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P49600

- SP2E_BACME

UniProt

P49600 - SP2E_BACME

Protein

Stage II sporulation protein E

Gene

spoIIE

Organism
Bacillus megaterium
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Normally needed for pro-sigma E processing during sporulation but can be bypassed in vegetative cells. Activates SpoIIAA by dephosphorylation By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Sporulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stage II sporulation protein E (EC:3.1.3.16)
    Gene namesi
    Name:spoIIE
    OrganismiBacillus megaterium
    Taxonomic identifieri1404 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Polar septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 585›585Stage II sporulation protein EPRO_0000057793Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP49600.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 5718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 8617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini366 – 585220PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR014221. Spore_II_E.
    [Graphical view]
    PfamiPF07228. SpoIIE. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    TIGRFAMsiTIGR02865. spore_II_E. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P49600-1 [UniParc]FASTAAdd to Basket

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    TVGVVTGLIL SFANVSSLYE MSLLAFSGLL GGLLKDGKKL GARLGLVVGS    50
    LLIGLYAQAD QGLTTNLYES LTAVVLFLLT PSFVLKNLSK LVPGTSENML 100
    EQQQYVRKIR DVTANRVEQF SNVFQALSKS FTQNGFYDEK PSADKEVDYF 150
    LSSVTERTCQ FCFKKEQCWA QQFDTTYEYM KEIMLEVDNG TLEQNPRLIR 200
    EMDKHCVKSK KVIDVIEHEL TYFKANQHLK AQIQESRRIV AEQLHGVSEV 250
    MGNFAKEIKR ERENLNVQEE QILEALRNFG MEINQIEIYS LEPGNVDIEM 300
    WVPYCHGRGE CEKIIAPMLT DILGESIVVK NEECAKYPQG YCHVSFGCTK 350
    AYVVDTGVAH AAKGGGFVSG DSYSMIELNA GKYALAISDG MGNGERAHYE 400
    SSETLQLLKQ ILQTGIEETI AIKSINSILS LRTNDEIFST LDLAMIDLQD 450
    ANVNFLKIGS TPSFIKRGDK VIKIQASNLP MGIIEEFEVD VVNEQMKAED 500
    LLIMMSDGVF EGPKHVENYE MWMKRKIGEL QTNDPQEIAD LIMEEVIRTK 550
    VGLIEDDMTV VVAKLQHNTP KWSSIPSYAY RNLAQ 585
    Length:585
    Mass (Da):65,690
    Last modified:February 1, 1996 - v1
    Checksum:i90E9ACF1D3E21D01
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26836 Genomic DNA. Translation: AAB58072.1.
    PIRiS71018.
    S73325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U26836 Genomic DNA. Translation: AAB58072.1 .
    PIRi S71018.
    S73325.

    3D structure databases

    ProteinModelPortali P49600.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR014221. Spore_II_E.
    [Graphical view ]
    Pfami PF07228. SpoIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    TIGRFAMsi TIGR02865. spore_II_E. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and function of the Bacillus SpoIIE protein and its localization to sites of sporulation septum assembly."
      Barak I., Behari J., Olmedo G., Guzman P., Brown D.P., Castro E., Walker D., Westpheling J., Youngman P.
      Mol. Microbiol. 19:1047-1060(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35985 / VT1660.

    Entry informationi

    Entry nameiSP2E_BACME
    AccessioniPrimary (citable) accession number: P49600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3