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P49577

- ALF2_PLABA

UniProt

P49577 - ALF2_PLABA

Protein

Fructose-bisphosphate aldolase 2

Gene

ALDO2

Organism
Plasmodium berghei (strain Anka)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511SubstrateBy similarity
    Binding sitei141 – 1411SubstrateBy similarity
    Active sitei184 – 1841Proton acceptorBy similarity
    Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei358 – 3581Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
    Short name:
    ALDO-2
    Gene namesi
    Name:ALDO2
    OrganismiPlasmodium berghei (strain Anka)
    Taxonomic identifieri5823 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Fructose-bisphosphate aldolase 2PRO_0000216931Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP49577.
    SMRiP49577. Positions 2-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49577-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN    50
    RASYRDLLFG TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG 100
    IKVDKGLVSI PCTDDEKSTQ GLDGLAERCK EYYKAGARFA KWRAVLVIDP 150
    AKGKPTDLSI QEVSWGLARY ASICQQNKLV PIVEPEILAD GAHTIEVCAT 200
    VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT KTDDIGFFTV 250
    RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA 300
    LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS 350
    LYEKKYVY 358
    Length:358
    Mass (Da):38,733
    Last modified:February 1, 1996 - v1
    Checksum:i44D82D283FE4C47F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81793 Unassigned DNA. Translation: AAC37203.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81793 Unassigned DNA. Translation: AAC37203.1 .

    3D structure databases

    ProteinModelPortali P49577.
    SMRi P49577. Positions 2-356.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing."
      Certa U.
      Mol. Biochem. Parasitol. 63:291-297(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiALF2_PLABA
    AccessioniPrimary (citable) accession number: P49577
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3