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P49615 (CDK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 5

EC=2.7.11.22
Alternative name(s):
CR6 protein kinase
Short name=CRK6
Cell division protein kinase 5
Serine/threonine-protein kinase PSSALRE
Tau protein kinase II catalytic subunit
Short name=TPKII catalytic subunit
Gene names
Name:Cdk5
Synonyms:Cdkn5, Crk6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Ref.9 Ref.12 Ref.13 Ref.14 Ref.15

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration By similarity. Ref.6

Subunit structure

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2. Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons By similarity. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4M. Interacts with PTK2/FAK1. The complex p35/CDK5 interacts with CLOCK By similarity. Ref.5 Ref.8 Ref.9 Ref.13 Ref.15

Subcellular location

Nucleus By similarity. Cytoplasm. Cell membrane; Peripheral membrane protein By similarity. Perikaryon By similarity. Cell projectionlamellipodium. Cell projectiongrowth cone. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Note: In axonal growth cone with extension to the peripheral lamellipodia. Under neurotoxic stress and neuronal injury conditions, CDK5R1 (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5 By similarity. Ref.6

Tissue specificity

Specifically expressed in post-mitotic neurons and postsynaptic muscle. Ref.10

Post-translational modification

Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity By similarity.

Phosphorylation at Ser-159 is essential for maximal catalytic activity By similarity.

Disruption phenotype

Perinatal mortality associated with severe disruption of the cytoarchitecture of the brain cortex as a result of defects in neuronal migration and cohesiveness, and degenerative changes in large neurons of the brain stem, such as motor neurons in the lower cranial nerve nuclei and spinal cord. Disruption of lamination in the cerebral cortex, hippocampus, and cerebellum. Hypomyelination caused by impaired differentiation of oligodendrocytes. Ref.6 Ref.7 Ref.10 Ref.14

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processApoptosis
Biological rhythms
Cell cycle
Cell division
Neurogenesis
   Cellular componentCell junction
Cell membrane
Cell projection
Cytoplasm
Membrane
Nucleus
Postsynaptic cell membrane
Synapse
   DiseaseNeurodegeneration
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSchwann cell development

Inferred from mutant phenotype Ref.10. Source: MGI

apoptotic process

Inferred from direct assay PubMed 9126296. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 11978846. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 11163260. Source: MGI

behavioral response to cocaine

Inferred from mutant phenotype PubMed 18032670. Source: MGI

calcium ion import

Inferred from mutant phenotype PubMed 18054859. Source: MGI

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

cell migration

Inferred from direct assay PubMed 12496365. Source: MGI

cell-matrix adhesion

Inferred from direct assay PubMed 12496365. Source: MGI

central nervous system neuron development

Inferred from mutant phenotype PubMed 8855328. Source: MGI

cerebellar cortex development

Inferred from mutant phenotype PubMed 8855328. Source: MGI

cerebellar cortex formation

Inferred from mutant phenotype PubMed 10407039. Source: MGI

cerebellum development

Inferred from mutant phenotype Ref.7. Source: MGI

cerebral cortex development

Inferred from mutant phenotype PubMed 9698328. Source: MGI

corpus callosum development

Inferred from mutant phenotype PubMed 18032654. Source: MGI

cortical actin cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

dendrite morphogenesis

Inferred from mutant phenotype PubMed 12372285Ref.12. Source: MGI

embryo development

Inferred from sequence or structural similarity. Source: UniProtKB

forebrain development

Inferred from mutant phenotype PubMed 17694053. Source: MGI

hippocampus development

Inferred from mutant phenotype Ref.6. Source: MGI

intracellular protein transport

Inferred from mutant phenotype PubMed 8855328. Source: MGI

layer formation in cerebral cortex

Inferred from mutant phenotype Ref.6. Source: MGI

motor neuron axon guidance

Inferred from mutant phenotype Ref.10. Source: MGI

negative regulation of axon extension

Inferred from genetic interaction PubMed 22573681. Source: MGI

negative regulation of cell cycle

Inferred from mutant phenotype PubMed 16237170. Source: MGI

negative regulation of protein export from nucleus

Inferred from mutant phenotype PubMed 17591690. Source: MGI

negative regulation of protein ubiquitination

Inferred from mutant phenotype PubMed 17591690. Source: MGI

negative regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 17529984. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from mutant phenotype PubMed 17591690. Source: MGI

