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P49620

- DGKG_RAT

UniProt

P49620 - DGKG_RAT

Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi185 – 196121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi230 – 241122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. diacylglycerol kinase activity Source: RGD
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. neuron development Source: RGD
    3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase gamma (EC:2.7.1.107)
    Short name:
    DAG kinase gamma
    Alternative name(s):
    88 kDa diacylglycerol kinase
    Diglyceride kinase gamma
    Short name:
    DGK-gamma
    Gene namesi
    Name:Dgkg
    Synonyms:Dagk3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi2499. Dgkg.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 788788Diacylglycerol kinase gammaPRO_0000218461Add
    BLAST

    Proteomic databases

    PaxDbiP49620.
    PRIDEiP49620.

    PTM databases

    PhosphoSiteiP49620.

    Expressioni

    Tissue specificityi

    Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells.

    Gene expression databases

    GenevestigatoriP49620.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002452.

    Structurei

    3D structure databases

    ProteinModelPortaliP49620.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 20736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini217 – 25236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini427 – 561135DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG47311.
    GeneTreeiENSGT00750000117569.
    HOGENOMiHOG000252931.
    HOVERGENiHBG051345.
    InParanoidiP49620.
    KOiK00901.
    OMAiCYQSVTA.
    OrthoDBiEOG75XGK8.
    PhylomeDBiP49620.
    TreeFamiTF313104.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49620-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI    50
    SYDVFKLFMR AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP 100
    NVSDSNAEST AKADAACAPD TESKPIKTQV PSEELEAAAP WGEPNAPASS 150
    SDAPIVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENE LLDQAELDQI 200
    VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE EWVSGGMTTI 250
    PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI 300
    YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK 350
    SIKCYQSVTA RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR 400
    DRQAGKSDSG AAAKGELVMQ YKIIPSPGTH PLLVLVNPKS GGRQGERILQ 450
    KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP DFRVLACGGD GTVGWILDCI 500
    DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV 550
    MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP 600
    EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE 650
    GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ 700
    LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW 750
    MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD 788
    Length:788
    Mass (Da):88,521
    Last modified:February 1, 1996 - v1
    Checksum:iE77BCA40B22C1DA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38448 mRNA. Translation: BAA07480.1.
    RefSeqiNP_037258.1. NM_013126.1.
    UniGeneiRn.10544.

    Genome annotation databases

    EnsembliENSRNOT00000002452; ENSRNOP00000002452; ENSRNOG00000001796.
    GeneIDi25666.
    KEGGirno:25666.
    UCSCiRGD:2499. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38448 mRNA. Translation: BAA07480.1 .
    RefSeqi NP_037258.1. NM_013126.1.
    UniGenei Rn.10544.

    3D structure databases

    ProteinModelPortali P49620.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002452.

    PTM databases

    PhosphoSitei P49620.

    Proteomic databases

    PaxDbi P49620.
    PRIDEi P49620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002452 ; ENSRNOP00000002452 ; ENSRNOG00000001796 .
    GeneIDi 25666.
    KEGGi rno:25666.
    UCSCi RGD:2499. rat.

    Organism-specific databases

    CTDi 1608.
    RGDi 2499. Dgkg.

    Phylogenomic databases

    eggNOGi NOG47311.
    GeneTreei ENSGT00750000117569.
    HOGENOMi HOG000252931.
    HOVERGENi HBG051345.
    InParanoidi P49620.
    KOi K00901.
    OMAi CYQSVTA.
    OrthoDBi EOG75XGK8.
    PhylomeDBi P49620.
    TreeFami TF313104.

    Miscellaneous databases

    NextBioi 607585.

    Gene expression databases

    Genevestigatori P49620.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cytoskeleton-associated diacylglycerol kinase that is dominantly expressed in cerebellum."
      Goto K., Funayama M., Kondo H.
      Proc. Natl. Acad. Sci. U.S.A. 91:13042-13046(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiDGKG_RAT
    AccessioniPrimary (citable) accession number: P49620
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3