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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

Chrna7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • associative learning Source: MGI
  • B cell activation Source: MGI
  • behavioral response to ethanol Source: MGI
  • behavioral response to nicotine Source: MGI
  • calcium ion transport Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cognition Source: MGI
  • dendrite arborization Source: ARUK-UCL
  • dendritic spine organization Source: ARUK-UCL
  • endocytosis Source: MGI
  • flagellated sperm motility Source: MGI
  • generation of ovulation cycle rhythm Source: MGI
  • ion transmembrane transport Source: MGI
  • ion transport Source: MGI
  • learning or memory Source: ARUK-UCL
  • memory Source: MGI
  • modulation of chemical synaptic transmission Source: ARUK-UCL
  • modulation of excitatory postsynaptic potential Source: ARUK-UCL
  • negative regulation of amyloid-beta formation Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of interleukin-1 beta production Source: MGI
  • negative regulation of interleukin-6 production Source: MGI
  • negative regulation of protein phosphorylation Source: ARUK-UCL
  • negative regulation of tumor necrosis factor production Source: MGI
  • ovulation cycle Source: MGI
  • positive regulation of acetylcholine biosynthetic process Source: ARUK-UCL
  • positive regulation of amyloid-beta formation Source: ARUK-UCL
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of CoA-transferase activity Source: ARUK-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
  • positive regulation of excitatory postsynaptic potential Source: ARUK-UCL
  • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure Source: MGI
  • positive regulation of long-term synaptic potentiation Source: ARUK-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
  • positive regulation of protein metabolic process Source: ARUK-UCL
  • positive regulation of protein phosphorylation Source: ARUK-UCL
  • regulation of amyloid fibril formation Source: ARUK-UCL
  • regulation of amyloid precursor protein catabolic process Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of membrane potential Source: MGI
  • regulation of neuron death Source: ARUK-UCL
  • regulation of norepinephrine secretion Source: MGI
  • regulation of synapse structural plasticity Source: ARUK-UCL
  • regulation of synaptic transmission, cholinergic Source: ARUK-UCL
  • regulation of synaptic transmission, dopaminergic Source: MGI
  • response to acetylcholine Source: MGI
  • response to amyloid-beta Source: ARUK-UCL
  • response to cold Source: ARUK-UCL
  • response to ethanol Source: MGI
  • response to food Source: MGI
  • response to hypoxia Source: MGI
  • response to nicotine Source: MGI
  • sensory processing Source: ARUK-UCL
  • signal transduction Source: MGI
  • synapse organization Source: ARUK-UCL
  • synaptic transmission, cholinergic Source: MGI
  • T cell activation Source: MGI

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
Gene namesi
Name:Chrna7
Synonyms:Acra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99779. Chrna7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 230ExtracellularSequence analysisAdd BLAST208
Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei296 – 317HelicalSequence analysisAdd BLAST22
Topological domaini318 – 469CytoplasmicSequence analysisAdd BLAST152
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000036823 – 502Neuronal acetylcholine receptor subunit alpha-7Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49582.
PRIDEiP49582.

PTM databases

iPTMnetiP49582.
PhosphoSitePlusiP49582.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030525.
ExpressionAtlasiP49582. baseline and differential.
GenevisibleiP49582. MM.

Interactioni

Subunit structurei

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. Interacts with the alpha-conotoxin RgIA (By similarity). Interacts with alpha-conotoxins ImI and ImII (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197934. 2 interactors.
DIPiDIP-48732N.
IntActiP49582. 3 interactors.
STRINGi10090.ENSMUSP00000032738.

Chemistry databases

BindingDBiP49582.

Structurei

3D structure databases

ProteinModelPortaliP49582.
SMRiP49582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP49582.
KOiK04809.
OMAiEAICNEW.
OrthoDBiEOG091G0R20.
PhylomeDBiP49582.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.58.390. 1 hit.
2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR036734. Neur_chan_lig-bd_sf.
IPR006201. Neur_channel.
IPR036719. Neuro-gated_channel_TM_sf.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNASGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL QMQEADISSY IPNGEWDLMG
210 220 230 240 250
IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT
410 420 430 440 450
PDSGVVCGRL ACSPTHDEHL MHGTHPSDGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEVICSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,632
Last modified:February 1, 1996 - v1
Checksum:iC9312E5226D120E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37663 mRNA. Translation: AAC42053.1.
CCDSiCCDS21329.1.
PIRiA57175.
RefSeqiNP_031416.3. NM_007390.3.
UniGeneiMm.113464.

Genome annotation databases

EnsembliENSMUST00000032738; ENSMUSP00000032738; ENSMUSG00000030525.
GeneIDi11441.
KEGGimmu:11441.
UCSCiuc009vel.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiACHA7_MOUSE
AccessioniPrimary (citable) accession number: P49582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families