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P49620

- DGKG_RAT

UniProt

P49620 - DGKG_RAT

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Protein
Diacylglycerol kinase gamma
Gene
Dgkg, Dagk3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi185 – 196121 Reviewed prediction
Add
BLAST
Calcium bindingi230 – 241122 Reviewed prediction
Add
BLAST
Zinc fingeri268 – 31851Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri333 – 38048Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. calcium ion binding Source: InterPro
  4. diacylglycerol kinase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. neuron development Source: RGD
  3. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi2499. Dgkg.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Diacylglycerol kinase gamma
PRO_0000218461Add
BLAST

Proteomic databases

PaxDbiP49620.
PRIDEiP49620.

PTM databases

PhosphoSiteiP49620.

Expressioni

Tissue specificityi

Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells.

Gene expression databases

GenevestigatoriP49620.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002452.

Structurei

3D structure databases

ProteinModelPortaliP49620.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 20736EF-hand 1
Add
BLAST
Domaini217 – 25236EF-hand 2
Add
BLAST
Domaini427 – 561135DAGKc
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00750000117569.
HOGENOMiHOG000252931.
HOVERGENiHBG051345.
InParanoidiP49620.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG75XGK8.
PhylomeDBiP49620.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49620-1 [UniParc]FASTAAdd to Basket

« Hide

MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI    50
SYDVFKLFMR AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP 100
NVSDSNAEST AKADAACAPD TESKPIKTQV PSEELEAAAP WGEPNAPASS 150
SDAPIVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENE LLDQAELDQI 200
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE EWVSGGMTTI 250
PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI 300
YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK 350
SIKCYQSVTA RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR 400
DRQAGKSDSG AAAKGELVMQ YKIIPSPGTH PLLVLVNPKS GGRQGERILQ 450
KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP DFRVLACGGD GTVGWILDCI 500
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV 550
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP 600
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE 650
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ 700
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW 750
MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD 788
Length:788
Mass (Da):88,521
Last modified:February 1, 1996 - v1
Checksum:iE77BCA40B22C1DA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38448 mRNA. Translation: BAA07480.1.
RefSeqiNP_037258.1. NM_013126.1.
UniGeneiRn.10544.

Genome annotation databases

EnsembliENSRNOT00000002452; ENSRNOP00000002452; ENSRNOG00000001796.
GeneIDi25666.
KEGGirno:25666.
UCSCiRGD:2499. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38448 mRNA. Translation: BAA07480.1 .
RefSeqi NP_037258.1. NM_013126.1.
UniGenei Rn.10544.

3D structure databases

ProteinModelPortali P49620.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002452.

PTM databases

PhosphoSitei P49620.

Proteomic databases

PaxDbi P49620.
PRIDEi P49620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002452 ; ENSRNOP00000002452 ; ENSRNOG00000001796 .
GeneIDi 25666.
KEGGi rno:25666.
UCSCi RGD:2499. rat.

Organism-specific databases

CTDi 1608.
RGDi 2499. Dgkg.

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00750000117569.
HOGENOMi HOG000252931.
HOVERGENi HBG051345.
InParanoidi P49620.
KOi K00901.
OMAi CYQSVTA.
OrthoDBi EOG75XGK8.
PhylomeDBi P49620.
TreeFami TF313104.

Miscellaneous databases

NextBioi 607585.

Gene expression databases

Genevestigatori P49620.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a cytoskeleton-associated diacylglycerol kinase that is dominantly expressed in cerebellum."
    Goto K., Funayama M., Kondo H.
    Proc. Natl. Acad. Sci. U.S.A. 91:13042-13046(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiDGKG_RAT
AccessioniPrimary (citable) accession number: P49620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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