Reviewed, UniProtKB/Swiss-Prot P49452 (CENPC_MOUSE)

Names and origin

Protein names

Recommended name:
    Centromere protein C 1
      Short name=CENP-C
Alternative name(s):
    Centromere autoantigen C

Gene names

Name:	Cenpc1
Synonyms:	Cenpc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres By similarity.
Subunit structure	Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX By similarity.
Subcellular location	Nucleus By similarity. Centromere By similarity. Kinetochore By similarity. Note: Localizes exclusively in the kinetochore domain of centromeres By similarity.

Ontologies

Keywords
Cellular component	Centromere Chromosomal protein Kinetochore Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PTEN	P60484	1	EBI-1186252,EBI-696162	From a different organism.
Pten	O08586	1	EBI-1186252,EBI-1186266

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 906	906	Centromere protein C 1		PRO_0000089475
Amino acid modifications
	Modified residue	302	1	Phosphoserine By similarity
	Modified residue	487	1	Phosphoserine By similarity
	Modified residue	491	1	Phosphoserine By similarity
	Modified residue	505	1	Phosphoserine By similarity
	Modified residue	728	1	Phosphoserine By similarity
	Modified residue	737	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49452-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 43D529B202E9D71E	FASTA	906	102,226
	10 20 30 40 50 60 MAMFHLDHLK NYHRRYCRSS RAPNIHTKKG QNMLEILQDC FEDQSKASFL DDFTESLTSS 70 80 90 100 110 120 TQKKKANYSQ SSSKKCPESH SKPVPVSSRT GEASLQASAE PSEAAGGSVQ ANEVHHGASD 130 140 150 160 170 180 ELDLCVGSPV VLLDANVNTL QKAASPAGQK RVASVSRSPV DRQASNKNIS FKTRKRLNFE 190 200 210 220 230 240 DKVTSSTAET ENSVLQVEDN LSKGQEGTSS EITQKRDDLS SDVQSRSKKN FSELFLETVK 250 260 270 280 290 300 RKSKSSSVVR HTAAVPFSPP PPSDMKLLED EFIIDRSDRS FSSRLWVMIP SKDRHLSAHK 310 320 330 340 350 360 PSPENTALLQ GKKSREKSHS LSAMTFARNT QSDKAHPIEE AQLSVEENPA TTCTDELEND 370 380 390 400 410 420 CRSPENKMQS ETAKTPPAWE RTTKQSQRRV SKPKAAEELR KGQSSWENSN VSNTGQDTLQ 430 440 450 460 470 480 INSKRNMKDC EEVRNEPNPK KQKPALENKR KTNSTQTNKE KSGKKFFSGG SKNKFVPKKV 490 500 510 520 530 540 TLTSRRSRRI SQRPSEWWRV KSDESSVDRN PSKENNSPVV YPNKKKQTKR NHVSKRAGKK 550 560 570 580 590 600 PGSSKRQKTE MSPRVQKSLN VKDSGGTVSG HDDTSRSQRK PLKIIEADPT QKSLAISRPK 610 620 630 640 650 660 RGCKYRNNVM TSPNVHLKSH TEEYTSKTQM ESASNSEMSK RSVWEESGPS RFKNYEMPGS 670 680 690 700 710 720 SNSEMGDEQD QKSLHFTTRS FNMVPDKKLH HKLVLPSNSP NVRRSNRIRL KPLEYWRGER 730 740 750 760 770 780 VDYQESSSGQ LVLEIISPSS VPTKIKAQRN LGKVNKKVTK KPTHLNSHEK AKMELPLDMR 790 800 810 820 830 840 LGDPFQATLA KDPETAELVP MDLIRPRDTY RFFVEQHGLK VFKTLDTIYF STGKLVLGPY 850 860 870 880 890 900 EEKGKQHVGQ DILVFYVNFG DLLCTLHETP YKLTTGDSFY VPSGNHYNIK NLLNVESSLL FTQIKR

References

[1]	"Sequence homologies and linkage group conservation of the human and mouse Cenpc genes." McKay S., Thomson E., Cooke H. Genomics 22:36-40(1994) [PubMed: 7959789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U03113 mRNA. Translation: AAC04314.1.
IPI	IPI00114808.
PIR	A54654.
UniGene	Mm.4649
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P49452. 2 interactions.
PTM databases
PhosphoSite	P49452.
Proteomic databases
PRIDE	P49452.
Genome annotation databases
Ensembl	ENSMUSG00000029253. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:99700. Cenpc1.
Phylogenomic databases
HOGENOM	P49452.
HOVERGEN	P49452.
Gene expression databases
ArrayExpress	P49452.
Bgee	P49452.
CleanEx	MM_CENPC1.
GermOnline	ENSMUSG00000029253. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CENPC_MOUSE

Accession

Primary (citable) accession number: P49452

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)