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P49576

- PPX1_PARTE

UniProt

P49576 - PPX1_PARTE

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Protein

Serine/threonine-protein phosphatase PP-X homolog 1

Gene

Ppx1

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Manganese 1By similarity
Metal bindingi53 – 531Manganese 1By similarity
Metal bindingi79 – 791Manganese 1By similarity
Metal bindingi79 – 791Manganese 2By similarity
Metal bindingi111 – 1111Manganese 2By similarity
Active sitei112 – 1121Proton donorBy similarity
Metal bindingi161 – 1611Manganese 2By similarity
Metal bindingi235 – 2351Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X homolog 1 (EC:3.1.3.16)
Gene namesi
Name:Ppx1
ORF Names:GSPATT00019262001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Serine/threonine-protein phosphatase PP-X homolog 1PRO_0000058888Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP49576.
SMRiP49576. Positions 3-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP49576.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49576-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIDQWIET LKNGENLKET DVKILCNKAK DILNNEDNVI RVEAPVTICG
60 70 80 90 100
DIHGQFYDLM ELFKVGGDVP ETNYLFLGDF VDRGYNSVET FLLLLALKVR
110 120 130 140 150
YPDQITLIRG NHESRQITQV YGFYDECLRK YSTLNVWKYC TEVFDYLALA
160 170 180 190 200
AVVNDNIFCV HGGLSPYIKT IDEIRIINRK QEVPHEGVMC DLMWSDPDEI
210 220 230 240 250
EGWSQSARGA GFVFGADVVK EFNRRNGISL ICRAHQLAME GFKLMFDNSL
260 270 280 290 300
VTVWSAPNYC YRCGNVASIL ELDENLKKYY KLFEAAPTDR AQNSKKVIAD

YFL
Length:303
Mass (Da):34,745
Last modified:October 23, 2007 - v2
Checksum:i9A00E5F88F5C810D
GO

Sequence cautioni

The sequence CAK85545.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161N → D in AAA75081. 1 PublicationCurated
Sequence conflicti20 – 201T → S in AAA75081. 1 PublicationCurated
Sequence conflicti47 – 471T → A in AAA75081. 1 PublicationCurated
Sequence conflicti62 – 621L → V in AAA75081. 1 PublicationCurated
Sequence conflicti130 – 1301K → E in AAA75081. 1 PublicationCurated
Sequence conflicti297 – 2971V → T in AAA75081. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31445 Genomic DNA. Translation: AAA75081.1.
CT868541 Genomic DNA. Translation: CAK85545.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31445 Genomic DNA. Translation: AAA75081.1 .
CT868541 Genomic DNA. Translation: CAK85545.1 . Sequence problems.

3D structure databases

ProteinModelPortali P49576.
SMRi P49576. Positions 3-303.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi P49576.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Russell C.B., Johnson J., Hinrichsen R.D.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock 51.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPPX1_PARTE
AccessioniPrimary (citable) accession number: P49576
Secondary accession number(s): A0DR78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3