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P49576 (PPX1_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP-X homolog 1

EC=3.1.3.16
Gene names
Name:Ppx1
ORF Names:GSPATT00019262001
OrganismParamecium tetraurelia [Reference proteome]
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Sequence caution

The sequence CAK85545.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Serine/threonine-protein phosphatase PP-X homolog 1
PRO_0000058888

Sites

Active site1121Proton donor By similarity
Metal binding511Manganese 1 By similarity
Metal binding531Manganese 1 By similarity
Metal binding791Manganese 1 By similarity
Metal binding791Manganese 2 By similarity
Metal binding1111Manganese 2 By similarity
Metal binding1611Manganese 2 By similarity
Metal binding2351Manganese 2 By similarity

Experimental info

Sequence conflict161N → D in AAA75081. Ref.1
Sequence conflict201T → S in AAA75081. Ref.1
Sequence conflict471T → A in AAA75081. Ref.1
Sequence conflict621L → V in AAA75081. Ref.1
Sequence conflict1301K → E in AAA75081. Ref.1
Sequence conflict2971V → T in AAA75081. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49576 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 9A00E5F88F5C810D

FASTA30334,745
        10         20         30         40         50         60 
MSDIDQWIET LKNGENLKET DVKILCNKAK DILNNEDNVI RVEAPVTICG DIHGQFYDLM 

        70         80         90        100        110        120 
ELFKVGGDVP ETNYLFLGDF VDRGYNSVET FLLLLALKVR YPDQITLIRG NHESRQITQV 

       130        140        150        160        170        180 
YGFYDECLRK YSTLNVWKYC TEVFDYLALA AVVNDNIFCV HGGLSPYIKT IDEIRIINRK 

       190        200        210        220        230        240 
QEVPHEGVMC DLMWSDPDEI EGWSQSARGA GFVFGADVVK EFNRRNGISL ICRAHQLAME 

       250        260        270        280        290        300 
GFKLMFDNSL VTVWSAPNYC YRCGNVASIL ELDENLKKYY KLFEAAPTDR AQNSKKVIAD 


YFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31445 Genomic DNA. Translation: AAA75081.1.
CT868541 Genomic DNA. Translation: CAK85545.1. Sequence problems.

3D structure databases

ProteinModelPortalP49576.
SMRP49576. Positions 3-303.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPX1_PARTE
AccessionPrimary (citable) accession number: P49576
Secondary accession number(s): A0DR78
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families