Reviewed,
UniProtKB/Swiss-Prot P49577 (ALF2_PLABA)
Last modified
June 16, 2009.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase 2 Short name=ALDO-2 EC=4.1.2.13 | ||
| Gene names |
| ||
| Organism | Plasmodium berghei (strain Anka) | ||
| Taxonomic identifier | 5823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Vinckeia) |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Pathway | |
| Sequence similarities | Belongs to the class I fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Fructose-bisphosphate aldolase 2 | PRO_0000216931 | |||||
Sites | |||||||||
| Active site | 184 | 1 | Proton acceptor By similarity | ||||||
| Active site | 226 | 1 | Schiff-base intermediate with dihydroxyacetone-P By similarity | ||||||
| Binding site | 51 | 1 | Substrate By similarity | ||||||
| Binding site | 141 | 1 | Substrate By similarity | ||||||
| Site | 358 | 1 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate | ||||||
Sequences
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References
| [1] | "Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing." Certa U. Mol. Biochem. Parasitol. 63:291-297(1994) [PubMed: 8008025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
Cross-references
Sequence databases | |
|---|---|
| M81793 Unassigned DNA. Translation: AAC37203.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1A5C based on UniProtKB P14223. |
| SMR | P49577. Positions 2-350. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11627. Aldolase_I. 1 hit. |
| Pfam | PF00274. Glycolytic. 1 hit. [Graphical view] |
| ProDom | PD001128. Aldolase_I. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALF2_PLABA | ||||||||
| Accession | Primary (citable) accession number: P49577 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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