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P49452

- CENPC_MOUSE

UniProt

P49452 - CENPC_MOUSE

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Protein

Centromere protein C

Gene

Cenpc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions (By similarity).By similarity

GO - Molecular functioni

  1. centromeric DNA binding Source: InterPro

GO - Biological processi

  1. chromosome segregation Source: UniProtKB
  2. kinetochore assembly Source: UniProtKB
  3. mitotic cell cycle Source: UniProtKB
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein C
Short name:
CENP-C
Alternative name(s):
Centromere autoantigen C
Centromere protein C 1
Short name:
CENP-C 1
Gene namesi
Name:Cenpc
Synonyms:Cenpc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:99700. Cenpc1.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes exclusively in the kinetochore domain of centromeres.By similarity

GO - Cellular componenti

  1. condensed nuclear chromosome, centromeric region Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. kinetochore Source: UniProtKB
  4. pericentric heterochromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Centromere protein CPRO_0000089475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei404 – 4041PhosphoserineBy similarity
Modified residuei505 – 5051PhosphoserineBy similarity
Modified residuei673 – 6731PhosphoserineBy similarity
Modified residuei728 – 7281PhosphoserineBy similarity
Modified residuei737 – 7371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49452.
PRIDEiP49452.

PTM databases

PhosphoSiteiP49452.

Expressioni

Gene expression databases

BgeeiP49452.
CleanExiMM_CENPC1.
ExpressionAtlasiP49452. baseline and differential.
GenevestigatoriP49452.

Interactioni

Subunit structurei

Oligomer (By similarity). Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX (By similarity). Interacts directly with CENPA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PtenO085862EBI-1186252,EBI-1186266

Protein-protein interaction databases

IntActiP49452. 151 interactions.
STRINGi10090.ENSMUSP00000031170.

Structurei

3D structure databases

ProteinModelPortaliP49452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni702 – 72423MIF2 homology domain IIBy similarityAdd
BLAST
Regioni853 – 90654MIF2 homology domain IIIBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi228 – 24215Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi449 – 46618Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi525 – 54016Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi744 – 76219Nuclear localization signalSequence AnalysisAdd
BLAST

Domaini

The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.

Sequence similaritiesi

Belongs to the CENPC family.Curated

Phylogenomic databases

eggNOGiNOG307418.
GeneTreeiENSGT00390000016737.
HOGENOMiHOG000090256.
HOVERGENiHBG050891.
InParanoidiP49452.
KOiK11497.
OMAiGYRRRFC.
OrthoDBiEOG73FQQ8.
TreeFamiTF101132.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 2 hits.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P49452-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASFHLDHLK NYHRRYCRSS RAPNIHTKKG QNMLEILQDC FEDQSKASFL
60 70 80 90 100
DDFTESLTSS TQKKKANYSQ SSSKKCPESH SKPVPVSSRT GEASLQASAE
110 120 130 140 150
PSEAAGGSVQ ANEVHHGASD ELDLCVGSPV VLLDANVNTL QKAASPAGQK
160 170 180 190 200
RVASVSRSPV DRQASNKNIS FKTRKRLNFE DKVTLSTAET ENSVLQVEDN
210 220 230 240 250
LSKGQEGTSS EITQKRDDLS SDVQSRSKKN FSELFLETVK RKSKSSSVVR
260 270 280 290 300
HTAAVPFSPP PPSDMKLLED EFIIDRSDRS FSSRLWVMIP SKDRHLSAHK
310 320 330 340 350
PSPENTALLQ GKKSREKSHS LSAMTFARNT QSDKAHPIEE AQLSVEENPA
360 370 380 390 400
TTCTDELEND CRSPENKMQS ETAKTPPAWE RTTKQSQRRV SKPKAAEELR
410 420 430 440 450
KGQSSWENSN VSNTGQDKLQ INSKRNMKDC EEVRNEPNPK KQKPALENKK
460 470 480 490 500
KTNSTQTNKE KSGKKFFSGG SKNKFVPKKV TLTSRRSCRI SQRPSEWWRV
510 520 530 540 550
KSDESSVDRN PSKENNSPVV YPNKKKQTKR NHVSKRAGKK PGSSKRQKTE
560 570 580 590 600
MSPRVQKSLN VKDSGGTVSG HDDTSRSQRK PLKIIEADPT QKSLAISRPK
610 620 630 640 650
RGCKYRNNVM TSPNVHLKSH TEEYTSKTQM ESASNSEMSK RSVWEESGPS
660 670 680 690 700
RFKNYEMPGS SNSEMGDEQD QKSLHFTTRS FNMVPDKKLH HKLVLPSNSP
710 720 730 740 750
NVRRSNRIRL KPLEYWRGER VDYQESSSGQ LVLEIISPSS VPTKIKAQRN
760 770 780 790 800
LGKVNKKVTK KPTHLNSHEK AKMELPLDMR LGDPFQATLA KDPETAELVP
810 820 830 840 850
MDLIRPRDTY RFFVEQHGLK VFKTLDTIYF STGKLVLGPY EEKGKQHVGQ
860 870 880 890 900
DILVFYVNFG DLLCTLHETP YKLTTGDSFY VPSGNHYNIK NLLNVESSLL

