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Protein

Homeobox even-skipped homolog protein 1

Gene

EVX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the specification of neuronal cell types.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi183 – 242HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SIGNORiP49640

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox even-skipped homolog protein 1
Alternative name(s):
EVX-1
Gene namesi
Name:EVX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106038.12
HGNCiHGNC:3506 EVX1
MIMi142996 gene
neXtProtiNX_P49640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2128
OpenTargetsiENSG00000106038
PharmGKBiPA27919

Polymorphism and mutation databases

BioMutaiEVX1
DMDMi1352398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488701 – 407Homeobox even-skipped homolog protein 1Add BLAST407

Proteomic databases

PaxDbiP49640
PRIDEiP49640

Expressioni

Gene expression databases

BgeeiENSG00000106038
CleanExiHS_EVX1
ExpressionAtlasiP49640 baseline and differential
GenevisibleiP49640 HS

Organism-specific databases

HPAiHPA055132

Interactioni

Protein-protein interaction databases

BioGridi108429, 1 interactor
STRINGi9606.ENSP00000419266

Structurei

3D structure databases

ProteinModelPortaliP49640
SMRiP49640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 124Asp/Glu-rich (acidic)Add BLAST11
Compositional biasi289 – 297Ala-rich9
Compositional biasi361 – 368Ala-rich8

Sequence similaritiesi

Belongs to the even-skipped homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0844 Eukaryota
ENOG4111RMB LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000231897
HOVERGENiHBG005620
InParanoidiP49640
KOiK09320
OMAiCHSGPAN
OrthoDBiEOG091G0JVN
PhylomeDBiP49640
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49640-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP
60 70 80 90 100
RAVPPATRER GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS
110 120 130 140 150
VDSLSGQGQP SSSDTESDFY EEIEVSCTPD CATGNAEYQH SKGSGSEALV
160 170 180 190 200
GSPNGGSETP KSNGGSGGGG SQGTLACSAS DQMRRYRTAF TREQIARLEK
210 220 230 240 250
EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR QRLAMTWPHP
260 270 280 290 300
ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF
310 320 330 340 350
SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL
360 370 380 390 400
ACHSGPANGL APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR

EEVPLTR
Length:407
Mass (Da):42,440
Last modified:February 1, 1996 - v1
Checksum:i75D696ECA1431D5A
GO
Isoform 2 (identifier: P49640-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):24,576
Checksum:iD854DB0639FDA287
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565021 – 182Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60655 mRNA Translation: CAA43062.1
U68782, U68781 Genomic DNA Translation: AAB07598.1
AK298822 mRNA Translation: BAG60952.1
AC004080 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93892.1
CH236948 Genomic DNA Translation: EAL24216.1
CCDSiCCDS5413.1 [P49640-1]
PIRiS22586
RefSeqiNP_001291448.1, NM_001304519.1 [P49640-2]
NP_001291449.1, NM_001304520.1 [P49640-2]
NP_001980.1, NM_001989.4 [P49640-1]
UniGeneiHs.369879

Genome annotation databases

EnsembliENST00000496902; ENSP00000419266; ENSG00000106038 [P49640-1]
GeneIDi2128
KEGGihsa:2128
UCSCiuc003szd.2 human [P49640-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEVX1_HUMAN
AccessioniPrimary (citable) accession number: P49640
Secondary accession number(s): A4D199, B4DQJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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