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P49639

- HXA1_HUMAN

UniProt

P49639 - HXA1_HUMAN

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Protein

Homeobox protein Hox-A1

Gene

HOXA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi229 – 28860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. abducens nerve formation Source: DFLAT
  2. anatomical structure morphogenesis Source: DFLAT
  3. anterior/posterior pattern specification Source: Ensembl
  4. artery development Source: DFLAT
  5. artery morphogenesis Source: DFLAT
  6. central nervous system neuron differentiation Source: Ensembl
  7. cochlea development Source: DFLAT
  8. cochlea morphogenesis Source: DFLAT
  9. cognition Source: DFLAT
  10. embryonic neurocranium morphogenesis Source: DFLAT
  11. facial nerve structural organization Source: Ensembl
  12. facial nucleus development Source: Ensembl
  13. inner ear development Source: DFLAT
  14. motor neuron axon guidance Source: Ensembl
  15. multicellular organismal development Source: ProtInc
  16. neuromuscular process Source: DFLAT
  17. optokinetic behavior Source: DFLAT
  18. outer ear morphogenesis Source: DFLAT
  19. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. regulation of behavior Source: DFLAT
  21. rhombomere 3 development Source: Ensembl
  22. rhombomere 4 development Source: Ensembl
  23. rhombomere 5 development Source: Ensembl
  24. semicircular canal formation Source: DFLAT
  25. sensory perception of sound Source: DFLAT
  26. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A1
Alternative name(s):
Homeobox protein Hox-1F
Gene namesi
Name:HOXA1
Synonyms:HOX1F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:5099. HOXA1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Athabaskan brainstem dysgenesis syndrome (ABDS) [MIM:601536]: Characterized by horizontal gaze palsy, sensorineural deafness, central hypoventilation, and developmental delay. Some patients had swallowing dysfunction, vocal cord paralysis, facial paresis, seizures, and cardiac outflow tract anomalies.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Bosley-Salih-Alorainy syndrome (BSAS) [MIM:601536]: A disease characterized by horizontal gaze abnormalities, deafness, facial weakness, vascular malformations of the internal carotid arteries and cardiac outflow trac. Some patients manifest mental retardation and autism spectrum disorder. Affected individuals do not suffer from central hypoventilation.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi601536. phenotype.
Orphaneti69739. Athabaskan brainstem dysgenesis syndrome.
69737. Bosley-Salih-Alorainy syndrome.
PharmGKBiPA29376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Homeobox protein Hox-A1PRO_0000200030Add
BLAST

Proteomic databases

PaxDbiP49639.
PRIDEiP49639.

PTM databases

PhosphoSiteiP49639.

Expressioni

Gene expression databases

BgeeiP49639.
CleanExiHS_HOXA1.
ExpressionAtlasiP49639. baseline and differential.
GenevestigatoriP49639.

Organism-specific databases

HPAiHPA004933.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090224EBI-740785,EBI-3957603From a different organism.
PRNPP041564EBI-740785,EBI-977302
SUV39H1O434632EBI-740785,EBI-349968

Protein-protein interaction databases

BioGridi109438. 57 interactions.
IntActiP49639. 16 interactions.
MINTiMINT-1437157.
STRINGi9606.ENSP00000343246.

Structurei

3D structure databases

ProteinModelPortaliP49639.
SMRiP49639. Positions 202-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi204 – 2096Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 7410Poly-His
Compositional biasi142 – 1465Poly-His
Compositional biasi314 – 3174Poly-Ser

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236971.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiP49639.
KOiK09301.
OrthoDBiEOG7PK91P.
PhylomeDBiP49639.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: P49639-1) [UniParc]FASTAAdd to Basket

Also known as: 36 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNARMNSFL EYPILSSGDS GTCSARAYPS DHRITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLVGRGVQ IGSPHHHHHH HHHHPQPATY QTSGNLGVSY SHSSCGPSYG
110 120 130 140 150
SQNFSAPYSP YALNQEADVS GGYPQCAPAV YSGNLSSPMV QHHHHHQGYA
160 170 180 190 200
GGAVGSPQYI HHSYGQEHQS LALATYNNSL SPLHASHQEA CRSPASETSS
210 220 230 240 250
PAQTFDWMKV KRNPPKTGKV GEYGYLGQPN AVRTNFTTKQ LTELEKEFHF
260 270 280 290 300
NKYLTRARRV EIAASLQLNE TQVKIWFQNR RMKQKKREKE GLLPISPATP
310 320 330
PGNDEKAEES SEKSSSSPCV PSPGSSTSDT LTTSH
Length:335
Mass (Da):36,641
Last modified:July 15, 1999 - v2
Checksum:i3C3A2D0A59A4181C
GO
Isoform 1 (identifier: P49639-2) [UniParc]FASTAAdd to Basket

Also known as: 14 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     119-137: VSGGYPQCAPAVYSGNLSS → PPRSLSLPRIGDIFSSADF
     138-335: Missing.

Note: Lacks the homeobox domain.

Show »
Length:137
Mass (Da):14,816
Checksum:i9F0067A9E6AD51DE
GO
Isoform 2 (identifier: P49639-3) [UniParc]FASTAAdd to Basket

Also known as: 24 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     219-227: KVGEYGYLG → QSCWLVDAP
     228-335: Missing.

Note: Lacks the homeobox domain.