FTQIKR
Length:906
Mass (Da):102,154
Last modified:July 27, 2011 - v2
Checksum:i0DCFE76496B33946
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → M in AAC04314. (PubMed:7959789)Curated
Sequence conflicti185 – 1851L → S in AAC04314. (PubMed:7959789)Curated
Sequence conflicti418 – 4181K → T in AAC04314. (PubMed:7959789)Curated
Sequence conflicti450 – 4501K → R in AAC04314. (PubMed:7959789)Curated
Sequence conflicti488 – 4881C → R in AAC04314. (PubMed:7959789)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03113 mRNA. Translation: AAC04314.1.
CH466524 Genomic DNA. Translation: EDL37951.1.
BC150700 mRNA. Translation: AAI50701.1.
CCDSiCCDS39123.1.
PIRiA54654.
RefSeqiNP_031709.2. NM_007683.3.
UniGeneiMm.4649.

Genome annotation databases

EnsembliENSMUST00000031170; ENSMUSP00000031170; ENSMUSG00000029253.
GeneIDi12617.
KEGGimmu:12617.
UCSCiuc008xxc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03113 mRNA. Translation: AAC04314.1 .
CH466524 Genomic DNA. Translation: EDL37951.1 .
BC150700 mRNA. Translation: AAI50701.1 .
CCDSi CCDS39123.1.
PIRi A54654.
RefSeqi NP_031709.2. NM_007683.3.
UniGenei Mm.4649.

3D structure databases

ProteinModelPortali P49452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49452. 151 interactions.
STRINGi 10090.ENSMUSP00000031170.

PTM databases

PhosphoSitei P49452.

Proteomic databases

MaxQBi P49452.
PRIDEi P49452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031170 ; ENSMUSP00000031170 ; ENSMUSG00000029253 .
GeneIDi 12617.
KEGGi mmu:12617.
UCSCi uc008xxc.2. mouse.

Organism-specific databases

CTDi 12617.
MGIi MGI:99700. Cenpc1.

Phylogenomic databases

eggNOGi NOG307418.
GeneTreei ENSGT00390000016737.
HOGENOMi HOG000090256.
HOVERGENi HBG050891.
InParanoidi P49452.
KOi K11497.
OMAi GYRRRFC.
OrthoDBi EOG73FQQ8.
TreeFami TF101132.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 281786.
PROi P49452.
SOURCEi Search...

Gene expression databases

Bgeei P49452.
CleanExi MM_CENPC1.
ExpressionAtlasi P49452. baseline and differential.
Genevestigatori P49452.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR16684. PTHR16684. 1 hit.
Pfami PF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 2 hits.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes."
    McKay S., Thomson E., Cooke H.
    Genomics 22:36-40(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCENPC_MOUSE
AccessioniPrimary (citable) accession number: P49452
Secondary accession number(s): B9EK81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3