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Protein

Somatostatin receptor type 4

Gene

Sstr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:Sstr4
Synonyms:Smstr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105372. Sstr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 7028Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini71 – 8010CytoplasmicSequence analysis
Transmembranei81 – 10626Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini107 – 11711ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence analysisAdd
BLAST
Transmembranei162 – 18221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini183 – 20422ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22925Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 25526CytoplasmicSequence analysisAdd
BLAST
Transmembranei256 – 28126Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 2887ExtracellularSequence analysis
Transmembranei289 – 31224Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini313 – 38573CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111427.
GuidetoPHARMACOLOGYi358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Somatostatin receptor type 4PRO_0000070128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 195PROSITE-ProRule annotation
Lipidationi324 – 3241S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP49660.
PRIDEiP49660.

PTM databases

PhosphoSiteiP49660.

Expressioni

Gene expression databases

CleanExiMM_SSTR4.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621083EBI-7665342,EBI-300895

Protein-protein interaction databases

IntActiP49660. 2 interactions.
MINTiMINT-6504774.
STRINGi10090.ENSMUSP00000044573.

Structurei

3D structure databases

ProteinModelPortaliP49660.
SMRiP49660. Positions 45-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP49660.
KOiK04220.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPATLPPG VEDTTWTPGI NASWAPDEEE EDAMGSDGTG TAGMVTIQCI
60 70 80 90 100
YALVCLVGLV GNALVIFVIL RYAKMKTATN IYLLNLAVAD ELFMLSVPFA
110 120 130 140 150
RSAAALRHWP FGAVLCRAVL SVDGLNMFTS VFCLTVLSVD RYVAVVHPLA
160 170 180 190 200
TATYRRPSVA KLINLGVWLA SLLVTLPIAV FADTRPARGG EAVACNLHWP
210 220 230 240 250
HPAWSAVFVI YTFLLGFLPP VLAIGLCYLL IVGKMRAVAL AGGWQQRRRS
260 270 280 290 300
EKKITRLVLM VVTVFVLCWM PFYVVQLLNL FVTSLDATVN HVSLILSYAN
310 320 330 340 350
SCANPILYGF LSDNFRRSFQ RVLCLRCCLL ETTGGAEEEP LDYYATALKS
360 370 380
RGGAGCICPP LPCQQEPVQA EPGCKQVPFT KTTTF
Length:385
Mass (Da):41,932
Last modified:October 16, 2013 - v2
Checksum:i64B3A272947A81BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92PP → LR in AAA67561 (PubMed:8654950).Curated
Sequence conflicti27 – 293DEE → EQ in AAA67561 (PubMed:8654950).Curated
Sequence conflicti100 – 1001A → V in AAA67561 (PubMed:8654950).Curated
Sequence conflicti150 – 1501A → R in AAA67561 (PubMed:8654950).Curated
Sequence conflicti241 – 2411A → R in AAA67561 (PubMed:8654950).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26176 Genomic DNA. Translation: AAA67561.1.
AY902332 Genomic DNA. Translation: AAX90617.1.
AK051189 mRNA. Translation: BAC34552.1.
AL935149 Genomic DNA. No translation available.
BC138487 mRNA. Translation: AAI38488.1.
BC138488 mRNA. Translation: AAI38489.1.
CCDSiCCDS38260.1.
PIRiJC4629.
RefSeqiNP_033245.2. NM_009219.3.
UniGeneiMm.35324.

Genome annotation databases

GeneIDi20608.
KEGGimmu:20608.
UCSCiuc008mtc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26176 Genomic DNA. Translation: AAA67561.1.
AY902332 Genomic DNA. Translation: AAX90617.1.
AK051189 mRNA. Translation: BAC34552.1.
AL935149 Genomic DNA. No translation available.
BC138487 mRNA. Translation: AAI38488.1.
BC138488 mRNA. Translation: AAI38489.1.
CCDSiCCDS38260.1.
PIRiJC4629.
RefSeqiNP_033245.2. NM_009219.3.
UniGeneiMm.35324.

3D structure databases

ProteinModelPortaliP49660.
SMRiP49660. Positions 45-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49660. 2 interactions.
MINTiMINT-6504774.
STRINGi10090.ENSMUSP00000044573.

Chemistry

ChEMBLiCHEMBL2111427.
GuidetoPHARMACOLOGYi358.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP49660.

Proteomic databases

PaxDbiP49660.
PRIDEiP49660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20608.
KEGGimmu:20608.
UCSCiuc008mtc.1. mouse.

Organism-specific databases

CTDi6754.
MGIiMGI:105372. Sstr4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP49660.
KOiK04220.
OrthoDBiEOG7BKCVQ.
TreeFamiTF315737.

Miscellaneous databases

NextBioi298959.
PROiP49660.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SSTR4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4)."
    Schwabe W., Brennan M.B., Hochgeschwender U.
    Gene 168:233-235(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  2. "Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains."
    Farber C.R., Corva P.M., Medrano J.F.
    BMC Genomics 7:102-102(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CAST/EiJ.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal ganglion.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSSR4_MOUSE
AccessioniPrimary (citable) accession number: P49660
Secondary accession number(s): Q8BQ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 16, 2013
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.