Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin-D2

Gene

CCND2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D2
Gene namesi
Name:CCND2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291G1/S-specific cyclin-D2PRO_0000080440Add
BLAST

Proteomic databases

PaxDbiP49706.

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036477.

Structurei

3D structure databases

ProteinModelPortaliP49706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP49706.
KOiK10151.
OMAiCATDFNF.
OrthoDBiEOG7J447H.
PhylomeDBiP49706.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF66. PTHR10177:SF66. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEVDP MRRALPDPNL LYDDRVLHNL LTIEERYLPQ CSYFKCVQKD
60 70 80 90 100
IQPFMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAV VPTRKCHLQL
110 120 130 140 150
LGAVCMFLAS KLKETIPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN
160 170 180 190 200
LAAVTPHDFI EHILRKLPLP KDKLVLIRKH AQTFIALCAT DFNFAMYPPS
210 220 230 240 250
MIATGSVGAA ICGLQLDDGD RSLSGDSLTD FLAKITSTDV DCLKACQEQI
260 270 280 290
ESVLVSNLRQ VRQQQQQSNP SKTIEELDQA STPTDVRDIN L
Length:291
Mass (Da):33,164
Last modified:October 1, 1996 - v1
Checksum:i43A7E646AEAF3109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28980 Genomic DNA. Translation: AAA96955.1.
PIRiJC4579.
RefSeqiNP_989544.1. NM_204213.1.
XP_015147604.1. XM_015292118.1.
UniGeneiGga.35482.
Gga.3974.

Genome annotation databases

EnsembliENSGALT00000027938; ENSGALP00000027885; ENSGALG00000017283.
GeneIDi374047.
KEGGigga:374047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28980 Genomic DNA. Translation: AAA96955.1.
PIRiJC4579.
RefSeqiNP_989544.1. NM_204213.1.
XP_015147604.1. XM_015292118.1.
UniGeneiGga.35482.
Gga.3974.

3D structure databases

ProteinModelPortaliP49706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036477.

Proteomic databases

PaxDbiP49706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027938; ENSGALP00000027885; ENSGALG00000017283.
GeneIDi374047.
KEGGigga:374047.

Organism-specific databases

CTDi894.

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP49706.
KOiK10151.
OMAiCATDFNF.
OrthoDBiEOG7J447H.
PhylomeDBiP49706.

Miscellaneous databases

PROiP49706.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF66. PTHR10177:SF66. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and gene expression of avian cyclin D2."
    Li H., Grenet J., Kidd V.J.
    Gene 167:341-342(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCND2_CHICK
AccessioniPrimary (citable) accession number: P49706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.