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P49452 (CENPC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein C

Short name=CENP-C
Alternative name(s):
Centromere autoantigen C
Centromere protein C 1
Short name=CENP-C 1
Gene names
Name:Cenpc
Synonyms:Cenpc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions By similarity.

Subunit structure

Oligomer By similarity. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX By similarity. Interacts directly with CENPA By similarity.

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity. Note: Localizes exclusively in the kinetochore domain of centromeres By similarity.

Domain

The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.

Sequence similarities

Belongs to the CENPC family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PtenO085862EBI-1186252,EBI-1186266

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 906906Centromere protein C
PRO_0000089475

Regions

Region702 – 72423MIF2 homology domain II By similarity
Region853 – 90654MIF2 homology domain III By similarity
Motif228 – 24215Nuclear localization signal Potential
Motif449 – 46618Nuclear localization signal Potential
Motif525 – 54016Nuclear localization signal Potential
Motif744 – 76219Nuclear localization signal Potential

Amino acid modifications

Modified residue941Phosphoserine By similarity
Modified residue4041Phosphoserine By similarity
Modified residue5051Phosphoserine By similarity
Modified residue6731Phosphoserine By similarity
Modified residue7281Phosphoserine By similarity
Modified residue7371Phosphoserine By similarity

Experimental info

Sequence conflict31S → M in AAC04314. Ref.1
Sequence conflict1851L → S in AAC04314. Ref.1
Sequence conflict4181K → T in AAC04314. Ref.1
Sequence conflict4501K → R in AAC04314. Ref.1
Sequence conflict4881C → R in AAC04314. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49452 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 0DCFE76496B33946

FASTA906102,154
        10         20         30         40         50         60 
MASFHLDHLK NYHRRYCRSS RAPNIHTKKG QNMLEILQDC FEDQSKASFL DDFTESLTSS 

        70         80         90        100        110        120 
TQKKKANYSQ SSSKKCPESH SKPVPVSSRT GEASLQASAE PSEAAGGSVQ ANEVHHGASD 

       130        140        150        160        170        180 
ELDLCVGSPV VLLDANVNTL QKAASPAGQK RVASVSRSPV DRQASNKNIS FKTRKRLNFE 

       190        200        210        220        230        240 
DKVTLSTAET ENSVLQVEDN LSKGQEGTSS EITQKRDDLS SDVQSRSKKN FSELFLETVK 

       250        260        270        280        290        300 
RKSKSSSVVR HTAAVPFSPP PPSDMKLLED EFIIDRSDRS FSSRLWVMIP SKDRHLSAHK 

       310        320        330        340        350        360 
PSPENTALLQ GKKSREKSHS LSAMTFARNT QSDKAHPIEE AQLSVEENPA TTCTDELEND 

       370        380        390        400        410        420 
CRSPENKMQS ETAKTPPAWE RTTKQSQRRV SKPKAAEELR KGQSSWENSN VSNTGQDKLQ 

       430        440        450        460        470        480 
INSKRNMKDC EEVRNEPNPK KQKPALENKK KTNSTQTNKE KSGKKFFSGG SKNKFVPKKV 

       490        500        510        520        530        540 
TLTSRRSCRI SQRPSEWWRV KSDESSVDRN PSKENNSPVV YPNKKKQTKR NHVSKRAGKK 

       550        560        570        580        590        600 
PGSSKRQKTE MSPRVQKSLN VKDSGGTVSG HDDTSRSQRK PLKIIEADPT QKSLAISRPK 

       610        620        630        640        650        660 
RGCKYRNNVM TSPNVHLKSH TEEYTSKTQM ESASNSEMSK RSVWEESGPS RFKNYEMPGS 

       670        680        690        700        710        720 
SNSEMGDEQD QKSLHFTTRS FNMVPDKKLH HKLVLPSNSP NVRRSNRIRL KPLEYWRGER 

       730        740        750        760        770        780 
VDYQESSSGQ LVLEIISPSS VPTKIKAQRN LGKVNKKVTK KPTHLNSHEK AKMELPLDMR 

       790        800        810        820        830        840 
LGDPFQATLA KDPETAELVP MDLIRPRDTY RFFVEQHGLK VFKTLDTIYF STGKLVLGPY 

       850        860        870        880        890        900 
EEKGKQHVGQ DILVFYVNFG DLLCTLHETP YKLTTGDSFY VPSGNHYNIK NLLNVESSLL 


FTQIKR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence homologies and linkage group conservation of the human and mouse Cenpc genes."
McKay S., Thomson E., Cooke H.
Genomics 22:36-40(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03113 mRNA. Translation: AAC04314.1.
CH466524 Genomic DNA. Translation: EDL37951.1.
BC150700 mRNA. Translation: AAI50701.1.
PIRA54654.
RefSeqNP_031709.2. NM_007683.3.
UniGeneMm.4649.

3D structure databases

ProteinModelPortalP49452.
SMRP49452. Positions 824-905.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP49452. 151 interactions.
STRING10090.ENSMUSP00000031170.

PTM databases

PhosphoSiteP49452.

Proteomic databases

PRIDEP49452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031170; ENSMUSP00000031170; ENSMUSG00000029253.
GeneID12617.
KEGGmmu:12617.
UCSCuc008xxc.2. mouse.

Organism-specific databases

CTD12617.
MGIMGI:99700. Cenpc1.

Phylogenomic databases

eggNOGNOG307418.
GeneTreeENSGT00390000016737.
HOGENOMHOG000090256.
HOVERGENHBG050891.
InParanoidP49452.
KOK11497.
OMAGYRRRFC.
OrthoDBEOG73FQQ8.
TreeFamTF101132.

Gene expression databases

ArrayExpressP49452.
BgeeP49452.
CleanExMM_CENPC1.
GenevestigatorP49452.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR16684. PTHR16684. 1 hit.
PfamPF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 2 hits.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Other

NextBio281786.
PROP49452.
SOURCESearch...

Entry information

Entry nameCENPC_MOUSE
AccessionPrimary (citable) accession number: P49452
Secondary accession number(s): B9EK81
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot