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P49447

- CY561_HUMAN

UniProt

P49447 - CY561_HUMAN

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Protein

Cytochrome b561

Gene

CYB561

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi87 – 871Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi91 – 911Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi109 – 1091Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi121 – 1211Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi160 – 1601Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric-chelate reductase activity Source: HGNC
  2. metal ion binding Source: UniProtKB-KW
  3. transmembrane electron transfer carrier Source: UniProtKB

GO - Biological processi

  1. electron transport chain Source: UniProtKB
  2. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

TCDBi5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:2571. CYB561.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Cytochrome b561PRO_0000151027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP49447.
PRIDEiP49447.

PTM databases

PhosphoSiteiP49447.

Expressioni

Gene expression databases

BgeeiP49447.
CleanExiHS_CYB561.
ExpressionAtlasiP49447. baseline and differential.
GenevestigatoriP49447.

Organism-specific databases

HPAiHPA014753.

Interactioni

Protein-protein interaction databases

BioGridi107914. 1 interaction.
IntActiP49447. 1 interaction.
STRINGi9606.ENSP00000354028.

Structurei

3D structure databases

ProteinModelPortaliP49447.
SMRiP49447. Positions 21-216.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini220 – 25132CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 220202Cytochrome b561PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262597.
GeneTreeiENSGT00390000010986.
HOVERGENiHBG054164.
InParanoidiP49447.
KOiK08360.
OrthoDBiEOG7SJD5W.
PhylomeDBiP49447.
TreeFamiTF314222.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_euk.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF6. PTHR10106:SF6. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49447-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF
60 70 80 90 100
NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV
110 120 130 140 150
GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF
160 170 180 190 200
SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL
210 220 230 240 250
ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS

Q
Length:251
Mass (Da):27,559
Last modified:November 25, 2002 - v2
Checksum:i8EE53AE4D2569B77
GO
Isoform 2 (identifier: P49447-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-251: WLVGFSFFLF...LTEGDSPGSQ → GQV

Note: No experimental confirmation available

Show »
Length:138
Mass (Da):15,206
Checksum:iFC34B9D5326D4222
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61A → S in AAH02976. (PubMed:15489334)Curated
Sequence conflicti171 – 1711S → P in AAC50212. (PubMed:7559396)Curated
Sequence conflicti171 – 1711S → P in AAA50952. (PubMed:7980462)Curated
Sequence conflicti243 – 2442TE → RQ in AAC50212. (PubMed:7559396)Curated
Sequence conflicti243 – 2442TE → RQ in AAA50952. (PubMed:7980462)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 251116WLVGF…SPGSQ → GQV in isoform 2. 1 PublicationVSP_056950Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29462
, U29460, U29461, U29464, U29469 Genomic DNA. Translation: AAC50212.1.
BT007096 mRNA. Translation: AAP35760.1.
AK301541 mRNA. Translation: BAH13511.1.
AK316606 mRNA. Translation: BAG38193.1.
AC005828 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94322.1.
CH471109 Genomic DNA. Translation: EAW94323.1.
CH471109 Genomic DNA. Translation: EAW94326.1.
BC000021 mRNA. Translation: AAH00021.1.
BC002976 mRNA. Translation: AAH02976.1.
BC091485 mRNA. Translation: AAH91485.1.
U06715 mRNA. Translation: AAA50952.1.
CCDSiCCDS11636.1.
PIRiS53321.
RefSeqiNP_001017916.1. NM_001017916.1.
NP_001017917.1. NM_001017917.1.
NP_001906.3. NM_001915.3.
XP_005257148.1. XM_005257091.1.
UniGeneiHs.355264.

Genome annotation databases

EnsembliENST00000360793; ENSP00000354028; ENSG00000008283.
ENST00000392975; ENSP00000376701; ENSG00000008283.
ENST00000392976; ENSP00000376702; ENSG00000008283.
ENST00000581573; ENSP00000462325; ENSG00000008283.
ENST00000584291; ENSP00000462543; ENSG00000008283.
GeneIDi1534.
KEGGihsa:1534.
UCSCiuc002jap.3. human.

