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P49452

- CENPC_MOUSE

UniProt

P49452 - CENPC_MOUSE

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Protein

Centromere protein C

Gene
Cenpc, Cenpc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions By similarity.

GO - Molecular functioni

  1. centromeric DNA binding Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. chromosome segregation Source: UniProtKB
  2. kinetochore assembly Source: UniProtKB
  3. mitotic cell cycle Source: UniProtKB
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein C
Short name:
CENP-C
Alternative name(s):
Centromere autoantigen C
Centromere protein C 1
Short name:
CENP-C 1
Gene namesi
Name:Cenpc
Synonyms:Cenpc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:99700. Cenpc1.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes exclusively in the kinetochore domain of centromeres By similarity.

GO - Cellular componenti

  1. centromeric heterochromatin Source: UniProtKB
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. condensed nuclear chromosome, centromeric region Source: Ensembl
  4. cytoplasm Source: Ensembl
  5. kinetochore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Centromere protein CPRO_0000089475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941Phosphoserine By similarity
Modified residuei404 – 4041Phosphoserine By similarity
Modified residuei505 – 5051Phosphoserine By similarity
Modified residuei673 – 6731Phosphoserine By similarity
Modified residuei728 – 7281Phosphoserine By similarity
Modified residuei737 – 7371Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP49452.

PTM databases

PhosphoSiteiP49452.

Expressioni

Gene expression databases

ArrayExpressiP49452.
BgeeiP49452.
CleanExiMM_CENPC1.
GenevestigatoriP49452.

Interactioni

Subunit structurei

Oligomer By similarity. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX By similarity. Interacts directly with CENPA By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
PtenO085862EBI-1186252,EBI-1186266

Protein-protein interaction databases

IntActiP49452. 151 interactions.
STRINGi10090.ENSMUSP00000031170.

Structurei

3D structure databases

ProteinModelPortaliP49452.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni702 – 72423MIF2 homology domain II By similarityAdd
BLAST
Regioni853 – 90654MIF2 homology domain III By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi228 – 24215Nuclear localization signal Reviewed predictionAdd
BLAST
Motifi449 – 46618Nuclear localization signal Reviewed predictionAdd
BLAST
Motifi525 – 54016Nuclear localization signal Reviewed predictionAdd
BLAST
Motifi744 – 76219Nuclear localization signal Reviewed predictionAdd
BLAST

Domaini

The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.

Sequence similaritiesi

Belongs to the CENPC family.

Phylogenomic databases

eggNOGiNOG307418.
GeneTreeiENSGT00390000016737.
HOGENOMiHOG000090256.
HOVERGENiHBG050891.
InParanoidiP49452.
KOiK11497.
OMAiGYRRRFC.
OrthoDBiEOG73FQQ8.
TreeFamiTF101132.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 2 hits.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P49452-1 [UniParc]FASTAAdd to Basket

