P49596 (PP2C2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C T23F11.1
Short name=PP2C
EC=3.1.3.16

Gene names

ORF Names:

T23F11.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Probable protein phosphatase 2C T23F11.1		PRO_0000057763
Sites
	Metal binding	59	1	Manganese 1 By similarity
	Metal binding	59	1	Manganese 2 By similarity
	Metal binding	60	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	228	1	Manganese 2 By similarity
	Metal binding	277	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49596 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: EDCB0841CFB026B5	FASTA	356	39,064
	10 20 30 40 50 60 MGQTLSEPVT KKESASCANE NYLVGSSCMQ GWRVDMEDAH THLLSLPDDP KCAFFAVYDG 70 80 90 100 110 120 HGGSKVSQYS GINLHKKVVA QKEFSEGNMK EAIEKGFLEL DQQMRVDEET KDDVSGTTAV 130 140 150 160 170 180 VVLIKEGDVY CGNAGDSRAV SSVVGEARPL SFDHKPSHET EARRIIAAGG WVEFNRVNGN 190 200 210 220 230 240 LALSRALGDF AFKNCDTKPA EEQIVTAFPD VITDKLTPDH EFIVLACDGI WDVMTNQEVV 250 260 270 280 290 300 DFVREKLAEK RDPQSICEEL LTRCLAPDCQ MGGLGCDNMT VVLVGLLHGQ SPDTLFTKCA 310 320 330 340 350 RPAVFTGVNN EDGDQNQIQQ DISRVINNFD GEQRVNAANQ EEEEDDNEPA PANFQV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46343 Genomic DNA. Translation: CAA86456.2.
PIR	E88434. T25181.
RefSeq	NP_497949.1. NM_065548.5.
UniGene	Cel.6190.
3D structure databases
ProteinModelPortal	P49596.
SMR	P49596. Positions 1-284.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.T23F11.1.2.
Proteomic databases
PaxDb	P49596.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T23F11.1.1; T23F11.1.1; T23F11.1. T23F11.1.2; T23F11.1.2; T23F11.1. T23F11.1.3; T23F11.1.3; T23F11.1.
GeneID	175610.
KEGG	cel:CELE_T23F11.1.
UCSC	T23F11.1.1. c. elegans.
Organism-specific databases
CTD	175610.
WormBase	T23F11.1; CE24009; WBGene00011953.
Phylogenomic databases
eggNOG	COG0631.
GeneTree	ENSGT00650000093052.
HOGENOM	HOG000233896.
InParanoid	P49596.
KO	K14803.
OMA	ASCANEN.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	888896.

Entry information

Entry name

PP2C2_CAEEL

Accession

Primary (citable) accession number: P49596

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	August 14, 2001
Last modified:	May 29, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project