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Protein

Somatostatin

Gene

SST

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 34

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Propeptidei25 – 8864By similarityPRO_0000033083Add
BLAST
Peptidei89 – 11628Somatostatin-28PRO_0000033084Add
BLAST
Peptidei103 – 11614Somatostatin-14PRO_0000033085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP49670.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020465.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP49670.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG7H4DXK.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALSIVLALG GVTCAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,736
Last modified:February 1, 1996 - v1
Checksum:iAB49BD231E731C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42325 mRNA. Translation: AAA67099.1.
RefSeqiNP_001003307.1. NM_001003307.1.
UniGeneiCfa.3860.

Genome annotation databases

EnsembliENSCAFT00000022039; ENSCAFP00000020465; ENSCAFG00000013891.
GeneIDi403993.
KEGGicfa:403993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42325 mRNA. Translation: AAA67099.1.
RefSeqiNP_001003307.1. NM_001003307.1.
UniGeneiCfa.3860.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020465.

Proteomic databases

PaxDbiP49670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000022039; ENSCAFP00000020465; ENSCAFG00000013891.
GeneIDi403993.
KEGGicfa:403993.

Organism-specific databases

CTDi6750.

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP49670.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG7H4DXK.
TreeFamiTF333185.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Canine prosomatostatin: isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates."
    Dickinson C.J., Delvalle J., Todisco A., Gantz I., Tong L., Finniss S., Yamada T.
    Regul. Pept. 67:145-152(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gastric mucosa.

Entry informationi

Entry nameiSMS_CANLF
AccessioniPrimary (citable) accession number: P49670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.