Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49610

- STRH_STRPN

UniProt

P49610 - STRH_STRPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-N-acetylhexosaminidase

Gene

strH

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-63-MONOMER.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-N-acetylhexosaminidase (EC:3.2.1.52)
Gene namesi
Name:strH
Ordered Locus Names:SP_0057
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 12841251Beta-N-acetylhexosaminidasePRO_0000012020Add
BLAST
Propeptidei1285 – 131228Removed by sortasePROSITE-ProRule annotationPRO_0000012021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1284 – 12841Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0057.

Structurei

Secondary structure

1
1312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi181 – 1844Combined sources
Beta strandi186 – 1938Combined sources
Turni194 – 1963Combined sources
Helixi201 – 21414Combined sources
Beta strandi218 – 22811Combined sources
Beta strandi237 – 2393Combined sources
Beta strandi242 – 2443Combined sources
Helixi246 – 26015Combined sources
Helixi271 – 28313Combined sources
Beta strandi287 – 29711Combined sources
Helixi299 – 30810Combined sources
Beta strandi314 – 3174Combined sources
Beta strandi320 – 3267Combined sources
Helixi331 – 34818Combined sources
Turni349 – 3513Combined sources
Beta strandi353 – 3586Combined sources
Turni362 – 3687Combined sources
Helixi371 – 38010Combined sources
Beta strandi383 – 3853Combined sources
Helixi390 – 40718Combined sources
Beta strandi411 – 4166Combined sources
Turni417 – 4204Combined sources
Helixi421 – 4233Combined sources
Beta strandi435 – 4384Combined sources
Helixi451 – 4566Combined sources
Beta strandi461 – 4633Combined sources
Helixi466 – 4683Combined sources
Helixi484 – 49310Combined sources
Beta strandi510 – 5178Combined sources
Helixi527 – 54014Combined sources
Turni541 – 5444Combined sources
Helixi550 – 5578Combined sources
Helixi568 – 58215Combined sources
Helixi590 – 5923Combined sources
Helixi593 – 60816Combined sources
Helixi627 – 6304Combined sources
Beta strandi631 – 6388Combined sources
Turni639 – 6413Combined sources
Helixi646 – 65914Combined sources
Beta strandi663 – 67311Combined sources
Beta strandi682 – 6843Combined sources
Beta strandi687 – 6893Combined sources
Helixi691 – 70515Combined sources
Helixi716 – 72813Combined sources
Beta strandi732 – 74211Combined sources
Helixi744 – 7529Combined sources
Beta strandi759 – 77012Combined sources
Helixi775 – 79218Combined sources
Turni793 – 7953Combined sources
Beta strandi796 – 8027Combined sources
Helixi808 – 8103Combined sources
Helixi815 – 8217Combined sources
Helixi825 – 84117Combined sources
Beta strandi845 – 8506Combined sources
Turni851 – 8544Combined sources
Helixi855 – 8573Combined sources
Beta strandi868 – 8714Combined sources
Helixi884 – 8896Combined sources
Beta strandi893 – 8964Combined sources
Helixi899 – 9013Combined sources
Beta strandi902 – 9043Combined sources
Helixi909 – 9113Combined sources
Helixi916 – 92510Combined sources
Turni936 – 9383Combined sources
Beta strandi943 – 9519Combined sources
Helixi961 – 97414Combined sources
Turni975 – 9784Combined sources
Helixi984 – 9907Combined sources
Helixi1002 – 101312Combined sources
Helixi1021 – 10233Combined sources
Helixi1024 – 103613Combined sources
Beta strandi1055 – 10584Combined sources
Beta strandi1060 – 10634Combined sources
Beta strandi1065 – 10739Combined sources
Beta strandi1085 – 10884Combined sources
Beta strandi1092 – 10943Combined sources
Beta strandi1099 – 110911Combined sources
Beta strandi1118 – 11203Combined sources
Beta strandi1131 – 11344Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LTJNMR-A1050-1140[»]
2YL5X-ray2.15A/B/C/D627-1064[»]
2YL6X-ray1.60A181-614[»]
2YL8X-ray1.75A181-614[»]
2YL9X-ray2.65A/B/C/D627-1062[»]
2YLAX-ray2.70A/B/C/D627-1064[»]
2YLLX-ray1.85A181-614[»]
4AZ5X-ray1.73A181-614[»]
4AZ6X-ray1.36A181-613[»]
4AZ7X-ray1.70A181-613[»]
4AZBX-ray2.10A181-614[»]
4AZCX-ray2.09A/B/C/D627-1064[»]
4AZGX-ray2.40A/B627-1064[»]
4AZHX-ray2.22A/B/C/D627-1064[»]
4AZIX-ray1.98A/B627-1064[»]
ProteinModelPortaliP49610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1059 – 113880G5 1PROSITE-ProRule annotationAdd
BLAST
Domaini1150 – 123081G5 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 616441Catalytic domain 1Add
BLAST
Regioni621 – 1046426Catalytic domain 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1281 – 12855LPXTG sorting signalPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated
Contains 2 G5 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3525.
HOGENOMiHOG000285052.
KOiK12373.
OMAiTYASDDV.
OrthoDBiEOG6GFGKT.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHEKQQRFS IRKYAVGAAS VLIGFAFQAQ TVAADGVTPT TTENQPTIHT
60 70 80 90 100
VSDSPQSSEN RTEETPKAVL QPEAPKTVET ETPATDKVAS LPKTEEKPQE
110 120 130 140 150
EVSSTPSDKA EVVTPTSAEK ETANKKAEEA SPKKEEAKEV DSKESNTDKT
160 170 180 190 200
DKDKPAKKDE AKAEADKPAT EAGKERAATV NEKLAKKKIV SIDAGRKYFS
210 220 230 240 250
PEQLKEIIDK AKHYGYTDLH LLVGNDGLRF MLDDMSITAN GKTYASDDVK
260 270 280 290 300
RAIEKGTNDY YNDPNGNHLT ESQMTDLINY AKDKGIGLIP TVNSPGHMDA
310 320 330 340 350
ILNAMKELGI QNPNFSYFGK KSARTVDLDN EQAVAFTKAL IDKYAAYFAK
360 370 380 390 400
KTEIFNIGLD EYANDATDAK GWSVLQADKY YPNEGYPVKG YEKFIAYAND
410 420 430 440 450
LARIVKSHGL KPMAFNDGIY YNSDTSFGSF DKDIIVSMWT GGWGGYDVAS
460 470 480 490 500
SKLLAEKGHQ ILNTNDAWYY VLGRNADGQG WYNLDQGLNG IKNTPITSVP
510 520 530 540 550
KTEGADIPII GGMVAAWADT PSARYSPSRL FKLMRHFANA NAEYFAADYE
560 570 580 590 600
SAEQALNEVP KDLNRYTAES VTAVKEAEKA IRSLDSNLSR AQQDTIDQAI
610 620 630 640 650
AKLQETVNNL TLTPEAQKEE EAKREVEKLA KNKVISIDAG RKYFTLNQLK
660 670 680 690 700
RIVDKASELG YSDVHLLLGN DGLRFLLDDM TITANGKTYA SDDVKKAIIE
710 720 730 740 750
GTKAYYDDPN GTALTQAEVT ELIEYAKSKD IGLIPAINSP GHMDAMLVAM
760 770 780 790 800
EKLGIKNPQA HFDKVSKTTM DLKNEEAMNF VKALIGKYMD FFAGKTKIFN
810 820 830 840 850
FGTDEYANDA TSAQGWYYLK WYQLYGKFAE YANTLAAMAK ERGLQPMAFN
860 870 880 890 900
DGFYYEDKDD VQFDKDVLIS YWSKGWWGYN LASPQYLASK GYKFLNTNGD
910 920 930 940 950
WYYILGQKPE DGGGFLKKAI ENTGKTPFNQ LASTKYPEVD LPTVGSMLSI
960 970 980 990 1000
WADRPSAEYK EEEIFELMTA FADHNKDYFR ANYNALREEL AKIPTNLEGY
1010 1020 1030 1040 1050
SKESLEALDA AKTALNYNLN RNKQAELDTL VANLKAALQG LKPAVTHSGS
1060 1070 1080 1090 1100
LDENEVAANV ETRPELITRT EEIPFEVIKK ENPNLPAGQE NIITAGVKGE
1110 1120 1130 1140 1150
RTHYISVLTE NGKTTETVLD SQVTKEVINQ VVEVGAPVTH KGDESGLAPT
1160 1170 1180 1190 1200
TEVKPRLDIQ EEEIPFTTVT CENPLLLKGK TQVITKGVNG HRSNFYSVST
1210 1220 1230 1240 1250
SADGKEVKTL VNSVVAQEAV TQIVEVGTMV THVGDENGQA AIAEEKPKLE
1260 1270 1280 1290 1300
IPSQPAPSTA PAEESKVLPQ DPAPVVTEKK LPETGTHDSA GLVVAGLMST
1310
LAAYGLTKRK ED
Length:1,312
Mass (Da):144,550
Last modified:September 26, 2001 - v2
Checksum:i503375B5257A90B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391Missing in AAC41450. (PubMed:7721787)Curated
Sequence conflicti69 – 691V → E in AAC41450. (PubMed:7721787)Curated
Sequence conflicti169 – 1691A → E in AAC41450. (PubMed:7721787)Curated
Sequence conflicti617 – 6171Q → L in AAC41450. (PubMed:7721787)Curated
Sequence conflicti1045 – 10451V → A in AAC41450. (PubMed:7721787)Curated
Sequence conflicti1161 – 11611E → K in AAC41450. (PubMed:7721787)Curated
Sequence conflicti1171 – 11711C → R in AAC41450. (PubMed:7721787)Curated
Sequence conflicti1267 – 12671V → A in AAC41450. (PubMed:7721787)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1.
AE005672 Genomic DNA. Translation: AAK74246.1.
PIRiA56390.
E95006.
RefSeqiNP_344606.1. NC_003028.3.
WP_000679952.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74246; AAK74246; SP_0057.
GeneIDi929812.
KEGGispn:SP_0057.
PATRICi19704441. VBIStrPne105772_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36923 Genomic DNA. Translation: AAC41450.1 .
AE005672 Genomic DNA. Translation: AAK74246.1 .
PIRi A56390.
E95006.
RefSeqi NP_344606.1. NC_003028.3.
WP_000679952.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LTJ NMR - A 1050-1140 [» ]
2YL5 X-ray 2.15 A/B/C/D 627-1064 [» ]
2YL6 X-ray 1.60 A 181-614 [» ]
2YL8 X-ray 1.75 A 181-614 [» ]
2YL9 X-ray 2.65 A/B/C/D 627-1062 [» ]
2YLA X-ray 2.70 A/B/C/D 627-1064 [» ]
2YLL X-ray 1.85 A 181-614 [» ]
4AZ5 X-ray 1.73 A 181-614 [» ]
4AZ6 X-ray 1.36 A 181-613 [» ]
4AZ7 X-ray 1.70 A 181-613 [» ]
4AZB X-ray 2.10 A 181-614 [» ]
4AZC X-ray 2.09 A/B/C/D 627-1064 [» ]
4AZG X-ray 2.40 A/B 627-1064 [» ]
4AZH X-ray 2.22 A/B/C/D 627-1064 [» ]
4AZI X-ray 1.98 A/B 627-1064 [» ]
ProteinModelPortali P49610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0057.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74246 ; AAK74246 ; SP_0057 .
GeneIDi 929812.
KEGGi spn:SP_0057.
PATRICi 19704441. VBIStrPne105772_0065.

Phylogenomic databases

eggNOGi COG3525.
HOGENOMi HOG000285052.
KOi K12373.
OMAi TYASDDV.
OrthoDBi EOG6GFGKT.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-63-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR011098. G5_dom.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF07501. G5. 2 hits.
PF00728. Glyco_hydro_20. 2 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS51109. G5. 2 hits.
PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the beta-N-acetylglucosaminidase gene from Streptococcus pneumoniae. Generation of truncated enzymes with modified aglycon specificity."
    Clarke V.A., Platt N., Butters T.D.
    J. Biol. Chem. 270:8805-8814(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 12213.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiSTRH_STRPN
AccessioniPrimary (citable) accession number: P49610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 26, 2001
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3