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neuron migration

Inferred from mutant phenotype PubMed 10407039PubMed 15067135. Source: MGI

neuron projection development

Inferred from sequence or structural similarity. Source: UniProtKB

nucleocytoplasmic transport

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

peptidyl-serine phosphorylation

Inferred from direct assay PubMed 18054859. Source: MGI

peptidyl-threonine phosphorylation

Inferred from direct assay PubMed 18054859. Source: MGI

positive regulation of calcium ion-dependent exocytosis

Inferred from direct assay PubMed 15123626. Source: MGI

positive regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein binding

Inferred from mutant phenotype PubMed 18054859. Source: MGI

positive regulation of protein kinase activity

Inferred from mutant phenotype Ref.10. Source: MGI

positive regulation of protein targeting to membrane

Inferred from mutant phenotype PubMed 18054859. Source: MGI

positive regulation of receptor activity

Inferred from direct assay PubMed 11276227. Source: GOC

protein autophosphorylation

Inferred from electronic annotation. Source: Ensembl

protein localization to synapse

Inferred from mutant phenotype PubMed 18054859. Source: MGI

protein phosphorylation

Inferred from direct assay Ref.6PubMed 12372285PubMed 15123626PubMed 15489224PubMed 17194758. Source: MGI

receptor catabolic process

Inferred from mutant phenotype PubMed 17529984. Source: MGI

receptor clustering

Inferred from mutant phenotype Ref.10. Source: MGI

regulated secretory pathway

Inferred from electronic annotation. Source: Ensembl

regulation of cell migration

Inferred from mutant phenotype Ref.9. Source: MGI

regulation of dendritic spine morphogenesis

Inferred from mutant phenotype Ref.12. Source: UniProtKB

regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype PubMed 17529984. Source: MGI

regulation of postsynaptic membrane potential

Inferred from mutant phenotype Ref.10. Source: MGI

regulation of synaptic plasticity

Inferred from sequence or structural similarity. Source: UniProtKB

response to cocaine

Inferred from mutant phenotype PubMed 14769920. Source: MGI

response to wounding

Inferred from electronic annotation. Source: Ensembl

rhythmic process

Inferred from electronic annotation. Source: UniProtKB-KW

sensory perception of pain

Inferred from mutant phenotype PubMed 17194758. Source: MGI

serine phosphorylation of STAT3 protein

Inferred from direct assay PubMed 15096606. Source: MGI

skeletal muscle tissue development

Inferred from direct assay PubMed 9191048. Source: MGI

synapse assembly

Inferred from mutant phenotype PubMed 18054859. Source: MGI

synaptic transmission, dopaminergic

Inferred from mutant phenotype PubMed 14769920. Source: MGI

synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 14769920. Source: MGI

synaptic vesicle endocytosis

Inferred from electronic annotation. Source: Ensembl

telencephalon development

Inferred from mutant phenotype PubMed 18032654. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 17529984. Source: MGI

   Cellular_componentaxon

Inferred from sequence or structural similarity. Source: UniProtKB

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein kinase 5 holoenzyme complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from direct assay PubMed 12496365PubMed 9202329. Source: MGI

dendrite

Inferred from sequence or structural similarity. Source: UniProtKB

filopodium

Inferred from direct assay PubMed 12496365. Source: MGI

growth cone

Inferred from sequence or structural similarity. Source: UniProtKB

lamellipodium

Inferred from direct assay PubMed 12496365. Source: MGI

membrane

Inferred from sequence or structural similarity. Source: UniProtKB

neuromuscular junction

Inferred from sequence or structural similarity. Source: UniProtKB

neuronal cell body

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

perikaryon

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic density

Inferred from sequence or structural similarity. Source: UniProtKB

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ErbB-2 class receptor binding

Inferred from direct assay PubMed 11276227. Source: UniProtKB

ErbB-3 class receptor binding

Inferred from direct assay PubMed 11276227. Source: UniProtKB

acetylcholine receptor activator activity

Inferred from direct assay PubMed 11276227. Source: UniProtKB

cyclin-dependent protein serine/threonine kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

p53 binding

Inferred from physical interaction PubMed 17591690. Source: MGI

protein binding

Inferred from physical interaction PubMed 11276227. Source: UniProtKB

protein kinase activity

Inferred from direct assay Ref.7PubMed 11343650Ref.6PubMed 12077184PubMed 12372285PubMed 15123626PubMed 17194758PubMed 9126296PubMed 9202329. Source: MGI

protein serine/threonine kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

tau-protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdk5r1P618092EBI-6510052,EBI-7840438

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Cyclin-dependent kinase 5
PRO_0000085785

Regions

Domain4 – 286283Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue151Phosphotyrosine; by ABL1, EPHA4 and FYN Ref.5
Modified residue561N6-acetyllysine Ref.16
Modified residue721Phosphoserine By similarity
Modified residue1591Phosphoserine By similarity

Experimental info

Mutagenesis151Y → F: Loss of tyrosine phosphorylations by CABLES1 and ABL1; decreased activity. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P49615 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4CB11CED9017D535

FASTA29233,288
        10         20         30         40         50         60 
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 

        70         80         90        100        110        120 
KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 

       130        140        150        160        170        180 
NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 

       190        200        210        220        230        240 
TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPAM TKLPDYKPYP 

