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P49596

- PP2C2_CAEEL

UniProt

P49596 - PP2C2_CAEEL

Protein

Probable protein phosphatase 2C T23F11.1

Gene

ppm-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Manganese 1By similarity
    Metal bindingi59 – 591Manganese 2By similarity
    Metal bindingi60 – 601Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi228 – 2281Manganese 2By similarity
    Metal bindingi277 – 2771Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C T23F11.1 (EC:3.1.3.16)
    Short name:
    PP2C
    Gene namesi
    Name:ppm-2
    ORF Names:T23F11.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiT23F11.1; CE24009; WBGene00011953; ppm-2.

    Subcellular locationi

    GO - Cellular componenti

    1. presynaptic active zone Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Probable protein phosphatase 2C T23F11.1PRO_0000057763Add
    BLAST

    Proteomic databases

    PaxDbiP49596.
    PRIDEiP49596.

    Interactioni

    Protein-protein interaction databases

    BioGridi40846. 1 interaction.
    STRINGi6239.T23F11.1.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP49596.
    SMRiP49596. Positions 1-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000115384.
    HOGENOMiHOG000233896.
    InParanoidiP49596.
    KOiK14803.
    OMAiEFRGPGV.
    PhylomeDBiP49596.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQTLSEPVT KKESASCANE NYLVGSSCMQ GWRVDMEDAH THLLSLPDDP    50
    KCAFFAVYDG HGGSKVSQYS GINLHKKVVA QKEFSEGNMK EAIEKGFLEL 100
    DQQMRVDEET KDDVSGTTAV VVLIKEGDVY CGNAGDSRAV SSVVGEARPL 150
    SFDHKPSHET EARRIIAAGG WVEFNRVNGN LALSRALGDF AFKNCDTKPA 200
    EEQIVTAFPD VITDKLTPDH EFIVLACDGI WDVMTNQEVV DFVREKLAEK 250
    RDPQSICEEL LTRCLAPDCQ MGGLGCDNMT VVLVGLLHGQ SPDTLFTKCA 300
    RPAVFTGVNN EDGDQNQIQQ DISRVINNFD GEQRVNAANQ EEEEDDNEPA 350
    PANFQV 356
    Length:356
    Mass (Da):39,064
    Last modified:August 14, 2001 - v2
    Checksum:iEDCB0841CFB026B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46343 Genomic DNA. Translation: CAA86456.2.
    PIRiE88434.
    T25181.
    RefSeqiNP_497949.1. NM_065548.5.
    UniGeneiCel.6190.

    Genome annotation databases

    EnsemblMetazoaiT23F11.1.1; T23F11.1.1; WBGene00011953.
    T23F11.1.2; T23F11.1.2; WBGene00011953.
    GeneIDi175610.
    KEGGicel:CELE_T23F11.1.
    UCSCiT23F11.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46343 Genomic DNA. Translation: CAA86456.2 .
    PIRi E88434.
    T25181.
    RefSeqi NP_497949.1. NM_065548.5.
    UniGenei Cel.6190.

    3D structure databases

    ProteinModelPortali P49596.
    SMRi P49596. Positions 1-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40846. 1 interaction.
    STRINGi 6239.T23F11.1.2.

    Proteomic databases

    PaxDbi P49596.
    PRIDEi P49596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T23F11.1.1 ; T23F11.1.1 ; WBGene00011953 .
    T23F11.1.2 ; T23F11.1.2 ; WBGene00011953 .
    GeneIDi 175610.
    KEGGi cel:CELE_T23F11.1.
    UCSCi T23F11.1.1. c. elegans.

    Organism-specific databases

    CTDi 175610.
    WormBasei T23F11.1 ; CE24009 ; WBGene00011953 ; ppm-2.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000115384.
    HOGENOMi HOG000233896.
    InParanoidi P49596.
    KOi K14803.
    OMAi EFRGPGV.
    PhylomeDBi P49596.

    Miscellaneous databases

    NextBioi 888896.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPP2C2_CAEEL
    AccessioniPrimary (citable) accession number: P49596
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3