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Protein

ADP-ribosylation factor-like protein 4D

Gene

ARL4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • protein secretion Source: ProtInc
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162980-MONOMER.
ZFISH:ENSG00000175906-MONOMER.
SignaLinkiP49703.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4D
Alternative name(s):
ADP-ribosylation factor-like protein 4L
Gene namesi
Name:ARL4D
Synonyms:ARF4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:656. ARL4D.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi379.
OpenTargetsiENSG00000175906.
PharmGKBiPA24938.

Polymorphism and mutation databases

BioMutaiARL4D.
DMDMi116241256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074642 – 201ADP-ribosylation factor-like protein 4DAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP49703.
PaxDbiP49703.
PRIDEiP49703.

PTM databases

iPTMnetiP49703.
PhosphoSitePlusiP49703.

Expressioni

Gene expression databases

BgeeiENSG00000175906.
CleanExiHS_ARL4D.
GenevisibleiP49703. HS.

Organism-specific databases

HPAiHPA060379.

Interactioni

Subunit structurei

Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H14EBI-711726,EBI-10171570

Protein-protein interaction databases

BioGridi106874. 18 interactors.
IntActiP49703. 15 interactors.
MINTiMINT-1371837.
STRINGi9606.ENSP00000322628.

Structurei

3D structure databases

ProteinModelPortaliP49703.
SMRiP49703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP49703.
KOiK07945.
OMAiRRTDGMV.
OrthoDBiEOG091G0LK5.
PhylomeDBiP49703.
TreeFamiTF105464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV
60 70 80 90 100
PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV
110 120 130 140 150
VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK
160 170 180 190 200
RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR

R
Length:201
Mass (Da):22,156
Last modified:October 17, 2006 - v2
Checksum:i18766BCF56A8127D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02820591T → N.1 PublicationCorresponds to variant rs1059968dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38490 mRNA. Translation: AAA57126.1.
U25771 mRNA. Translation: AAA93229.1.
AB060692 mRNA. Translation: BAB91080.1.
AK314951 mRNA. Translation: BAG37456.1.
CH471178 Genomic DNA. Translation: EAW51681.1.
CH471178 Genomic DNA. Translation: EAW51682.1.
BC000043 mRNA. Translation: AAH00043.1.
CCDSiCCDS11463.1.
PIRiA57646.
RefSeqiNP_001652.2. NM_001661.3.
XP_011523084.1. XM_011524782.2.
UniGeneiHs.183153.
Hs.709866.

Genome annotation databases

EnsembliENST00000320033; ENSP00000322628; ENSG00000175906.
GeneIDi379.
KEGGihsa:379.
UCSCiuc002idt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38490 mRNA. Translation: AAA57126.1.
U25771 mRNA. Translation: AAA93229.1.
AB060692 mRNA. Translation: BAB91080.1.
AK314951 mRNA. Translation: BAG37456.1.
CH471178 Genomic DNA. Translation: EAW51681.1.
CH471178 Genomic DNA. Translation: EAW51682.1.
BC000043 mRNA. Translation: AAH00043.1.
CCDSiCCDS11463.1.
PIRiA57646.
RefSeqiNP_001652.2. NM_001661.3.
XP_011523084.1. XM_011524782.2.
UniGeneiHs.183153.
Hs.709866.

3D structure databases

ProteinModelPortaliP49703.
SMRiP49703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106874. 18 interactors.
IntActiP49703. 15 interactors.
MINTiMINT-1371837.
STRINGi9606.ENSP00000322628.

PTM databases

iPTMnetiP49703.
PhosphoSitePlusiP49703.

Polymorphism and mutation databases

BioMutaiARL4D.
DMDMi116241256.

Proteomic databases

EPDiP49703.
PaxDbiP49703.
PRIDEiP49703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320033; ENSP00000322628; ENSG00000175906.
GeneIDi379.
KEGGihsa:379.
UCSCiuc002idt.4. human.

Organism-specific databases

CTDi379.
DisGeNETi379.
GeneCardsiARL4D.
HGNCiHGNC:656. ARL4D.
HPAiHPA060379.
MIMi600732. gene.
neXtProtiNX_P49703.
OpenTargetsiENSG00000175906.
PharmGKBiPA24938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP49703.
KOiK07945.
OMAiRRTDGMV.
OrthoDBiEOG091G0LK5.
PhylomeDBiP49703.
TreeFamiTF105464.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162980-MONOMER.
ZFISH:ENSG00000175906-MONOMER.
SignaLinkiP49703.

Miscellaneous databases

ChiTaRSiARL4D. human.
GeneWikiiARL4D.
GenomeRNAii379.
PROiP49703.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175906.
CleanExiHS_ARL4D.
GenevisibleiP49703. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL4D_HUMAN
AccessioniPrimary (citable) accession number: P49703
Secondary accession number(s): B2RC59, D3DX43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.