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Protein

ADP-ribosylation factor-like protein 4D

Gene

ARL4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • metabolic process Source: GOC
  • protein secretion Source: ProtInc
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP49703.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4D
Alternative name(s):
ADP-ribosylation factor-like protein 4L
Gene namesi
Name:ARL4D
Synonyms:ARF4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:656. ARL4D.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24938.

Polymorphism and mutation databases

BioMutaiARL4D.
DMDMi116241256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 201200ADP-ribosylation factor-like protein 4DPRO_0000207464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP49703.
PRIDEiP49703.

PTM databases

PhosphoSiteiP49703.

Expressioni

Gene expression databases

BgeeiP49703.
CleanExiHS_ARL4D.
GenevisibleiP49703. HS.

Organism-specific databases

HPAiHPA060379.

Interactioni

Subunit structurei

Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC102BA1A4H14EBI-711726,EBI-10171570

Protein-protein interaction databases

BioGridi106874. 15 interactions.
IntActiP49703. 15 interactions.
MINTiMINT-1371837.
STRINGi9606.ENSP00000322628.

Structurei

3D structure databases

ProteinModelPortaliP49703.
SMRiP49703. Positions 22-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP49703.
KOiK07945.
OMAiITRTSEN.
OrthoDBiEOG7H793N.
PhylomeDBiP49703.
TreeFamiTF105464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV
60 70 80 90 100
PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV
110 120 130 140 150
VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK
160 170 180 190 200
RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR

R
Length:201
Mass (Da):22,156
Last modified:October 17, 2006 - v2
Checksum:i18766BCF56A8127D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911T → N.1 Publication
Corresponds to variant rs1059968 [ dbSNP | Ensembl ].
VAR_028205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38490 mRNA. Translation: AAA57126.1.
U25771 mRNA. Translation: AAA93229.1.
AB060692 mRNA. Translation: BAB91080.1.
AK314951 mRNA. Translation: BAG37456.1.
CH471178 Genomic DNA. Translation: EAW51681.1.
CH471178 Genomic DNA. Translation: EAW51682.1.
BC000043 mRNA. Translation: AAH00043.1.
CCDSiCCDS11463.1.
PIRiA57646.
RefSeqiNP_001652.2. NM_001661.3.
UniGeneiHs.183153.
Hs.709866.

Genome annotation databases

EnsembliENST00000320033; ENSP00000322628; ENSG00000175906.
GeneIDi379.
KEGGihsa:379.
UCSCiuc002idt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38490 mRNA. Translation: AAA57126.1.
U25771 mRNA. Translation: AAA93229.1.
AB060692 mRNA. Translation: BAB91080.1.
AK314951 mRNA. Translation: BAG37456.1.
CH471178 Genomic DNA. Translation: EAW51681.1.
CH471178 Genomic DNA. Translation: EAW51682.1.
BC000043 mRNA. Translation: AAH00043.1.
CCDSiCCDS11463.1.
PIRiA57646.
RefSeqiNP_001652.2. NM_001661.3.
UniGeneiHs.183153.
Hs.709866.

3D structure databases

ProteinModelPortaliP49703.
SMRiP49703. Positions 22-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106874. 15 interactions.
IntActiP49703. 15 interactions.
MINTiMINT-1371837.
STRINGi9606.ENSP00000322628.

PTM databases

PhosphoSiteiP49703.

Polymorphism and mutation databases

BioMutaiARL4D.
DMDMi116241256.

Proteomic databases

PaxDbiP49703.
PRIDEiP49703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320033; ENSP00000322628; ENSG00000175906.
GeneIDi379.
KEGGihsa:379.
UCSCiuc002idt.3. human.

Organism-specific databases

CTDi379.
GeneCardsiGC17P041476.
HGNCiHGNC:656. ARL4D.
HPAiHPA060379.
MIMi600732. gene.
neXtProtiNX_P49703.
PharmGKBiPA24938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP49703.
KOiK07945.
OMAiITRTSEN.
OrthoDBiEOG7H793N.
PhylomeDBiP49703.
TreeFamiTF105464.

Enzyme and pathway databases

SignaLinkiP49703.

Miscellaneous databases

ChiTaRSiARL4D. human.
GeneWikiiARL4D.
GenomeRNAii379.
NextBioi1589.
PROiP49703.
SOURCEiSearch...

Gene expression databases

BgeeiP49703.
CleanExiHS_ARL4D.
GenevisibleiP49703. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21."
    Smith S.A., Holik P.R., Stevens J., Melis R., White R., Albertsen H.
    Genomics 28:113-115(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-91.
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  3. "Two brain-related proteins are a tumor-rejection antigen recognized by HLA-A2-restriction."
    Tuda N., Shichijo S., Itoh K.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin."
    Bhamidipati A., Lewis S.A., Cowan N.J.
    J. Cell Biol. 149:1087-1096(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF INTERACTION WITH ARL4D.
  8. "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."
    Hofmann I., Thompson A., Sanderson C.M., Munro S.
    Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CYTH2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiARL4D_HUMAN
AccessioniPrimary (citable) accession number: P49703
Secondary accession number(s): B2RC59, D3DX43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.