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P49599

- P2C57_ARATH

UniProt

P49599 - P2C57_ARATH

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Protein

Protein phosphatase 2C 57

Gene

PPH1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Manganese 1By similarity
Metal bindingi93 – 931Manganese 2By similarity
Metal bindingi94 – 941Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi296 – 2961Manganese 2By similarity
Metal bindingi339 – 3391Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatase activity Source: TAIR
  3. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. dephosphorylation Source: TAIR
  2. photosynthetic electron transport chain Source: TAIR
  3. photosystem stoichiometry adjustment Source: TAIR
  4. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G27800-MONOMER.
ARA:GQT-2819-MONOMER.
ARA:GQT-2820-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 57 (EC:3.1.3.16)
Short name:
AtPP2C57
Alternative name(s):
Protein phosphatase 2C PPH1
Short name:
PP2C PPH1
Gene namesi
Name:PPH1
Ordered Locus Names:At4g27800
ORF Names:T27E11.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G27800.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast stroma Source: TAIR
  3. cytoplasm Source: TAIR
  4. integral component of membrane Source: UniProtKB-KW
  5. nucleolus Source: TAIR
  6. nucleus Source: TAIR
  7. thylakoid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Protein phosphatase 2C 57PRO_0000057768Add
BLAST

Proteomic databases

PaxDbiP49599.
PRIDEiP49599.

Expressioni

Gene expression databases

ExpressionAtlasiP49599. baseline and differential.
GenevestigatoriP49599.

Structurei

3D structure databases

ProteinModelPortaliP49599.
SMRiP49599. Positions 60-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 341284PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000029436.
InParanoidiP49599.
OMAiIVNGRIC.
PhylomeDBiP49599.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49599-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLRPHLHR FHSNTLRHSA YPSADAGGGL VVYPTYGRHR CSAIAIDAPS
60 70 80 90 100
SLTGVTPIRW GYTSVQGFRD EMEDDIVIRS DAVDSFSYAA VFDGHAGSSS
110 120 130 140 150
VKFLREELYK ECVGALQAGS LLNGGDFAAI KEALIKAFES VDRNLLKWLE
160 170 180 190 200
ANGDEEDESG STATVMIIRN DVSFIAHIGD SCAVLSRSGQ IEELTDYHRP
210 220 230 240 250
YGSSRAAIQE VKRVKEAGGW IVNGRICGDI AVSRAFGDIR FKTKKNDMLK
260 270 280 290 300
KGVDEGRWSE KFVSRIEFKG DMVVATPDIF QVPLTSDVEF IILASDGLWD
310 320 330 340 350
YMKSSDVVSY VRDQLRKHGN VQLACESLAQ VALDRRSQDN ISIIIADLGR
360 370 380
TEWKNLPAQR QNVVVELVQA ATTIGLVTVG IWMSSHLS
Length:388
Mass (Da):42,719
Last modified:January 24, 2001 - v2
Checksum:i496ECCC786AEB802
GO
Isoform 2 (identifier: P49599-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-335: DR → VK
     336-388: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:335
Mass (Da):36,863
Checksum:i5DD6AB6CDFC20D92
GO
Isoform 3 (identifier: P49599-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-326: LACE → ATCL
     327-388: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:326
Mass (Da):35,925
Checksum:i3554FE275D389482
GO

Sequence cautioni

The sequence AAA92889.1 differs from that shown. Reason: Frameshift at position 360. Curated
The sequence CAB43968.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 44MALL → SNSS in AAA92889. (PubMed:7569999)Curated
Sequence conflicti69 – 702RD → QY in AAA92889. (PubMed:7569999)Curated
Sequence conflicti271 – 2711D → N in AAA92889. (PubMed:7569999)Curated
Sequence conflicti353 – 3531W → C in AAA92889. (PubMed:7569999)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei323 – 3264LACE → ATCL in isoform 3. CuratedVSP_034835
Alternative sequencei327 – 38862Missing in isoform 3. CuratedVSP_034836Add
BLAST
Alternative sequencei334 – 3352DR → VK in isoform 2. CuratedVSP_034837
Alternative sequencei336 – 38853Missing in isoform 2. CuratedVSP_034838Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078579 Genomic DNA. Translation: CAB43968.1. Sequence problems.
AL161571 Genomic DNA. Translation: CAB81429.1.
CP002687 Genomic DNA. Translation: AEE85393.1.
CP002687 Genomic DNA. Translation: AEE85394.1.
CP002687 Genomic DNA. Translation: AEE85395.1.
AY080875 mRNA. Translation: AAL87346.1.
AY114060 mRNA. Translation: AAM45108.1.
U34803 mRNA. Translation: AAA92889.1. Frameshift.
PIRiC85323.
T09019.
RefSeqiNP_194509.1. NM_118918.4. [P49599-1]
NP_849459.1. NM_179128.1. [P49599-2]
NP_849460.1. NM_179129.1. [P49599-3]
UniGeneiAt.23824.

Genome annotation databases

EnsemblPlantsiAT4G27800.1; AT4G27800.1; AT4G27800. [P49599-1]
GeneIDi828893.
KEGGiath:AT4G27800.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078579 Genomic DNA. Translation: CAB43968.1 . Sequence problems.
AL161571 Genomic DNA. Translation: CAB81429.1 .
CP002687 Genomic DNA. Translation: AEE85393.1 .
CP002687 Genomic DNA. Translation: AEE85394.1 .
CP002687 Genomic DNA. Translation: AEE85395.1 .
AY080875 mRNA. Translation: AAL87346.1 .
AY114060 mRNA. Translation: AAM45108.1 .
U34803 mRNA. Translation: AAA92889.1 . Frameshift.
PIRi C85323.
T09019.
RefSeqi NP_194509.1. NM_118918.4. [P49599-1 ]
NP_849459.1. NM_179128.1. [P49599-2 ]
NP_849460.1. NM_179129.1. [P49599-3 ]
UniGenei At.23824.

3D structure databases

ProteinModelPortali P49599.
SMRi P49599. Positions 60-348.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P49599.
PRIDEi P49599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G27800.1 ; AT4G27800.1 ; AT4G27800 . [P49599-1 ]
GeneIDi 828893.
KEGGi ath:AT4G27800.

Organism-specific databases

TAIRi AT4G27800.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000029436.
InParanoidi P49599.
OMAi IVNGRIC.
PhylomeDBi P49599.

Enzyme and pathway databases

BioCyci ARA:AT4G27800-MONOMER.
ARA:GQT-2819-MONOMER.
ARA:GQT-2820-MONOMER.

Gene expression databases

ExpressionAtlasi P49599. baseline and differential.
Genevestigatori P49599.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Quantitative monitoring of gene expression patterns with a complementary DNA microarray."
    Schena M., Shalon D., Davis R.W., Brown P.O.
    Science 270:467-470(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-365 (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Plant PP2C phosphatases: emerging functions in stress signaling."
    Schweighofer A., Hirt H., Meskiene I.
    Trends Plant Sci. 9:236-243(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C57_ARATH
AccessioniPrimary (citable) accession number: P49599
Secondary accession number(s): Q3E9V3
, Q3E9V4, Q9M0J6, Q9STP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2001
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3