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P49576

- PPX1_PARTE

UniProt

P49576 - PPX1_PARTE

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Protein

Serine/threonine-protein phosphatase PP-X homolog 1

Gene
Ppx1, GSPATT00019262001
Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Manganese 1 By similarity
Metal bindingi53 – 531Manganese 1 By similarity
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi79 – 791Manganese 2 By similarity
Metal bindingi111 – 1111Manganese 2 By similarity
Active sitei112 – 1121Proton donor By similarity
Metal bindingi161 – 1611Manganese 2 By similarity
Metal bindingi235 – 2351Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X homolog 1 (EC:3.1.3.16)
Gene namesi
Name:Ppx1
ORF Names:GSPATT00019262001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Serine/threonine-protein phosphatase PP-X homolog 1PRO_0000058888Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP49576.
SMRiP49576. Positions 3-303.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49576-1 [UniParc]FASTAAdd to Basket

« Hide

MSDIDQWIET LKNGENLKET DVKILCNKAK DILNNEDNVI RVEAPVTICG    50
DIHGQFYDLM ELFKVGGDVP ETNYLFLGDF VDRGYNSVET FLLLLALKVR 100
YPDQITLIRG NHESRQITQV YGFYDECLRK YSTLNVWKYC TEVFDYLALA 150
AVVNDNIFCV HGGLSPYIKT IDEIRIINRK QEVPHEGVMC DLMWSDPDEI 200
EGWSQSARGA GFVFGADVVK EFNRRNGISL ICRAHQLAME GFKLMFDNSL 250
VTVWSAPNYC YRCGNVASIL ELDENLKKYY KLFEAAPTDR AQNSKKVIAD 300
YFL 303
Length:303
Mass (Da):34,745
Last modified:October 23, 2007 - v2
Checksum:i9A00E5F88F5C810D
GO

Sequence cautioni

The sequence CAK85545.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161N → D in AAA75081. 1 Publication
Sequence conflicti20 – 201T → S in AAA75081. 1 Publication
Sequence conflicti47 – 471T → A in AAA75081. 1 Publication
Sequence conflicti62 – 621L → V in AAA75081. 1 Publication
Sequence conflicti130 – 1301K → E in AAA75081. 1 Publication
Sequence conflicti297 – 2971V → T in AAA75081. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31445 Genomic DNA. Translation: AAA75081.1.
CT868541 Genomic DNA. Translation: CAK85545.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31445 Genomic DNA. Translation: AAA75081.1 .
CT868541 Genomic DNA. Translation: CAK85545.1 . Sequence problems.

3D structure databases

ProteinModelPortali P49576.
SMRi P49576. Positions 3-303.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Russell C.B., Johnson J., Hinrichsen R.D.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock 51.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPPX1_PARTE
AccessioniPrimary (citable) accession number: P49576
Secondary accession number(s): A0DR78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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