Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-N-acetylhexosaminidase

Gene

strH

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-N-acetylhexosaminidase (EC:3.2.1.52)
Gene namesi
Name:strH
Ordered Locus Names:SP_0057
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001202034 – 1284Beta-N-acetylhexosaminidaseAdd BLAST1251
PropeptideiPRO_00000120211285 – 1312Removed by sortasePROSITE-ProRule annotationAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1284Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRIDEiP49610.

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0057.

Structurei

Secondary structure

11312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi181 – 184Combined sources4
Beta strandi186 – 193Combined sources8
Turni194 – 196Combined sources3
Helixi201 – 214Combined sources14
Beta strandi218 – 228Combined sources11
Beta strandi237 – 239Combined sources3
Beta strandi242 – 244Combined sources3
Helixi246 – 260Combined sources15
Helixi271 – 283Combined sources13
Beta strandi287 – 297Combined sources11
Helixi299 – 308Combined sources10
Beta strandi314 – 317Combined sources4
Beta strandi320 – 326Combined sources7
Helixi331 – 348Combined sources18
Turni349 – 351Combined sources3
Beta strandi353 – 358Combined sources6
Turni362 – 368Combined sources7
Helixi371 – 380Combined sources10
Beta strandi383 – 385Combined sources3
Helixi390 – 407Combined sources18
Beta strandi411 – 416Combined sources6
Turni417 – 420Combined sources4
Helixi421 – 423Combined sources3
Beta strandi435 – 438Combined sources4
Helixi451 – 456Combined sources6
Beta strandi461 – 463Combined sources3
Helixi466 – 468Combined sources3
Helixi484 – 493Combined sources10
Beta strandi510 – 517Combined sources8
Helixi527 – 540Combined sources14
Turni541 – 544Combined sources4
Helixi550 – 557Combined sources8
Helixi568 – 582Combined sources15
Helixi590 – 592Combined sources3
Helixi593 – 608Combined sources16
Helixi627 – 630Combined sources4
Beta strandi631 – 638Combined sources8
Turni639 – 641Combined sources3
Helixi646 – 659Combined sources14
Beta strandi663 – 673Combined sources11
Beta strandi682 – 684Combined sources3
Beta strandi687 – 689Combined sources3
Helixi691 – 705Combined sources15
Helixi716 – 728Combined sources13
Beta strandi732 – 742Combined sources11
Helixi744 – 752Combined sources9
Beta strandi759 – 770Combined sources12
Helixi775 – 792Combined sources18
Turni793 – 795Combined sources3
Beta strandi796 – 802Combined sources7
Helixi808 – 810Combined sources3
Helixi815 – 821Combined sources7
Helixi825 – 841Combined sources17
Beta strandi845 – 850Combined sources6
Turni851 – 854Combined sources4
Helixi855 – 857Combined sources3
Beta strandi868 – 871Combined sources4
Helixi884 – 889Combined sources6
Beta strandi893 – 896Combined sources4
Helixi899 – 901Combined sources3
Beta strandi902 – 904Combined sources3
Helixi909 – 911Combined sources3
Helixi916 – 925Combined sources10
Turni936 – 938Combined sources3
Beta strandi943 – 951Combined sources9
Helixi961 – 974Combined sources14
Turni975 – 978Combined sources4
Helixi984 – 990Combined sources7
Helixi1002 – 1013Combined sources12
Helixi1021 – 1023Combined sources3
Helixi1024 – 1036Combined sources13
Beta strandi1055 – 1058Combined sources4
Beta strandi1060 – 1063Combined sources4
Beta strandi1065 – 1073Combined sources9
Beta strandi1085 – 1088Combined sources4
Beta strandi1092 – 1094Combined sources3
Beta strandi1099 – 1109Combined sources11
Beta strandi1118 – 1120Combined sources3
Beta strandi1131 – 1134Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LTJNMR-A1050-1140[»]
2YL5X-ray2.15A/B/C/D627-1064[»]
2YL6X-ray1.60A181-614[»]
2YL8X-ray1.75A181-614[»]
2YL9X-ray2.65A/B/C/D627-1062[»]
2YLAX-ray2.70A/B/C/D627-1064[»]
2YLLX-ray1.85A181-614[»]
4AZ5X-ray1.73A181-614[»]
4AZ6X-ray1.36A181-613[»]
4AZ7X-ray1.70A181-613[»]
4AZBX-ray2.10A181-614[»]
4AZCX-ray2.09A/B/C/D627-1064[»]
4AZGX-ray2.40A/B627-1064[»]
4AZHX-ray2.22A/B/C/D627-1064[»]
4AZIX-ray1.98A/B627-1064[»]
ProteinModelPortaliP49610.
SMRiP49610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1059 – 1138G5 1PROSITE-ProRule annotationAdd BLAST80
Domaini1150 – 1230G5 2PROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 616Catalytic domain 1Add BLAST441
Regioni621 – 1046Catalytic domain 2Add BLAST426

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1281 – 1285LPXTG sorting signalPROSITE-ProRule annotation5

