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Protein

ATP-sensitive inward rectifier potassium channel 10

Gene

Kcnj10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei158Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 217ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • inflammatory response Source: RGD
  • L-glutamate import Source: RGD
  • membrane hyperpolarization Source: RGD
  • optic nerve development Source: RGD
  • potassium ion import Source: RGD
  • protein homotetramerization Source: RGD
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • regulation of sensory perception of pain Source: RGD
  • response to blue light Source: RGD
  • response to glucocorticoid Source: RGD
  • response to mineralocorticoid Source: RGD

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 10
Alternative name(s):
ATP-sensitive inward rectifier potassium channel KAB-2
BIR10
Brain-specific inwardly rectifying K(+) channel 1
Short name:
BIRK1
Inward rectifier K(+) channel Kir4.1
Potassium channel, inwardly rectifying subfamily J member 10
Gene namesi
Name:Kcnj10
Synonyms:Kab-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61822 Kcnj10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64CytoplasmicBy similarityAdd BLAST64
Transmembranei65 – 89Helical; Name=M1By similarityAdd BLAST25
Topological domaini90 – 114ExtracellularBy similarityAdd BLAST25
Intramembranei115 – 126Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei127 – 133Pore-formingBy similarity7
Topological domaini134 – 142ExtracellularBy similarity9
Transmembranei143 – 164Helical; Name=M2By similarityAdd BLAST22
Topological domaini165 – 379CytoplasmicBy similarityAdd BLAST215

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549551 – 379ATP-sensitive inward rectifier potassium channel 10Add BLAST379

Proteomic databases

PaxDbiP49655
PRIDEiP49655

PTM databases

iPTMnetiP49655
PhosphoSitePlusiP49655

Expressioni

Tissue specificityi

Predominantly expressed in the brain, including in glial cells of the cerebellum and forebrain. Expressed at lower levels in the kidney, and other peripheral tissues.2 Publications

Gene expression databases

GenevisibleiP49655 RN

Interactioni

Subunit structurei

Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells (By similarity). Interacts with PATJ (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi248335, 2 interactors
CORUMiP49655
IntActiP49655, 3 interactors
MINTiP49655
STRINGi10116.ENSRNOP00000010146

Structurei

3D structure databases

ProteinModelPortaliP49655
SMRiP49655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi128 – 133Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
HOGENOMiHOG000237326
HOVERGENiHBG006178
InParanoidiP49655
KOiK05003
OrthoDBiEOG091G08HC
PhylomeDBiP49655
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003269 K_chnl_inward-rec_Kir1.2
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF21 PTHR11767:SF21, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01322 KIR12CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P49655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL
60 70 80 90 100
YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG
110 120 130 140 150
PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ
160 170 180 190 200
LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVAYH NGKLCLMIRV
210 220 230 240 250
ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI
260 270 280 290 300
LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY
310 320 330 340 350
LPEEILWGYE FTPAISLSAS GKYVADFSLF DQVVKVASPG GLRDSTVRYG
360 370
DPEKLKLEES LREQAEKEGS ALSVRISNV
Length:379
Mass (Da):42,480
Last modified:February 1, 1996 - v1
Checksum:i77B3671907B68CB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → P in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti76A → T in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti110 – 112VQV → GAGA (PubMed:7624316).Curated3
Sequence conflicti115 – 116LT → YL (PubMed:7624316).Curated2
Sequence conflicti145V → E in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti190H → L in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti228N → D in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti266K → Q in AAA87811 (PubMed:7624316).Curated1
Sequence conflicti304E → R in CAA58568 (PubMed:7874445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86818 mRNA Translation: CAA60501.1
X83585 mRNA Translation: CAA58568.1
U27558 mRNA Translation: AAA87811.1
PIRiA57477
RefSeqiNP_113790.2, NM_031602.2
XP_008767959.1, XM_008769737.2
XP_017454263.1, XM_017598774.1
UniGeneiRn.10196

Genome annotation databases

GeneIDi29718
KEGGirno:29718
UCSCiRGD:61822 rat

Similar proteinsi

Entry informationi

Entry nameiKCJ10_RAT
AccessioniPrimary (citable) accession number: P49655
Secondary accession number(s): Q62790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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