SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49640

- EVX1_HUMAN

UniProt

P49640 - EVX1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox even-skipped homolog protein 1

Gene
EVX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the specification of neuronal cell types.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi183 – 24260HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox even-skipped homolog protein 1
Alternative name(s):
EVX-1
Gene namesi
Name:EVX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3506. EVX1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Homeobox even-skipped homolog protein 1PRO_0000048870Add
BLAST

Proteomic databases

PaxDbiP49640.
PRIDEiP49640.

Expressioni

Gene expression databases

ArrayExpressiP49640.
BgeeiP49640.
CleanExiHS_EVX1.
GenevestigatoriP49640.

Interactioni

Protein-protein interaction databases

BioGridi108429. 1 interaction.
STRINGi9606.ENSP00000419266.

Structurei

3D structure databases

ProteinModelPortaliP49640.
SMRiP49640. Positions 185-241.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi114 – 12411Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi289 – 2979Ala-rich
Compositional biasi361 – 3688Ala-rich

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG298527.
HOGENOMiHOG000231897.
HOVERGENiHBG005620.
InParanoidiP49640.
KOiK09320.
OMAiHMGLGAT.
OrthoDBiEOG7M98GX.
PhylomeDBiP49640.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49640-1 [UniParc]FASTAAdd to Basket

« Hide

MESRKDMVVF LDGGQLGTLV GKRVSNLSEA VGSPLPEPPE KMVPRGCLSP    50
RAVPPATRER GGGGPEEEPV DGLAGSAAGP GAEPQVAGAA MLGPGPPAPS 100
VDSLSGQGQP SSSDTESDFY EEIEVSCTPD CATGNAEYQH SKGSGSEALV 150
GSPNGGSETP KSNGGSGGGG SQGTLACSAS DQMRRYRTAF TREQIARLEK 200
EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR QRLAMTWPHP 250
ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF 300
SGSLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAGGPCSCL 350
ACHSGPANGL APRAAAASDF TCASTSRSDS FLTFAPSVLS KASSVALDQR 400
EEVPLTR 407
Length:407
Mass (Da):42,440
Last modified:February 1, 1996 - v1
Checksum:i75D696ECA1431D5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60655 mRNA. Translation: CAA43062.1.
U68782, U68781 Genomic DNA. Translation: AAB07598.1.
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93892.1.
CH236948 Genomic DNA. Translation: EAL24216.1.
CCDSiCCDS5413.1.
PIRiS22586.
RefSeqiNP_001980.1. NM_001989.3.
UniGeneiHs.369879.

Genome annotation databases

EnsembliENST00000496902; ENSP00000419266; ENSG00000106038.
GeneIDi2128.
KEGGihsa:2128.
UCSCiuc003szd.1. human.

Polymorphism databases

DMDMi1352398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60655 mRNA. Translation: CAA43062.1 .
U68782 , U68781 Genomic DNA. Translation: AAB07598.1 .
AC004080 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93892.1 .
CH236948 Genomic DNA. Translation: EAL24216.1 .
CCDSi CCDS5413.1.
PIRi S22586.
RefSeqi NP_001980.1. NM_001989.3.
UniGenei Hs.369879.

3D structure databases

ProteinModelPortali P49640.
SMRi P49640. Positions 185-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108429. 1 interaction.
STRINGi 9606.ENSP00000419266.

Polymorphism databases

DMDMi 1352398.

Proteomic databases

PaxDbi P49640.
PRIDEi P49640.

Protocols and materials databases

DNASUi 2128.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000496902 ; ENSP00000419266 ; ENSG00000106038 .
GeneIDi 2128.
KEGGi hsa:2128.
UCSCi uc003szd.1. human.

Organism-specific databases

CTDi 2128.
GeneCardsi GC07P027282.
HGNCi HGNC:3506. EVX1.
MIMi 142996. gene.
neXtProti NX_P49640.
PharmGKBi PA27919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298527.
HOGENOMi HOG000231897.
HOVERGENi HBG005620.
InParanoidi P49640.
KOi K09320.
OMAi HMGLGAT.
OrthoDBi EOG7M98GX.
PhylomeDBi P49640.
TreeFami TF315938.

Miscellaneous databases

GenomeRNAii 2128.
NextBioi 8601.
PROi P49640.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49640.
Bgeei P49640.
CleanExi HS_EVX1.
Genevestigatori P49640.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7."
    Faiella A., D'Esposito M., Rambaldi M., Acampora D., Balsofiore S., Stornaiuolo A., Mallamaci M., Migliaccio E., Gulisano M.
    Nucleic Acids Res. 19:6541-6545(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells."
    Briata P., van de Werken R., Airoldi I., Ilengo C., di Blas E., Boncinelli E., Corte G.
    J. Biol. Chem. 270:27695-27701(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiEVX1_HUMAN
AccessioniPrimary (citable) accession number: P49640
Secondary accession number(s): A4D199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi