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Protein

4-aminobutyrate aminotransferase

Gene

GATA

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Deaminates gamma-aminobutyric acid (GABA) to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Not required for the utilization of GABA as nitrogen source.By similarity1 Publication

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei223SubstrateBy similarity1
Binding sitei387Pyridoxal phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Gene namesi
Name:GATA
ORF Names:UMAG_01080
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_01080

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203811 – 5094-aminobutyrate aminotransferaseAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei363N6-(pyridoxal phosphate)lysineBy similarity1

Expressioni

Inductioni

Up-regulated by GABA and beta-alanine. Is not subject to nitrogen catabolite repression.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5270.UM01080P0

Structurei

3D structure databases

ProteinModelPortaliP49604
SMRiP49604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 167Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020208
InParanoidiP49604
KOiK13524
OMAiIQTGGCG
OrthoDBiEOG092C208V

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

P49604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSKATSAA RACARTSRVM QQQQRRLLAT VVSSSSLFPG EPSSPHVVTS
60 70 80 90 100
QIPGPKSKEL SDRIGTFQEN RTHGFVVDYA KSQGNWIADA DGNVLLDMFA
110 120 130 140 150
QIASIAIGYN NPDLLALAKT DEFITATMNR AALGSFPPTN WQELVETSFG
160 170 180 190 200
TVKPDGLNNI FTAMCGSCAN ENAFKASFMA YRARERGEKA EFTPEEMSSC
210 220 230 240 250
MKNQSPGSPD LSILSFTSAF HGRLFGSLSA TRSKAIHKLD IPSFNWPVVE
260 270 280 290 300
WPDVKYPFAQ NSRENAEAEK VALAAVEEAI VSSKKTGSSY GPVAALIVEP
310 320 330 340 350
IQSEGGDNHA SPAFFQGLRD VTKKHGVFMI VDEVQTGVGA TGAFWAHSKW
360 370 380 390 400
NLTSPPDFVT FSKKMQAAGF YHNIETRPSL PYRNYNTWMG DPARTLQARQ
410 420 430 440 450
IIRTIQDHNL IQKTDKVGNY IYEKLFDLIE NGAGRGKIEK LRGENAGTFL
460 470 480 490 500
AFDGRTAKVR DQLIMEMRKL GVHMGGCGDK ALRLRPMLVF EQKHADIFLD

KLETALGQL
Length:509
Mass (Da):55,993
Last modified:December 12, 2006 - v2
Checksum:i9ECAFAE83FE4DD4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337G → GT in AAA98560 (PubMed:8598057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28655 Genomic DNA Translation: AAA98560.1
CM003141 Genomic DNA Translation: KIS71171.1
PIRiS68116
RefSeqiXP_011387041.1, XM_011388739.1

Genome annotation databases

EnsemblFungiiKIS71171; KIS71171; UMAG_01080
GeneIDi23562197
KEGGiuma:UMAG_01080

Similar proteinsi

Entry informationi

Entry nameiGABAT_USTMA
AccessioniPrimary (citable) accession number: P49604
Secondary accession number(s): A0A0D1E6G7, Q4PFN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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