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Protein

Urokinase plasminogen activator surface receptor

Gene

Plaur

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

GO - Molecular functioni

  • urokinase plasminogen activator receptor activity Source: RGD

GO - Biological processi

  • epithelial cell differentiation involved in prostate gland development Source: RGD
  • mesenchymal cell differentiation Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • positive regulation of gene expression Source: RGD
  • regulation of proteolysis Source: InterPro
  • skeletal muscle tissue regeneration Source: RGD
  • spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
CD_antigen: CD87
Gene namesi
Name:Plaur
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620597. Plaur.

Subcellular locationi

Isoform 1 :
Isoform 2 :
  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 299275Urokinase plasminogen activator surface receptorPRO_0000036099Add
BLAST
Propeptidei300 – 32829Removed in mature formSequence analysisPRO_0000036100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 48By similarity
Disulfide bondi30 ↔ 36By similarity
Disulfide bondi41 ↔ 69By similarity
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 100By similarity
Disulfide bondi120 ↔ 147By similarity
Disulfide bondi123 ↔ 130By similarity
Disulfide bondi140 ↔ 169By similarity
Disulfide bondi175 ↔ 192By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi193 ↔ 198By similarity
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi216 ↔ 244By similarity
Disulfide bondi219 ↔ 227By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi237 ↔ 263By similarity
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi269 ↔ 288By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi289 ↔ 294By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis
Lipidationi299 – 2991GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP49616.
PRIDEiP49616.

Expressioni

Inductioni

Up-regulated in transformed thyroid cell lines.1 Publication

Interactioni

Subunit structurei

Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2 (By similarity). Interacts with SORL1 (By similarity).By similarityCurated

Protein-protein interaction databases

IntActiP49616. 1 interaction.
STRINGi10116.ENSRNOP00000063960.

Chemistry

BindingDBiP49616.

Structurei

3D structure databases

ProteinModelPortaliP49616.
SMRiP49616. Positions 25-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11894UPAR/Ly6 1Add
BLAST
Domaini118 – 21396UPAR/Ly6 2Add
BLAST
Domaini214 – 29986UPAR/Ly6 3Add
BLAST

Sequence similaritiesi

Contains 3 UPAR/Ly6 domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
HOVERGENiHBG000245.
InParanoidiP49616.
KOiK03985.
PhylomeDBiP49616.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49616-1) [UniParc]FASTAAdd to basket

Also known as: GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLRRRLLL LVVVVTTCVP ASQGLRCIQC ESNQDCLVEE CALGQDLCRT
60 70 80 90 100
TVLREWEDAE ELEVVTRGCA HKEKTNRTMS YRMGSVIVSL TETVCATNLC
110 120 130 140 150
NRPRPGARGR PFPRGRYLEC ASCTSLDQSC ERGREQSLQC RYPTEHCIEV
160 170 180 190 200
VTLQSTERSV KDEPYTKGCG SLPGCPGTAG FHSNQTFHFL KCCNFTQCNG
210 220 230 240 250
GPVLDLQSLP PNGFQCYSCE GNSTFGCSYE ETSLIDCRGP MNQCLEATGL
260 270 280 290 300
DVLGNRSYTV RGCATASWCQ GSHVADSFQT HVNLSISCCN GSGCNRPTGG
310 320
APGPGPAHLI LIASLLLTLR LWGIPLWT
Note: GPI-anchored form.
Length:328
Mass (Da):35,753
Last modified:October 23, 2007 - v2
Checksum:i9CF24A90B07B2E0A
GO
Isoform 2 (identifier: P49616-3) [UniParc] [UniParc]FASTAAdd to basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     159-220: SVKDEPYTKG...PNGFQCYSCE → KLPAAGSPLG...LVVSHILLSF
     221-328: Missing.

Show »
Length:220
Mass (Da):24,417
Checksum:i224AB98959FE7F88
GO

Sequence cautioni

The sequence CAA50717.1 differs from that shown. Reason: Frameshift at position 223. Curated
The sequence CAA50718.1 differs from that shown. Reason: Frameshift at position 223. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2343TSL → SSF in CAA50718 (PubMed:8307160).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951C → S.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 22062SVKDE…CYSCE → KLPAAGSPLGCPKEISKFQA CKQNSHSHATAHSVPGSSES LDQLESDQELSYLVVSHILL SF in isoform 2. 1 PublicationVSP_031840Add
BLAST
Alternative sequencei221 – 328108Missing in isoform 2. 1 PublicationVSP_031841Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71898 mRNA. Translation: CAA50717.1. Frameshift.
X71899 mRNA. Translation: CAA50718.1. Frameshift.
X76129 Genomic DNA. Translation: CAA53732.1.
AF007789 mRNA. Translation: AAB62974.1.
BC127499 mRNA. Translation: AAI27500.1.
PIRiS42152.
S42429.
RefSeqiNP_059046.1. NM_017350.1.
NP_599179.1. NM_134352.1.
UniGeneiRn.82711.

Genome annotation databases

GeneIDi50692.
KEGGirno:50692.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71898 mRNA. Translation: CAA50717.1. Frameshift.
X71899 mRNA. Translation: CAA50718.1. Frameshift.
X76129 Genomic DNA. Translation: CAA53732.1.
AF007789 mRNA. Translation: AAB62974.1.
BC127499 mRNA. Translation: AAI27500.1.
PIRiS42152.
S42429.
RefSeqiNP_059046.1. NM_017350.1.
NP_599179.1. NM_134352.1.
UniGeneiRn.82711.

3D structure databases

ProteinModelPortaliP49616.
SMRiP49616. Positions 25-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49616. 1 interaction.
STRINGi10116.ENSRNOP00000063960.

Chemistry

BindingDBiP49616.

Proteomic databases

PaxDbiP49616.
PRIDEiP49616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50692.
KEGGirno:50692.

Organism-specific databases

CTDi5329.
RGDi620597. Plaur.

Phylogenomic databases

eggNOGiENOG410IJ50. Eukaryota.
ENOG410Z47S. LUCA.
HOVERGENiHBG000245.
InParanoidiP49616.
KOiK03985.
PhylomeDBiP49616.

Miscellaneous databases

PROiP49616.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
IPR033084. U-PAR.
[Graphical view]
PANTHERiPTHR10624:SF6. PTHR10624:SF6. 1 hit.
PfamiPF00021. UPAR_LY6. 3 hits.
[Graphical view]
SMARTiSM00134. LU. 3 hits.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts."
    Rabbani S.A., Rajwans N., Achbarou A., Murthy K.K., Goltzman D.
    FEBS Lett. 338:69-74(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
    Tissue: Osteoblast.
  2. DeYoung M.B., Wohlgemuth J., Dichek D.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.
    Tissue: Aortic smooth muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  4. "The receptor for the plasminogen activator of urokinase type is up-regulated in transformed rat thyroid cells."
    Ragno P., Cassano S., Degen J., Kessler C., Blasi F., Rossi G.
    FEBS Lett. 306:193-198(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiUPAR_RAT
AccessioniPrimary (citable) accession number: P49616
Secondary accession number(s): O35771, P51573, Q7TN35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.