P49660 (SSR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 95.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Somatostatin receptor type 4 Short name=SS-4-R Short name=SS4-R Short name=SS4R | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 384 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | somatostatin signaling pathway Inferred from electronic annotation. Source: GOC |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | somatostatin receptor activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 384 | 384 | Somatostatin receptor type 4 | PRO_0000070128 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 41 | 41 | Extracellular Potential | ||||||||
| Transmembrane | 42 – 69 | 28 | Helical; Name=1; Potential | ||||||||
| Topological domain | 70 – 79 | 10 | Cytoplasmic Potential | ||||||||
| Transmembrane | 80 – 105 | 26 | Helical; Name=2; Potential | ||||||||
| Topological domain | 106 – 116 | 11 | Extracellular Potential | ||||||||
| Transmembrane | 117 – 138 | 22 | Helical; Name=3; Potential | ||||||||
| Topological domain | 139 – 160 | 22 | Cytoplasmic Potential | ||||||||
| Transmembrane | 161 – 181 | 21 | Helical; Name=4; Potential | ||||||||
| Topological domain | 182 – 203 | 22 | Extracellular Potential | ||||||||
| Transmembrane | 204 – 228 | 25 | Helical; Name=5; Potential | ||||||||
| Topological domain | 229 – 254 | 26 | Cytoplasmic Potential | ||||||||
| Transmembrane | 255 – 280 | 26 | Helical; Name=6; Potential | ||||||||
| Topological domain | 281 – 287 | 7 | Extracellular Potential | ||||||||
| Transmembrane | 288 – 311 | 24 | Helical; Name=7; Potential | ||||||||
| Topological domain | 312 – 384 | 73 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 323 | 1 | S-palmitoyl cysteine Potential | ||||||||
| Glycosylation | 21 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 115 ↔ 194 | By similarity | |||||||||
Sequences
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References
| [1] | "Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4)." Schwabe W., Brennan M.B., Hochgeschwender U. Gene 168:233-235(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U26176 Genomic DNA. Translation: AAA67561.1. |
| IPI | IPI00116214. |
| PIR | JC4629. |
| UniGene | Mm.35324. |
3D structure databases | |
| ProteinModelPortal | P49660. |
| SMR | P49660. Positions 44-319. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-6504774. |
| STRING | 10090.ENSMUSP00000105588. |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | P49660. |
Proteomic databases | |
| PRIDE | P49660. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| MGI | MGI:105372. Sstr4. |
Phylogenomic databases | |
| eggNOG | NOG235424. |
| HOVERGEN | HBG106919. |
| InParanoid | P49660. |
| OrthoDB | EOG44J2J9. |
Gene expression databases | |
| CleanEx | MM_SSTR4. |
| Genevestigator | P49660. |
| GermOnline | ENSMUSG00000037014. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001512. Somatstn_rcpt_4. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00590. SOMATOSTTN4R. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | P49660. |
| ChEMBL | CHEMBL4397. |
| SOURCE | Search... |
Entry information
| Entry name | SSR4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P49660 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
