Reviewed, UniProtKB/Swiss-Prot P49703 (ARL4D_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 4D
Alternative name(s):
    ADP-ribosylation factor-like protein 4L

Gene names

Name:	ARL4D
Synonyms:	ARF4L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not act as an allosteric activator of the cholera toxin catalytic subunit By similarity.
Subcellular location	Nucleus › nucleolusBy similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Biological process	protein secretion Ref.1 Traceable author statement. Source: ProtInc small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 201	200	ADP-ribosylation factor-like protein 4D		PRO_0000207464
Regions
	Nucleotide binding	28 – 35	8	GTP By similarity
	Nucleotide binding	76 – 80	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential
Natural variations
	Natural variant	91	1	T → N: dbSNP rs1059968.		VAR_028205

Sequences

	Sequence		Length	Mass (Da)
	P49703-1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 18766BCF56A8127D	FASTA	201	22,156
	10 20 30 40 50 60 MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI 70 80 90 100 110 120 RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS 130 140 150 160 170 180 RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL 190 200 ERLYEMILKR KKAARGGKKR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21." Smith S.A., Holik P.R., Stevens J., Melis R., White R., Albertsen H. Genomics 28:113-115(1995) [PubMed: 7590735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-91. Tissue: Retina.
[2]	"Comparison of the positional cloning methods used to isolate the BRCA1 gene." Harshman K., Bell R., Rosenthal J., Katcher H., Miki Y., Swenson J., Gholami Z., Frye C., Ding W., Dayananth P., Eddington K., Norris F.H., Bristow P.K., Phelps R., Hattier T., Stone S., Shaffer D., Bayer S. , Hussey C., Tran T., Lai M., Rosteck P.R. Jr., Skolnick M.H., Shattuck-Eidens D., Kamb A. Hum. Mol. Genet. 4:1259-1266(1995) [PubMed: 7581362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[3]	"Two brain-related proteins are a tumor-rejection antigen recognized by HLA-A2-restriction." Tuda N., Shichijo S., Itoh K. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L38490 mRNA. Translation: AAA57126.1. U25771 mRNA. Translation: AAA93229.1. AB060692 mRNA. Translation: BAB91080.1. BC000043 mRNA. Translation: AAH00043.1.
PIR	A57646.
RefSeq	NP_001652.2.
UniGene	Hs.183153 Hs.705646
3D structure databases
HSSP	HSSP built from PDB template 1RRF based on UniProtKB P32889.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49703.
Genome annotation databases
Ensembl	ENSG00000175906. Homo sapiens. [Contig view]
GeneID	379.
KEGG	hsa:379.
Organism-specific databases
HGNC	HGNC:656. ARL4D.
MIM	600732. gene.
PharmGKB	PA24938.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P49703.
HOVERGEN	P49703.
Gene expression databases
ArrayExpress	P49703.
CleanEx	HS_ARL4D.
GermOnline	ENSG00000175906. Homo sapiens.
Family and domain databases
InterPro	IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_trnsfrmng. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG. PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS01019. ARF. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P49703.
NextBio	1589.
SOURCE	Search...

Entry information

Entry name

ARL4D_HUMAN

Accession

Primary (citable) accession number: P49703

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 17, 2006
Last modified:	November 25, 2008
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)