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P49452

- CENPC_MOUSE

UniProt

P49452 - CENPC_MOUSE

Protein

Centromere protein C

Gene

Cenpc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions By similarity.By similarity

    GO - Molecular functioni

    1. centromeric DNA binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB
    2. kinetochore assembly Source: UniProtKB
    3. mitotic cell cycle Source: UniProtKB
    4. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein C
    Short name:
    CENP-C
    Alternative name(s):
    Centromere autoantigen C
    Centromere protein C 1
    Short name:
    CENP-C 1
    Gene namesi
    Name:Cenpc
    Synonyms:Cenpc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:99700. Cenpc1.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
    Note: Localizes exclusively in the kinetochore domain of centromeres.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. condensed nuclear chromosome, centromeric region Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. kinetochore Source: UniProtKB
    5. pericentric heterochromatin Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 906906Centromere protein CPRO_0000089475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941PhosphoserineBy similarity
    Modified residuei404 – 4041PhosphoserineBy similarity
    Modified residuei505 – 5051PhosphoserineBy similarity
    Modified residuei673 – 6731PhosphoserineBy similarity
    Modified residuei728 – 7281PhosphoserineBy similarity
    Modified residuei737 – 7371PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP49452.

    PTM databases

    PhosphoSiteiP49452.

    Expressioni

    Gene expression databases

    ArrayExpressiP49452.
    BgeeiP49452.
    CleanExiMM_CENPC1.
    GenevestigatoriP49452.

    Interactioni

    Subunit structurei

    Oligomer By similarity. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX By similarity. Interacts directly with CENPA By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PtenO085862EBI-1186252,EBI-1186266

    Protein-protein interaction databases

    IntActiP49452. 151 interactions.
    STRINGi10090.ENSMUSP00000031170.

    Structurei

    3D structure databases

    ProteinModelPortaliP49452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni702 – 72423MIF2 homology domain IIBy similarityAdd
    BLAST
    Regioni853 – 90654MIF2 homology domain IIIBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi228 – 24215Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi449 – 46618Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi525 – 54016Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi744 – 76219Nuclear localization signalSequence AnalysisAdd
    BLAST

    Domaini

    The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.

    Sequence similaritiesi

    Belongs to the CENPC family.Curated

    Phylogenomic databases

    eggNOGiNOG307418.
    GeneTreeiENSGT00390000016737.
    HOGENOMiHOG000090256.
    HOVERGENiHBG050891.
    InParanoidiP49452.
    KOiK11497.
    OMAiGYRRRFC.
    OrthoDBiEOG73FQQ8.
    TreeFamiTF101132.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR028386. CENP-C/Mif2/cnp3.
    IPR028931. CENP-C_mid.
    IPR028052. CENP_C_N_dom.
    IPR025974. Mif2/CENP-C_cupin.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR16684. PTHR16684. 1 hit.
    PfamiPF11699. CENP-C_C. 1 hit.
    PF15620. CENP-C_mid. 1 hit.
    PF15622. CENP_C_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P49452-1 [UniParc]FASTAAdd to Basket

