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P49578 (ACM3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Muscarinic acetylcholine receptor M3
Gene names
Name:CHRM3
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain, heart atria, and ventricle.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 639639Muscarinic acetylcholine receptor M3
PRO_0000069035

Regions

Topological domain1 – 115115Extracellular By similarity
Transmembrane116 – 13924Helical; Name=1; By similarity
Topological domain140 – 15213Cytoplasmic By similarity
Transmembrane153 – 17321Helical; Name=2; By similarity
Topological domain174 – 19017Extracellular By similarity
Transmembrane191 – 21222Helical; Name=3; By similarity
Topological domain213 – 23220Cytoplasmic By similarity
Transmembrane233 – 25523Helical; Name=4; By similarity
Topological domain256 – 27722Extracellular By similarity
Transmembrane278 – 30023Helical; Name=5; By similarity
Topological domain301 – 542242Cytoplasmic By similarity
Transmembrane543 – 56321Helical; Name=6; By similarity
Topological domain564 – 57613Extracellular By similarity
Transmembrane577 – 59620Helical; Name=7; By similarity
Topological domain597 – 63943Cytoplasmic By similarity

Amino acid modifications

Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Disulfide bond189 ↔ 269 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49578 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 7243F132B561B446

FASTA63971,977
        10         20         30         40         50         60 
MLTHYQLCFQ KRSSQNYTVP DPTSCFDVPP WTILCQRATM IMHNNSSALP LFSNVSSFWK 

        70         80         90        100        110        120 
RDSHGPGLLD EGASLIGSYD SPETTESFPF STVETTNSSL NATIKDPLGG HAVWQVVLIA 

       130        140        150        160        170        180 
FLTGIIALVT IIGNILVIVS FKVNKQLKTV NNYFLLSLAC ADLIIGVISM NLFTTYIIMG 

       190        200        210        220        230        240 
HWALGNLACD LWLSIDYVAS NASVMNLLVI SFDRYFSITR PLTYRAKRTT KRAGVMIGLA 

       250        260        270        280        290        300 
WIISFVLWAP AILFWQYFVG KRTVPLDECF IQFLSEPIIT FGTAIAAFYL PVTIMSILYW 

       310        320        330        340        350        360 
RIYKETEKRT KELAGLQASG SEAETARFVH QTGSSRSLSS YELQRQSTKR SSRRKYRRCH 

       370        380        390        400        410        420 
FWLTMKSWEP NTDQGDQEHS SSDSWNNNDA AASLENSASS DEEDITAETR AIYSIVLKLP 

       430        440        450        460        470        480 
GHSAILNSTK LPSSEDLNES ADELQKSDTD SQEKKPKKLQ PPKSIQDGGS FQKSFSKLPI 

       490        500        510        520        530        540 
QPGSAETATA SDGISSVTKT SAALPLSFKE ATLAKKFALK TRSQITKRKR MSLIKEKKAA 

       550        560        570        580        590        600 
QTLSAILFAF IITWTPYNIM VLVNTFCDCV PKTVWNLGYW LCYINSTVNP VCYALCNKMF 

       610        620        630 
RNTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRIPREAS

« Hide

References

[1]"A novel M3 muscarinic acetylcholine receptor is expressed in chick atrium and ventricle."
Gadbut A.P., Galper J.B.
J. Biol. Chem. 269:25823-25829(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L10617 mRNA. Translation: AAA65961.1.
IPIIPI00596361.
PIRA55019.
RefSeqNP_990730.1. NM_205399.1.
UniGeneGga.781.

3D structure databases

ProteinModelPortalP49578.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000017509.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbP49578.
PRIDEP49578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396364.
KEGGgga:396364.

Organism-specific databases

CTD1131.

Phylogenomic databases

eggNOGNOG250863.
HOGENOMHOG000231484.
HOVERGENHBG105720.
InParanoidP49578.
KOK04131.
OrthoDBEOG4NVZK1.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001183. Musac_M3_rcpt.
IPR000995. Musac_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00540. MUSCRINICM3R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816409.

Entry information

Entry nameACM3_CHICK
AccessionPrimary (citable) accession number: P49578
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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