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P49640

- EVX1_HUMAN

UniProt

P49640 - EVX1_HUMAN

Protein

Homeobox even-skipped homolog protein 1

Gene

EVX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May play a role in the specification of neuronal cell types.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi183 – 24260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox even-skipped homolog protein 1
    Alternative name(s):
    EVX-1
    Gene namesi
    Name:EVX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:3506. EVX1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Homeobox even-skipped homolog protein 1PRO_0000048870Add
    BLAST

    Proteomic databases

    PaxDbiP49640.
    PRIDEiP49640.

    Expressioni

    Gene expression databases

    ArrayExpressiP49640.
    BgeeiP49640.
    CleanExiHS_EVX1.
    GenevestigatoriP49640.

    Interactioni

    Protein-protein interaction databases

    BioGridi108429. 1 interaction.
    STRINGi9606.ENSP00000419266.

    Structurei

    3D structure databases

    ProteinModelPortaliP49640.
    SMRiP49640. Positions 185-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi114 – 12411Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi289 – 2979Ala-rich
    Compositional biasi361 – 3688Ala-rich

    Sequence similaritiesi

    Belongs to the even-skipped homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG298527.
    HOGENOMiHOG000231897.
    HOVERGENiHBG005620.
    InParanoidiP49640.
    KOiK09320.
    OMAiHMGLGAT.
    OrthoDBiEOG7M98GX.
    PhylomeDBiP49640.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49640-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP    50
    RAVPPATRER GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS 100
    VDSLSGQGQP SSSDTESDFY EEIEVSCTPD CATGNAEYQH SKGSGSEALV 150
    GSPNGGSETP KSNGGSGGGG SQGTLACSAS DQMRRYRTAF TREQIARLEK 200
    EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR QRLAMTWPHP 250
    ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF 300
    SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL 350
    ACHSGPANGL APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR 400
    EEVPLTR 407
    Length:407
    Mass (Da):42,440
    Last modified:February 1, 1996 - v1
    Checksum:i75D696ECA1431D5A
    GO
    Isoform 2 (identifier: P49640-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-182: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:225
    Mass (Da):24,576
    Checksum:iD854DB0639FDA287
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 182182Missing in isoform 2. 1 PublicationVSP_056502Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60655 mRNA. Translation: CAA43062.1.
    U68782, U68781 Genomic DNA. Translation: AAB07598.1.
    AK298822 mRNA. Translation: BAG60952.1.
    AC004080 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93892.1.
    CH236948 Genomic DNA. Translation: EAL24216.1.
    CCDSiCCDS5413.1.
    PIRiS22586.
    RefSeqiNP_001980.1. NM_001989.3.
    XP_005249696.1. XM_005249639.2.
    UniGeneiHs.369879.

    Genome annotation databases

    EnsembliENST00000496902; ENSP00000419266; ENSG00000106038.
    ENST00000535619; ENSP00000446458; ENSG00000106038.
    GeneIDi2128.
    KEGGihsa:2128.
    UCSCiuc003szd.1. human.

    Polymorphism databases

    DMDMi1352398.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60655 mRNA. Translation: CAA43062.1 .
    U68782 , U68781 Genomic DNA. Translation: AAB07598.1 .
    AK298822 mRNA. Translation: BAG60952.1 .
    AC004080 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93892.1 .
    CH236948 Genomic DNA. Translation: EAL24216.1 .
    CCDSi CCDS5413.1.
    PIRi S22586.
    RefSeqi NP_001980.1. NM_001989.3.
    XP_005249696.1. XM_005249639.2.
    UniGenei Hs.369879.

    3D structure databases

    ProteinModelPortali P49640.
    SMRi P49640. Positions 185-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108429. 1 interaction.
    STRINGi 9606.ENSP00000419266.

    Polymorphism databases

    DMDMi 1352398.

    Proteomic databases

    PaxDbi P49640.
    PRIDEi P49640.

    Protocols and materials databases

    DNASUi 2128.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000496902 ; ENSP00000419266 ; ENSG00000106038 .
    ENST00000535619 ; ENSP00000446458 ; ENSG00000106038 .
    GeneIDi 2128.
    KEGGi hsa:2128.
    UCSCi uc003szd.1. human.

    Organism-specific databases

    CTDi 2128.
    GeneCardsi GC07P027282.
    HGNCi HGNC:3506. EVX1.
    MIMi 142996. gene.
    neXtProti NX_P49640.
    PharmGKBi PA27919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298527.
    HOGENOMi HOG000231897.
    HOVERGENi HBG005620.
    InParanoidi P49640.
    KOi K09320.
    OMAi HMGLGAT.
    OrthoDBi EOG7M98GX.
    PhylomeDBi P49640.
    TreeFami TF315938.

    Miscellaneous databases

    GenomeRNAii 2128.
    NextBioi 8601.
    PROi P49640.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49640.
    Bgeei P49640.
    CleanExi HS_EVX1.
    Genevestigatori P49640.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7."
      Faiella A., D'Esposito M., Rambaldi M., Acampora D., Balsofiore S., Stornaiuolo A., Mallamaci M., Migliaccio E., Gulisano M.
      Nucleic Acids Res. 19:6541-6545(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells."
      Briata P., van de Werken R., Airoldi I., Ilengo C., di Blas E., Boncinelli E., Corte G.
      J. Biol. Chem. 270:27695-27701(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEVX1_HUMAN
    AccessioniPrimary (citable) accession number: P49640
    Secondary accession number(s): A4D199, B4DQJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3