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    MASFHLDHLK NYHRRYCRSS RAPNIHTKKG QNMLEILQDC FEDQSKASFL    50
    DDFTESLTSS TQKKKANYSQ SSSKKCPESH SKPVPVSSRT GEASLQASAE 100
    PSEAAGGSVQ ANEVHHGASD ELDLCVGSPV VLLDANVNTL QKAASPAGQK 150
    RVASVSRSPV DRQASNKNIS FKTRKRLNFE DKVTLSTAET ENSVLQVEDN 200
    LSKGQEGTSS EITQKRDDLS SDVQSRSKKN FSELFLETVK RKSKSSSVVR 250
    HTAAVPFSPP PPSDMKLLED EFIIDRSDRS FSSRLWVMIP SKDRHLSAHK 300
    PSPENTALLQ GKKSREKSHS LSAMTFARNT QSDKAHPIEE AQLSVEENPA 350
    TTCTDELEND CRSPENKMQS ETAKTPPAWE RTTKQSQRRV SKPKAAEELR 400
    KGQSSWENSN VSNTGQDKLQ INSKRNMKDC EEVRNEPNPK KQKPALENKK 450
    KTNSTQTNKE KSGKKFFSGG SKNKFVPKKV TLTSRRSCRI SQRPSEWWRV 500
    KSDESSVDRN PSKENNSPVV YPNKKKQTKR NHVSKRAGKK PGSSKRQKTE 550
    MSPRVQKSLN VKDSGGTVSG HDDTSRSQRK PLKIIEADPT QKSLAISRPK 600
    RGCKYRNNVM TSPNVHLKSH TEEYTSKTQM ESASNSEMSK RSVWEESGPS 650
    RFKNYEMPGS SNSEMGDEQD QKSLHFTTRS FNMVPDKKLH HKLVLPSNSP 700
    NVRRSNRIRL KPLEYWRGER VDYQESSSGQ LVLEIISPSS VPTKIKAQRN 750
    LGKVNKKVTK KPTHLNSHEK AKMELPLDMR LGDPFQATLA KDPETAELVP 800
    MDLIRPRDTY RFFVEQHGLK VFKTLDTIYF STGKLVLGPY EEKGKQHVGQ 850
    DILVFYVNFG DLLCTLHETP YKLTTGDSFY VPSGNHYNIK NLLNVESSLL 900
    FTQIKR 906
    Length:906
    Mass (Da):102,154
    Last modified:July 27, 2011 - v2
    Checksum:i0DCFE76496B33946
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31S → M in AAC04314. (PubMed:7959789)Curated
    Sequence conflicti185 – 1851L → S in AAC04314. (PubMed:7959789)Curated
    Sequence conflicti418 – 4181K → T in AAC04314. (PubMed:7959789)Curated
    Sequence conflicti450 – 4501K → R in AAC04314. (PubMed:7959789)Curated
    Sequence conflicti488 – 4881C → R in AAC04314. (PubMed:7959789)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03113 mRNA. Translation: AAC04314.1.
    CH466524 Genomic DNA. Translation: EDL37951.1.
    BC150700 mRNA. Translation: AAI50701.1.
    CCDSiCCDS39123.1.
    PIRiA54654.
    RefSeqiNP_031709.2. NM_007683.3.
    UniGeneiMm.4649.

    Genome annotation databases

    EnsembliENSMUST00000031170; ENSMUSP00000031170; ENSMUSG00000029253.
    GeneIDi12617.
    KEGGimmu:12617.
    UCSCiuc008xxc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03113 mRNA. Translation: AAC04314.1 .
    CH466524 Genomic DNA. Translation: EDL37951.1 .
    BC150700 mRNA. Translation: AAI50701.1 .
    CCDSi CCDS39123.1.
    PIRi A54654.
    RefSeqi NP_031709.2. NM_007683.3.
    UniGenei Mm.4649.

    3D structure databases

    ProteinModelPortali P49452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49452. 151 interactions.
    STRINGi 10090.ENSMUSP00000031170.

    PTM databases

    PhosphoSitei P49452.

    Proteomic databases

    PRIDEi P49452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031170 ; ENSMUSP00000031170 ; ENSMUSG00000029253 .
    GeneIDi 12617.
    KEGGi mmu:12617.
    UCSCi uc008xxc.2. mouse.

    Organism-specific databases

    CTDi 12617.
    MGIi MGI:99700. Cenpc1.

    Phylogenomic databases

    eggNOGi NOG307418.
    GeneTreei ENSGT00390000016737.
    HOGENOMi HOG000090256.
    HOVERGENi HBG050891.
    InParanoidi P49452.
    KOi K11497.
    OMAi GYRRRFC.
    OrthoDBi EOG73FQQ8.
    TreeFami TF101132.

    Enzyme and pathway databases

    Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 281786.
    PROi P49452.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49452.
    Bgeei P49452.
    CleanExi MM_CENPC1.
    Genevestigatori P49452.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR028386. CENP-C/Mif2/cnp3.
    IPR028931. CENP-C_mid.
    IPR028052. CENP_C_N_dom.
    IPR025974. Mif2/CENP-C_cupin.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR16684. PTHR16684. 1 hit.
    Pfami PF11699. CENP-C_C. 1 hit.
    PF15620. CENP-C_mid. 1 hit.
    PF15622. CENP_C_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes."
      McKay S., Thomson E., Cooke H.
      Genomics 22:36-40(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCENPC_MOUSE
    AccessioniPrimary (citable) accession number: P49452
    Secondary accession number(s): B9EK81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3