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Protein

Diacylglycerol kinase gamma

Gene

Dgkg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi185 – 1961PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi230 – 2412PROSITE-ProRule annotationAdd BLAST12
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • diacylglycerol kinase activity Source: RGD
  • NAD+ kinase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-114508. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
88 kDa diacylglycerol kinase
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:Dgkg
Synonyms:Dagk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2499. Dgkg.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184611 – 788Diacylglycerol kinase gammaAdd BLAST788

Proteomic databases

PaxDbiP49620.
PRIDEiP49620.

PTM databases

iPTMnetiP49620.
PhosphoSitePlusiP49620.

Expressioni

Tissue specificityi

Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells.

Gene expression databases

BgeeiENSRNOG00000001796.
GenevisibleiP49620. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002452.

Structurei

3D structure databases

ProteinModelPortaliP49620.
SMRiP49620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 207EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini217 – 252EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini427 – 561DAGKcPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 318Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri333 – 380Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1169. Eukaryota.
ENOG410XQVB. LUCA.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000252931.
HOVERGENiHBG051345.
InParanoidiP49620.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG091G04A5.
PhylomeDBiP49620.
TreeFamiTF313104.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di3.40.50.10330. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
PfamiView protein in Pfam
PF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF47473. SSF47473. 3 hits.
PROSITEiView protein in PROSITE
PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P49620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP
110 120 130 140 150
NVSDSNAEST AKADAACAPD TESKPIKTQV PSEELEAAAP WGEPNAPASS
160 170 180 190 200
SDAPIVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENE LLDQAELDQI
210 220 230 240 250
VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE EWVSGGMTTI
260 270 280 290 300
PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI
310 320 330 340 350
YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK
360 370 380 390 400
SIKCYQSVTA RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR
410 420 430 440 450
DRQAGKSDSG AAAKGELVMQ YKIIPSPGTH PLLVLVNPKS GGRQGERILQ
460 470 480 490 500
KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP DFRVLACGGD GTVGWILDCI
510 520 530 540 550
DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV
560 570 580 590 600
MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP
610 620 630 640 650
EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE
660 670 680 690 700
GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ
710 720 730 740 750
LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW
760 770 780
MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD
Length:788
Mass (Da):88,521
Last modified:February 1, 1996 - v1
Checksum:iE77BCA40B22C1DA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38448 mRNA. Translation: BAA07480.1.
RefSeqiNP_037258.1. NM_013126.1.
UniGeneiRn.10544.

Genome annotation databases

EnsembliENSRNOT00000002452; ENSRNOP00000002452; ENSRNOG00000001796.
GeneIDi25666.
KEGGirno:25666.
UCSCiRGD:2499. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDGKG_RAT
AccessioniPrimary (citable) accession number: P49620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families