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P49610

- STRH_STRPN

UniProt

P49610 - STRH_STRPN

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Protein

Beta-N-acetylhexosaminidase

Gene
strH, SP_0057
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-63-MONOMER.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-N-acetylhexosaminidase (EC:3.2.1.52)
Gene namesi
Name:strH
Ordered Locus Names:SP_0057
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Secretedcell wall; Peptidoglycan-anchor Reviewed prediction

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 12841251Beta-N-acetylhexosaminidasePRO_0000012020Add
BLAST
Propeptidei1285 – 131228Removed by sortase Reviewed predictionPRO_0000012021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1284 – 12841Pentaglycyl murein peptidoglycan amidated threonine Reviewed prediction

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0057.

Structurei

Secondary structure

1
1312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi181 – 1844
Beta strandi186 – 1938
Turni194 – 1963
Helixi201 – 21414
Beta strandi218 – 22811
Beta strandi237 – 2393
Beta strandi242 – 2443
Helixi246 – 26015
Helixi271 – 28313
Beta strandi287 – 29711
Helixi299 – 30810
Beta strandi314 – 3174
Beta strandi320 – 3267
Helixi331 – 34818
Turni349 – 3513
Beta strandi353 – 3586
Turni362 – 3687
Helixi371 – 38010
Beta strandi383 – 3853
Helixi390 – 40718
Beta strandi411 – 4166
Turni417 – 4204
Helixi421 – 4233
Beta strandi435 – 4384
Helixi451 – 4566
Beta strandi461 – 4633
Helixi466 – 4683
Helixi484 – 49310
Beta strandi510 – 5178
Helixi527 – 54014
Turni541 – 5444
Helixi550 – 5578
Helixi568 – 58215
Helixi590 – 5923
Helixi593 – 60816
Helixi627 – 6304
Beta strandi631 – 6388
Turni639 – 6413
Helixi646 – 65914
Beta strandi663 – 67311
Beta strandi682 – 6843
Beta strandi687 – 6893
Helixi691 – 70515
Helixi716 – 72813
Beta strandi732 – 74211
Helixi744 – 7529
Beta strandi759 – 77012
Helixi775 – 79218
Turni793 – 7953
Beta strandi796 – 8027
Helixi808 – 8103
Helixi815 – 8217
Helixi825 – 84117
Beta strandi845 – 8506
Turni851 – 8544
Helixi855 – 8573
Beta strandi868 – 8714
Helixi884 – 8896
Beta strandi893 – 8964
Helixi899 – 9013
Beta strandi902 – 9043
Helixi909 – 9113
Helixi916 – 92510
Turni936 – 9383
Beta strandi943 – 9519
Helixi961 – 97414
Turni975 – 9784
Helixi984 – 9907
Helixi1002 – 101312
Helixi1021 – 10233
Helixi1024 – 103613
Beta strandi1055 – 10584
Beta strandi1060 – 10634
Beta strandi1065 – 10739
Beta strandi1085 – 10884
Beta strandi1092 – 10943
Beta strandi1099 – 110911
Beta strandi1118 – 11203
Beta strandi1131 – 11344

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LTJNMR-A1050-1140[»]
2YL5X-ray2.15A/B/C/D627-1064[»]
2YL6X-ray1.60A181-614[»]
2YL8X-ray1.75A181-614[»]
2YL9X-ray2.65A/B/C/D627-1062[»]
2YLAX-ray2.70A/B/C/D627-1064[»]
2YLLX-ray1.85A181-614[»]
4AZ5X-ray1.73A181-614[»]
4AZ6X-ray1.36A181-613[»]
4AZ7X-ray1.70A181-613[»]
4AZBX-ray2.10A181-614[»]
4AZCX-ray2.09A/B/C/D627-1064[»]
4AZGX-ray2.40A/B627-1064[»]
4AZHX-ray2.22A/B/C/D627-1064[»]
4AZIX-ray1.98A/B627-1064[»]
ProteinModelPortaliP49610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1059 – 113880G5 1Add
BLAST
Domaini1150 – 123081G5 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 616441Catalytic domain 1Add
BLAST
Regioni621 – 1046426Catalytic domain 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1281 – 12855LPXTG sorting signal Reviewed prediction

Sequence similaritiesi

Contains 2 G5 domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3525.
HOGENOMiHOG000285052.
KOiK12373.
OMAiTYASDDV.
OrthoDBiEOG6GFGKT.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49610-1 [UniParc]FASTAAdd to Basket

« Hide

MKHEKQQRFS IRKYAVGAAS VLIGFAFQAQ TVAADGVTPT TTENQPTIHT     50
VSDSPQSSEN RTEETPKAVL QPEAPKTVET ETPATDKVAS LPKTEEKPQE 100
EVSSTPSDKA EVVTPTSAEK ETANKKAEEA SPKKEEAKEV DSKESNTDKT 150
DKDKPAKKDE AKAEADKPAT EAGKERAATV NEKLAKKKIV SIDAGRKYFS 200
PEQLKEIIDK AKHYGYTDLH LLVGNDGLRF MLDDMSITAN GKTYASDDVK 250
RAIEKGTNDY YNDPNGNHLT ESQMTDLINY AKDKGIGLIP TVNSPGHMDA 300
ILNAMKELGI QNPNFSYFGK KSARTVDLDN EQAVAFTKAL IDKYAAYFAK 350
KTEIFNIGLD EYANDATDAK GWSVLQADKY YPNEGYPVKG YEKFIAYAND 400
LARIVKSHGL KPMAFNDGIY YNSDTSFGSF DKDIIVSMWT GGWGGYDVAS 450
SKLLAEKGHQ ILNTNDAWYY VLGRNADGQG WYNLDQGLNG IKNTPITSVP 500
KTEGADIPII GGMVAAWADT PSARYSPSRL FKLMRHFANA NAEYFAADYE 550
SAEQALNEVP KDLNRYTAES VTAVKEAEKA IRSLDSNLSR AQQDTIDQAI 600
AKLQETVNNL TLTPEAQKEE EAKREVEKLA KNKVISIDAG RKYFTLNQLK 650
RIVDKASELG YSDVHLLLGN DGLRFLLDDM TITANGKTYA SDDVKKAIIE 700
GTKAYYDDPN GTALTQAEVT ELIEYAKSKD IGLIPAINSP GHMDAMLVAM 750
EKLGIKNPQA HFDKVSKTTM DLKNEEAMNF VKALIGKYMD FFAGKTKIFN 800
FGTDEYANDA TSAQGWYYLK WYQLYGKFAE YANTLAAMAK ERGLQPMAFN 850
DGFYYEDKDD VQFDKDVLIS YWSKGWWGYN LASPQYLASK GYKFLNTNGD 900
WYYILGQKPE DGGGFLKKAI ENTGKTPFNQ LASTKYPEVD LPTVGSMLSI 950
WADRPSAEYK EEEIFELMTA FADHNKDYFR ANYNALREEL AKIPTNLEGY 1000
SKESLEALDA AKTALNYNLN RNKQAELDTL VANLKAALQG LKPAVTHSGS 1050
LDENEVAANV ETRPELITRT EEIPFEVIKK ENPNLPAGQE NIITAGVKGE 1100
RTHYISVLTE NGKTTETVLD SQVTKEVINQ VVEVGAPVTH KGDESGLAPT 1150
TEVKPRLDIQ EEEIPFTTVT CENPLLLKGK TQVITKGVNG HRSNFYSVST 1200
SADGKEVKTL VNSVVAQEAV TQIVEVGTMV THVGDENGQA AIAEEKPKLE 1250
IPSQPAPSTA PAEESKVLPQ DPAPVVTEKK LPETGTHDSA GLVVAGLMST 1300
LAAYGLTKRK ED 1312
Length:1,312
Mass (Da):144,550
Last modified:September 26, 2001 - v2
Checksum:i503375B5257A90B5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391Missing in AAC41450. 1 Publication
Sequence conflicti69 – 691V → E in AAC41450. 1 Publication
Sequence conflicti169 – 1691A → E in AAC41450. 1 Publication
Sequence conflicti617 – 6171Q → L in AAC41450. 1 Publication
Sequence conflicti1045 – 10451V → A in AAC41450. 1 Publication
Sequence conflicti1161 – 11611E → K in AAC41450. 1 Publication
Sequence conflicti1171 – 11711C → R in AAC41450. 1 Publication
Sequence conflicti1267 – 12671V → A in AAC41450. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1.
AE005672 Genomic DNA. Translation: AAK74246.1.
PIRiA56390.
E95006.
RefSeqiNP_344606.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK74246; AAK74246; SP_0057.
GeneIDi929812.
KEGGispn:SP_0057.
PATRICi19704441. VBIStrPne105772_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1 .
AE005672 Genomic DNA. Translation: AAK74246.1 .
PIRi A56390.
E95006.
RefSeqi NP_344606.1. NC_003028.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LTJ NMR - A 1050-1140 [» ]
2YL5 X-ray 2.15 A/B/C/D 627-1064 [» ]
2YL6 X-ray 1.60 A 181-614 [» ]
2YL8 X-ray 1.75 A 181-614 [» ]
2YL9 X-ray 2.65 A/B/C/D 627-1062 [» ]
2YLA X-ray 2.70 A/B/C/D 627-1064 [» ]
2YLL X-ray 1.85 A 181-614 [» ]
4AZ5 X-ray 1.73 A 181-614 [» ]
4AZ6 X-ray 1.36 A 181-613 [» ]
4AZ7 X-ray 1.70 A 181-613 [» ]
4AZB X-ray 2.10 A 181-614 [» ]
4AZC X-ray 2.09 A/B/C/D 627-1064 [» ]
4AZG X-ray 2.40 A/B 627-1064 [» ]
4AZH X-ray 2.22 A/B/C/D 627-1064 [» ]
4AZI X-ray 1.98 A/B 627-1064 [» ]
ProteinModelPortali P49610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0057.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74246 ; AAK74246 ; SP_0057 .
GeneIDi 929812.
KEGGi spn:SP_0057.
PATRICi 19704441. VBIStrPne105772_0065.

Phylogenomic databases

eggNOGi COG3525.
HOGENOMi HOG000285052.
KOi K12373.
OMAi TYASDDV.
OrthoDBi EOG6GFGKT.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-63-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the beta-N-acetylglucosaminidase gene from Streptococcus pneumoniae. Generation of truncated enzymes with modified aglycon specificity."
    Clarke V.A., Platt N., Butters T.D.
    J. Biol. Chem. 270:8805-8814(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 12213.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiSTRH_STRPN
AccessioniPrimary (citable) accession number: P49610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 26, 2001
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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