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P49447

- CY561_HUMAN

UniProt

P49447 - CY561_HUMAN

Protein

Cytochrome b561

Gene

CYB561

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    Secretory vesicle-specific electron transport protein.

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi87 – 871Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi91 – 911Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi109 – 1091Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi121 – 1211Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi160 – 1601Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric-chelate reductase activity Source: HGNC
    2. metal ion binding Source: UniProtKB-KW
    3. transmembrane electron transfer carrier Source: UniProtKB

    GO - Biological processi

    1. electron transport chain Source: UniProtKB
    2. transmembrane transport Source: GOC

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Protein family/group databases

    TCDBi5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b561
    Alternative name(s):
    Cytochrome b-561
    Gene namesi
    Name:CYB561
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:2571. CYB561.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27069.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Cytochrome b561PRO_0000151027Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP49447.
    PRIDEiP49447.

    PTM databases

    PhosphoSiteiP49447.

    Expressioni

    Gene expression databases

    ArrayExpressiP49447.
    BgeeiP49447.
    CleanExiHS_CYB561.
    GenevestigatoriP49447.

    Organism-specific databases

    HPAiHPA014753.

    Interactioni

    Protein-protein interaction databases

    BioGridi107914. 1 interaction.
    IntActiP49447. 1 interaction.
    STRINGi9606.ENSP00000354028.

    Structurei

    3D structure databases

    ProteinModelPortaliP49447.
    SMRiP49447. Positions 21-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini220 – 25132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 220202Cytochrome b561PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262597.
    HOVERGENiHBG054164.
    InParanoidiP49447.
    KOiK08360.
    OrthoDBiEOG7SJD5W.
    PhylomeDBiP49447.
    TreeFamiTF314222.

    Family and domain databases

    InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    IPR028837. Cytochrome_b561.
    [Graphical view]
    PANTHERiPTHR10106:SF6. PTHR10106:SF6. 1 hit.
    PfamiPF03188. Cytochrom_B561. 1 hit.
    [Graphical view]
    SMARTiSM00665. B561. 1 hit.
    [Graphical view]
    PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49447-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF    50
    NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV 100
    GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF 150
    SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL 200
    ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS 250
    Q 251
    Length:251
    Mass (Da):27,559
    Last modified:November 25, 2002 - v2
    Checksum:i8EE53AE4D2569B77
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61A → S in AAH02976. (PubMed:15489334)Curated
    Sequence conflicti171 – 1711S → P in AAC50212. (PubMed:7559396)Curated
    Sequence conflicti171 – 1711S → P in AAA50952. (PubMed:7980462)Curated
    Sequence conflicti243 – 2442TE → RQ in AAC50212. (PubMed:7559396)Curated
    Sequence conflicti243 – 2442TE → RQ in AAA50952. (PubMed:7980462)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29462
    , U29460, U29461, U29464, U29469 Genomic DNA. Translation: AAC50212.1.
    BT007096 mRNA. Translation: AAP35760.1.
    AK316606 mRNA. Translation: BAG38193.1.
    CH471109 Genomic DNA. Translation: EAW94322.1.
    CH471109 Genomic DNA. Translation: EAW94323.1.
    CH471109 Genomic DNA. Translation: EAW94326.1.
    BC000021 mRNA. Translation: AAH00021.1.
    BC002976 mRNA. Translation: AAH02976.1.
    BC091485 mRNA. Translation: AAH91485.1.
    U06715 mRNA. Translation: AAA50952.1.
    CCDSiCCDS11636.1.
    PIRiS53321.
    RefSeqiNP_001017916.1. NM_001017916.1.
    NP_001017917.1. NM_001017917.1.
    NP_001906.3. NM_001915.3.
    XP_005257148.1. XM_005257091.1.
    UniGeneiHs.355264.

    Genome annotation databases

    EnsembliENST00000360793; ENSP00000354028; ENSG00000008283.
    ENST00000392975; ENSP00000376701; ENSG00000008283.
    ENST00000392976; ENSP00000376702; ENSG00000008283.
    ENST00000581573; ENSP00000462325; ENSG00000008283.
    ENST00000584291; ENSP00000462543; ENSG00000008283.
    GeneIDi1534.
    KEGGihsa:1534.
    UCSCiuc002jap.3. human.