Show »
Length:227
Mass (Da):24,489
Checksum:i81A54EF51FB0F033
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731H → R Frequent polymorphism in individuals of European or African origin. 2 Publications
Corresponds to variant rs10951154 [ dbSNP | Ensembl ].
VAR_010305
Natural varianti189 – 1891E → A.
Corresponds to variant rs17500494 [ dbSNP | Ensembl ].
VAR_030576

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 13719VSGGY…GNLSS → PPRSLSLPRIGDIFSSADF in isoform 1. 1 PublicationVSP_002376Add
BLAST
Alternative sequencei138 – 335198Missing in isoform 1. 1 PublicationVSP_002377Add
BLAST
Alternative sequencei219 – 2279KVGEYGYLG → QSCWLVDAP in isoform 2. 1 PublicationVSP_002378
Alternative sequencei228 – 335108Missing in isoform 2. 1 PublicationVSP_002379Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10421 mRNA. Translation: AAA86954.1.
AK313514 mRNA. Translation: BAG36294.1.
AC004079 Genomic DNA. Translation: AAS00374.1.
CH236948 Genomic DNA. Translation: EAL24228.1.
CH471073 Genomic DNA. Translation: EAW93861.1.
BC032547 mRNA. Translation: AAH32547.1.
U37431 mRNA. Translation: AAC50248.1.
U37431 mRNA. Translation: AAC50249.1.
U37431 mRNA. Translation: AAC50250.1.
S79869 mRNA. Translation: AAB35424.2.
S79871 mRNA. Translation: AAB35425.1.
S79910 mRNA. Translation: AAB35423.2.
CCDSiCCDS5401.1. [P49639-1]
CCDS5402.2. [P49639-2]
PIRiG01448.
RefSeqiNP_005513.1. NM_005522.4. [P49639-1]
NP_705873.2. NM_153620.2. [P49639-2]
UniGeneiHs.67397.

Genome annotation databases

EnsembliENST00000343060; ENSP00000343246; ENSG00000105991.
GeneIDi3198.
KEGGihsa:3198.
UCSCiuc003syd.3. human. [P49639-2]
uc003sye.3. human. [P49639-1]
uc022aao.1. human. [P49639-3]

Polymorphism databases

DMDMi6166216.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10421 mRNA. Translation: AAA86954.1 .
AK313514 mRNA. Translation: BAG36294.1 .
AC004079 Genomic DNA. Translation: AAS00374.1 .
CH236948 Genomic DNA. Translation: EAL24228.1 .
CH471073 Genomic DNA. Translation: EAW93861.1 .
BC032547 mRNA. Translation: AAH32547.1 .
U37431 mRNA. Translation: AAC50248.1 .
U37431 mRNA. Translation: AAC50249.1 .
U37431 mRNA. Translation: AAC50250.1 .
S79869 mRNA. Translation: AAB35424.2 .
S79871 mRNA. Translation: AAB35425.1 .
S79910 mRNA. Translation: AAB35423.2 .
CCDSi CCDS5401.1. [P49639-1 ]
CCDS5402.2. [P49639-2 ]
PIRi G01448.
RefSeqi NP_005513.1. NM_005522.4. [P49639-1 ]
NP_705873.2. NM_153620.2. [P49639-2 ]
UniGenei Hs.67397.

3D structure databases

ProteinModelPortali P49639.
SMRi P49639. Positions 202-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109438. 57 interactions.
IntActi P49639. 16 interactions.
MINTi MINT-1437157.
STRINGi 9606.ENSP00000343246.

PTM databases

PhosphoSitei P49639.

Polymorphism databases

DMDMi 6166216.

Proteomic databases

PaxDbi P49639.
PRIDEi P49639.

Protocols and materials databases

DNASUi 3198.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343060 ; ENSP00000343246 ; ENSG00000105991 .
GeneIDi 3198.
KEGGi hsa:3198.
UCSCi uc003syd.3. human. [P49639-2 ]
uc003sye.3. human. [P49639-1 ]
uc022aao.1. human. [P49639-3 ]

Organism-specific databases

CTDi 3198.
GeneCardsi GC07M027099.
HGNCi HGNC:5099. HOXA1.
HPAi HPA004933.
MIMi 142955. gene.
601536. phenotype.
neXtProti NX_P49639.
Orphaneti 69739. Athabaskan brainstem dysgenesis syndrome.
69737. Bosley-Salih-Alorainy syndrome.
PharmGKBi PA29376.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236971.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000247020.
HOVERGENi HBG006089.
InParanoidi P49639.
KOi K09301.
OrthoDBi EOG7PK91P.
PhylomeDBi P49639.
TreeFami TF317730.

Miscellaneous databases

GeneWikii Homeobox_A1.
GenomeRNAii 3198.
NextBioi 12718.
PROi P49639.
SOURCEi Search...

Gene expression databases

Bgeei P49639.
CleanExi HS_HOXA1.
ExpressionAtlasi P49639. baseline and differential.
Genevestigatori P49639.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of the HOX A1 human homeobox gene cDNA."
    Hong Y.S., Kim S.Y., Bhattacharya A., Pratt D.R., Hong W.K., Tainsky M.A.
    Gene 159:209-214(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Ovary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-73.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Skin.
  7. "Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7 breast cancer cells."
    Chariot A., Moreau L., Senterre G., Sobel M., Castronovo V.
    Biochem. Biophys. Res. Commun. 215:713-720(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-335 (ISOFORMS 1; 2 AND 3).
  8. "Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders."
    Ingram J.L., Stodgell C.J., Hyman S.L., Figlewicz D.A., Weitkamp L.R., Rodier P.M.
    Teratology 62:393-405(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-73.
  9. "Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development."
    Tischfield M.A., Bosley T.M., Salih M.A.M., Alorainy I.A., Sener E.C., Nester M.J., Oystreck D.T., Chan W.-M., Andrews C., Erickson R.P., Engle E.C.
    Nat. Genet. 37:1035-1037(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ABDS AND BSAS.

Entry informationi

Entry nameiHXA1_HUMAN
AccessioniPrimary (citable) accession number: P49639
Secondary accession number(s): A4D184, B2R8U7, O43363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1999
Last modified: November 26, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3