GPR15

Protein namesⁱ	Recommended name: G-protein coupled receptor 15 Alternative name(s): Brother of Bonzo Short name: BoB
Gene namesⁱ	Name:GPR15
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4469. GPR15.

HGNCⁱ

HGNC:4469. GPR15.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	55 – 69	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	70 – 90	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	91 – 120	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	121 – 141	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	142 – 149	CytoplasmicSequence analysis	8
Transmembraneⁱ	150 – 170	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	171 – 192	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	193 – 213	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	214 – 239	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	240 – 260	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	261 – 284	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	285 – 305	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	306 – 360	CytoplasmicSequence analysisAdd BLAST	55

GO - Cellular componentⁱ

integral component of plasma membrane
Source: ProtInc
Traceable author statementⁱ
- 8838812
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2838.
Open Targets More...OpenTargetsⁱ	ENSG00000154165.
PharmGKBⁱ	PA28858.

Polymorphism and mutation databases

DMDMⁱ	1346170.

DMDMⁱ

1346170.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069531	1 – 360	G-protein coupled receptor 15Add BLAST		360

Proteomic databases

PaxDbⁱ	P49685.
PeptideAtlas More...PeptideAtlasⁱ	P49685.
PRIDEⁱ	P49685.

PTM databases

iPTMnetⁱ	P49685.
PhosphoSitePlusⁱ	P49685.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000154165.
CleanExⁱ	HS_GPR15.
ExpressionAtlasⁱ	P49685. baseline and differential.
Genevisibleⁱ	P49685. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013775.

HPAⁱ

HPA013775.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109098. 2 interactors.
STRINGⁱ	9606.ENSP00000284311.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49685.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJEK. Eukaryota. ENOG410YCV2. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119055.
HOGENOMⁱ	HOG000077773.
HOVERGENⁱ	HBG101112.
InParanoidⁱ	P49685.
KEGG Orthology (KO) More...KOⁱ	K08403.
OMAⁱ	FLLTCMS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AX0.
PhylomeDBⁱ	P49685.
TreeFamⁱ	TF330024.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P49685-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG 
        60         70         80         90        100
NLVLMGALHF KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR 
       110        120        130        140        150
TGSFLCKGSS YMISVNMHCS VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA 
       160        170        180        190        200
YVVCASIWFI SCLLGLPTLL SRELTLIDDK PYCAEKKATP IKLIWSLVAL 
       210        220        230        240        250
IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI KIIFIVVAAF 
       260        270        280        290        300
LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF 
       310        320        330        340        350
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF 
       360
ARRRKRSVSL

Length:360

Mass (Da):40,787

Last modified:February 1, 1996 - v1

Checksum:ⁱF781F28B7E312390

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020075	37	P → S. Corresponds to variant dbSNP:rs2230344Ensembl.		1
Natural variantⁱVAR_049391	112	M → V. Corresponds to variant dbSNP:rs35320046Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34806 Genomic DNA. Translation: AAC50826.1. BC069437 mRNA. Translation: AAH69437.1. BC101779 mRNA. Translation: AAI01780.1. BC101781 mRNA. Translation: AAI01782.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2931.1.
PIRⁱ	G02064.
NCBI Reference Sequences More...RefSeqⁱ	NP_005281.1. NM_005290.3.
UniGeneⁱ	Hs.162987. Hs.563128.

Genome annotation databases

Ensemblⁱ	ENST00000284311; ENSP00000284311; ENSG00000154165.
GeneIDⁱ	2838.
KEGGⁱ	hsa:2838.
UCSC genome browser More...UCSCⁱ	uc011bgy.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34806 Genomic DNA. Translation: AAC50826.1. BC069437 mRNA. Translation: AAH69437.1. BC101779 mRNA. Translation: AAI01780.1. BC101781 mRNA. Translation: AAI01782.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2931.1.
PIRⁱ	G02064.
NCBI Reference Sequences More...RefSeqⁱ	NP_005281.1. NM_005290.3.
UniGeneⁱ	Hs.162987. Hs.563128.

3D structure databases

ProteinModelPortalⁱ	P49685.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109098. 2 interactors.
STRINGⁱ	9606.ENSP00000284311.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P49685.
PhosphoSitePlusⁱ	P49685.

Polymorphism and mutation databases

DMDMⁱ	1346170.

DMDMⁱ

1346170.

Proteomic databases

PaxDbⁱ	P49685.
PeptideAtlas More...PeptideAtlasⁱ	P49685.
PRIDEⁱ	P49685.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2838.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000284311; ENSP00000284311; ENSG00000154165.
GeneIDⁱ	2838.
KEGGⁱ	hsa:2838.
UCSC genome browser More...UCSCⁱ	uc011bgy.3. human.

Organism-specific databases

CTDⁱ	2838.
DisGeNET More...DisGeNETⁱ	2838.
GeneCardsⁱ	GPR15.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4469. GPR15.
Human Protein Atlas More...HPAⁱ	HPA013775.
MIMⁱ	601166. gene.
neXtProtⁱ	NX_P49685.
Open Targets More...OpenTargetsⁱ	ENSG00000154165.
PharmGKBⁱ	PA28858.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJEK. Eukaryota. ENOG410YCV2. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119055.
HOGENOMⁱ	HOG000077773.
HOVERGENⁱ	HBG101112.
InParanoidⁱ	P49685.
KEGG Orthology (KO) More...KOⁱ	K08403.
OMAⁱ	FLLTCMS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AX0.
PhylomeDBⁱ	P49685.
TreeFamⁱ	TF330024.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555. G alpha (s) signalling events.

Reactomeⁱ

R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiⁱ	GPR15.
GenomeRNAiⁱ	2838.
Protein Ontology More...PROⁱ	PR:P49685.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154165.
CleanExⁱ	HS_GPR15.
ExpressionAtlasⁱ	P49685. baseline and differential.
Genevisibleⁱ	P49685. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPR15_HUMAN
Accessionⁱ	P49685Primary (citable) accession number: P49685 Secondary accession number(s): Q3MIL4, Q6ISN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	June 7, 2017
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49685 (GPR15_HUMAN)

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G-protein coupled receptor 15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