P49577 (ALF2_PLABA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase 2
Short name=ALDO-2
EC=4.1.2.13

Gene names

Name:

ALDO2

Organism

Plasmodium berghei (strain Anka)

Taxonomic identifier

5823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Vinckeia) › Plasmodium berghei

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Fructose-bisphosphate aldolase 2		PRO_0000216931
Sites
	Active site	184	1	Proton acceptor By similarity
	Active site	226	1	Schiff-base intermediate with dihydroxyacetone-P By similarity
	Binding site	51	1	Substrate By similarity
	Binding site	141	1	Substrate By similarity
	Site	358	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

	Sequence		Length	Mass (Da)
	P49577 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 44D82D283FE4C47F	FASTA	358	38,733
	10 20 30 40 50 60 MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN RASYRDLLFG 70 80 90 100 110 120 TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG IKVDKGLVSI PCTDDEKSTQ 130 140 150 160 170 180 GLDGLAERCK EYYKAGARFA KWRAVLVIDP AKGKPTDLSI QEVSWGLARY ASICQQNKLV 190 200 210 220 230 240 PIVEPEILAD GAHTIEVCAT VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT 250 260 270 280 290 300 KTDDIGFFTV RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA 310 320 330 340 350 LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS LYEKKYVY

References

[1]	"Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing." Certa U. Mol. Biochem. Parasitol. 63:291-297(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81793 Unassigned DNA. Translation: AAC37203.1.
3D structure databases
ProteinModelPortal	P49577.
SMR	P49577. Positions 2-356.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00109; UER00183.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF2_PLABA

Accession

Primary (citable) accession number: P49577

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)