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Protein

Putative choline-phosphate cytidylyltransferase

Gene

F08C6.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphocholine = diphosphate + CDP-choline.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylcholine from phosphocholine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative choline-phosphate cytidylyltransferase (F08C6.2)
  2. no protein annotated in this organism
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylcholine from phosphocholine, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261CTPBy similarity
Binding sitei126 – 1261SubstrateBy similarity
Binding sitei155 – 1551SubstrateBy similarity
Binding sitei177 – 1771CTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 969CTPBy similarity
Nucleotide bindingi172 – 1732CTPBy similarity
Nucleotide bindingi200 – 2045CTPBy similarity

GO - Molecular functioni

  • choline-phosphate cytidylyltransferase activity Source: WormBase

GO - Biological processi

  • CDP-choline pathway Source: GOC
  • phosphatidylcholine biosynthetic process Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1483191. Synthesis of PC.
UniPathwayiUPA00753; UER00739.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline-phosphate cytidylyltransferase (EC:2.7.7.15)
Alternative name(s):
CTP:phosphocholine cytidylyltransferase
Short name:
CCT
Short name:
CT
Phosphorylcholine transferase
Gene namesi
ORF Names:F08C6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF08C6.2a; CE30937; WBGene00017241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Putative choline-phosphate cytidylyltransferasePRO_0000208458Add
BLAST

Proteomic databases

EPDiP49583.
PaxDbiP49583.
PRIDEiP49583.

PTM databases

iPTMnetiP49583.

Expressioni

Gene expression databases

ExpressionAtlasiP49583. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.F08C6.2a.

Structurei

3D structure databases

ProteinModelPortaliP49583.
SMRiP49583. Positions 44-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

eggNOGiKOG2804. Eukaryota.
COG0615. LUCA.
GeneTreeiENSGT00390000000269.
HOGENOMiHOG000230945.
InParanoidiP49583.
KOiK00968.
OMAiGVCGDRD.
OrthoDBiEOG7X9G6S.
PhylomeDBiP49583.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

P49583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIHKQEKMP QRKRTMDSPQ EEDVEVKKKA TEVEYVVRSL ASDEPAPFSD
60 70 80 90 100
EALAITTREA VDYSKKITLA MAEANEAGRP VRIYADGIYD LFHHGHANQL
110 120 130 140 150
RQVKKMFPNV YLIVGVCGDR DTHKYKGRTV TSEEERYDGV RHCRYVDEVY
160 170 180 190 200
REAPWFCTVE FLKNLKVDFI AHDAIPYVAP GEEDLYEKFR REGMFLETER
210 220 230 240 250
TEGVSTSDVV CRIIRDYDKY VRRNLQRGYS PKELNVGFLA ASKYQIQNKV
260 270 280 290 300
DSLKSKGIEL LSTWKSKSDD IIRDFIDTFH KDGGLNAFGG RLKGIMSMSR
310 320 330 340 350
SPSPSPHEGS PTGIEHHLET QDEEEEEEAL EEEKVVEQKI VEKKEVVKKR
360
SSRNKAKTPL EY
Length:362
Mass (Da):41,769
Last modified:June 20, 2003 - v2
Checksum:iE2845D72C326C199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080866 Genomic DNA. Translation: CCD67344.1.
PIRiT15975.
RefSeqiNP_001033539.1. NM_001038450.2.
UniGeneiCel.4920.

Genome annotation databases

EnsemblMetazoaiF08C6.2a; F08C6.2a; WBGene00017241.
GeneIDi181021.
KEGGicel:CELE_F08C6.2.
UCSCiF08C6.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080866 Genomic DNA. Translation: CCD67344.1.
PIRiT15975.
RefSeqiNP_001033539.1. NM_001038450.2.
UniGeneiCel.4920.

3D structure databases

ProteinModelPortaliP49583.
SMRiP49583. Positions 44-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F08C6.2a.

PTM databases

iPTMnetiP49583.

Proteomic databases

EPDiP49583.
PaxDbiP49583.
PRIDEiP49583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08C6.2a; F08C6.2a; WBGene00017241.
GeneIDi181021.
KEGGicel:CELE_F08C6.2.
UCSCiF08C6.2a. c. elegans.

Organism-specific databases

CTDi181021.
WormBaseiF08C6.2a; CE30937; WBGene00017241.

Phylogenomic databases

eggNOGiKOG2804. Eukaryota.
COG0615. LUCA.
GeneTreeiENSGT00390000000269.
HOGENOMiHOG000230945.
InParanoidiP49583.
KOiK00968.
OMAiGVCGDRD.
OrthoDBiEOG7X9G6S.
PhylomeDBiP49583.

Enzyme and pathway databases

UniPathwayiUPA00753; UER00739.
ReactomeiR-CEL-1483191. Synthesis of PC.

Miscellaneous databases

NextBioi912020.
PROiP49583.

Gene expression databases

ExpressionAtlasiP49583. baseline and differential.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPCY1_CAEEL
AccessioniPrimary (citable) accession number: P49583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 20, 2003
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.