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Protein

P2Y purinoceptor 1

Gene

P2ry1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP. In pancreatic islets, may mediate some of the effects of extracellular ATP on insulin secretion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.
R-MMU-418592. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2ry1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:105049. P2ry1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 74Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini75 – 87CytoplasmicSequence analysisAdd BLAST13
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 126ExtracellularSequence analysisAdd BLAST17
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 166CytoplasmicSequence analysisAdd BLAST19
Transmembranei167 – 188Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini189 – 218ExtracellularSequence analysisAdd BLAST30
Transmembranei219 – 238Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini239 – 265CytoplasmicSequence analysisAdd BLAST27
Transmembranei266 – 285Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini286 – 303ExtracellularSequence analysisAdd BLAST18
Transmembranei304 – 328Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini329 – 373CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700071 – 373P2Y purinoceptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49650.
PRIDEiP49650.

PTM databases

PhosphoSitePlusiP49650.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027765.
CleanExiMM_P2RY1.
ExpressionAtlasiP49650. baseline and differential.
GenevisibleiP49650. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029331.

Structurei

3D structure databases

ProteinModelPortaliP49650.
SMRiP49650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP49650.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP49650.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVPWSVVP NGTDAAFLAG LGSLWGNSTV ASTAAVSSSF QCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIY VSVLVWLIVV VAISPILFYS GTGTRKNKTV
210 220 230 240 250
TCYDTTSNDY LRSYFIYSMC TTVAMFCIPL VLILGCYGLI VKALIYNDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPEMCDFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEEMTLN ILSEFKQNGD TSL
Length:373
Mass (Da):42,213
Last modified:February 1, 1996 - v1
Checksum:i944125E9F4560BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22829 mRNA. Translation: AAA91302.1.
AJ245636 Genomic DNA. Translation: CAB57317.1.
CCDSiCCDS17377.1.
RefSeqiNP_001268945.1. NM_001282016.1.
NP_032798.1. NM_008772.5.
UniGeneiMm.281452.

Genome annotation databases

EnsembliENSMUST00000029331; ENSMUSP00000029331; ENSMUSG00000027765.
ENSMUST00000193201; ENSMUSP00000142006; ENSMUSG00000027765.
ENSMUST00000193943; ENSMUSP00000141371; ENSMUSG00000027765.
GeneIDi18441.
KEGGimmu:18441.
UCSCiuc008pjj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22829 mRNA. Translation: AAA91302.1.
AJ245636 Genomic DNA. Translation: CAB57317.1.
CCDSiCCDS17377.1.
RefSeqiNP_001268945.1. NM_001282016.1.
NP_032798.1. NM_008772.5.
UniGeneiMm.281452.

3D structure databases

ProteinModelPortaliP49650.
SMRiP49650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029331.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP49650.

Proteomic databases

PaxDbiP49650.
PRIDEiP49650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029331; ENSMUSP00000029331; ENSMUSG00000027765.
ENSMUST00000193201; ENSMUSP00000142006; ENSMUSG00000027765.
ENSMUST00000193943; ENSMUSP00000141371; ENSMUSG00000027765.
GeneIDi18441.
KEGGimmu:18441.
UCSCiuc008pjj.2. mouse.

Organism-specific databases

CTDi5028.
MGIiMGI:105049. P2ry1.

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP49650.
KOiK04270.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
PhylomeDBiP49650.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.
R-MMU-418592. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

PROiP49650.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027765.
CleanExiMM_P2RY1.
ExpressionAtlasiP49650. baseline and differential.
GenevisibleiP49650. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY1_MOUSE
AccessioniPrimary (citable) accession number: P49650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.