Reviewed,
UniProtKB/Swiss-Prot P49459 (UBE2A_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 A EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase A Ubiquitin carrier protein A HR6A hHR6A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 152 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Subunit structure | Interacts with RAD18. |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
Keywords | |
|---|---|
| Biological process | DNA damage DNA repair Ubl conjugation pathway |
| Molecular function | Ligase |
Gene Ontology (GO) | |
| Biological process | post-translational protein modification Inferred from electronic annotation. Source: InterPro postreplication repairTraceable author statement. Source: ProtInc regulation of protein metabolic processInferred from electronic annotation. Source: InterPro ubiquitin-dependent protein catabolic processTraceable author statement. Source: ProtInc |
| Molecular function | ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6." Koken M.H.M., Reynolds P., Jaspers-Dekker I., Prakash L., Prakash S., Bootsma D., Hoeijmakers J.H.J. Proc. Natl. Acad. Sci. U.S.A. 88:8865-8869(1991) [PubMed: 1717990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M74524 mRNA. Translation: AAA35981.1. DQ068065 Genomic DNA. Translation: AAY46159.1. CH471161 Genomic DNA. Translation: EAW89862.1. BC010175 mRNA. Translation: AAH10175.1. | |
| PIR | A41222. |
| RefSeq | NP_003327.2. NP_861427.1. |
| UniGene | Hs.379466 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2AAK based on UniProtKB P25865. |
| SMR | P49459. Positions 1-151. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:24260N. |
PTM databases | |
| PhosphoSite | P49459. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000077721. Homo sapiens. [Contig view] |
| GeneID | 7319. |
| KEGG | hsa:7319. |
Organism-specific databases | |
| HGNC | HGNC:12472. UBE2A. |
| MIM | 312180. gene. |
| Orphanet | 98464. Mental retardation, X-linked, syndromic. |
| PharmGKB | PA37122. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P49459. |
Gene expression databases | |
| ArrayExpress | P49459. |
| CleanEx | HS_UBE2A. |
| GermOnline | ENSG00000077721. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] |
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. |
| PANTHER | PTHR11621. UBQ-conjugat_E2. 1 hit. |
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] |
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00212. UBCc. 1 hit. [Graphical view] |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 28614. |
| SOURCE | Search... |
Entry information
| Entry name | UBE2A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49459 Secondary accession number(s): A6NMF5, Q4TTG1, Q96FX4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


