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P49655

- KCJ10_RAT

UniProt

P49655 - KCJ10_RAT

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Protein
ATP-sensitive inward rectifier potassium channel 10
Gene
Kcnj10, Kab-2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei158 – 1581Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2178ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. identical protein binding Source: RGD
  3. inward rectifier potassium channel activity Source: Ensembl
  4. protein binding Source: UniProtKB
  5. receptor binding Source: RGD

GO - Biological processi

  1. L-glutamate import Source: RGD
  2. L-glutamate uptake involved in synaptic transmission Source: Ensembl
  3. adult walking behavior Source: Ensembl
  4. central nervous system myelination Source: Ensembl
  5. inflammatory response Source: RGD
  6. membrane hyperpolarization Source: RGD
  7. optic nerve development Source: RGD
  8. potassium ion homeostasis Source: Ensembl
  9. potassium ion import Source: RGD
  10. protein homotetramerization Source: RGD
  11. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  12. regulation of resting membrane potential Source: Ensembl
  13. regulation of sensory perception of pain Source: RGD
  14. response to blue light Source: RGD
  15. response to glucocorticoid Source: RGD
  16. response to mineralocorticoid Source: RGD
  17. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199204. Potassium transport channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 10
Alternative name(s):
ATP-sensitive inward rectifier potassium channel KAB-2
BIR10
Brain-specific inwardly rectifying K(+) channel 1
Short name:
BIRK1
Inward rectifier K(+) channel Kir4.1
Potassium channel, inwardly rectifying subfamily J member 10
Gene namesi
Name:Kcnj10
Synonyms:Kab-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi61822. Kcnj10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Cytoplasmic By similarity
Add
BLAST
Transmembranei65 – 8925Helical; Name=M1; By similarity
Add
BLAST
Topological domaini90 – 11425Extracellular By similarity
Add
BLAST
Intramembranei115 – 12612Helical; Pore-forming; Name=H5; By similarity
Add
BLAST
Intramembranei127 – 1337Pore-forming; By similarity
Topological domaini134 – 1429Extracellular By similarity
Transmembranei143 – 16422Helical; Name=M2; By similarity
Add
BLAST
Topological domaini165 – 379215Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. basolateral plasma membrane Source: RGD
  3. dystrophin-associated glycoprotein complex Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379ATP-sensitive inward rectifier potassium channel 10
PRO_0000154955Add
BLAST

Proteomic databases

PaxDbiP49655.
PRIDEiP49655.

PTM databases

PhosphoSiteiP49655.

Expressioni

Tissue specificityi

Predominantly in glial cells of the cerebellum and forebrain. Expressed to a lesser extent in the kidney, and other peripheral tissues.

Gene expression databases

GenevestigatoriP49655.

Interactioni

Subunit structurei

Interacts with INADL By similarity. Seems to form heterodimer with Kir5.1/KCNJ16.

Protein-protein interaction databases

BioGridi248335. 2 interactions.
IntActiP49655. 3 interactions.
MINTiMINT-103719.
STRINGi10116.ENSRNOP00000010146.

Structurei

3D structure databases

ProteinModelPortaliP49655.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi128 – 1336Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284842.
GeneTreeiENSGT00690000102074.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiP49655.
KOiK05003.
OMAiFYHVVDD.
OrthoDBiEOG7GFB4Z.
PhylomeDBiP49655.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P49655-1 [UniParc]FASTAAdd to Basket

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MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL    50
YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG 100
PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ 150
LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVAYH NGKLCLMIRV 200
ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI 250
LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 300
LPEEILWGYE FTPAISLSAS GKYVADFSLF DQVVKVASPG GLRDSTVRYG 350
DPEKLKLEES LREQAEKEGS ALSVRISNV 379
Length:379
Mass (Da):42,480
Last modified:February 1, 1996 - v1
Checksum:i77B3671907B68CB2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731A → P in AAA87811. 1 Publication
Sequence conflicti76 – 761A → T in AAA87811. 1 Publication
Sequence conflicti110 – 1123VQV → GAGA1 Publication
Sequence conflicti115 – 1162LT → YL1 Publication
Sequence conflicti145 – 1451V → E in AAA87811. 1 Publication
Sequence conflicti190 – 1901H → L in AAA87811. 1 Publication
Sequence conflicti228 – 2281N → D in AAA87811. 1 Publication
Sequence conflicti266 – 2661K → Q in AAA87811. 1 Publication
Sequence conflicti304 – 3041E → R in CAA58568. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86818 mRNA. Translation: CAA60501.1.
X83585 mRNA. Translation: CAA58568.1.
U27558 mRNA. Translation: AAA87811.1.
PIRiA57477.
RefSeqiNP_113790.1. NM_031602.1.
UniGeneiRn.10196.

Genome annotation databases

EnsembliENSRNOT00000010146; ENSRNOP00000010146; ENSRNOG00000007705.
GeneIDi29718.
KEGGirno:29718.
UCSCiRGD:61822. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86818 mRNA. Translation: CAA60501.1 .
X83585 mRNA. Translation: CAA58568.1 .
U27558 mRNA. Translation: AAA87811.1 .
PIRi A57477.
RefSeqi NP_113790.1. NM_031602.1.
UniGenei Rn.10196.

3D structure databases

ProteinModelPortali P49655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248335. 2 interactions.
IntActi P49655. 3 interactions.
MINTi MINT-103719.
STRINGi 10116.ENSRNOP00000010146.

Chemistry

GuidetoPHARMACOLOGYi 438.

PTM databases

PhosphoSitei P49655.

Proteomic databases

PaxDbi P49655.
PRIDEi P49655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010146 ; ENSRNOP00000010146 ; ENSRNOG00000007705 .
GeneIDi 29718.
KEGGi rno:29718.
UCSCi RGD:61822. rat.

Organism-specific databases

CTDi 3766.
RGDi 61822. Kcnj10.

Phylogenomic databases

eggNOGi NOG284842.
GeneTreei ENSGT00690000102074.
HOGENOMi HOG000237326.
HOVERGENi HBG006178.
InParanoidi P49655.
KOi K05003.
OMAi FYHVVDD.
OrthoDBi EOG7GFB4Z.
PhylomeDBi P49655.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_199204. Potassium transport channels.

Miscellaneous databases

NextBioi 610177.
PROi P49655.

Gene expression databases

Genevestigatori P49655.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells."
    Takumi T., Ishii T., Horio Y., Morishige K., Takahashi N., Yamada M., Yamashita T., Kiyama H., Sohmiya K., Nakanishi S., Kurachi Y.
    J. Biol. Chem. 270:16339-16346(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Cloning and expression of a family of inward rectifier potassium channels."
    Bond C.T., Pessia M., Xia X.-M., Lagrutta A., Kavanaugh M.P., Adelman J.P.
    Recept. Channels 2:183-191(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Cloning and expression of two brain-specific inwardly rectifying potassium channels."
    Bredt D.S., Wang T.L., Cohen N.A., Guggino W.B., Snyder S.H.
    Proc. Natl. Acad. Sci. U.S.A. 92:6753-6757(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCJ10_RAT
AccessioniPrimary (citable) accession number: P49655
Secondary accession number(s): Q62790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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