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P49654 (P2RX3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
P2X purinoceptor 3
Short name=P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene names
Name:P2rx3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Subunit structure

Homo- or heteropolymers.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Selectively expressed in sensory ganglia.

Sequence similarities

Belongs to the P2X receptor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397P2X purinoceptor 3
PRO_0000161552

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Name=1; Potential
Topological domain44 – 317274Extracellular Potential
Transmembrane318 – 33821Helical; Name=2; Potential
Topological domain339 – 39759Cytoplasmic Potential

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict961M → I in CAA62223. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P49654 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: AA7ED5410F639D25

FASTA39744,392
        10         20         30         40         50         60 
MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV 

        70         80         90        100        110        120 
VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPEN EEKYRCVSDS 

       130        140        150        160        170        180 
QCGPERFPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR 

       190        200        210        220        230        240 
FPLFNFEKGN LLPNLTDKDI KRCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG 

       250        260        270        280        290        300 
IKIGWVCDLD KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 

       310        320        330        340        350        360 
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DHYKARKFEE 

       370        380        390 
VTETTLKGTA STNPVFASDQ ATVEKQSTDS GAYSIGH

« Hide

References

[1]"Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons."
Lewis C., Neidhart S., Holy C., North R.A., Buell G.N., Surprenant A.
Nature 377:432-435(1995) [PubMed: 7566120] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spinal ganglion.
[2]"A P2X purinoceptor expressed by a subset of sensory neurons."
Chen C.-C., Akopian A.N., Sivilotti L., Colquhoun D., Burnstock G., Wood J.N.
Nature 377:428-432(1995) [PubMed: 7566119] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Spinal ganglion.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X91167 mRNA. Translation: CAA62594.1.
X90651 mRNA. Translation: CAA62223.1.
IPIIPI00324850.
PIRI58099.
S60334.
RefSeqNP_112337.1. NM_031075.1.
UniGeneRn.10388.

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP49654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81739.
KEGGrno:81739.
UCSCBC081783. rat.

Organism-specific databases

CTD5024.
RGD620253. P2rx3.

Phylogenomic databases

eggNOGroNOG04746.
GeneTreeENSGT00390000016028.
HOVERGENHBG053086.
OrthoDBEOG4HX513.

Gene expression databases

GenevestigatorP49654.

Family and domain databases

InterProIPR003046. P2X3_purnocptor.
IPR001429. P2X_purnocptor.
[Graphical view]
KOK05217.
PANTHERPTHR10125. ATP_P2X_rcpt. 1 hit.
PTHR10125:SF8. P2X3_purnocptor. 1 hit.
PfamPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsTIGR00863. P2X. 1 hit.
PROSITEPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615440.

Entry information

Entry nameP2RX3_RAT
AccessionPrimary (citable) accession number: P49654
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 16, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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