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P49595

- PP2C1_CAEEL

UniProt

P49595 - PP2C1_CAEEL

Protein

Probable protein phosphatase 2C F42G9.1

Gene

F42G9.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Manganese 1By similarity
    Metal bindingi57 – 571Manganese 2By similarity
    Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi428 – 4281Manganese 2By similarity
    Metal bindingi477 – 4771Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C F42G9.1 (EC:3.1.3.16)
    Short name:
    PP2C
    Gene namesi
    ORF Names:F42G9.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF42G9.1a; CE07231; WBGene00018362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Probable protein phosphatase 2C F42G9.1PRO_0000057762Add
    BLAST

    Proteomic databases

    PaxDbiP49595.
    PRIDEiP49595.

    Expressioni

    Gene expression databases

    ArrayExpressiP49595.

    Interactioni

    Protein-protein interaction databases

    IntActiP49595. 2 interactions.
    STRINGi6239.F42G9.1a.

    Structurei

    3D structure databases

    ProteinModelPortaliP49595.
    SMRiP49595. Positions 4-103, 305-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    HOGENOMiHOG000233896.
    InParanoidiP49595.
    KOiK17499.
    OMAiIWNSMES.
    PhylomeDBiP49595.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49595-1 [UniParc]FASTAAdd to Basket

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    MGAYLNKPII EKEKEEGSGN GLSYACTTMQ GWRVNQEDAH NCVVDLHTDW    50
    HMFGVYDGHG GTEVSKFTSA KLPDFLKERK FWEADDVAEC LQKAFVDFDD 100
    FIRAEESMKE LKDIGDEGKP KKAGGEADSE DEADRIDTIE EASVPLAELL 150
    KRYGGAGVGK SLLSAFLAKG DVSDDSEDED EDEEEAEEQD DTEEKKENED 200
    ASAEVVIENA EDKEEEEGSP KKKGQKRCQK SPIQSEAKKS KSETDAETAP 250
    SSSSGVDGVA TEEEDEDDSD KEFVADEEED DEDAEDEQSD EEMVDGSLAP 300
    LLLGSGGAEV PGEDSGTTAC VCLVGKDKVI VANAGDSRAV LCRNGKAVDL 350
    SVDHKPEDEV ETNRIHAAGG QIEDGRVNGG LNLSRAFGDH AYKKNQELGL 400
    KEQMITALPD VKIEALTPED EFIVVACDGI WNSMESQQVV DFVRDLLAKG 450
    SSCAEVCDAL CDACLADSTD GDGTGCDNMT VICTTFDRKS K 491
    Length:491
    Mass (Da):53,142
    Last modified:October 1, 1996 - v2
    Checksum:iF110D12E343953D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080196 Genomic DNA. Translation: CCD61882.1.
    PIRiT16354.
    RefSeqiNP_741086.1. NM_171075.4.
    UniGeneiCel.7334.

    Genome annotation databases

    EnsemblMetazoaiF42G9.1a; F42G9.1a; WBGene00018362.
    GeneIDi175233.
    KEGGicel:CELE_F42G9.1.
    UCSCiF42G9.1a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080196 Genomic DNA. Translation: CCD61882.1 .
    PIRi T16354.
    RefSeqi NP_741086.1. NM_171075.4.
    UniGenei Cel.7334.

    3D structure databases

    ProteinModelPortali P49595.
    SMRi P49595. Positions 4-103, 305-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49595. 2 interactions.
    STRINGi 6239.F42G9.1a.

    Proteomic databases

    PaxDbi P49595.
    PRIDEi P49595.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F42G9.1a ; F42G9.1a ; WBGene00018362 .
    GeneIDi 175233.
    KEGGi cel:CELE_F42G9.1.
    UCSCi F42G9.1a. c. elegans.

    Organism-specific databases

    CTDi 175233.
    WormBasei F42G9.1a ; CE07231 ; WBGene00018362 .

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    HOGENOMi HOG000233896.
    InParanoidi P49595.
    KOi K17499.
    OMAi IWNSMES.
    PhylomeDBi P49595.

    Miscellaneous databases

    NextBioi 887334.
    PROi P49595.

    Gene expression databases

    ArrayExpressi P49595.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPP2C1_CAEEL
    AccessioniPrimary (citable) accession number: P49595
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3