Reviewed, UniProtKB/Swiss-Prot P49606 (CYAA_USTMA)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:	UAC1
Synonyms:	REM1
ORF Names:	UM05232

Organism

Ustilago maydis (Smut fungus) [Complete proteome]

Taxonomic identifier

5270 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago

Protein attributes

Sequence length	2493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain. Contains 21 LRR (leucine-rich) repeats. Contains 1 PP2C-like domain. Contains 1 Ras-associating domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Domain	Leucine-rich repeat Repeat
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2493	2493	Adenylate cyclase		PRO_0000195730
Regions
	Domain	970 – 1072	103	Ras-associating
	Repeat	1084 – 1106	23	LRR 1
	Repeat	1108 – 1131	24	LRR 2
	Repeat	1132 – 1155	24	LRR 3
	Repeat	1157 – 1178	22	LRR 4
	Repeat	1179 – 1201	23	LRR 5
	Repeat	1202 – 1225	24	LRR 6
	Repeat	1227 – 1248	22	LRR 7
	Repeat	1249 – 1271	23	LRR 8
	Repeat	1273 – 1295	23	LRR 9
	Repeat	1314 – 1337	24	LRR 10
	Repeat	1338 – 1360	23	LRR 11
	Repeat	1361 – 1384	24	LRR 12
	Repeat	1386 – 1407	22	LRR 13
	Repeat	1408 – 1430	23	LRR 14
	Repeat	1432 – 1455	24	LRR 15
	Repeat	1509 – 1529	21	LRR 16
	Repeat	1533 – 1556	24	LRR 17
	Repeat	1557 – 1580	24	LRR 18
	Repeat	1581 – 1604	24	LRR 19
	Repeat	1606 – 1628	23	LRR 20
	Repeat	1633 – 1656	24	LRR 21
	Domain	1722 – 2001	280	PP2C-like
	Domain	2058 – 2194	137	Guanylate cyclase
	Compositional bias	759 – 763	5	Poly-Asp
	Compositional bias	888 – 897	10	Poly-Ala
Sites
	Metal binding	2063	1	Magnesium By similarity
	Metal binding	2105	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49606-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 106A872C3C1C5BF8	FASTA	2,493	271,983
	10 20 30 40 50 60 MLFTMQFTTR STVASPEQQH QHQQRSISYS DIELGLERIS SRDSNGSSNF THRAYPPPLS 70 80 90 100 110 120 QQYDDTSTNS FHSSQPDITA SSSTLSSRLV SANYSRPRFE HAHTQPPTPD QDRSSSGSGS 130 140 150 160 170 180 GSGSRSYFPA NSHSDSLPGP STHSISPSFD EDELRQIMSH IPANQATSSS DGDVGKAVQS 190 200 210 220 230 240 ANHQDISPFL FQSENAAPFS SSHSNRTSVN PSAASTASPS TSAATRTRPR GGTNASQYNT 250 260 270 280 290 300 LDTSFGSIDR PGLSSSRSQY SLRPQTPPSA STSTSTLNGS KDTHASAVKK TRNPFGFLKK 310 320 330 340 350 360 KSSAHSNASS NHPTRHDIGS VSSLSSRYGP NAAANVNPMR PPAWLDNHCT LANSNSPSSA 370 380 390 400 410 420 SLRSHYHQPP ASSNPPPWQN PLVSRADSTP SAMSLEDEVE AEHHLKKDPR KRIKGVRHHL 430 440 450 460 470 480 AKTTKPGEDA DSARDPAFAA QSQSIEQEVE LSLDMNFDQL DDFVDTNAAR QRLQGSITES 490 500 510 520 530 540 ASPSEHRSPN GSEAGVYRSP SPSQTPIAER QTSVTSTVES PSHASEASLA PSGSLRTPSR 550 560 570 580 590 600 TTASTSTSSA STVLSDRLPS QVNMLPRNSV PRLSLAEMQN YQSLRKLSNN LIDMSQTQNP 610 620 630 640 650 660 SAMGASYRRG SIAAAQAPVD APQLGVAPRT DSELSDRKDS VVSTHSMRSN HSGISPKTSY 670 680 690 700 710 720 ANLPSVIQER QKPATALPSA ANWTSSITRD KTANGHADHA YQFPPATEYQ SNLLLSVRKS 730 740 750 760 770 780 SASSGQEPSS SWMAPDSWAV QPDKMRDYLR DDNVGEEEDD DDDQHQARAA LATDGKRRGS 790 800 810 820 830 840 SSGISSTHAS SMFRTSSTDP FKKTASLAGS RRGTDDSVDP LTALPPLPGS KSVDEAAANK 850 860 870 880 890 900 VDVLQQTNNL AQSALVQQQS QSQNHHQPSP NVRPTSRGGA GAHMFASAGA SAAAAAAGKL 910 920 930 940 950 960 GLHRPSKHRM NARPNTAGSV GATRPSTTTL GSTLSAEDDT SINGSIRRDG HPLKRSATAN 970 980 990 1000 1010 1020 TNNATGTLPR NHFIRVYKTD GTFATLSCSL VSTANEVQTI LARKSLTTES AAYRLFVRDK 1030 1040 1050 1060 1070 1080 GSERPLGISD KPSQLQRRRL IQAGYTENDG LEDMGRDDLS YLLRFVFRPD SVPTFDSESI 1090 1100 1110 1120 1130 1140 GHSEHTFQHL DLHSRNLEMV PIFLYKHADW IVSLDLSGNP MSDLPLDFVQ LCSSLRTLRL 1150 1160 1170 1180 1190 1200 SNLALKRIPQ SVRHSETLTH LDVSNNRIVE LAHVSLDLIP ELMSLKVQNN RLFDLPSYFS 1210 1220 1230 1240 1250 1260 