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Protein

P2X purinoceptor 3

Gene

P2rx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  • ATP binding Source: RGD
  • extracellular ATP-gated cation channel activity Source: RGD
  • purinergic nucleotide receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620253. P2rx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 317274ExtracellularSequence analysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini339 – 39759CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendritic spine Source: RGD
  • Golgi apparatus Source: RGD
  • integral component of plasma membrane Source: InterPro
  • membrane Source: RGD
  • membrane raft Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • receptor complex Source: Ensembl
  • rough endoplasmic reticulum Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3137277.
GuidetoPHARMACOLOGYi480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397P2X purinoceptor 3PRO_0000161552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 153By similarity
Disulfide bondi116 ↔ 137By similarity
Disulfide bondi122 ↔ 147By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi203 ↔ 213By similarity
Disulfide bondi247 ↔ 256By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49654.

PTM databases

PhosphoSiteiP49654.

Expressioni

Tissue specificityi

Selectively expressed in sensory ganglia.

Gene expression databases

ExpressionAtlasiP49654. baseline and differential.
GenevisibleiP49654. RN.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031629.

Chemistry

BindingDBiP49654.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP49654.
KOiK05217.
OMAiVLRTCEI.
OrthoDBiEOG78PV92.
PhylomeDBiP49654.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ
60 70 80 90 100
VRDTAIESSV VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE
110 120 130 140 150
NQMQGFCPEN EEKYRCVSDS QCGPERFPGG GILTGRCVNY SSVLRTCEIQ
160 170 180 190 200
GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTDKDI
210 220 230 240 250
KRCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD
260 270 280 290 300
KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
310 320 330 340 350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA
360 370 380 390
DHYKARKFEE VTETTLKGTA STNPVFASDQ ATVEKQSTDS GAYSIGH
Length:397
Mass (Da):44,392
Last modified:February 1, 1996 - v1
Checksum:iAA7ED5410F639D25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961M → I in CAA62223 (PubMed:7566119).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91167 mRNA. Translation: CAA62594.1.
X90651 mRNA. Translation: CAA62223.1.
PIRiI58099.
S60334.
RefSeqiNP_001257550.1. NM_001270621.1.
NP_112337.2. NM_031075.2.
UniGeneiRn.10388.

Genome annotation databases

EnsembliENSRNOT00000033427; ENSRNOP00000031629; ENSRNOG00000008552.
GeneIDi81739.
KEGGirno:81739.
UCSCiRGD:620253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91167 mRNA. Translation: CAA62594.1.
X90651 mRNA. Translation: CAA62223.1.
PIRiI58099.
S60334.
RefSeqiNP_001257550.1. NM_001270621.1.
NP_112337.2. NM_031075.2.
UniGeneiRn.10388.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031629.

Chemistry

BindingDBiP49654.
ChEMBLiCHEMBL3137277.
GuidetoPHARMACOLOGYi480.

PTM databases

PhosphoSiteiP49654.

Proteomic databases

PaxDbiP49654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033427; ENSRNOP00000031629; ENSRNOG00000008552.
GeneIDi81739.
KEGGirno:81739.
UCSCiRGD:620253. rat.

Organism-specific databases

CTDi5024.
RGDi620253. P2rx3.

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP49654.
KOiK05217.
OMAiVLRTCEI.
OrthoDBiEOG78PV92.
PhylomeDBiP49654.

Miscellaneous databases

NextBioi615440.
PROiP49654.

Gene expression databases

ExpressionAtlasiP49654. baseline and differential.
GenevisibleiP49654. RN.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons."
    Lewis C., Neidhart S., Holy C., North R.A., Buell G.N., Surprenant A.
    Nature 377:432-435(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spinal ganglion.
  2. "A P2X purinoceptor expressed by a subset of sensory neurons."
    Chen C.-C., Akopian A.N., Sivilotti L., Colquhoun D., Burnstock G., Wood J.N.
    Nature 377:428-432(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.

Entry informationi

Entry nameiP2RX3_RAT
AccessioniPrimary (citable) accession number: P49654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.