P49607 (PTH_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	TC_0183

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187717
Experimental info
	Sequence conflict	146	1	V → G Ref.1
	Sequence conflict	146	1	V → G Ref.3
	Sequence conflict	161	1	S → G Ref.1
	Sequence conflict	161	1	S → G Ref.3
	Sequence conflict	178 – 179	2	GF → AFNLKGIYCSLFEKKSS Ref.1
	Sequence conflict	178 – 179	2	GF → AFNLKGIYCSLFEKKSS Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P49607 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 5D682B5269C0564B	FASTA	179	19,915
	10 20 30 40 50 60 MVKLVVGIGN PGRQYVWTRH NIGFLFLDML ASRFSGAFRE APRLFSSFMK VETSCGVIVL 70 80 90 100 110 120 IKPSTYVNLT GKAVLAAKRF FGVSVEGILI VADDINREFG SIRFRQDCGA GGHNGLKNTT 130 140 150 160 170 QVLQSNHYWQ LRLGVGRPSN PESEGVADYV LSNFSFNERK SLNGFFEKGI EEISPWLGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coli." de la Vega F.M., Galindo J.M., Old I.G., Guarneros G. Gene 169:97-100(1996) [PubMed: 8635758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MoPn.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.
[3]	"Heat shock response of murine Chlamydia trachomatis." Engel J.N., Pollack J., Perara E., Ganem D. J. Bacteriol. 172:6959-6972(1990) [PubMed: 2254267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-179. Strain: MoPn.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31570 Genomic DNA. Translation: AAB06184.1. AE002160 Genomic DNA. Translation: AAF39057.1. M62820 Genomic DNA. Translation: AAA23133.1.
PIR	C37840. C81732.
RefSeq	NP_296562.1. NC_002620.2.
3D structure databases
ProteinModelPortal	P49607.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1246309.
GenomeReviews	Gene locus TC_0183 in contig AE002160_GR.
KEGG	cmu:TC0183.
PATRIC	20371740. VBIChlMur19118_0199.
TIGR	TC_0183.
Phylogenomic databases
HOGENOM	HBG610927.
OMA	SHAGHNG.
PhylomeDB	P49607.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0183-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_CHLMU

Accession

Primary (citable) accession number: P49607

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program