       250        260        270        280        290 
MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 

« Hide

References

« Hide 'large scale' references
[1]"Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems."
Ino H., Ishizuka T., Chiba T., Tatibana M.
Brain Res. 661:196-206(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Novel CDC2-related protein kinases produced in murine hematopoietic stem cells."
Ershler M.A., Nagorskaya T.V., Visser J.W.M., Belyavsky A.V.
Gene 124:305-306(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-165.
Strain: CBA.
Tissue: Bone marrow.
[4]"Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene."
Ohshima T., Nagle J.W., Pant H.C., Joshi J.B., Kozak C.A., Brady R.O., Kulkarni A.B.
Genomics 28:585-588(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-12.
[5]"Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth."
Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.-L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.-H.
Neuron 26:633-646(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CABLES1 AND ABL1, INTERACTION WITH CABLES1, PHOSPHORYLATION AT TYR-15, MUTAGENESIS OF TYR-15.
[6]"p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment."
Ko J., Humbert S., Bronson R.T., Takahashi S., Kulkarni A.B., Li E., Tsai L.H.
J. Neurosci. 21:6758-6771(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, ENZYME REGULATION.
[7]"Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain."
Ohshima T., Ogawa M., Veeranna A., Hirasawa M., Longenecker G., Ishiguro K., Pant H.C., Brady R.O., Kulkarni A.B., Mikoshiba K.
Proc. Natl. Acad. Sci. U.S.A. 98:2764-2769(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[8]"Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl."
Sato H., Nishimoto I., Matsuoka M.
Biochim. Biophys. Acta 1574:157-163(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CABLES2.
[9]"Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration."
Xie Z., Sanada K., Samuels B.A., Shih H., Tsai L.H.
Cell 114:469-482(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PTK2/FAK1.
[10]"Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice."
Fu A.K.Y., Ip F.C.F., Fu W.-Y., Cheung J., Wang J.H., Yung W.-H., Ip N.Y.
Proc. Natl. Acad. Sci. U.S.A. 102:15224-15229(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
[11]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[12]"Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
Fu W.Y., Chen Y., Sahin M., Zhao X.S., Shi L., Bikoff J.B., Lai K.O., Yung W.H., Fu A.K., Greenberg M.E., Ip N.Y.
Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN DENDRITIC SPINE MORPHOGENESIS.
[13]"The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death."
Huang E., Qu D., Zhang Y., Venderova K., Haque M.E., Rousseaux M.W.C., Slack R.S., Woulfe J.M., Park D.S.
Nat. Cell Biol. 12:563-571(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS APEX1 KINASE, INTERACTION WITH APEX1.
[14]"Hypomyelination Phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice."
He X., Takahashi S., Suzuki H., Hashikawa T., Kulkarni A.B., Mikoshiba K., Ohshima T.
Neurochem. Res. 36:1293-1303(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION IN OLIGODENDROCYTE DIFFERENTIATION.
[15]"Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."
Kwak Y., Jeong J., Lee S., Park Y.U., Lee S.A., Han D.H., Kim J.H., Ohshima T., Mikoshiba K., Suh Y.H., Cho S., Park S.K.
J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CLOCK.
[16]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D29678 mRNA. Translation: BAA06148.1.
BC052007 mRNA. Translation: AAH52007.1.
X64604 mRNA. Translation: CAA45888.1.
S80121 Genomic DNA. No translation available.
CCDSCCDS51434.1.
PIRI49592.
RefSeqNP_031694.1. NM_007668.3.
UniGeneMm.298798.
Mm.445256.

3D structure databases

ProteinModelPortalP49615.
SMRP49615. Positions 1-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198646. 4 interactions.
DIPDIP-29353N.
IntActP49615. 5 interactions.
MINTMINT-4090424.
STRING10090.ENSMUSP00000030814.

PTM databases

PhosphoSiteP49615.

Proteomic databases

MaxQBP49615.
PaxDbP49615.
PRIDEP49615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030814; ENSMUSP00000030814; ENSMUSG00000028969.
GeneID12568.
KEGGmmu:12568.
UCSCuc008wrl.1. mouse.

Organism-specific databases

CTD1020.
MGIMGI:101765. Cdk5.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidP49615.
KOK02090.
OMATMTKLPD.
OrthoDBEOG7966H8.
PhylomeDBP49615.
TreeFamTF101023.

Enzyme and pathway databases

BRENDA2.7.11.22. 3474.
ReactomeREACT_194409. Developmental Biology.
REACT_224553. Hemostasis.

Gene expression databases

ArrayExpressP49615.
BgeeP49615.
CleanExMM_CDK5.
GenevestigatorP49615.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDK5. mouse.
NextBio281666.
PROP49615.
SOURCESearch...

Entry information

Entry nameCDK5_MOUSE
AccessionPrimary (citable) accession number: P49615
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot