Reviewed, UniProtKB/Swiss-Prot P49673 (KAPC_ASCSU)

Names and origin

Protein names

Recommended name:
    cAMP-dependent protein kinase catalytic subunit
      Short name=PKA C
    EC=2.7.11.11

Gene names

Name:

CAPK

Organism

Ascaris suum (Pig roundworm) (Ascaris lumbricoides)

Taxonomic identifier

6253 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Ascarididae › Ascaris

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Phosphorylates phosphofructokinase to activate it.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Composed of two regulatory chains and two catalytic chains By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding cAMP
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cAMP-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	cAMP-dependent protein kinase catalytic subunit		PRO_0000086066
Regions
	Domain	29 – 283	255	Protein kinase
	Domain	284 – 337	54	AGC-kinase C-terminal
	Nucleotide binding	35 – 43	9	ATP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	58	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49673-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 5D031EC3AF403E5D	FASTA	337	39,172
	10 20 30 40 50 60 MENREQEEIE PCVSITIDPN NNKLNVDDFD RICTIGTGSF GRVYLVQHRA SEQYFALKKM 70 80 90 100 110 120 AIREVVSMRQ TEHVHSEKRL LSRLSHPFIV KMYCASWDKY NLYMLFEYLA GGELFSYLRA 130 140 150 160 170 180 SRTFSNSMAR FYAAEIVCAL QYLHSKNIAY RDLKPENLML NKEGHLKMTD FGFAKEVIDR 190 200 210 220 230 240 TWTMCGTPEY LAPEVIGNKG HDTAVDWWSL GVLIYEMMIG IPPFRGKTLD EIYEKIILGK 250 260 270 280 290 300 LRFTRSFDLF AKDLVKKLLQ VDRTQRLGNQ KDGAADVMNH KWFTDIDWDD VQNMKLTPPI 310 320 330 IPTLYSNGDT GNFDSYDECS DDEIAAPQHE LELFEDW

References

[1]

"The catalytic subunit of cAMP-dependent protein kinase from Ascaris suum. The cloning and structure of a novel subtype of protein kinase A." Jung S., Hoffmann R., Rodriguez P.H., Mutzel R., Hofer H.W. Eur. J. Biochem. 232:111-117(1995) [PubMed: 7556139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X69806 mRNA. Translation: CAA49464.1.
PIR	S66515.
3D structure databases
HSSP	HSSP built from PDB template 1CTP based on UniProtKB P36887.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.11. 649.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAPC_ASCSU

Accession

Primary (citable) accession number: P49673

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)