Reviewed,
UniProtKB/Swiss-Prot P49615 (CDK5_MOUSE)
Last modified
July 7, 2009.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division protein kinase 5 EC=2.7.11.22 Alternative name(s): Cyclin-dependent kinase 5 Tau protein kinase II catalytic subunit Short name=TPKII catalytic subunit Serine/threonine-protein kinase PSSALRE CRK6 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 292 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subunit structure | Interacts with AATK By similarity. Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1. |
| Subcellular location | Cytoplasm. Cell projection › growth cone. Cell projection › lamellipodium. Note: In axonal growth cone with extension to the peripheral lamellipodia. |
| Tissue specificity | Specifically expressed in post-mitotic neurons. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 292 | 292 | Cell division protein kinase 5 | PRO_0000085785 | |||||
Regions | |||||||||
| Domain | 4 – 286 | 283 | Protein kinase | ||||||
| Nucleotide binding | 10 – 18 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 126 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 33 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 14 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphotyrosine; by ABL1 Ref.5 | ||||||
| Modified residue | 17 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 72 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 159 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Mutagenesis | 15 | 1 | Y → F: Loss of thyrosine phosphorylations by CABLES1 and ABL1; decreased activity. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems." Ino H., Ishizuka T., Chiba T., Tatibana M. Brain Res. 661:196-206(1994) [PubMed: 7834371] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain. |
| [3] | "Novel CDC2-related protein kinases produced in murine hematopoietic stem cells." Ershler M.A., Nagorskaya T.V., Visser J.W.M., Belyavsky A.V. Gene 124:305-306(1993) [PubMed: 8444355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-165. Strain: CBA. Tissue: Bone marrow. |
| [4] | "Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene." Ohshima T., Nagle J.W., Pant H.C., Joshi J.B., Kozak C.A., Brady R.O., Kulkarni A.B. Genomics 28:585-588(1995) [PubMed: 7490100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-12. |
| [5] | "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth." Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.-L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.-H. Neuron 26:633-646(2000) [PubMed: 10896159] [Abstract] Cited for: IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CABLES1 AND ABL1, INTERACTION WITH CABLES1, PHOSPHORYLATION AT TYR-15, MUTAGENESIS OF TYR-15. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D29678 mRNA. Translation: BAA06148.1. BC052007 mRNA. Translation: AAH52007.1. X64604 mRNA. Translation: CAA45888.1. S80121 Genomic DNA. No translation available. | |
| IPI | IPI00309262. |
| PIR | I49592. |
| RefSeq | NP_031694.1. |
| UniGene | Mm.298798 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1H0V based on UniProtKB P24941. |
| SMR | P49615. Positions 1-292. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P49615. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000028969. Mus musculus. [Contig view] |
| GeneID | 12568. |
| KEGG | mmu:12568. |
Organism-specific databases | |
| MGI | MGI:101765. Cdk5. |
Phylogenomic databases | |
| HOGENOM | P49615. |
| HOVERGEN | P49615. |
| OMA | P49615. RCFSAEV. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 244. |
Gene expression databases | |
| ArrayExpress | P49615. |
| Bgee | P49615. |
| CleanEx | MM_CDK5. |
| GermOnline | ENSMUSG00000028969. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 281666. |
| SOURCE | Search... |
Entry information
| Entry name | CDK5_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P49615 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


