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P49705 (IBP2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 2

Short name=IBP-2
Short name=IGF-binding protein 2
Short name=IGFBP-2
Gene names
Name:IGFBP2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits IGF-mediated growth and developmental rates By similarity. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit structure

Binds IGF2 more than IGF1 By similarity.

Subcellular location

Secreted.

Developmental stage

Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver. Ref.1

Domain

The C-terminus is required for IGF-binding and growth inhibition By similarity.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 By similarity
Chain37 – 311275Insulin-like growth factor-binding protein 2
PRO_0000014375

Regions

Domain38 – 12083IGFBP N-terminal
Domain209 – 29183Thyroglobulin type-1
Motif286 – 2883Cell attachment site Potential

Amino acid modifications

Disulfide bond212 ↔ 246 By similarity
Disulfide bond257 ↔ 268 By similarity
Disulfide bond270 ↔ 291 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49705 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5AC8D3E08121F45E

FASTA31133,538
        10         20         30         40         50         60 
MALGGVGRGG AARAAWPRLL LAALAPALAL AGPALPEVLF RCPPCTAERL AACSPAARPP 

        70         80         90        100        110        120 
CPELVREPGC GCCPVCARLE DEACGVYTPR CAAGLRCYPD PGAELPPQAL VQGQGTCARP 

       130        140        150        160        170        180 
PDTDEYGAST EPPADNGDDR SESILAENHV DSTGGMMSGA SSRKPLKTGM KEMPVMREKV 

       190        200        210        220        230        240 
NEQQRQMGKV GKAHHNHEDS KKSRMPTGRT PCQQELDQVL ERISTMRLPD ERGPLEHLYS 

       250        260        270        280        290        300 
LHIPNCDKHG LYNLKQCKMS VNGQRGECWC VDPIHGKVIQ GAPTIRGDPE CHLFYTAHEQ 

       310 
EDRGAHALRS Q 

« Hide

References

[1]"Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2."
Schoen T.J., Mazuruk K., Waldbillig R.J., Potts J., Beebe D.C., Chader G.J., Rodriguez I.R.
J. Mol. Endocrinol. 15:49-59(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Tissue: Embryonic retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15086 mRNA. Translation: AAA92885.1.
RefSeqNP_990690.1. NM_205359.1.
UniGeneGga.759.

3D structure databases

ProteinModelPortalP49705.
SMRP49705. Positions 206-311.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI31.953.

Proteomic databases

PRIDEP49705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396315.
KEGGgga:396315.

Organism-specific databases

CTD3485.

Phylogenomic databases

eggNOGNOG47500.
HOGENOMHOG000253012.
HOVERGENHBG002631.
InParanoidP49705.
PhylomeDBP49705.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816363.
PROP49705.

Entry information

Entry nameIBP2_CHICK
AccessionPrimary (citable) accession number: P49705
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families