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Protein

G-protein coupled receptor 15

Gene

GPR15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
  • T cell migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154165-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 15
Alternative name(s):
Brother of Bonzo
Short name:
BoB
Gene namesi
Name:GPR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4469. GPR15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 69CytoplasmicSequence analysisAdd BLAST15
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 120ExtracellularSequence analysisAdd BLAST30
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 149CytoplasmicSequence analysis8
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 192ExtracellularSequence analysisAdd BLAST22
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 239CytoplasmicSequence analysisAdd BLAST26
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 284ExtracellularSequence analysisAdd BLAST24
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 360CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2838.
OpenTargetsiENSG00000154165.
PharmGKBiPA28858.

Polymorphism and mutation databases

DMDMi1346170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695311 – 360G-protein coupled receptor 15Add BLAST360

Proteomic databases

PaxDbiP49685.
PeptideAtlasiP49685.
PRIDEiP49685.

PTM databases

iPTMnetiP49685.
PhosphoSitePlusiP49685.

Expressioni

Gene expression databases

BgeeiENSG00000154165.
CleanExiHS_GPR15.
ExpressionAtlasiP49685. baseline and differential.
GenevisibleiP49685. HS.

Organism-specific databases

HPAiHPA013775.

Interactioni

Protein-protein interaction databases

BioGridi109098. 2 interactors.
STRINGi9606.ENSP00000284311.

Structurei

3D structure databases

ProteinModelPortaliP49685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJEK. Eukaryota.
ENOG410YCV2. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000077773.
HOVERGENiHBG101112.
InParanoidiP49685.
KOiK08403.
OMAiRRRDCAY.
OrthoDBiEOG091G0AX0.
PhylomeDBiP49685.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG
60 70 80 90 100
NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR
110 120 130 140 150
TGSFLCKGSS YMISVNMHCS VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA
160 170 180 190 200
YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP IKLIWSLVAL
210 220 230 240 250
IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI KIIFIVVAAF
260 270 280 290 300
LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
310 320 330 340 350
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF
360
ARRRKRSVSL
Length:360
Mass (Da):40,787
Last modified:February 1, 1996 - v1
Checksum:iF781F28B7E312390
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02007537P → S.Corresponds to variant rs2230344dbSNPEnsembl.1
Natural variantiVAR_049391112M → V.Corresponds to variant rs35320046dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34806 Genomic DNA. Translation: AAC50826.1.
BC069437 mRNA. Translation: AAH69437.1.
BC101779 mRNA. Translation: AAI01780.1.
BC101781 mRNA. Translation: AAI01782.1.
CCDSiCCDS2931.1.
PIRiG02064.
RefSeqiNP_005281.1. NM_005290.3.
UniGeneiHs.162987.
Hs.563128.

Genome annotation databases

EnsembliENST00000284311; ENSP00000284311; ENSG00000154165.
GeneIDi2838.
KEGGihsa:2838.
UCSCiuc011bgy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34806 Genomic DNA. Translation: AAC50826.1.
BC069437 mRNA. Translation: AAH69437.1.
BC101779 mRNA. Translation: AAI01780.1.
BC101781 mRNA. Translation: AAI01782.1.
CCDSiCCDS2931.1.
PIRiG02064.
RefSeqiNP_005281.1. NM_005290.3.
UniGeneiHs.162987.
Hs.563128.

3D structure databases

ProteinModelPortaliP49685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109098. 2 interactors.
STRINGi9606.ENSP00000284311.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP49685.
PhosphoSitePlusiP49685.

Polymorphism and mutation databases

DMDMi1346170.

Proteomic databases

PaxDbiP49685.
PeptideAtlasiP49685.
PRIDEiP49685.

Protocols and materials databases

DNASUi2838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284311; ENSP00000284311; ENSG00000154165.
GeneIDi2838.
KEGGihsa:2838.
UCSCiuc011bgy.3. human.

Organism-specific databases

CTDi2838.
DisGeNETi2838.
GeneCardsiGPR15.
HGNCiHGNC:4469. GPR15.
HPAiHPA013775.
MIMi601166. gene.
neXtProtiNX_P49685.
OpenTargetsiENSG00000154165.
PharmGKBiPA28858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJEK. Eukaryota.
ENOG410YCV2. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000077773.
HOVERGENiHBG101112.
InParanoidiP49685.
KOiK08403.
OMAiRRRDCAY.
OrthoDBiEOG091G0AX0.
PhylomeDBiP49685.
TreeFamiTF330024.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154165-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR15.
GenomeRNAii2838.
PROiP49685.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154165.
CleanExiHS_GPR15.
ExpressionAtlasiP49685. baseline and differential.
GenevisibleiP49685. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR15_HUMAN
AccessioniPrimary (citable) accession number: P49685
Secondary accession number(s): Q3MIL4, Q6ISN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.