Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropeptides B/W receptor type 1

Gene

Npbwr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • regulation of metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:Npbwr1
Synonyms:Gpr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:891989. Npbwr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7511CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11216ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15825CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 20930ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 25020CytoplasmicSequence analysisAdd
BLAST
Transmembranei251 – 27121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 28918ExtracellularSequence analysisAdd
BLAST
Transmembranei290 – 31223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini313 – 32917CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1938219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Neuropeptides B/W receptor type 1PRO_0000069519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49681.
PRIDEiP49681.

Expressioni

Gene expression databases

BgeeiP49681.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046233.

Chemistry

BindingDBiP49681.

Structurei

3D structure databases

ProteinModelPortaliP49681.
SMRiP49681. Positions 4-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP49681.
KOiK05268.
OMAiLGCPNAS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP49681.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNLTLFESG GDNVSCGGSS LGCPNGSSLA PLPLPQPLAV AVPVVYGVIC
60 70 80 90 100
AVGLAGNSAV LYVLLRTPRM KTVTNVFILN LAIADELFTL VLPINIADFL
110 120 130 140 150
LRRWPFGEVM CKLIVAVDQY NTFSSLYFLA VMSADRYLVV LATAESRRVS
160 170 180 190 200
GRTYGAARAV SLAVWALVTL VVLPFAVFAR LDEEQGRRQC VLVFPQPEAF
210 220 230 240 250
WWRASRLYTL VLGFAIPVTT ICALYTTLLC RLRAIQLDSH AKALDRAKKR
260 270 280 290 300
VTLLVAAILA VCLLCWTPYH LSTIVALTTD LPQTPLVIGI SYFITSLSYA
310 320
NSCLNPFLYA FLDDSFRRSL RQLVSCRSA
Length:329
Mass (Da):36,076
Last modified:January 9, 2007 - v2
Checksum:iF6100C1F58377EDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118196 Genomic DNA. No translation available.
U23807 Genomic DNA. Translation: AAA86386.1.
CCDSiCCDS48214.1.
RefSeqiNP_034472.1. NM_010342.1.
UniGeneiMm.291110.

Genome annotation databases

EnsembliENSMUST00000044180; ENSMUSP00000046233; ENSMUSG00000033774.
GeneIDi226304.
KEGGimmu:226304.
UCSCiuc011whw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118196 Genomic DNA. No translation available.
U23807 Genomic DNA. Translation: AAA86386.1.
CCDSiCCDS48214.1.
RefSeqiNP_034472.1. NM_010342.1.
UniGeneiMm.291110.

3D structure databases

ProteinModelPortaliP49681.
SMRiP49681. Positions 4-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046233.

Chemistry

BindingDBiP49681.
ChEMBLiCHEMBL1938219.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP49681.
PRIDEiP49681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044180; ENSMUSP00000046233; ENSMUSG00000033774.
GeneIDi226304.
KEGGimmu:226304.
UCSCiuc011whw.1. mouse.

Organism-specific databases

CTDi2831.
MGIiMGI:891989. Npbwr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP49681.
KOiK05268.
OMAiLGCPNAS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP49681.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi378100.
PROiP49681.
SOURCEiSearch...

Gene expression databases

BgeeiP49681.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain."
    O'Dowd B.F., Scheideler M.A., Nguyen T., Cheng R., Rasmussen J.S., Marchese A., Zastawny R., Heng H.H.Q., Tsui L.-C., Shi X., Asa S., Puy L., George S.R.
    Genomics 28:84-91(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-221.

Entry informationi

Entry nameiNPBW1_MOUSE
AccessioniPrimary (citable) accession number: P49681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.