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P49705

- IBP2_CHICK

UniProt

P49705 - IBP2_CHICK

Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Inhibits IGF-mediated growth and developmental rates By similarity. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: UniProtKB
    2. insulin-like growth factor II binding Source: UniProtKB

    GO - Biological processi

    1. regulation of cell growth Source: InterPro
    2. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Short name:
    IBP-2
    Short name:
    IGF-binding protein 2
    Short name:
    IGFBP-2
    Gene namesi
    Name:IGFBP2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636By similarityAdd
    BLAST
    Chaini37 – 311275Insulin-like growth factor-binding protein 2PRO_0000014375Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi212 ↔ 246PROSITE-ProRule annotation
    Disulfide bondi257 ↔ 268PROSITE-ProRule annotation
    Disulfide bondi270 ↔ 291PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP49705.

    Expressioni

    Developmental stagei

    Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver.1 Publication

    Interactioni

    Subunit structurei

    Binds IGF2 more than IGF1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49705.
    SMRiP49705. Positions 206-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 12083IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini209 – 29183Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi286 – 2883Cell attachment siteSequence Analysis

    Domaini

    The C-terminus is required for IGF-binding and growth inhibition.By similarity

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47500.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP49705.
    PhylomeDBiP49705.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGGVGRGG AARAAWPRLL LAALAPALAL AGPALPEVLF RCPPCTAERL    50
    AACSPAARPP CPELVREPGC GCCPVCARLE DEACGVYTPR CAAGLRCYPD 100
    PGAELPPQAL VQGQGTCARP PDTDEYGAST EPPADNGDDR SESILAENHV 150
    DSTGGMMSGA SSRKPLKTGM KEMPVMREKV NEQQRQMGKV GKAHHNHEDS 200
    KKSRMPTGRT PCQQELDQVL ERISTMRLPD ERGPLEHLYS LHIPNCDKHG 250
    LYNLKQCKMS VNGQRGECWC VDPIHGKVIQ GAPTIRGDPE CHLFYTAHEQ 300
    EDRGAHALRS Q 311
    Length:311
    Mass (Da):33,538
    Last modified:October 1, 1996 - v1
    Checksum:i5AC8D3E08121F45E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15086 mRNA. Translation: AAA92885.1.
    RefSeqiNP_990690.1. NM_205359.1.
    UniGeneiGga.759.

    Genome annotation databases

    GeneIDi396315.
    KEGGigga:396315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15086 mRNA. Translation: AAA92885.1 .
    RefSeqi NP_990690.1. NM_205359.1.
    UniGenei Gga.759.

    3D structure databases

    ProteinModelPortali P49705.
    SMRi P49705. Positions 206-311.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I31.953.

    Proteomic databases

    PRIDEi P49705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396315.
    KEGGi gga:396315.

    Organism-specific databases

    CTDi 3485.

    Phylogenomic databases

    eggNOGi NOG47500.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P49705.
    PhylomeDBi P49705.

    Miscellaneous databases

    NextBioi 20816363.
    PROi P49705.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2."
      Schoen T.J., Mazuruk K., Waldbillig R.J., Potts J., Beebe D.C., Chader G.J., Rodriguez I.R.
      J. Mol. Endocrinol. 15:49-59(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Embryonic retina.

    Entry informationi

    Entry nameiIBP2_CHICK
    AccessioniPrimary (citable) accession number: P49705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3