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Protein

Probable protein phosphatase 2C F42G9.1

Gene

F42G9.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi428 – 4281Manganese 2By similarity
Metal bindingi477 – 4771Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C F42G9.1 (EC:3.1.3.16)
Short name:
PP2C
Gene namesi
ORF Names:F42G9.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF42G9.1a; CE07231; WBGene00018362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable protein phosphatase 2C F42G9.1PRO_0000057762Add
BLAST

Proteomic databases

PaxDbiP49595.
PRIDEiP49595.

Expressioni

Gene expression databases

ExpressionAtlasiP49595. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiP49595. 2 interactions.
STRINGi6239.F42G9.1a.

Structurei

3D structure databases

ProteinModelPortaliP49595.
SMRiP49595. Positions 4-103, 305-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
InParanoidiP49595.
KOiK17499.
OMAiIWNSMES.
PhylomeDBiP49595.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLNKPII EKEKEEGSGN GLSYACTTMQ GWRVNQEDAH NCVVDLHTDW
60 70 80 90 100
HMFGVYDGHG GTEVSKFTSA KLPDFLKERK FWEADDVAEC LQKAFVDFDD
110 120 130 140 150
FIRAEESMKE LKDIGDEGKP KKAGGEADSE DEADRIDTIE EASVPLAELL
160 170 180 190 200
KRYGGAGVGK SLLSAFLAKG DVSDDSEDED EDEEEAEEQD DTEEKKENED
210 220 230 240 250
ASAEVVIENA EDKEEEEGSP KKKGQKRCQK SPIQSEAKKS KSETDAETAP
260 270 280 290 300
SSSSGVDGVA TEEEDEDDSD KEFVADEEED DEDAEDEQSD EEMVDGSLAP
310 320 330 340 350
LLLGSGGAEV PGEDSGTTAC VCLVGKDKVI VANAGDSRAV LCRNGKAVDL
360 370 380 390 400
SVDHKPEDEV ETNRIHAAGG QIEDGRVNGG LNLSRAFGDH AYKKNQELGL
410 420 430 440 450
KEQMITALPD VKIEALTPED EFIVVACDGI WNSMESQQVV DFVRDLLAKG
460 470 480 490
SSCAEVCDAL CDACLADSTD GDGTGCDNMT VICTTFDRKS K
Length:491
Mass (Da):53,142
Last modified:October 1, 1996 - v2
Checksum:iF110D12E343953D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080196 Genomic DNA. Translation: CCD61882.1.
PIRiT16354.
RefSeqiNP_741086.1. NM_171075.4.
UniGeneiCel.7334.

Genome annotation databases

EnsemblMetazoaiF42G9.1a; F42G9.1a; WBGene00018362.
GeneIDi175233.
KEGGicel:CELE_F42G9.1.
UCSCiF42G9.1a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080196 Genomic DNA. Translation: CCD61882.1.
PIRiT16354.
RefSeqiNP_741086.1. NM_171075.4.
UniGeneiCel.7334.

3D structure databases

ProteinModelPortaliP49595.
SMRiP49595. Positions 4-103, 305-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49595. 2 interactions.
STRINGi6239.F42G9.1a.

Proteomic databases

PaxDbiP49595.
PRIDEiP49595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42G9.1a; F42G9.1a; WBGene00018362.
GeneIDi175233.
KEGGicel:CELE_F42G9.1.
UCSCiF42G9.1a. c. elegans.

Organism-specific databases

CTDi175233.
WormBaseiF42G9.1a; CE07231; WBGene00018362.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
InParanoidiP49595.
KOiK17499.
OMAiIWNSMES.
PhylomeDBiP49595.

Miscellaneous databases

NextBioi887334.
PROiP49595.

Gene expression databases

ExpressionAtlasiP49595. baseline and differential.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPP2C1_CAEEL
AccessioniPrimary (citable) accession number: P49595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.