P49685 (GPR15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 15

Alternative name(s):
Brother of Bonzo
Short name=BoB

Gene names

Name:

GPR15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	G-protein coupled receptor 15		PRO_0000069531
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 54	21	Helical; Name=1; Potential
	Topological domain	55 – 69	15	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Name=2; Potential
	Topological domain	91 – 120	30	Extracellular Potential
	Transmembrane	121 – 141	21	Helical; Name=3; Potential
	Topological domain	142 – 149	8	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Name=4; Potential
	Topological domain	171 – 192	22	Extracellular Potential
	Transmembrane	193 – 213	21	Helical; Name=5; Potential
	Topological domain	214 – 239	26	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Name=6; Potential
	Topological domain	261 – 284	24	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=7; Potential
	Topological domain	306 – 360	55	Cytoplasmic Potential
Natural variations
	Natural variant	37	1	P → S. Corresponds to variant rs2230344 [ dbSNP | Ensembl ].		VAR_020075
	Natural variant	112	1	M → V. Corresponds to variant rs35320046 [ dbSNP | Ensembl ].		VAR_049391

Sequences

	Sequence		Length	Mass (Da)
	P49685 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: F781F28B7E312390	FASTA	360	40,787
	10 20 30 40 50 60 MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF 70 80 90 100 110 120 KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS 130 140 150 160 170 180 VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK 190 200 210 220 230 240 PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI 250 260 270 280 290 300 KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF 310 320 330 340 350 360 IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3." Heiber M., Marchese A., Nguyen T., Heng H.H.Q., George S.R., O'Dowd B.F. Genomics 32:462-465(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34806 Genomic DNA. Translation: AAC50826.1. BC069437 mRNA. Translation: AAH69437.1. BC101779 mRNA. Translation: AAI01780.1. BC101781 mRNA. Translation: AAI01782.1.
IPI	IPI00027756.
PIR	G02064.
RefSeq	NP_005281.1. NM_005290.2.
UniGene	Hs.563128.
3D structure databases
ProteinModelPortal	P49685.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000284311.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P49685.
Polymorphism databases
DMDM	1346170.
Proteomic databases
PaxDb	P49685.
PRIDE	P49685.
Protocols and materials databases
DNASU	2838.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284311; ENSP00000284311; ENSG00000154165.
GeneID	2838.
KEGG	hsa:2838.
UCSC	uc011bgy.2. human.
Organism-specific databases
CTD	2838.
GeneCards	GC03P098250.
HGNC	HGNC:4469. GPR15.
HPA	HPA013775.
MIM	601166. gene.
neXtProt	NX_P49685.
PharmGKB	PA28858.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148034.
HOGENOM	HOG000077773.
HOVERGEN	HBG101112.
InParanoid	P49685.
KO	K08403.
OMA	HNKKLRK.
OrthoDB	EOG4FJ898.
PhylomeDB	P49685.
Gene expression databases
ArrayExpress	P49685.
Bgee	P49685.
CleanEx	HS_GPR15.
Genevestigator	P49685.
GermOnline	ENSG00000154165. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2838.
NextBio	11197.
SOURCE	Search...

Entry information

Entry name

GPR15_HUMAN

Accession

Primary (citable) accession number: P49685
Secondary accession number(s): Q3MIL4, Q6ISN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.