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P49577

- ALF2_PLABA

UniProt

P49577 - ALF2_PLABA

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Protein

Fructose-bisphosphate aldolase 2

Gene

ALDO2

Organism
Plasmodium berghei (strain Anka)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SubstrateBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Active sitei184 – 1841Proton acceptorBy similarity
Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei358 – 3581Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Short name:
ALDO-2
Gene namesi
Name:ALDO2
OrganismiPlasmodium berghei (strain Anka)
Taxonomic identifieri5823 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Fructose-bisphosphate aldolase 2PRO_0000216931Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP49577.
SMRiP49577. Positions 2-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49577-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN
60 70 80 90 100
RASYRDLLFG TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG
110 120 130 140 150
IKVDKGLVSI PCTDDEKSTQ GLDGLAERCK EYYKAGARFA KWRAVLVIDP
160 170 180 190 200
AKGKPTDLSI QEVSWGLARY ASICQQNKLV PIVEPEILAD GAHTIEVCAT
210 220 230 240 250
VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT KTDDIGFFTV
260 270 280 290 300
RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA
310 320 330 340 350
LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS

LYEKKYVY
Length:358
Mass (Da):38,733
Last modified:February 1, 1996 - v1
Checksum:i44D82D283FE4C47F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81793 Unassigned DNA. Translation: AAC37203.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81793 Unassigned DNA. Translation: AAC37203.1 .

3D structure databases

ProteinModelPortali P49577.
SMRi P49577. Positions 2-356.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing."
    Certa U.
    Mol. Biochem. Parasitol. 63:291-297(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiALF2_PLABA
AccessioniPrimary (citable) accession number: P49577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3