Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49596

- PP2C2_CAEEL

UniProt

P49596 - PP2C2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable protein phosphatase 2C T23F11.1

Gene

ppm-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Manganese 1By similarity
Metal bindingi59 – 591Manganese 2By similarity
Metal bindingi60 – 601Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi228 – 2281Manganese 2By similarity
Metal bindingi277 – 2771Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C T23F11.1 (EC:3.1.3.16)
Short name:
PP2C
Gene namesi
Name:ppm-2
ORF Names:T23F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiT23F11.1; CE24009; WBGene00011953; ppm-2.

Subcellular locationi

GO - Cellular componenti

  1. presynaptic active zone Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Probable protein phosphatase 2C T23F11.1PRO_0000057763Add
BLAST

Proteomic databases

PaxDbiP49596.
PRIDEiP49596.

Interactioni

Protein-protein interaction databases

BioGridi40846. 1 interaction.
STRINGi6239.T23F11.1.2.

Structurei

3D structure databases

ProteinModelPortaliP49596.
SMRiP49596. Positions 1-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233896.
InParanoidiP49596.
KOiK14803.
OMAiEFRGPGV.
PhylomeDBiP49596.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49596 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQTLSEPVT KKESASCANE NYLVGSSCMQ GWRVDMEDAH THLLSLPDDP
60 70 80 90 100
KCAFFAVYDG HGGSKVSQYS GINLHKKVVA QKEFSEGNMK EAIEKGFLEL
110 120 130 140 150
DQQMRVDEET KDDVSGTTAV VVLIKEGDVY CGNAGDSRAV SSVVGEARPL
160 170 180 190 200
SFDHKPSHET EARRIIAAGG WVEFNRVNGN LALSRALGDF AFKNCDTKPA
210 220 230 240 250
EEQIVTAFPD VITDKLTPDH EFIVLACDGI WDVMTNQEVV DFVREKLAEK
260 270 280 290 300
RDPQSICEEL LTRCLAPDCQ MGGLGCDNMT VVLVGLLHGQ SPDTLFTKCA
310 320 330 340 350
RPAVFTGVNN EDGDQNQIQQ DISRVINNFD GEQRVNAANQ EEEEDDNEPA

PANFQV
Length:356
Mass (Da):39,064
Last modified:August 14, 2001 - v2
Checksum:iEDCB0841CFB026B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46343 Genomic DNA. Translation: CAA86456.2.
PIRiE88434.
T25181.
RefSeqiNP_497949.1. NM_065548.5.
UniGeneiCel.6190.

Genome annotation databases

EnsemblMetazoaiT23F11.1.1; T23F11.1.1; WBGene00011953.
T23F11.1.2; T23F11.1.2; WBGene00011953.
GeneIDi175610.
KEGGicel:CELE_T23F11.1.
UCSCiT23F11.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46343 Genomic DNA. Translation: CAA86456.2 .
PIRi E88434.
T25181.
RefSeqi NP_497949.1. NM_065548.5.
UniGenei Cel.6190.

3D structure databases

ProteinModelPortali P49596.
SMRi P49596. Positions 1-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40846. 1 interaction.
STRINGi 6239.T23F11.1.2.

Proteomic databases

PaxDbi P49596.
PRIDEi P49596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T23F11.1.1 ; T23F11.1.1 ; WBGene00011953 .
T23F11.1.2 ; T23F11.1.2 ; WBGene00011953 .
GeneIDi 175610.
KEGGi cel:CELE_T23F11.1.
UCSCi T23F11.1.1. c. elegans.

Organism-specific databases

CTDi 175610.
WormBasei T23F11.1 ; CE24009 ; WBGene00011953 ; ppm-2.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000115384.
HOGENOMi HOG000233896.
InParanoidi P49596.
KOi K14803.
OMAi EFRGPGV.
PhylomeDBi P49596.

Miscellaneous databases

NextBioi 888896.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPP2C2_CAEEL
AccessioniPrimary (citable) accession number: P49596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: October 1, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3