Reviewed,
UniProtKB/Swiss-Prot P49703 (ARL4D_HUMAN)
Last modified
November 25, 2008.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ADP-ribosylation factor-like protein 4D Alternative name(s): ADP-ribosylation factor-like protein 4L | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Does not act as an allosteric activator of the cholera toxin catalytic subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the small GTPase superfamily. Arf family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Myristate |
Gene Ontology (GO) | |
| Biological process | protein secretion Ref.1 Traceable author statement. Source: ProtInc small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Potential | ||||||
| Chain | 2 – 201 | 200 | ADP-ribosylation factor-like protein 4D | PRO_0000207464 | |||||
Regions | |||||||||
| Nucleotide binding | 28 – 35 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 76 – 80 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 135 – 138 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Lipidation | 2 | 1 | N-myristoyl glycine Potential | ||||||
Natural variations | |||||||||
| Natural variant | 91 | 1 | T → N: dbSNP rs1059968. | VAR_028205 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21." Smith S.A., Holik P.R., Stevens J., Melis R., White R., Albertsen H. Genomics 28:113-115(1995) [PubMed: 7590735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-91. Tissue: Retina. |
| [2] | "Comparison of the positional cloning methods used to isolate the BRCA1 gene." Harshman K., Bell R., Rosenthal J., Katcher H., Miki Y., Swenson J., Gholami Z., Frye C., Ding W., Dayananth P., Eddington K., Norris F.H., Bristow P.K., Phelps R., Hattier T., Stone S., Shaffer D., Bayer S. Kamb A.Hum. Mol. Genet. 4:1259-1266(1995) [PubMed: 7581362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary. |
| [3] | "Two brain-related proteins are a tumor-rejection antigen recognized by HLA-A2-restriction." Tuda N., Shichijo S., Itoh K. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L38490 mRNA. Translation: AAA57126.1. U25771 mRNA. Translation: AAA93229.1. AB060692 mRNA. Translation: BAB91080.1. BC000043 mRNA. Translation: AAH00043.1. | |
| PIR | A57646. |
| RefSeq | NP_001652.2. |
| UniGene | Hs.183153 Hs.705646 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RRF based on UniProtKB P32889. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P49703. |
Genome annotation databases | |
| Ensembl | ENSG00000175906. Homo sapiens. [Contig view] |
| GeneID | 379. |
| KEGG | hsa:379. |
Organism-specific databases | |
| HGNC | HGNC:656. ARL4D. |
| MIM | 600732. gene. |
| PharmGKB | PA24938. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P49703. |
| HOVERGEN | P49703. |
Gene expression databases | |
| ArrayExpress | P49703. |
| CleanEx | HS_ARL4D. |
| GermOnline | ENSG00000175906. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_trnsfrmng. IPR005225. Small_GTP_bd. [Graphical view] |
| PANTHER | PTHR11711. ARF/SAR. 1 hit. |
| Pfam | PF00025. Arf. 1 hit. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. PR00328. SAR1GTPBP. |
| SMART | SM00177. ARF. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS01019. ARF. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P49703. |
| NextBio | 1589. |
| SOURCE | Search... |
Entry information
| Entry name | ARL4D_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49703 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


