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P49619

- DGKG_HUMAN

UniProt

P49619 - DGKG_HUMAN

Protein

Diacylglycerol kinase gamma

Gene

DGKG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Enzyme regulationi

    Requires phosphatidylserine for maximal activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi188 – 199121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi233 – 244122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 32151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 38550Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. diacylglycerol kinase activity Source: ProtInc
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. intracellular signal transduction Source: InterPro
    3. neuron development Source: Ensembl
    4. platelet activation Source: Reactome
    5. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_2202. Effects of PIP2 hydrolysis.
    SABIO-RKP49619.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase gamma (EC:2.7.1.107)
    Short name:
    DAG kinase gamma
    Alternative name(s):
    Diglyceride kinase gamma
    Short name:
    DGK-gamma
    Gene namesi
    Name:DGKG
    Synonyms:DAGK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:2853. DGKG.

    Subcellular locationi

    Cytoplasm. Membrane
    Note: Can be loosely bound to the membranes.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: HPA
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 791791Diacylglycerol kinase gammaPRO_0000218459Add
    BLAST

    Proteomic databases

    PaxDbiP49619.
    PRIDEiP49619.

    PTM databases

    PhosphoSiteiP49619.

    Expressioni

    Tissue specificityi

    Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

    Gene expression databases

    ArrayExpressiP49619.
    BgeeiP49619.
    CleanExiHS_DGKG.
    GenevestigatoriP49619.

    Organism-specific databases

    HPAiHPA036577.

    Interactioni

    Protein-protein interaction databases

    BioGridi107978. 2 interactions.
    IntActiP49619. 2 interactions.
    STRINGi9606.ENSP00000265022.

    Structurei

    3D structure databases

    ProteinModelPortaliP49619.
    SMRiP49619. Positions 1-79, 161-248, 265-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 21036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini220 – 25536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 564135DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi151 – 1566Poly-Ser

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 32151Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 38550Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG47311.
    HOGENOMiHOG000252931.
    HOVERGENiHBG051345.
    InParanoidiP49619.
    KOiK00901.
    OMAiCYQSVTA.
    OrthoDBiEOG75XGK8.
    PhylomeDBiP49619.
    TreeFamiTF313104.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49619-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI    50
    SYDVFKLFMR AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA 100
    NSADTNIQNA DNATKADEAC APDTESNMAE KQAPAEDQVA ATPLEPPVPR 150
    SSSSESPVVY LKDVVCYLSL LETGRPQDKL EFMFRLYDSD ENGLLDQAEM 200
    DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV SLQEWVHGGM 250
    TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL 300
    CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR 350
    CHKSIKCYQS VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP 400
    ITRDRPGEKS DGCVSAKGEL VMQYKIIPTP GTHPLLVLVN PKSGGRQGER 450
    ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR DTPDFRVLAC GGDGTVGWIL 500
    DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL TKILKDIEQS 550
    PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE 600
    KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI 650
    FLEGIAILNI PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL 700
    SDQLLEVVGL EGAMEMGQIY TGLKSAGRRL AQCASVTIRT NKLLPMQVDG 750
    EPWMQPCCTI KITHKNQAPM MMGPPQKSSF FSLRRKSRSK D 791
    Length:791
    Mass (Da):89,124
    Last modified:November 2, 2010 - v3
    Checksum:iA1382CF1B2CD7362
    GO
    Isoform 2 (identifier: P49619-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         451-475: Missing.

    Note: May be inactive.

    Show »
    Length:766
    Mass (Da):86,303
    Checksum:i1D3F8C78BD59219F
    GO
    Isoform 3 (identifier: P49619-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         334-372: Missing.

    Show »
    Length:752
    Mass (Da):84,573
    Checksum:i4B58648DC4E785ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti271 – 2711R → G in BAA05132. (PubMed:8034597)Curated
    Sequence conflicti271 – 2711R → G in AAC04686. (PubMed:10071200)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti142 – 1421T → S.2 Publications
    Corresponds to variant rs1004588 [ dbSNP | Ensembl ].
    VAR_020259
    Natural varianti316 – 3161R → K.4 Publications
    Corresponds to variant rs2193587 [ dbSNP | Ensembl ].
    VAR_024430
    Natural varianti370 – 3701R → W.
    Corresponds to variant rs3213770 [ dbSNP | Ensembl ].
    VAR_020260
    Natural varianti706 – 7061E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036119

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei334 – 37239Missing in isoform 3. 1 PublicationVSP_039922Add
    BLAST
    Alternative sequencei451 – 47525Missing in isoform 2. 1 PublicationVSP_001267Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26135 mRNA. Translation: BAA05132.1.
    AF020945
    , AF020922, AF020923, AF020924, AF020925, AF020926, AF020927, AF020928, AF020929, AF020930, AF020931, AF020932, AF020933, AF020934, AF020935, AF020936, AF020937, AF020938, AF020939, AF020940, AF020941, AF020942, AF020943, AF020944 Genomic DNA. Translation: AAC04686.1.
    AK314192 mRNA. Translation: BAG36871.1.
    AC007917 Genomic DNA. No translation available.
    AC112649 Genomic DNA. No translation available.
    BC089411 mRNA. Translation: AAH89411.1.
    BC112363 mRNA. Translation: AAI12364.1.
    CCDSiCCDS3274.1. [P49619-1]
    CCDS43181.1. [P49619-3]
    CCDS43182.1. [P49619-2]
    PIRiA53691.
    RefSeqiNP_001074213.1. NM_001080744.1. [P49619-2]
    NP_001074214.1. NM_001080745.1. [P49619-3]
    NP_001337.2. NM_001346.2. [P49619-1]
    UniGeneiHs.683449.

