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Protein

Urotensin-2 receptor

Gene

Uts2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • urotensin II receptor activity Source: RGD

GO - Biological processi

  • negative regulation of blood pressure Source: RGD
  • negative regulation of glomerular filtration Source: RGD
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of circadian sleep/wake cycle, REM sleep Source: RGD
  • positive regulation of circadian sleep/wake cycle, wakefulness Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • regulation of vasodilation Source: InterPro
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Urotensin-2 receptor
Short name:
UR-2-R
Alternative name(s):
G-protein coupled receptor 14
G-protein coupled sensory epithelial neuropeptide-like receptor
Short name:
SENR
Urotensin II receptor
Short name:
UR-II-R
Gene namesi
Name:Uts2r
Synonyms:Gpr14, Senr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621884. Uts2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence analysisAdd
BLAST
Transmembranei55 – 7723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 8710CytoplasmicSequence analysis
Transmembranei88 – 11326Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini114 – 12411ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14622Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini147 – 16721CytoplasmicSequence analysisAdd
BLAST
Transmembranei168 – 18619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini187 – 20923ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 25826CytoplasmicSequence analysisAdd
BLAST
Transmembranei259 – 28426Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini285 – 29915ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32122Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini322 – 38665CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • early endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
  • recycling endosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4921.
GuidetoPHARMACOLOGYi365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Urotensin-2 receptorPRO_0000070196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49684.
PRIDEiP49684.

Expressioni

Tissue specificityi

Preferentially expressed in neural and sensory tissues.

Gene expression databases

GenevisibleiP49684. RN.

Interactioni

Protein-protein interaction databases

BioGridi248616. 1 interaction.
STRINGi10116.ENSRNOP00000051809.

Chemistry

BindingDBiP49684.

Structurei

3D structure databases

ProteinModelPortaliP49684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiP49684.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG76QFHM.
PhylomeDBiP49684.
TreeFamiTF334200.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLESTTS FHMLTVSGST VTELPGDSNV SLNSSWSGPT DPSSLKDLVA
60 70 80 90 100
TGVIGAVLSA MGVVGMVGNV YTLVVMCRFL RASASMYVYV VNLALADLLY
110 120 130 140 150
LLSIPFIIAT YVTKDWHFGD VGCRVLFSLD FLTMHASIFT LTIMSSERYA
160 170 180 190 200
AVLRPLDTVQ RSKGYRKLLV LGTWLLALLL TLPMMLAIQL VRRGSKSLCL
210 220 230 240 250
PAWGPRAHRT YLTLLFGTSI VGPGLVIGLL YVRLARAYWL SQQASFKQTR
260 270 280 290 300
RLPNPRVLYL ILGIVLLFWA CFLPFWLWQL LAQYHEAMPL TPETARIVNY
310 320 330 340 350
LTTCLTYGNS CINPFLYTLL TKNYREYLRG RQRSLGSSCH SPGSPGSFLP
360 370 380
SRVHLQQDSG RSLSSSSQQA TETLMLSPVP RNGALL
Length:386
Mass (Da):42,707
Last modified:July 15, 1999 - v2
Checksum:iFA4E95CC6A4CA27C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti315 – 3151F → L in AAC52593 (PubMed:8666380).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32673 Genomic DNA. Translation: AAC52593.1.
U23483 Genomic DNA. Translation: AAA80111.1.
AB012210 mRNA. Translation: BAA25251.1.
AB029611 mRNA. Translation: BAA82357.1.
PIRiI84612.
RefSeqiNP_065412.1. NM_020537.1.
UniGeneiRn.44230.

Genome annotation databases

EnsembliENSRNOT00000054926; ENSRNOP00000051809; ENSRNOG00000036669.
GeneIDi57305.
KEGGirno:57305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32673 Genomic DNA. Translation: AAC52593.1.
U23483 Genomic DNA. Translation: AAA80111.1.
AB012210 mRNA. Translation: BAA25251.1.
AB029611 mRNA. Translation: BAA82357.1.
PIRiI84612.
RefSeqiNP_065412.1. NM_020537.1.
UniGeneiRn.44230.

3D structure databases

ProteinModelPortaliP49684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248616. 1 interaction.
STRINGi10116.ENSRNOP00000051809.

Chemistry

BindingDBiP49684.
ChEMBLiCHEMBL4921.
GuidetoPHARMACOLOGYi365.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP49684.
PRIDEiP49684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054926; ENSRNOP00000051809; ENSRNOG00000036669.
GeneIDi57305.
KEGGirno:57305.

Organism-specific databases

CTDi2837.
RGDi621884. Uts2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00670000098072.
HOGENOMiHOG000060074.
HOVERGENiHBG098595.
InParanoidiP49684.
KOiK04241.
OMAiTVMSSER.
OrthoDBiEOG76QFHM.
PhylomeDBiP49684.
TreeFamiTF334200.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi611318.
PROiP49684.

Gene expression databases

GenevisibleiP49684. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000670. Urot_II_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00647. UROTENSIN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors."
    Marchese A., Heiber M., Nguyen T., Heng H.H.Q., Saldivia V.R., Cheng R., Murphy P.M., Tsui L.-C., Shi X., Gregor P., George S.R., O'Dowd B.F., Docherty J.M.
    Genomics 29:335-344(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia."
    Tal M., Ammar D.A., Karpuj M., Krizhanovsky V., Naim M., Thompson D.A.
    Biochem. Biophys. Res. Commun. 209:752-759(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Circumvallate papilla.
  3. "Expression of the rat SENR in the urinary bladder tissues."
    Suga H., Takao K.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Urinary bladder.
  4. "The SENR/GPR14 expresses in rat pheochromocytoma PC 12 cells."
    Liu H., Zou M., Suga H., Takao K.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  5. "Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain."
    Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.
    Biochem. Biophys. Res. Commun. 310:860-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A UROTENSIN-2B RECEPTOR.

Entry informationi

Entry nameiUR2R_RAT
AccessioniPrimary (citable) accession number: P49684
Secondary accession number(s): P48041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.