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P49655

- KCJ10_RAT

UniProt

P49655 - KCJ10_RAT

Protein

ATP-sensitive inward rectifier potassium channel 10

Gene

Kcnj10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei158 – 1581Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi210 – 2178ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. identical protein binding Source: RGD
    3. inward rectifier potassium channel activity Source: Ensembl
    4. protein binding Source: UniProtKB
    5. receptor binding Source: RGD

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. central nervous system myelination Source: Ensembl
    3. inflammatory response Source: RGD
    4. L-glutamate import Source: RGD
    5. L-glutamate uptake involved in synaptic transmission Source: Ensembl
    6. membrane hyperpolarization Source: RGD
    7. optic nerve development Source: RGD
    8. potassium ion homeostasis Source: Ensembl
    9. potassium ion import Source: RGD
    10. protein homotetramerization Source: RGD
    11. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    12. regulation of resting membrane potential Source: Ensembl
    13. regulation of sensory perception of pain Source: RGD
    14. response to blue light Source: RGD
    15. response to glucocorticoid Source: RGD
    16. response to mineralocorticoid Source: RGD
    17. visual perception Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199204. Potassium transport channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 10
    Alternative name(s):
    ATP-sensitive inward rectifier potassium channel KAB-2
    BIR10
    Brain-specific inwardly rectifying K(+) channel 1
    Short name:
    BIRK1
    Inward rectifier K(+) channel Kir4.1
    Potassium channel, inwardly rectifying subfamily J member 10
    Gene namesi
    Name:Kcnj10
    Synonyms:Kab-2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi61822. Kcnj10.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. astrocyte projection Source: RGD
    3. basolateral plasma membrane Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379ATP-sensitive inward rectifier potassium channel 10PRO_0000154955Add
    BLAST

    Proteomic databases

    PaxDbiP49655.
    PRIDEiP49655.

    PTM databases

    PhosphoSiteiP49655.

    Expressioni

    Tissue specificityi

    Predominantly in glial cells of the cerebellum and forebrain. Expressed to a lesser extent in the kidney, and other peripheral tissues.

    Gene expression databases

    GenevestigatoriP49655.

    Interactioni

    Subunit structurei

    Interacts with INADL By similarity. Seems to form heterodimer with Kir5.1/KCNJ16.By similarity

    Protein-protein interaction databases

    BioGridi248335. 2 interactions.
    IntActiP49655. 3 interactions.
    MINTiMINT-103719.
    STRINGi10116.ENSRNOP00000010146.

    Structurei

    3D structure databases

    ProteinModelPortaliP49655.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6464CytoplasmicBy similarityAdd
    BLAST
    Topological domaini90 – 11425ExtracellularBy similarityAdd
    BLAST
    Topological domaini134 – 1429ExtracellularBy similarity
    Topological domaini165 – 379215CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei115 – 12612Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei127 – 1337Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei65 – 8925Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei143 – 16422Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi128 – 1336Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284842.
    GeneTreeiENSGT00690000102074.
    HOGENOMiHOG000237326.
    HOVERGENiHBG006178.
    InParanoidiP49655.
    KOiK05003.
    OMAiFYHVVDD.
    OrthoDBiEOG7GFB4Z.
    PhylomeDBiP49655.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P49655-1 [UniParc]FASTAAdd to Basket

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    MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL    50
    YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG 100
    PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ 150
    LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVAYH NGKLCLMIRV 200
    ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI 250
    LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 300
    LPEEILWGYE FTPAISLSAS GKYVADFSLF DQVVKVASPG GLRDSTVRYG 350
    DPEKLKLEES LREQAEKEGS ALSVRISNV 379
    Length:379
    Mass (Da):42,480
    Last modified:February 1, 1996 - v1
    Checksum:i77B3671907B68CB2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731A → P in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti76 – 761A → T in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti110 – 1123VQV → GAGA(PubMed:7624316)Curated
    Sequence conflicti115 – 1162LT → YL(PubMed:7624316)Curated
    Sequence conflicti145 – 1451V → E in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti190 – 1901H → L in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti228 – 2281N → D in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti266 – 2661K → Q in AAA87811. (PubMed:7624316)Curated
    Sequence conflicti304 – 3041E → R in CAA58568. (PubMed:7874445)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86818 mRNA. Translation: CAA60501.1.
    X83585 mRNA. Translation: CAA58568.1.
    U27558 mRNA. Translation: AAA87811.1.
    PIRiA57477.
    RefSeqiNP_113790.1. NM_031602.1.
    UniGeneiRn.10196.

    Genome annotation databases

    EnsembliENSRNOT00000010146; ENSRNOP00000010146; ENSRNOG00000007705.
    GeneIDi29718.
    KEGGirno:29718.
    UCSCiRGD:61822. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86818 mRNA. Translation: CAA60501.1 .
    X83585 mRNA. Translation: CAA58568.1 .
    U27558 mRNA. Translation: AAA87811.1 .
    PIRi A57477.
    RefSeqi NP_113790.1. NM_031602.1.
    UniGenei Rn.10196.

    3D structure databases

    ProteinModelPortali P49655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248335. 2 interactions.
    IntActi P49655. 3 interactions.
    MINTi MINT-103719.
    STRINGi 10116.ENSRNOP00000010146.

    Chemistry

    GuidetoPHARMACOLOGYi 438.

    PTM databases

    PhosphoSitei P49655.

    Proteomic databases

    PaxDbi P49655.
    PRIDEi P49655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010146 ; ENSRNOP00000010146 ; ENSRNOG00000007705 .
    GeneIDi 29718.
    KEGGi rno:29718.
    UCSCi RGD:61822. rat.

    Organism-specific databases

    CTDi 3766.
    RGDi 61822. Kcnj10.

    Phylogenomic databases

    eggNOGi NOG284842.
    GeneTreei ENSGT00690000102074.
    HOGENOMi HOG000237326.
    HOVERGENi HBG006178.
    InParanoidi P49655.
    KOi K05003.
    OMAi FYHVVDD.
    OrthoDBi EOG7GFB4Z.
    PhylomeDBi P49655.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199204. Potassium transport channels.

    Miscellaneous databases

    NextBioi 610177.
    PROi P49655.

    Gene expression databases

    Genevestigatori P49655.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells."
      Takumi T., Ishii T., Horio Y., Morishige K., Takahashi N., Yamada M., Yamashita T., Kiyama H., Sohmiya K., Nakanishi S., Kurachi Y.
      J. Biol. Chem. 270:16339-16346(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Cloning and expression of a family of inward rectifier potassium channels."
      Bond C.T., Pessia M., Xia X.-M., Lagrutta A., Kavanaugh M.P., Adelman J.P.
      Recept. Channels 2:183-191(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    3. "Cloning and expression of two brain-specific inwardly rectifying potassium channels."
      Bredt D.S., Wang T.L., Cohen N.A., Guggino W.B., Snyder S.H.
      Proc. Natl. Acad. Sci. U.S.A. 92:6753-6757(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCJ10_RAT
    AccessioniPrimary (citable) accession number: P49655
    Secondary accession number(s): Q62790
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3