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P49596 (PP2C2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C T23F11.1

Short name=PP2C
EC=3.1.3.16
Gene names
Name:ppm-2
ORF Names:T23F11.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Probable protein phosphatase 2C T23F11.1
PRO_0000057763

Sites

Metal binding591Manganese 1 By similarity
Metal binding591Manganese 2 By similarity
Metal binding601Manganese 1; via carbonyl oxygen By similarity
Metal binding2281Manganese 2 By similarity
Metal binding2771Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49596 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: EDCB0841CFB026B5

FASTA35639,064
        10         20         30         40         50         60 
MGQTLSEPVT KKESASCANE NYLVGSSCMQ GWRVDMEDAH THLLSLPDDP KCAFFAVYDG 

        70         80         90        100        110        120 
HGGSKVSQYS GINLHKKVVA QKEFSEGNMK EAIEKGFLEL DQQMRVDEET KDDVSGTTAV 

       130        140        150        160        170        180 
VVLIKEGDVY CGNAGDSRAV SSVVGEARPL SFDHKPSHET EARRIIAAGG WVEFNRVNGN 

       190        200        210        220        230        240 
LALSRALGDF AFKNCDTKPA EEQIVTAFPD VITDKLTPDH EFIVLACDGI WDVMTNQEVV 

       250        260        270        280        290        300 
DFVREKLAEK RDPQSICEEL LTRCLAPDCQ MGGLGCDNMT VVLVGLLHGQ SPDTLFTKCA 

       310        320        330        340        350 
RPAVFTGVNN EDGDQNQIQQ DISRVINNFD GEQRVNAANQ EEEEDDNEPA PANFQV 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46343 Genomic DNA. Translation: CAA86456.2.
PIRE88434.
T25181.
RefSeqNP_497949.1. NM_065548.5.
UniGeneCel.6190.

3D structure databases

ProteinModelPortalP49596.
SMRP49596. Positions 1-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40846. 1 interaction.
STRING6239.T23F11.1.2.

Proteomic databases

PaxDbP49596.
PRIDEP49596.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT23F11.1.1; T23F11.1.1; WBGene00011953.
T23F11.1.2; T23F11.1.2; WBGene00011953.
GeneID175610.
KEGGcel:CELE_T23F11.1.
UCSCT23F11.1.1. c. elegans.

Organism-specific databases

CTD175610.
WormBaseT23F11.1; CE24009; WBGene00011953; ppm-2.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00740000115384.
HOGENOMHOG000233896.
InParanoidP49596.
KOK14803.
OMAEFRGPGV.
PhylomeDBP49596.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio888896.

Entry information

Entry namePP2C2_CAEEL
AccessionPrimary (citable) accession number: P49596
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase