Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49705

- IBP2_CHICK

UniProt

P49705 - IBP2_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

  1. insulin-like growth factor I binding Source: UniProtKB
  2. insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  1. regulation of cell growth Source: InterPro
  2. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Gene namesi
Name:IGFBP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636By similarityAdd
BLAST
Chaini37 – 311275Insulin-like growth factor-binding protein 2PRO_0000014375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi212 ↔ 246PROSITE-ProRule annotation
Disulfide bondi257 ↔ 268PROSITE-ProRule annotation
Disulfide bondi270 ↔ 291PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP49705.

Expressioni

Developmental stagei

Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver.1 Publication

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49705.
SMRiP49705. Positions 206-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 12083IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini209 – 29183Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi286 – 2883Cell attachment siteSequence Analysis

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47500.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP49705.
PhylomeDBiP49705.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49705-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGGVGRGG AARAAWPRLL LAALAPALAL AGPALPEVLF RCPPCTAERL
60 70 80 90 100
AACSPAARPP CPELVREPGC GCCPVCARLE DEACGVYTPR CAAGLRCYPD
110 120 130 140 150
PGAELPPQAL VQGQGTCARP PDTDEYGAST EPPADNGDDR SESILAENHV
160 170 180 190 200
DSTGGMMSGA SSRKPLKTGM KEMPVMREKV NEQQRQMGKV GKAHHNHEDS
210 220 230 240 250
KKSRMPTGRT PCQQELDQVL ERISTMRLPD ERGPLEHLYS LHIPNCDKHG
260 270 280 290 300
LYNLKQCKMS VNGQRGECWC VDPIHGKVIQ GAPTIRGDPE CHLFYTAHEQ
310
EDRGAHALRS Q
Length:311
Mass (Da):33,538
Last modified:October 1, 1996 - v1
Checksum:i5AC8D3E08121F45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15086 mRNA. Translation: AAA92885.1.
RefSeqiNP_990690.1. NM_205359.1.
UniGeneiGga.759.

Genome annotation databases

GeneIDi396315.
KEGGigga:396315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15086 mRNA. Translation: AAA92885.1 .
RefSeqi NP_990690.1. NM_205359.1.
UniGenei Gga.759.

3D structure databases

ProteinModelPortali P49705.
SMRi P49705. Positions 206-311.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I31.953.

Proteomic databases

PRIDEi P49705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396315.
KEGGi gga:396315.

Organism-specific databases

CTDi 3485.

Phylogenomic databases

eggNOGi NOG47500.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P49705.
PhylomeDBi P49705.

Miscellaneous databases

NextBioi 20816363.
PROi P49705.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2."
    Schoen T.J., Mazuruk K., Waldbillig R.J., Potts J., Beebe D.C., Chader G.J., Rodriguez I.R.
    J. Mol. Endocrinol. 15:49-59(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryonic retina.

Entry informationi

Entry nameiIBP2_CHICK
AccessioniPrimary (citable) accession number: P49705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3