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Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi185 – 1961PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi230 – 2412PROSITE-ProRule annotationAdd BLAST12
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • diacylglycerol kinase activity Source: RGD
  • NAD+ kinase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-114508 Effects of PIP2 hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2499 Dgkg

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184611 – 788Diacylglycerol kinase gammaAdd BLAST788

Proteomic databases

PaxDbiP49620
PRIDEiP49620

PTM databases

iPTMnetiP49620
PhosphoSitePlusiP49620

Expressioni

Tissue specificityi

Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells.

Gene expression databases

BgeeiENSRNOG00000001796
GenevisibleiP49620 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002452

Structurei

3D structure databases

ProteinModelPortaliP49620
SMRiP49620
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 207EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini217 – 252EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini427 – 561DAGKcPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1169 Eukaryota
ENOG410XQVB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000252931
HOVERGENiHBG051345
InParanoidiP49620
KOiK00901
OMAiCYQSVTA
OrthoDBiEOG091G04A5
PhylomeDBiP49620
TreeFamiTF313104

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
Gene3Di1.10.238.110, 2 hits
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR029477 DAG_kinase_typeI_N
IPR037607 DGK
IPR038199 DGK_typeI_N_sf
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF14513 DAG_kinase_N, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00054 EFh, 2 hits
SUPFAMiSSF111331 SSF111331, 1 hit
SSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P49620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP
110 120 130 140 150
NVSDSNAEST AKADAACAPD TESKPIKTQV PSEELEAAAP WGEPNAPASS
160 170 180 190 200
SDAPIVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENE LLDQAELDQI
210 220 230 240 250
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE EWVSGGMTTI
260 270 280 290 300
PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI
310 320 330 340 350
YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK
360 370 380 390 400
SIKCYQSVTA RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR
410 420 430 440 450
DRQAGKSDSG AAAKGELVMQ YKIIPSPGTH PLLVLVNPKS GGRQGERILQ
460 470 480 490 500
KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP DFRVLACGGD GTVGWILDCI
510 520 530 540 550
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV
560 570 580 590 600
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP
610 620 630 640 650
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE
660 670 680 690 700
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ
710 720 730 740 750
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW
760 770 780
MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD
Length:788
Mass (Da):88,521
Last modified:February 1, 1996 - v1
Checksum:iE77BCA40B22C1DA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38448 mRNA Translation: BAA07480.1
RefSeqiNP_037258.1, NM_013126.1
UniGeneiRn.10544

Genome annotation databases

EnsembliENSRNOT00000002452; ENSRNOP00000002452; ENSRNOG00000001796
GeneIDi25666
KEGGirno:25666
UCSCiRGD:2499 rat

Similar proteinsi

Entry informationi

Entry nameiDGKG_RAT
AccessioniPrimary (citable) accession number: P49620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health