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P49447 (CY561_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene names
Name:CYB561
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Secretory vesicle-specific electron transport protein.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Contains 1 cytochrome b561 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Cytochrome b561
PRO_0000151027

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 25132Cytoplasmic Potential
Domain19 – 220202Cytochrome b561

Sites

Metal binding531Iron (heme axial ligand) Potential
Metal binding871Iron (heme axial ligand) Potential
Metal binding911Iron (heme axial ligand) Potential
Metal binding1091Iron (heme axial ligand) Potential
Metal binding1211Iron (heme axial ligand) Potential
Metal binding1601Iron (heme axial ligand) Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict61A → S in AAH02976. Ref.5
Sequence conflict1711S → P in AAC50212. Ref.1
Sequence conflict1711S → P in AAA50952. Ref.6
Sequence conflict243 – 2442TE → RQ in AAC50212. Ref.1
Sequence conflict243 – 2442TE → RQ in AAA50952. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P49447 [UniParc].

Last modified November 25, 2002. Version 2.
Checksum: 8EE53AE4D2569B77

FASTA25127,559
        10         20         30         40         50         60 
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF NAHPLCMVIG 

        70         80         90        100        110        120 
LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV GLVAVFDYHR KKGYADLYSL 

       130        140        150        160        170        180 
HSWCGILVFV LYFVQWLVGF SFFLFPGASF SLRSRYRPQH IFFGATIFLL SVGTALLGLK 

       190        200        210        220        230        240 
EALLFNLGGK YSAFEPEGVL ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK 

       250 
TLTEGDSPGS Q 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane."
Srivastava M.
J. Biol. Chem. 270:22714-22720(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lung and PNS.
[6]"Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information."
Srivastava M., Gibson K.R., Pollard H.B., Fleming P.J.
Biochem. J. 303:915-921(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-251.
Tissue: Caudate nucleus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29462 expand/collapse EMBL AC list , U29460, U29461, U29464, U29469 Genomic DNA. Translation: AAC50212.1.
BT007096 mRNA. Translation: AAP35760.1.
AK316606 mRNA. Translation: BAG38193.1.
CH471109 Genomic DNA. Translation: EAW94322.1.
CH471109 Genomic DNA. Translation: EAW94323.1.
CH471109 Genomic DNA. Translation: EAW94326.1.
BC000021 mRNA. Translation: AAH00021.1.
BC002976 mRNA. Translation: AAH02976.1.
BC091485 mRNA. Translation: AAH91485.1.
U06715 mRNA. Translation: AAA50952.1.
PIRS53321.
RefSeqNP_001017916.1. NM_001017916.1.
NP_001017917.1. NM_001017917.1.
NP_001906.3. NM_001915.3.
XP_005257148.1. XM_005257091.1.
UniGeneHs.355264.

3D structure databases

ProteinModelPortalP49447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107914. 1 interaction.
IntActP49447. 1 interaction.
STRING9606.ENSP00000354028.

Protein family/group databases

TCDB5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

PTM databases

PhosphoSiteP49447.

Polymorphism databases

DMDM25453426.

Proteomic databases

PRIDEP49447.

Protocols and materials databases

DNASU1534.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360793; ENSP00000354028; ENSG00000008283.
ENST00000392975; ENSP00000376701; ENSG00000008283.
ENST00000392976; ENSP00000376702; ENSG00000008283.
ENST00000581573; ENSP00000462325; ENSG00000008283.
ENST00000584291; ENSP00000462543; ENSG00000008283.
GeneID1534.
KEGGhsa:1534.
UCSCuc002jap.3. human.

Organism-specific databases

CTD1534.
GeneCardsGC17M061509.
HGNCHGNC:2571. CYB561.
HPAHPA014753.
MIM600019. gene.
neXtProtNX_P49447.
PharmGKBPA27069.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262597.
HOVERGENHBG054164.
InParanoidP49447.
KOK08360.
OrthoDBEOG7SJD5W.
PhylomeDBP49447.
TreeFamTF314222.

Gene expression databases

ArrayExpressP49447.
BgeeP49447.
CleanExHS_CYB561.
GenevestigatorP49447.

Family and domain databases

InterProIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_euk.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERPTHR10106:SF4. PTHR10106:SF4. 1 hit.
PfamPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTSM00665. B561. 1 hit.
[Graphical view]
PROSITEPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCYB561. human.
GeneWikiCYB561.
GenomeRNAi1534.
NextBio6341.
PROP49447.
SOURCESearch...

Entry information

Entry nameCY561_HUMAN
AccessionPrimary (citable) accession number: P49447
Secondary accession number(s): B2RE96 expand/collapse secondary AC list , D3DU11, Q5BJG9, Q9BU05, Q9BWR9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2002
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM