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Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Gene namesi
Name:IGFBP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36By similarityAdd BLAST36
ChainiPRO_000001437537 – 311Insulin-like growth factor-binding protein 2Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi212 ↔ 246PROSITE-ProRule annotation
Disulfide bondi257 ↔ 268PROSITE-ProRule annotation
Disulfide bondi270 ↔ 291PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP49705.
PRIDEiP49705.

Expressioni

Developmental stagei

Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver.1 Publication

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037367.

Structurei

3D structure databases

ProteinModelPortaliP49705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 120IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini209 – 291Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi286 – 288Cell attachment siteSequence analysis3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR. Eukaryota.
ENOG4111GWQ. LUCA.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP49705.
PhylomeDBiP49705.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGGVGRGG AARAAWPRLL LAALAPALAL AGPALPEVLF RCPPCTAERL
60 70 80 90 100
AACSPAARPP CPELVREPGC GCCPVCARLE DEACGVYTPR CAAGLRCYPD
110 120 130 140 150
PGAELPPQAL VQGQGTCARP PDTDEYGAST EPPADNGDDR SESILAENHV
160 170 180 190 200
DSTGGMMSGA SSRKPLKTGM KEMPVMREKV NEQQRQMGKV GKAHHNHEDS
210 220 230 240 250
KKSRMPTGRT PCQQELDQVL ERISTMRLPD ERGPLEHLYS LHIPNCDKHG
260 270 280 290 300
LYNLKQCKMS VNGQRGECWC VDPIHGKVIQ GAPTIRGDPE CHLFYTAHEQ
310
EDRGAHALRS Q
Length:311
Mass (Da):33,538
Last modified:October 1, 1996 - v1
Checksum:i5AC8D3E08121F45E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15086 mRNA. Translation: AAA92885.1.
RefSeqiNP_990690.1. NM_205359.1.
UniGeneiGga.759.

Genome annotation databases

GeneIDi396315.
KEGGigga:396315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15086 mRNA. Translation: AAA92885.1.
RefSeqiNP_990690.1. NM_205359.1.
UniGeneiGga.759.

3D structure databases

ProteinModelPortaliP49705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037367.

Protein family/group databases

MEROPSiI31.953.

Proteomic databases

PaxDbiP49705.
PRIDEiP49705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396315.
KEGGigga:396315.

Organism-specific databases

CTDi3485.

Phylogenomic databases

eggNOGiENOG410IHUR. Eukaryota.
ENOG4111GWQ. LUCA.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP49705.
PhylomeDBiP49705.

Miscellaneous databases

PROiP49705.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP2_CHICK
AccessioniPrimary (citable) accession number: P49705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.