP_989544.1, NM_204213.1
XP_015147604.1, XM_015292118.1
UniGeneiGga.35482
Gga.3974

Genome annotation databases

EnsembliENSGALT00000027938; ENSGALP00000027885; ENSGALG00000017283
GeneIDi374047
KEGGigga:374047

Similar proteinsi

Entry informationi

Entry nameiCCND2_CHICK
AccessioniPrimary (citable) accession number: P49706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health