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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

Chrna7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • associative learning Source: MGI
  • B cell activation Source: MGI
  • behavioral response to ethanol Source: MGI
  • behavioral response to nicotine Source: MGI
  • calcium ion transport Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cognition Source: MGI
  • endocytosis Source: MGI
  • generation of ovulation cycle rhythm Source: MGI
  • ion transmembrane transport Source: MGI
  • ion transport Source: MGI
  • memory Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interleukin-1 beta production Source: MGI
  • negative regulation of interleukin-6 production Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • ovulation cycle Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of membrane potential Source: MGI
  • regulation of norepinephrine secretion Source: MGI
  • regulation of synaptic transmission, dopaminergic Source: MGI
  • response to ethanol Source: MGI
  • response to food Source: MGI
  • response to hypoxia Source: MGI
  • response to nicotine Source: MGI
  • signal transduction Source: MGI
  • sperm motility Source: MGI
  • synaptic transmission, cholinergic Source: MGI
  • T cell activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:Chrna7
Synonyms:Acra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99779. Chrna7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 230208ExtracellularSequence analysisAdd
BLAST
Transmembranei231 – 25525HelicalSequence analysisAdd
BLAST
Transmembranei262 – 28019HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31722HelicalSequence analysisAdd
BLAST
Topological domaini318 – 469152CytoplasmicSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: MGI
  • apical plasma membrane Source: MGI
  • axolemma Source: MGI
  • cell junction Source: UniProtKB-KW
  • external side of plasma membrane Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: MGI
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3350222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 502480Neuronal acetylcholine receptor subunit alpha-7PRO_0000000368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49582.
PRIDEiP49582.

PTM databases

iPTMnetiP49582.
PhosphoSiteiP49582.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030525.
ExpressionAtlasiP49582. baseline and differential.
GenevisibleiP49582. MM.

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197934. 2 interactions.
DIPiDIP-48732N.
IntActiP49582. 1 interaction.
STRINGi10090.ENSMUSP00000032738.

Chemistry

BindingDBiP49582.

Structurei

3D structure databases

ProteinModelPortaliP49582.
SMRiP49582. Positions 23-323, 467-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP49582.
KOiK04809.
OMAiQGGVWLA.
OrthoDBiEOG091G0R20.
PhylomeDBiP49582.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNASGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL QMQEADISSY IPNGEWDLMG
210 220 230 240 250
IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT
410 420 430 440 450
PDSGVVCGRL ACSPTHDEHL MHGTHPSDGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEVICSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,632
Last modified:February 1, 1996 - v1
Checksum:iC9312E5226D120E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37663 mRNA. Translation: AAC42053.1.
CCDSiCCDS21329.1.
PIRiA57175.
RefSeqiNP_031416.3. NM_007390.3.
UniGeneiMm.113464.

Genome annotation databases

EnsembliENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525.
GeneIDi11441.
KEGGimmu:11441.
UCSCiuc009vel.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37663 mRNA. Translation: AAC42053.1.
CCDSiCCDS21329.1.
PIRiA57175.
RefSeqiNP_031416.3. NM_007390.3.
UniGeneiMm.113464.

3D structure databases

ProteinModelPortaliP49582.
SMRiP49582. Positions 23-323, 467-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197934. 2 interactions.
DIPiDIP-48732N.
IntActiP49582. 1 interaction.
STRINGi10090.ENSMUSP00000032738.

Chemistry

BindingDBiP49582.
ChEMBLiCHEMBL3350222.

PTM databases

iPTMnetiP49582.
PhosphoSiteiP49582.

Proteomic databases

PaxDbiP49582.
PRIDEiP49582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525.
GeneIDi11441.
KEGGimmu:11441.
UCSCiuc009vel.1. mouse.

Organism-specific databases

CTDi1139.
MGIiMGI:99779. Chrna7.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP49582.
KOiK04809.
OMAiQGGVWLA.
OrthoDBiEOG091G0R20.
PhylomeDBiP49582.
TreeFamiTF315605.

Miscellaneous databases

PROiP49582.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030525.
ExpressionAtlasiP49582. baseline and differential.
GenevisibleiP49582. MM.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA7_MOUSE
AccessioniPrimary (citable) accession number: P49582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.