Polymorphism databases

DMDMi25453426.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29462
, U29460 , U29461 , U29464 , U29469 Genomic DNA. Translation: AAC50212.1 .
BT007096 mRNA. Translation: AAP35760.1 .
AK301541 mRNA. Translation: BAH13511.1 .
AK316606 mRNA. Translation: BAG38193.1 .
AC005828 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94322.1 .
CH471109 Genomic DNA. Translation: EAW94323.1 .
CH471109 Genomic DNA. Translation: EAW94326.1 .
BC000021 mRNA. Translation: AAH00021.1 .
BC002976 mRNA. Translation: AAH02976.1 .
BC091485 mRNA. Translation: AAH91485.1 .
U06715 mRNA. Translation: AAA50952.1 .
CCDSi CCDS11636.1.
PIRi S53321.
RefSeqi NP_001017916.1. NM_001017916.1.
NP_001017917.1. NM_001017917.1.
NP_001906.3. NM_001915.3.
XP_005257148.1. XM_005257091.1.
UniGenei Hs.355264.

3D structure databases

ProteinModelPortali P49447.
SMRi P49447. Positions 21-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107914. 1 interaction.
IntActi P49447. 1 interaction.
STRINGi 9606.ENSP00000354028.

Protein family/group databases

TCDBi 5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

PTM databases

PhosphoSitei P49447.

Polymorphism databases

DMDMi 25453426.

Proteomic databases

MaxQBi P49447.
PRIDEi P49447.

Protocols and materials databases

DNASUi 1534.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360793 ; ENSP00000354028 ; ENSG00000008283 .
ENST00000392975 ; ENSP00000376701 ; ENSG00000008283 .
ENST00000392976 ; ENSP00000376702 ; ENSG00000008283 .
ENST00000581573 ; ENSP00000462325 ; ENSG00000008283 .
ENST00000584291 ; ENSP00000462543 ; ENSG00000008283 .
GeneIDi 1534.
KEGGi hsa:1534.
UCSCi uc002jap.3. human.

Organism-specific databases

CTDi 1534.
GeneCardsi GC17M061509.
HGNCi HGNC:2571. CYB561.
HPAi HPA014753.
MIMi 600019. gene.
neXtProti NX_P49447.
PharmGKBi PA27069.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262597.
GeneTreei ENSGT00390000010986.
HOVERGENi HBG054164.
InParanoidi P49447.
KOi K08360.
OrthoDBi EOG7SJD5W.
PhylomeDBi P49447.
TreeFami TF314222.

Miscellaneous databases

ChiTaRSi CYB561. human.
GeneWikii CYB561.
GenomeRNAii 1534.
NextBioi 6341.
PROi P49447.
SOURCEi Search...

Gene expression databases

Bgeei P49447.
CleanExi HS_CYB561.
ExpressionAtlasi P49447. baseline and differential.
Genevestigatori P49447.

Family and domain databases

InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_euk.
IPR028837. Cytochrome_b561.
[Graphical view ]
PANTHERi PTHR10106:SF6. PTHR10106:SF6. 1 hit.
Pfami PF03188. Cytochrom_B561. 1 hit.
[Graphical view ]
SMARTi SM00665. B561. 1 hit.
[Graphical view ]
PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane."
    Srivastava M.
    J. Biol. Chem. 270:22714-22720(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Peripheral blood.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland and Testis.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Lung and PNS.
  7. "Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information."
    Srivastava M., Gibson K.R., Pollard H.B., Fleming P.J.
    Biochem. J. 303:915-921(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-251.
    Tissue: Caudate nucleus.

Entry informationi

Entry nameiCY561_HUMAN
AccessioniPrimary (citable) accession number: P49447
Secondary accession number(s): B2RE96
, B7Z775, D3DU11, Q5BJG9, Q9BU05, Q9BWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2002
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3