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P49577 (ALF2_PLABA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase 2

Short name=ALDO-2
EC=4.1.2.13
Gene names
Name:ALDO2
OrganismPlasmodium berghei (strain Anka)
Taxonomic identifier5823 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Fructose-bisphosphate aldolase 2
PRO_0000216931

Sites

Active site1841Proton acceptor By similarity
Active site2261Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site511Substrate By similarity
Binding site1411Substrate By similarity
Site3581Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

Sequence LengthMass (Da)Tools
P49577 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 44D82D283FE4C47F

FASTA35838,733
        10         20         30         40         50         60 
MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN RASYRDLLFG 

        70         80         90        100        110        120 
TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG IKVDKGLVSI PCTDDEKSTQ 

       130        140        150        160        170        180 
GLDGLAERCK EYYKAGARFA KWRAVLVIDP AKGKPTDLSI QEVSWGLARY ASICQQNKLV 

       190        200        210        220        230        240 
PIVEPEILAD GAHTIEVCAT VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT 

       250        260        270        280        290        300 
KTDDIGFFTV RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA 

       310        320        330        340        350 
LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS LYEKKYVY 

« Hide

References

[1]"Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing."
Certa U.
Mol. Biochem. Parasitol. 63:291-297(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81793 Unassigned DNA. Translation: AAC37203.1.

3D structure databases

ProteinModelPortalP49577.
SMRP49577. Positions 2-356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF2_PLABA
AccessionPrimary (citable) accession number: P49577
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways