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Protein

Fructose-bisphosphate aldolase 2

Gene

ALDO2

Organism
Plasmodium berghei (strain Anka)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PB301360.00.0), Glucose-6-phosphate isomerase (PBANKA_100880), Glucose-6-phosphate isomerase (PB001005.02.0)
  3. Probable ATP-dependent 6-phosphofructokinase (PBANKA_081640)
  4. Fructose-bisphosphate aldolase (PBANKA_130860), Fructose-bisphosphate aldolase 2 (ALDO2), Fructose-bisphosphate aldolase (PB000757.02.0)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51SubstrateBy similarity1
Binding sitei141SubstrateBy similarity1
Active sitei184Proton acceptorBy similarity1
Active sitei226Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei358Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Short name:
ALDO-2
Gene namesi
Name:ALDO2
OrganismiPlasmodium berghei (strain Anka)
Taxonomic identifieri5823 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169311 – 358Fructose-bisphosphate aldolase 2Add BLAST358

Structurei

3D structure databases

ProteinModelPortaliP49577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPKEDAQE LAETAKKLVA AGKGILAADE STQTIKKRFD NIKIENTVQN
60 70 80 90 100
RASYRDLLFG TKGLGKFISG AILFEETLFQ KNEAGVPLVN LLHDEGIIPG
110 120 130 140 150
IKVDKGLVSI PCTDDEKSTQ GLDGLAERCK EYYKAGARFA KWRAVLVIDP
160 170 180 190 200
AKGKPTDLSI QEVSWGLARY ASICQQNKLV PIVEPEILAD GAHTIEVCAT
210 220 230 240 250
VTQKVLASVF KALHDNGVLL EGASLKPNMV TAGYDCTEKT KTDDIGFFTV
260 270 280 290 300
RTLRRTVPPA LPGVAFLSGG QSEEDASINL NSINVLGPHP WALTFSYGRA
310 320 330 340 350
LQASVLNTWQ GKKENVAKAR RVLLQRAEAN SLATYGKYKG GAGGSTAGAS

LYEKKYVY
Length:358
Mass (Da):38,733
Last modified:February 1, 1996 - v1
Checksum:i44D82D283FE4C47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81793 Unassigned DNA. Translation: AAC37203.1.

Genome annotation databases

GeneDBiPBANKA_1308600.1:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81793 Unassigned DNA. Translation: AAC37203.1.

3D structure databases

ProteinModelPortaliP49577.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiPBANKA_1308600.1:pep.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF2_PLABA
AccessioniPrimary (citable) accession number: P49577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.