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Protein

P2Y purinoceptor 1

Gene

P2ry1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In pancreatic islets, may mediate some of the effects of extracellular ATP on insulin secretion.

GO - Molecular functioni

  • A1 adenosine receptor binding Source: BHF-UCL
  • ADP-activated adenosine receptor activity Source: BHF-UCL
  • ADP binding Source: RGD
  • ATP-activated adenosine receptor activity Source: BHF-UCL
  • ATP binding Source: RGD
  • G-protein coupled purinergic nucleotide receptor activity Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

  • adenosine receptor signaling pathway Source: BHF-UCL
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: BHF-UCL
  • aging Source: RGD
  • cellular response to organic cyclic compound Source: Ensembl
  • eating behavior Source: RGD
  • glial cell migration Source: RGD
  • G-protein coupled purinergic nucleotide receptor signaling pathway Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • negative regulation of binding Source: BHF-UCL
  • negative regulation of norepinephrine secretion Source: RGD
  • platelet activation Source: InterPro
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
  • positive regulation of ion transport Source: Ensembl
  • positive regulation of penile erection Source: RGD
  • positive regulation of protein phosphorylation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • protein localization to plasma membrane Source: BHF-UCL
  • regulation of receptor activity Source: BHF-UCL
  • regulation of vasodilation Source: RGD
  • relaxation of muscle Source: InterPro
  • response to growth factor Source: RGD
  • response to mechanical stimulus Source: RGD
  • sensory perception of pain Source: RGD
  • signal transduction involved in regulation of gene expression Source: BHF-UCL
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.
R-RNO-418592. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2ry1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3242. P2ry1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7422Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini75 – 8713CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini110 – 12617ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 16619CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18822Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini189 – 21830ExtracellularSequence analysisAdd
BLAST
Transmembranei219 – 23820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini239 – 26527CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28520Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 30318ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32825Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini329 – 37345CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell body Source: BHF-UCL
  • cell surface Source: Ensembl
  • dendrite Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: BHF-UCL
  • postsynaptic density Source: BHF-UCL
  • postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373P2Y purinoceptor 1PRO_0000070008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49651.
PRIDEiP49651.

PTM databases

PhosphoSiteiP49651.

Expressioni

Tissue specificityi

Expressed in muscle, heart, liver, kidney, lung, brain, spleen, but not in testis.

Gene expression databases

BgeeiENSRNOG00000014232.
GenevisibleiP49651. RN.

Interactioni

GO - Molecular functioni

  • A1 adenosine receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

MINTiMINT-242266.
STRINGi10116.ENSRNOP00000019304.

Chemistry

BindingDBiP49651.

Structurei

3D structure databases

ProteinModelPortaliP49651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP49651.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP49651.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVPWSAVP NGTDAAFLAG LGSLWGNSTI ASTAAVSSSF RCALIKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DVMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIY VSVLVWLIVV VAISPILFYS GTGIRKNKTV
210 220 230 240 250
TCYDSTSDEY LRSYFIYSMC TTVAMFCIPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPEMCDFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEEMTLN ILSEFKQNGD TSL
Length:373
Mass (Da):42,322
Last modified:February 1, 1996 - v1
Checksum:i6DDF676287B5E648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22830 mRNA. Translation: AAA91303.1.
RefSeqiNP_036932.1. NM_012800.1.
UniGeneiRn.10217.

Genome annotation databases

EnsembliENSRNOT00000019305; ENSRNOP00000019304; ENSRNOG00000014232.
GeneIDi25265.
KEGGirno:25265.
UCSCiRGD:3242. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22830 mRNA. Translation: AAA91303.1.
RefSeqiNP_036932.1. NM_012800.1.
UniGeneiRn.10217.

3D structure databases

ProteinModelPortaliP49651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-242266.
STRINGi10116.ENSRNOP00000019304.

Chemistry

BindingDBiP49651.
ChEMBLiCHEMBL2497.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP49651.

Proteomic databases

PaxDbiP49651.
PRIDEiP49651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019305; ENSRNOP00000019304; ENSRNOG00000014232.
GeneIDi25265.
KEGGirno:25265.
UCSCiRGD:3242. rat.

Organism-specific databases

CTDi5028.
RGDi3242. P2ry1.

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP49651.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP49651.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.
R-RNO-418592. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

PROiP49651.

Gene expression databases

BgeeiENSRNOG00000014232.
GenevisibleiP49651. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY1_RAT
AccessioniPrimary (citable) accession number: P49651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.