« Hide

MASFHLDHLK NYHRRYCRSS RAPNIHTKKG QNMLEILQDC FEDQSKASFL    50
DDFTESLTSS TQKKKANYSQ SSSKKCPESH SKPVPVSSRT GEASLQASAE 100
PSEAAGGSVQ ANEVHHGASD ELDLCVGSPV VLLDANVNTL QKAASPAGQK 150
RVASVSRSPV DRQASNKNIS FKTRKRLNFE DKVTLSTAET ENSVLQVEDN 200
LSKGQEGTSS EITQKRDDLS SDVQSRSKKN FSELFLETVK RKSKSSSVVR 250
HTAAVPFSPP PPSDMKLLED EFIIDRSDRS FSSRLWVMIP SKDRHLSAHK 300
PSPENTALLQ GKKSREKSHS LSAMTFARNT QSDKAHPIEE AQLSVEENPA 350
TTCTDELEND CRSPENKMQS ETAKTPPAWE RTTKQSQRRV SKPKAAEELR 400
KGQSSWENSN VSNTGQDKLQ INSKRNMKDC EEVRNEPNPK KQKPALENKK 450
KTNSTQTNKE KSGKKFFSGG SKNKFVPKKV TLTSRRSCRI SQRPSEWWRV 500
KSDESSVDRN PSKENNSPVV YPNKKKQTKR NHVSKRAGKK PGSSKRQKTE 550
MSPRVQKSLN VKDSGGTVSG HDDTSRSQRK PLKIIEADPT QKSLAISRPK 600
RGCKYRNNVM TSPNVHLKSH TEEYTSKTQM ESASNSEMSK RSVWEESGPS 650
RFKNYEMPGS SNSEMGDEQD QKSLHFTTRS FNMVPDKKLH HKLVLPSNSP 700
NVRRSNRIRL KPLEYWRGER VDYQESSSGQ LVLEIISPSS VPTKIKAQRN 750
LGKVNKKVTK KPTHLNSHEK AKMELPLDMR LGDPFQATLA KDPETAELVP 800
MDLIRPRDTY RFFVEQHGLK VFKTLDTIYF STGKLVLGPY EEKGKQHVGQ 850
DILVFYVNFG DLLCTLHETP YKLTTGDSFY VPSGNHYNIK NLLNVESSLL 900
FTQIKR 906
Length:906
Mass (Da):102,154
Last modified:July 27, 2011 - v2
Checksum:i0DCFE76496B33946
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → M in AAC04314. 1 Publication
Sequence conflicti185 – 1851L → S in AAC04314. 1 Publication
Sequence conflicti418 – 4181K → T in AAC04314. 1 Publication
Sequence conflicti450 – 4501K → R in AAC04314. 1 Publication
Sequence conflicti488 – 4881C → R in AAC04314. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03113 mRNA. Translation: AAC04314.1.
CH466524 Genomic DNA. Translation: EDL37951.1.
BC150700 mRNA. Translation: AAI50701.1.
CCDSiCCDS39123.1.
PIRiA54654.
RefSeqiNP_031709.2. NM_007683.3.
UniGeneiMm.4649.

Genome annotation databases

EnsembliENSMUST00000031170; ENSMUSP00000031170; ENSMUSG00000029253.
GeneIDi12617.
KEGGimmu:12617.
UCSCiuc008xxc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03113 mRNA. Translation: AAC04314.1 .
CH466524 Genomic DNA. Translation: EDL37951.1 .
BC150700 mRNA. Translation: AAI50701.1 .
CCDSi CCDS39123.1.
PIRi A54654.
RefSeqi NP_031709.2. NM_007683.3.
UniGenei Mm.4649.

3D structure databases

ProteinModelPortali P49452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49452. 151 interactions.
STRINGi 10090.ENSMUSP00000031170.

PTM databases

PhosphoSitei P49452.

Proteomic databases

PRIDEi P49452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031170 ; ENSMUSP00000031170 ; ENSMUSG00000029253 .
GeneIDi 12617.
KEGGi mmu:12617.
UCSCi uc008xxc.2. mouse.

Organism-specific databases

CTDi 12617.
MGIi MGI:99700. Cenpc1.

Phylogenomic databases

eggNOGi NOG307418.
GeneTreei ENSGT00390000016737.
HOGENOMi HOG000090256.
HOVERGENi HBG050891.
InParanoidi P49452.
KOi K11497.
OMAi GYRRRFC.
OrthoDBi EOG73FQQ8.
TreeFami TF101132.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 281786.
PROi P49452.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49452.
Bgeei P49452.
CleanExi MM_CENPC1.
Genevestigatori P49452.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR16684. PTHR16684. 1 hit.
Pfami PF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 2 hits.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes."
    McKay S., Thomson E., Cooke H.
    Genomics 22:36-40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCENPC_MOUSE
AccessioniPrimary (citable) accession number: P49452
Secondary accession number(s): B9EK81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi