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P49619

- DGKG_HUMAN

UniProt

P49619 - DGKG_HUMAN

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Protein

Diacylglycerol kinase gamma

Gene

DGKG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Enzyme regulationi

Requires phosphatidylserine for maximal activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi188 – 199121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi233 – 244122PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 32151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 38550Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. diacylglycerol kinase activity Source: ProtInc
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. neuron development Source: Ensembl
  4. platelet activation Source: Reactome
  5. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_2202. Effects of PIP2 hydrolysis.
SABIO-RKP49619.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase gamma (EC:2.7.1.107)
Short name:
DAG kinase gamma
Alternative name(s):
Diglyceride kinase gamma
Short name:
DGK-gamma
Gene namesi
Name:DGKG
Synonyms:DAGK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:2853. DGKG.

Subcellular locationi

Cytoplasm. Membrane
Note: Can be loosely bound to the membranes.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: HPA
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791Diacylglycerol kinase gammaPRO_0000218459Add
BLAST

Proteomic databases

PaxDbiP49619.
PRIDEiP49619.

PTM databases

PhosphoSiteiP49619.

Expressioni

Tissue specificityi

Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Gene expression databases

BgeeiP49619.
CleanExiHS_DGKG.
ExpressionAtlasiP49619. baseline and differential.
GenevestigatoriP49619.

Organism-specific databases

HPAiHPA036577.

Interactioni

Protein-protein interaction databases

BioGridi107978. 2 interactions.
IntActiP49619. 2 interactions.
STRINGi9606.ENSP00000265022.

Structurei

3D structure databases

ProteinModelPortaliP49619.
SMRiP49619. Positions 1-79, 161-248, 265-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 21036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini220 – 25536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 564135DAGKcPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 1566Poly-Ser

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 32151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 38550Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000252931.
HOVERGENiHBG051345.
InParanoidiP49619.
KOiK00901.
OMAiCYQSVTA.
OrthoDBiEOG75XGK8.
PhylomeDBiP49619.
TreeFamiTF313104.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49619-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI
60 70 80 90 100
SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA
110 120 130 140 150
NSADTNIQNA DNATKADEAC APDTESNMAE KQAPAEDQVA ATPLEPPVPR
160 170 180 190 200
SSSSESPVVY LKDVVCYLSL LETGRPQDKL EFMFRLYDSD ENGLLDQAEM
210 220 230 240 250
DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV SLQEWVHGGM
260 270 280 290 300
TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL
310 320 330 340 350
CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR
360 370 380 390 400
CHKSIKCYQS VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP
410 420 430 440 450
ITRDRPGEKS DGCVSAKGEL VMQYKIIPTP GTHPLLVLVN PKSGGRQGER
460 470 480 490 500
ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR DTPDFRVLAC GGDGTVGWIL
510 520 530 540 550
DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL TKILKDIEQS
560 570 580 590 600
PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE
610 620 630 640 650
KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI
660 670 680 690 700
FLEGIAILNI PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL
710 720 730 740 750
SDQLLEVVGL EGAMEMGQIY TGLKSAGRRL AQCASVTIRT NKLLPMQVDG
760 770 780 790
EPWMQPCCTI KITHKNQAPM MMGPPQKSSF FSLRRKSRSK D
Length:791
Mass (Da):89,124
Last modified:November 2, 2010 - v3
Checksum:iA1382CF1B2CD7362
GO
Isoform 2 (identifier: P49619-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     451-475: Missing.

Note: May be inactive.

Show »
Length:766
Mass (Da):86,303
Checksum:i1D3F8C78BD59219F
GO
Isoform 3 (identifier: P49619-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-372: Missing.

Show »
Length:752
Mass (Da):84,573
Checksum:i4B58648DC4E785ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711R → G in BAA05132. (PubMed:8034597)Curated
Sequence conflicti271 – 2711R → G in AAC04686. (PubMed:10071200)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421T → S.2 Publications
Corresponds to variant rs1004588 [ dbSNP | Ensembl ].
VAR_020259
Natural varianti316 – 3161R → K.4 Publications
Corresponds to variant rs2193587 [ dbSNP | Ensembl ].
VAR_024430
Natural varianti370 – 3701R → W.
Corresponds to variant rs3213770 [ dbSNP | Ensembl ].
VAR_020260
Natural varianti706 – 7061E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_036119

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei334 – 37239Missing in isoform 3. 1 PublicationVSP_039922Add
BLAST
Alternative sequencei451 – 47525Missing in isoform 2. 1 PublicationVSP_001267Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26135 mRNA. Translation: BAA05132.1.
AF020945
, AF020922, AF020923, AF020924, AF020925, AF020926, AF020927, AF020928, AF020929, AF020930, AF020931, AF020932, AF020933, AF020934, AF020935, AF020936, AF020937, AF020938, AF020939, AF020940, AF020941, AF020942, AF020943, AF020944 Genomic DNA. Translation: AAC04686.1.
AK314192 mRNA. Translation: BAG36871.1.
AC007917 Genomic DNA. No translation available.
AC112649 Genomic DNA. No translation available.
BC089411 mRNA. Translation: AAH89411.1.
BC112363 mRNA. Translation: AAI12364.1.
CCDSiCCDS3274.1. [P49619-1]
CCDS43181.1. [P49619-3]
CCDS43182.1. [P49619-2]
PIRiA53691.
RefSeqiNP_001074213.1. NM_001080744.1. [P49619-2]
NP_001074214.1. NM_001080745.1. [P49619-3]
NP_001337.2. NM_001346.2. [P49619-1]
UniGeneiHs.683449.

