P49660 (SSR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 4
Short name=SS-4-R
Short name=SS4-R
Short name=SS4R

Gene names

Name:	Sstr4
Synonyms:	Smstr4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	somatostatin signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	somatostatin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Somatostatin receptor type 4		PRO_0000070128
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 69	28	Helical; Name=1; Potential
	Topological domain	70 – 79	10	Cytoplasmic Potential
	Transmembrane	80 – 105	26	Helical; Name=2; Potential
	Topological domain	106 – 116	11	Extracellular Potential
	Transmembrane	117 – 138	22	Helical; Name=3; Potential
	Topological domain	139 – 160	22	Cytoplasmic Potential
	Transmembrane	161 – 181	21	Helical; Name=4; Potential
	Topological domain	182 – 203	22	Extracellular Potential
	Transmembrane	204 – 228	25	Helical; Name=5; Potential
	Topological domain	229 – 254	26	Cytoplasmic Potential
	Transmembrane	255 – 280	26	Helical; Name=6; Potential
	Topological domain	281 – 287	7	Extracellular Potential
	Transmembrane	288 – 311	24	Helical; Name=7; Potential
	Topological domain	312 – 384	73	Cytoplasmic Potential
Amino acid modifications
	Lipidation	323	1	S-palmitoyl cysteine Potential
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	115 ↔ 194		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49660 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 04DB0751481C6BFB	FASTA	384	42,090
	10 20 30 40 50 60 MNAPATLLRG VEDTTWTPGI NASWAPEQEE DAMGSDGTGT AGMVTIQCIY ALVCLVGLVG 70 80 90 100 110 120 NALVIFVILR YAKMKTATNI YLLNLAVADE LFMLSVPFVR SAAALRHWPF GAVLCRAVLS 130 140 150 160 170 180 VDGLNMFTSV FCLTVLSVDR YVAVVHPLRT ATYRRPSVAK LINLGVWLAS LLVTLPIAVF 190 200 210 220 230 240 ADTRPARGGE AVACNLHWPH PAWSAVFVIY TFLLGFLPPV LAIGLCYLLI VGKMRAVALR 250 260 270 280 290 300 GGWQQRRRSE KKITRLVLMV VTVFVLCWMP FYVVQLLNLF VTSLDATVNH VSLILSYANS 310 320 330 340 350 360 CANPILYGFL SDNFRRSFQR VLCLRCCLLE TTGGAEEEPL DYYATALKSR GGAGCICPPL 370 380 PCQQEPVQAE PGCKQVPFTK TTTF

References

[1]	"Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4)." Schwabe W., Brennan M.B., Hochgeschwender U. Gene 168:233-235(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U26176 Genomic DNA. Translation: AAA67561.1.
IPI	IPI00116214.
PIR	JC4629.
UniGene	Mm.35324.
3D structure databases
ProteinModelPortal	P49660.
SMR	P49660. Positions 44-319.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6504774.
STRING	10090.ENSMUSP00000105588.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P49660.
Proteomic databases
PRIDE	P49660.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:105372. Sstr4.
Phylogenomic databases
eggNOG	NOG235424.
HOVERGEN	HBG106919.
InParanoid	P49660.
OrthoDB	EOG44J2J9.
Gene expression databases
CleanEx	MM_SSTR4.
Genevestigator	P49660.
GermOnline	ENSMUSG00000037014. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001512. Somatstn_rcpt_4. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00590. SOMATOSTTN4R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49660.
ChEMBL	CHEMBL4397.
SOURCE	Search...

Entry information

Entry name

SSR4_MOUSE

Accession

Primary (citable) accession number: P49660

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program