SISTLRNLNI SNNRFEEFPK VICDVPSLVD LDVSFNSITE LPAEIANLIN LERFILAGNE 1270 1280 1290 1300 1310 1320 LEKLPDSMSE LVSLRTIDLR RNKVQDVSSL LGLPRLQNIQ AESNNIKSFE ATLGPQLTQV 1330 1340 1350 1360 1370 1380 ELGRNPLSKV RIAALTTCDL TSLDLSSTNM TRLEEGLFPQ LPALVKLTLD GNQLVVLPDT 1390 1400 1410 1420 1430 1440 LGDLKRLEML SCSNNLLATL PESIGDLKAL KELLVHNNNL KTLPQTLWLC ESLAHINLSS 1450 1460 1470 1480 1490 1500 NLLESFPAVP DIRTDASVGD AAAAAGTSAV IAARKGSTSS SLTHRSNTGG ANGNINLSTP 1510 1520 1530 1540 1550 1560 SEVFVAPLSL SLQKLRLGDN RLGDDVFSVL SELTSLEVLN LSFNEIFEIP DFSLQTLTKL 1570 1580 1590 1600 1610 1620 RELYISGNQL STIPSDDLVV LQELRILHLN CNKLTTLPTE LGKLKKLANL DVGNNVLKYN 1630 1640 1650 1660 1670 1680 IANWHYDWNW NMNPELRYLN LSGNTRLEIK TKLSDMGFTR KSNISDFSRL TSLRMLGLMD 1690 1700 1710 1720 1730 1740 VTMPLHSNAT PDESDNRRVR TSLSQVNGMA YGIADALGKH DNLSVIDLVI PTFRKDEGEC 1750 1760 1770 1780 1790 1800 IFGLFDGRGH GAHVGSRIAH HLAEWSGHRL SWEFQKHQNE MTAEPVSVPD ALRRAFLRLQ 1810 1820 1830 1840 1850 1860 KDYADALIND GSRKLSEAHA EAAADVTRSS APAIAAASNK HDWRAGASAI LAYVVDHTLY 1870 1880 1890 1900 1910 1920 IANAGDALAV MSRNGGTAHL ISNKHEPFDR AEIERIRSAE GWVSLRGYVN DMLDVSRSFG 1930 1940 1950 1960 1970 1980 YFHLFPIVNA APAVTTVQLT DSDEFVIIAN RTLWQYVSYQ TAVDIARTQR NDPMIAAQKL 1990 2000 2010 2020 2030 2040 RDFAISYGAE ESIMVMVISV GDLFYRSDQR NGGGLNFASY KNSDAIQKAG RRFREELPGD 2050 2060 2070 2080 2090 2100 RTLARLDREV APPIGQVALV FTDIKNSTSL WETNNGMQTA MRLHNYLLRR QLRTIGGYEV 2110 2120 2130 2140 2150 2160 KTEGDAFMVS FPSVSAALLW CFTVQQQLLQ EDWPREILDS EDGKEVYDQS GELIHRGLSV 2170 2180 2190 2200 2210 2220 RMGIHWGRPV CEADPITRRM DYFGPMVNRA ARISGAADGG QILASKDVIK ELQGLLGTFD 2230 2240 2250 2260 2270 2280 ESSTAGGAGG EGENLEKTEE ELDEDAFRLL NPNVSRDVVL LRRMGFGLSQ LGERRLKGLE 2290 2300 2310 2320 2330 2340 TPEMLWLVYP KQLAGRLEQA KTDDAPDAPT AQVYEPTVQL LDIEDVKQVG MLCLRLEYLS 2350 2360 2370 2380 2390 2400 NSTVCPGIFA AKDEADRSQP STPLDDNGRN PIDGHGTAVP LLSHQARRKG VEAMLTMHPE 2410 2420 2430 2440 2450 2460 LLIYSIRDDA TDEELAGILD QLTTRIQNAV SSLMLNMLRD KTANGTKELG VDPGVLELLM 2470 2480 2490 GLLSQPPPRA STSALSLPSP RTSPRNRLLE LVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis." Gold S., Duncan G., Barrett K., Kronstad J.W. Genes Dev. 8:2805-2816(1994) [PubMed: 7995519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 518.
[2]	"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed: 17080091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L33918 Genomic DNA. Translation: AAA57469.1. AACP01000190 Genomic DNA. Translation: EAK82845.1.
PIR	A55481.
RefSeq	XP_761379.1.
3D structure databases
HSSP	HSSP built from PDB template 1FX4 based on UniProtKB Q99280.
ModBase	Search...
Protein-protein interaction databases
STRING	P49606.
Genome annotation databases
GeneID	3633359.
KEGG	uma:UM05232.1.
Enzyme and pathway databases
BRENDA	4.6.1.1. 2320.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR001932. PP2C-related. IPR014045. PP2C_N. IPR000159. Ras-assoc. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit. G3DSA:3.60.40.10. PP2C-related. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. PF00560. LRR_1. 7 hits. PF00481. PP2C. 1 hit. PF00788. RA. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. SM00369. LRR_TYP. 2 hits. SM00332. PP2Cc. 1 hit. SM00314. RA. 1 hit. [Graphical view]
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. PS50200. RA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_USTMA

Accession

Primary (citable) accession number: P49606
Secondary accession number(s): Q4P3T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	September 1, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)