Genome annotation databases

EnsembliENST00000265022; ENSP00000265022; ENSG00000058866. [P49619-1]
ENST00000344484; ENSP00000339777; ENSG00000058866. [P49619-2]
ENST00000382164; ENSP00000371599; ENSG00000058866. [P49619-3]
GeneIDi1608.
KEGGihsa:1608.
UCSCiuc003fqa.3. human. [P49619-1]
uc003fqb.3. human. [P49619-3]
uc003fqc.3. human. [P49619-2]

Polymorphism databases

DMDMi311033457.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26135 mRNA. Translation: BAA05132.1 .
AF020945
, AF020922 , AF020923 , AF020924 , AF020925 , AF020926 , AF020927 , AF020928 , AF020929 , AF020930 , AF020931 , AF020932 , AF020933 , AF020934 , AF020935 , AF020936 , AF020937 , AF020938 , AF020939 , AF020940 , AF020941 , AF020942 , AF020943 , AF020944 Genomic DNA. Translation: AAC04686.1 .
AK314192 mRNA. Translation: BAG36871.1 .
AC007917 Genomic DNA. No translation available.
AC112649 Genomic DNA. No translation available.
BC089411 mRNA. Translation: AAH89411.1 .
BC112363 mRNA. Translation: AAI12364.1 .
CCDSi CCDS3274.1. [P49619-1 ]
CCDS43181.1. [P49619-3 ]
CCDS43182.1. [P49619-2 ]
PIRi A53691.
RefSeqi NP_001074213.1. NM_001080744.1. [P49619-2 ]
NP_001074214.1. NM_001080745.1. [P49619-3 ]
NP_001337.2. NM_001346.2. [P49619-1 ]
UniGenei Hs.683449.

3D structure databases

ProteinModelPortali P49619.
SMRi P49619. Positions 1-79, 161-248, 265-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107978. 2 interactions.
IntActi P49619. 2 interactions.
STRINGi 9606.ENSP00000265022.

Chemistry

ChEMBLi CHEMBL1075157.
DrugBanki DB00144. Phosphatidylserine.

PTM databases

PhosphoSitei P49619.

Polymorphism databases

DMDMi 311033457.

Proteomic databases

PaxDbi P49619.
PRIDEi P49619.

Protocols and materials databases

DNASUi 1608.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265022 ; ENSP00000265022 ; ENSG00000058866 . [P49619-1 ]
ENST00000344484 ; ENSP00000339777 ; ENSG00000058866 . [P49619-2 ]
ENST00000382164 ; ENSP00000371599 ; ENSG00000058866 . [P49619-3 ]
GeneIDi 1608.
KEGGi hsa:1608.
UCSCi uc003fqa.3. human. [P49619-1 ]
uc003fqb.3. human. [P49619-3 ]
uc003fqc.3. human. [P49619-2 ]

Organism-specific databases

CTDi 1608.
GeneCardsi GC03M185823.
HGNCi HGNC:2853. DGKG.
HPAi HPA036577.
MIMi 601854. gene.
neXtProti NX_P49619.
PharmGKBi PA27314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47311.
GeneTreei ENSGT00760000119050.
HOGENOMi HOG000252931.
HOVERGENi HBG051345.
InParanoidi P49619.
KOi K00901.
OMAi CYQSVTA.
OrthoDBi EOG75XGK8.
PhylomeDBi P49619.
TreeFami TF313104.

Enzyme and pathway databases

Reactomei REACT_2202. Effects of PIP2 hydrolysis.
SABIO-RK P49619.

Miscellaneous databases

ChiTaRSi DGKG. human.
GeneWikii DGKG.
GenomeRNAii 1608.
NextBioi 6606.
PROi P49619.
SOURCEi Search...

Gene expression databases

Bgeei P49619.
CleanExi HS_DGKG.
ExpressionAtlasi P49619. baseline and differential.
Genevestigatori P49619.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.238.110. 2 hits.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells."
    Kai M., Sakane F., Imai S., Wada I., Kanoh H.
    J. Biol. Chem. 269:18492-18498(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-316.
    Tissue: Liver.
  2. "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)."
    Stoehr H., Klein J., Gehrig A., Koehler M.R., Jurklies B., Kellner U., Leo-Kottler B., Schmid M., Weber B.H.F.
    Hum. Genet. 104:99-105(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-316.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-142 AND LYS-316.
    Tissue: Thalamus.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS SER-142 AND LYS-316.
    Tissue: Lymph.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-706.

Entry informationi

Entry nameiDGKG_HUMAN
AccessioniPrimary (citable) accession number: P49619
Secondary accession number(s): B2RAH4, Q2M1H4, Q5FWG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3