P49603 (CHS1_BOTFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitin synthase 1
EC=2.4.1.16

Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Class-I chitin synthase 1

Gene names

Name:

chs1

Organism

Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)

Taxonomic identifier

40559 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Botryotinia

Protein attributes

Sequence length	189 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class I subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›189	›189	Chitin synthase 1		PRO_0000193685
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	189	1

Sequences

	Sequence		Length	Mass (Da)
	P49603 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 8106DF294AA06298	FASTA	189	21,027
	10 20 30 40 50 60 DVLFARTMHG VFKNIEFMCT RKDSKTWGKD AWKKIVVCVV SDGRAKINPR TRAVLAGLGV 70 80 90 100 110 120 YQDGIAKQQV NGKDVTAHIY EYTTQVGISL KKDIVTLTPK QQPVQLLFCL KEKNQKKINS 130 140 150 160 170 180 HRWFFQAFGR VLDPNICVLL DAGTKPGKDS IYHLWKAFDL EPHCAGACGE IKAMLGPGGK NLVNPLVAT

References

[1]	"Characterization of chitin synthase from Botrytis cinerea." Causier B.E., Milling R.J., Foster S.G., Adams D.J. Microbiology 140:2199-2205(1994) [PubMed: 7952170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SCHBC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77937 Genomic DNA. Translation: CAA54909.1.
PIR	S42870.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004834. Chitin_synth. [Graphical view]
Pfam	PF01644. Chitin_synth_1. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHS1_BOTFU

Accession

Primary (citable) accession number: P49603

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 31, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program