    Polymorphism databases

    DMDMi25453426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29462
    , U29460 , U29461 , U29464 , U29469 Genomic DNA. Translation: AAC50212.1 .
    BT007096 mRNA. Translation: AAP35760.1 .
    AK316606 mRNA. Translation: BAG38193.1 .
    CH471109 Genomic DNA. Translation: EAW94322.1 .
    CH471109 Genomic DNA. Translation: EAW94323.1 .
    CH471109 Genomic DNA. Translation: EAW94326.1 .
    BC000021 mRNA. Translation: AAH00021.1 .
    BC002976 mRNA. Translation: AAH02976.1 .
    BC091485 mRNA. Translation: AAH91485.1 .
    U06715 mRNA. Translation: AAA50952.1 .
    CCDSi CCDS11636.1.
    PIRi S53321.
    RefSeqi NP_001017916.1. NM_001017916.1.
    NP_001017917.1. NM_001017917.1.
    NP_001906.3. NM_001915.3.
    XP_005257148.1. XM_005257091.1.
    UniGenei Hs.355264.

    3D structure databases

    ProteinModelPortali P49447.
    SMRi P49447. Positions 21-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107914. 1 interaction.
    IntActi P49447. 1 interaction.
    STRINGi 9606.ENSP00000354028.

    Protein family/group databases

    TCDBi 5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

    PTM databases

    PhosphoSitei P49447.

    Polymorphism databases

    DMDMi 25453426.

    Proteomic databases

    MaxQBi P49447.
    PRIDEi P49447.

    Protocols and materials databases

    DNASUi 1534.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360793 ; ENSP00000354028 ; ENSG00000008283 .
    ENST00000392975 ; ENSP00000376701 ; ENSG00000008283 .
    ENST00000392976 ; ENSP00000376702 ; ENSG00000008283 .
    ENST00000581573 ; ENSP00000462325 ; ENSG00000008283 .
    ENST00000584291 ; ENSP00000462543 ; ENSG00000008283 .
    GeneIDi 1534.
    KEGGi hsa:1534.
    UCSCi uc002jap.3. human.

    Organism-specific databases

    CTDi 1534.
    GeneCardsi GC17M061509.
    HGNCi HGNC:2571. CYB561.
    HPAi HPA014753.
    MIMi 600019. gene.
    neXtProti NX_P49447.
    PharmGKBi PA27069.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262597.
    HOVERGENi HBG054164.
    InParanoidi P49447.
    KOi K08360.
    OrthoDBi EOG7SJD5W.
    PhylomeDBi P49447.
    TreeFami TF314222.

    Miscellaneous databases

    ChiTaRSi CYB561. human.
    GeneWikii CYB561.
    GenomeRNAii 1534.
    NextBioi 6341.
    PROi P49447.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49447.
    Bgeei P49447.
    CleanExi HS_CYB561.
    Genevestigatori P49447.

    Family and domain databases

    InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    IPR028837. Cytochrome_b561.
    [Graphical view ]
    PANTHERi PTHR10106:SF6. PTHR10106:SF6. 1 hit.
    Pfami PF03188. Cytochrom_B561. 1 hit.
    [Graphical view ]
    SMARTi SM00665. B561. 1 hit.
    [Graphical view ]
    PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane."
      Srivastava M.
      J. Biol. Chem. 270:22714-22720(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Peripheral blood.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and PNS.
    6. "Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information."
      Srivastava M., Gibson K.R., Pollard H.B., Fleming P.J.
      Biochem. J. 303:915-921(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-251.
      Tissue: Caudate nucleus.

    Entry informationi

    Entry nameiCY561_HUMAN
    AccessioniPrimary (citable) accession number: P49447
    Secondary accession number(s): B2RE96
    , D3DU11, Q5BJG9, Q9BU05, Q9BWR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3