    Genome annotation databases

    EnsembliENST00000265022; ENSP00000265022; ENSG00000058866. [P49619-1]
    ENST00000344484; ENSP00000339777; ENSG00000058866. [P49619-2]
    ENST00000382164; ENSP00000371599; ENSG00000058866. [P49619-3]
    GeneIDi1608.
    KEGGihsa:1608.
    UCSCiuc003fqa.3. human. [P49619-1]
    uc003fqb.3. human. [P49619-3]
    uc003fqc.3. human. [P49619-2]

    Polymorphism databases

    DMDMi311033457.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26135 mRNA. Translation: BAA05132.1 .
    AF020945
    , AF020922 , AF020923 , AF020924 , AF020925 , AF020926 , AF020927 , AF020928 , AF020929 , AF020930 , AF020931 , AF020932 , AF020933 , AF020934 , AF020935 , AF020936 , AF020937 , AF020938 , AF020939 , AF020940 , AF020941 , AF020942 , AF020943 , AF020944 Genomic DNA. Translation: AAC04686.1 .
    AK314192 mRNA. Translation: BAG36871.1 .
    AC007917 Genomic DNA. No translation available.
    AC112649 Genomic DNA. No translation available.
    BC089411 mRNA. Translation: AAH89411.1 .
    BC112363 mRNA. Translation: AAI12364.1 .
    CCDSi CCDS3274.1. [P49619-1 ]
    CCDS43181.1. [P49619-3 ]
    CCDS43182.1. [P49619-2 ]
    PIRi A53691.
    RefSeqi NP_001074213.1. NM_001080744.1. [P49619-2 ]
    NP_001074214.1. NM_001080745.1. [P49619-3 ]
    NP_001337.2. NM_001346.2. [P49619-1 ]
    UniGenei Hs.683449.

    3D structure databases

    ProteinModelPortali P49619.
    SMRi P49619. Positions 1-79, 161-248, 265-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107978. 2 interactions.
    IntActi P49619. 2 interactions.
    STRINGi 9606.ENSP00000265022.

    Chemistry

    ChEMBLi CHEMBL1075157.
    DrugBanki DB00144. Phosphatidylserine.

    PTM databases

    PhosphoSitei P49619.

    Polymorphism databases

    DMDMi 311033457.

    Proteomic databases

    PaxDbi P49619.
    PRIDEi P49619.

    Protocols and materials databases

    DNASUi 1608.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265022 ; ENSP00000265022 ; ENSG00000058866 . [P49619-1 ]
    ENST00000344484 ; ENSP00000339777 ; ENSG00000058866 . [P49619-2 ]
    ENST00000382164 ; ENSP00000371599 ; ENSG00000058866 . [P49619-3 ]
    GeneIDi 1608.
    KEGGi hsa:1608.
    UCSCi uc003fqa.3. human. [P49619-1 ]
    uc003fqb.3. human. [P49619-3 ]
    uc003fqc.3. human. [P49619-2 ]

    Organism-specific databases

    CTDi 1608.
    GeneCardsi GC03M185823.
    HGNCi HGNC:2853. DGKG.
    HPAi HPA036577.
    MIMi 601854. gene.
    neXtProti NX_P49619.
    PharmGKBi PA27314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47311.
    HOGENOMi HOG000252931.
    HOVERGENi HBG051345.
    InParanoidi P49619.
    KOi K00901.
    OMAi CYQSVTA.
    OrthoDBi EOG75XGK8.
    PhylomeDBi P49619.
    TreeFami TF313104.

    Enzyme and pathway databases

    Reactomei REACT_2202. Effects of PIP2 hydrolysis.
    SABIO-RK P49619.

    Miscellaneous databases

    GeneWikii DGKG.
    GenomeRNAii 1608.
    NextBioi 6606.
    PROi P49619.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49619.
    Bgeei P49619.
    CleanExi HS_DGKG.
    Genevestigatori P49619.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.238.110. 2 hits.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR029477. DAG_kinase_typeI_N.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF14513. DAG_kinase_N. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells."
      Kai M., Sakane F., Imai S., Wada I., Kanoh H.
      J. Biol. Chem. 269:18492-18498(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-316.
      Tissue: Liver.
    2. "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)."
      Stoehr H., Klein J., Gehrig A., Koehler M.R., Jurklies B., Kellner U., Leo-Kottler B., Schmid M., Weber B.H.F.
      Hum. Genet. 104:99-105(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-316.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-142 AND LYS-316.
      Tissue: Thalamus.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS SER-142 AND LYS-316.
      Tissue: Lymph.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-706.

    Entry informationi

    Entry nameiDGKG_HUMAN
    AccessioniPrimary (citable) accession number: P49619
    Secondary accession number(s): B2RAH4, Q2M1H4, Q5FWG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 146 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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