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P49703

- ARL4D_HUMAN

UniProt

P49703 - ARL4D_HUMAN

Protein

ADP-ribosylation factor-like protein 4D

Gene

ARL4D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi28 – 358GTPBy similarity
    Nucleotide bindingi76 – 805GTPBy similarity
    Nucleotide bindingi135 – 1384GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. protein secretion Source: ProtInc
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiP49703.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 4D
    Alternative name(s):
    ADP-ribosylation factor-like protein 4L
    Gene namesi
    Name:ARL4D
    Synonyms:ARF4L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:656. ARL4D.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cell membrane 1 Publication. Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleolus Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 201200ADP-ribosylation factor-like protein 4DPRO_0000207464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PaxDbiP49703.
    PRIDEiP49703.

    PTM databases

    PhosphoSiteiP49703.

    Expressioni

    Gene expression databases

    BgeeiP49703.
    CleanExiHS_ARL4D.
    GenevestigatoriP49703.

    Organism-specific databases

    HPAiHPA060379.

    Interactioni

    Subunit structurei

    Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.1 Publication

    Protein-protein interaction databases

    BioGridi106874. 14 interactions.
    IntActiP49703. 14 interactions.
    MINTiMINT-1371837.

    Structurei

    3D structure databases

    ProteinModelPortaliP49703.
    SMRiP49703. Positions 22-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    InParanoidiP49703.
    KOiK07945.
    OMAiITRTSEN.
    OrthoDBiEOG7H793N.
    PhylomeDBiP49703.
    TreeFamiTF105464.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49703-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV    50
    PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV 100
    VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK 150
    RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR 200
    R 201
    Length:201
    Mass (Da):22,156
    Last modified:October 17, 2006 - v2
    Checksum:i18766BCF56A8127D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911T → N.1 Publication
    Corresponds to variant rs1059968 [ dbSNP | Ensembl ].
    VAR_028205

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38490 mRNA. Translation: AAA57126.1.
    U25771 mRNA. Translation: AAA93229.1.
    AB060692 mRNA. Translation: BAB91080.1.
    AK314951 mRNA. Translation: BAG37456.1.
    CH471178 Genomic DNA. Translation: EAW51681.1.
    CH471178 Genomic DNA. Translation: EAW51682.1.
    BC000043 mRNA. Translation: AAH00043.1.
    CCDSiCCDS11463.1.
    PIRiA57646.
    RefSeqiNP_001652.2. NM_001661.3.
    UniGeneiHs.183153.
    Hs.709866.

    Genome annotation databases

    EnsembliENST00000320033; ENSP00000322628; ENSG00000175906.
    GeneIDi379.
    KEGGihsa:379.
    UCSCiuc002idt.3. human.

    Polymorphism databases

    DMDMi116241256.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38490 mRNA. Translation: AAA57126.1 .
    U25771 mRNA. Translation: AAA93229.1 .
    AB060692 mRNA. Translation: BAB91080.1 .
    AK314951 mRNA. Translation: BAG37456.1 .
    CH471178 Genomic DNA. Translation: EAW51681.1 .
    CH471178 Genomic DNA. Translation: EAW51682.1 .
    BC000043 mRNA. Translation: AAH00043.1 .
    CCDSi CCDS11463.1.
    PIRi A57646.
    RefSeqi NP_001652.2. NM_001661.3.
    UniGenei Hs.183153.
    Hs.709866.

    3D structure databases

    ProteinModelPortali P49703.
    SMRi P49703. Positions 22-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106874. 14 interactions.
    IntActi P49703. 14 interactions.
    MINTi MINT-1371837.

    PTM databases

    PhosphoSitei P49703.

    Polymorphism databases

    DMDMi 116241256.

    Proteomic databases

    PaxDbi P49703.
    PRIDEi P49703.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320033 ; ENSP00000322628 ; ENSG00000175906 .
    GeneIDi 379.
    KEGGi hsa:379.
    UCSCi uc002idt.3. human.

    Organism-specific databases

    CTDi 379.
    GeneCardsi GC17P041476.
    HGNCi HGNC:656. ARL4D.
    HPAi HPA060379.
    MIMi 600732. gene.
    neXtProti NX_P49703.
    PharmGKBi PA24938.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    InParanoidi P49703.
    KOi K07945.
    OMAi ITRTSEN.
    OrthoDBi EOG7H793N.
    PhylomeDBi P49703.
    TreeFami TF105464.

    Enzyme and pathway databases

    SignaLinki P49703.

    Miscellaneous databases

    GeneWikii ARL4D.
    GenomeRNAii 379.
    NextBioi 1589.
    PROi P49703.
    SOURCEi Search...

    Gene expression databases

    Bgeei P49703.
    CleanExi HS_ARL4D.
    Genevestigatori P49703.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21."
      Smith S.A., Holik P.R., Stevens J., Melis R., White R., Albertsen H.
      Genomics 28:113-115(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-91.
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    3. "Two brain-related proteins are a tumor-rejection antigen recognized by HLA-A2-restriction."
      Tuda N., Shichijo S., Itoh K.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin."
      Bhamidipati A., Lewis S.A., Cowan N.J.
      J. Cell Biol. 149:1087-1096(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF INTERACTION WITH ARL4D.
    8. "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."
      Hofmann I., Thompson A., Sanderson C.M., Munro S.
      Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CYTH2, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiARL4D_HUMAN
    AccessioniPrimary (citable) accession number: P49703
    Secondary accession number(s): B2RC59, D3DX43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3