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated
Contains 2 G5 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG41069UX. Bacteria.
COG3525. LUCA.
HOGENOMiHOG000285052.
KOiK12373.
OMAiTYASDDV.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM01208. G5. 2 hits.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHEKQQRFS IRKYAVGAAS VLIGFAFQAQ TVAADGVTPT TTENQPTIHT
60 70 80 90 100
VSDSPQSSEN RTEETPKAVL QPEAPKTVET ETPATDKVAS LPKTEEKPQE
110 120 130 140 150
EVSSTPSDKA EVVTPTSAEK ETANKKAEEA SPKKEEAKEV DSKESNTDKT
160 170 180 190 200
DKDKPAKKDE AKAEADKPAT EAGKERAATV NEKLAKKKIV SIDAGRKYFS
210 220 230 240 250
PEQLKEIIDK AKHYGYTDLH LLVGNDGLRF MLDDMSITAN GKTYASDDVK
260 270 280 290 300
RAIEKGTNDY YNDPNGNHLT ESQMTDLINY AKDKGIGLIP TVNSPGHMDA
310 320 330 340 350
ILNAMKELGI QNPNFSYFGK KSARTVDLDN EQAVAFTKAL IDKYAAYFAK
360 370 380 390 400
KTEIFNIGLD EYANDATDAK GWSVLQADKY YPNEGYPVKG YEKFIAYAND
410 420 430 440 450
LARIVKSHGL KPMAFNDGIY YNSDTSFGSF DKDIIVSMWT GGWGGYDVAS
460 470 480 490 500
SKLLAEKGHQ ILNTNDAWYY VLGRNADGQG WYNLDQGLNG IKNTPITSVP
510 520 530 540 550
KTEGADIPII GGMVAAWADT PSARYSPSRL FKLMRHFANA NAEYFAADYE
560 570 580 590 600
SAEQALNEVP KDLNRYTAES VTAVKEAEKA IRSLDSNLSR AQQDTIDQAI
610 620 630 640 650
AKLQETVNNL TLTPEAQKEE EAKREVEKLA KNKVISIDAG RKYFTLNQLK
660 670 680 690 700
RIVDKASELG YSDVHLLLGN DGLRFLLDDM TITANGKTYA SDDVKKAIIE
710 720 730 740 750
GTKAYYDDPN GTALTQAEVT ELIEYAKSKD IGLIPAINSP GHMDAMLVAM
760 770 780 790 800
EKLGIKNPQA HFDKVSKTTM DLKNEEAMNF VKALIGKYMD FFAGKTKIFN
810 820 830 840 850
FGTDEYANDA TSAQGWYYLK WYQLYGKFAE YANTLAAMAK ERGLQPMAFN
860 870 880 890 900
DGFYYEDKDD VQFDKDVLIS YWSKGWWGYN LASPQYLASK GYKFLNTNGD
910 920 930 940 950
WYYILGQKPE DGGGFLKKAI ENTGKTPFNQ LASTKYPEVD LPTVGSMLSI
960 970 980 990 1000
WADRPSAEYK EEEIFELMTA FADHNKDYFR ANYNALREEL AKIPTNLEGY
1010 1020 1030 1040 1050
SKESLEALDA AKTALNYNLN RNKQAELDTL VANLKAALQG LKPAVTHSGS
1060 1070 1080 1090 1100
LDENEVAANV ETRPELITRT EEIPFEVIKK ENPNLPAGQE NIITAGVKGE
1110 1120 1130 1140 1150
RTHYISVLTE NGKTTETVLD SQVTKEVINQ VVEVGAPVTH KGDESGLAPT
1160 1170 1180 1190 1200
TEVKPRLDIQ EEEIPFTTVT CENPLLLKGK TQVITKGVNG HRSNFYSVST
1210 1220 1230 1240 1250
SADGKEVKTL VNSVVAQEAV TQIVEVGTMV THVGDENGQA AIAEEKPKLE
1260 1270 1280 1290 1300
IPSQPAPSTA PAEESKVLPQ DPAPVVTEKK LPETGTHDSA GLVVAGLMST
1310
LAAYGLTKRK ED
Length:1,312
Mass (Da):144,550
Last modified:September 26, 2001 - v2
Checksum:i503375B5257A90B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Missing in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti69V → E in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti169A → E in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti617Q → L in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti1045V → A in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti1161E → K in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti1171C → R in AAC41450 (PubMed:7721787).Curated1
Sequence conflicti1267V → A in AAC41450 (PubMed:7721787).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1.
AE005672 Genomic DNA. Translation: AAK74246.1.
PIRiA56390.
E95006.
RefSeqiWP_000679952.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74246; AAK74246; SP_0057.
KEGGispn:SP_0057.
PATRICi19704441. VBIStrPne105772_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1.
AE005672 Genomic DNA. Translation: AAK74246.1.
PIRiA56390.
E95006.
RefSeqiWP_000679952.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LTJNMR-A1050-1140[»]
2YL5X-ray2.15A/B/C/D627-1064[»]
2YL6X-ray1.60A181-614[»]
2YL8X-ray1.75A181-614[»]
2YL9X-ray2.65A/B/C/D627-1062[»]
2YLAX-ray2.70A/B/C/D627-1064[»]
2YLLX-ray1.85A181-614[»]
4AZ5X-ray1.73A181-614[»]
4AZ6X-ray1.36A181-613[»]
4AZ7X-ray1.70A181-613[»]
4AZBX-ray2.10A181-614[»]
4AZCX-ray2.09A/B/C/D627-1064[»]
4AZGX-ray2.40A/B627-1064[»]
4AZHX-ray2.22A/B/C/D627-1064[»]
4AZIX-ray1.98A/B627-1064[»]
ProteinModelPortaliP49610.
SMRiP49610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_0057.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Proteomic databases

PRIDEiP49610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74246; AAK74246; SP_0057.
KEGGispn:SP_0057.
PATRICi19704441. VBIStrPne105772_0065.

Phylogenomic databases

eggNOGiENOG41069UX. Bacteria.
COG3525. LUCA.
HOGENOMiHOG000285052.
KOiK12373.
OMAiTYASDDV.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM01208. G5. 2 hits.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRH_STRPN
AccessioniPrimary (citable) accession number: P49610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.