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Protein

Cytochrome b561

Gene

CYB561

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi91Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi109Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi121Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi160Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: GO_Central
  • transmembrane electron transfer carrier Source: UniProtKB

GO - Biological processi

  • electron transport chain Source: UniProtKB
  • oxidation-reduction process Source: GO_Central

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Protein family/group databases

TCDBi5.B.2.1.4. the eukaryotic cytochrome b561 (cytb561) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:CYB561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:2571. CYB561.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 251CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • lysosomal membrane Source: GO_Central

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1534.
OpenTargetsiENSG00000008283.
PharmGKBiPA27069.

Polymorphism and mutation databases

BioMutaiCYB561.
DMDMi25453426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510271 – 251Cytochrome b561Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP49447.
MaxQBiP49447.
PaxDbiP49447.
PeptideAtlasiP49447.
PRIDEiP49447.

PTM databases

iPTMnetiP49447.
PhosphoSitePlusiP49447.

Expressioni

Gene expression databases

BgeeiENSG00000008283.
CleanExiHS_CYB561.
ExpressionAtlasiP49447. baseline and differential.
GenevisibleiP49447. HS.

Organism-specific databases

HPAiHPA014753.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107914. 4 interactors.
IntActiP49447. 10 interactors.
STRINGi9606.ENSP00000354028.

Structurei

3D structure databases

ProteinModelPortaliP49447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 220Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOVERGENiHBG054164.
InParanoidiP49447.
KOiK08360.
PhylomeDBiP49447.
TreeFamiTF314222.

Family and domain databases

InterProiView protein in InterPro
IPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
PANTHERiPTHR10106:SF23. PTHR10106:SF23. 1 hit.
PfamiView protein in Pfam
PF03188. Cytochrom_B561. 1 hit.
SMARTiView protein in SMART
SM00665. B561. 1 hit.
PROSITEiView protein in PROSITE
PS50939. CYTOCHROME_B561. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49447-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF
60 70 80 90 100
NAHPLCMVIG LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV
110 120 130 140 150
GLVAVFDYHR KKGYADLYSL HSWCGILVFV LYFVQWLVGF SFFLFPGASF
160 170 180 190 200
SLRSRYRPQH IFFGATIFLL SVGTALLGLK EALLFNLGGK YSAFEPEGVL
210 220 230 240 250
ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK TLTEGDSPGS

Q
Length:251
Mass (Da):27,559
Last modified:November 25, 2002 - v2
Checksum:i8EE53AE4D2569B77
GO
Isoform 2 (identifier: P49447-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-251: WLVGFSFFLF...LTEGDSPGSQ → GQV

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,206
Checksum:iFC34B9D5326D4222
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → S in AAH02976 (PubMed:15489334).Curated1
Sequence conflicti171S → P in AAC50212 (PubMed:7559396).Curated1
Sequence conflicti171S → P in AAA50952 (PubMed:7980462).Curated1
Sequence conflicti243 – 244TE → RQ in AAC50212 (PubMed:7559396).Curated2
Sequence conflicti243 – 244TE → RQ in AAA50952 (PubMed:7980462).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056950136 – 251WLVGF…SPGSQ → GQV in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29462
, U29460, U29461, U29464, U29469 Genomic DNA. Translation: AAC50212.1.
BT007096 mRNA. Translation: AAP35760.1.
AK301541 mRNA. Translation: BAH13511.1.
AK316606 mRNA. Translation: BAG38193.1.
AC005828 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94322.1.
CH471109 Genomic DNA. Translation: EAW94323.1.
CH471109 Genomic DNA. Translation: EAW94326.1.
BC000021 mRNA. Translation: AAH00021.1.
BC002976 mRNA. Translation: AAH02976.1.
BC091485 mRNA. Translation: AAH91485.1.
U06715 mRNA. Translation: AAA50952.1.
CCDSiCCDS11636.1. [P49447-1]
PIRiS53321.
RefSeqiNP_001017916.1. NM_001017916.1. [P49447-1]
NP_001017917.1. NM_001017917.1. [P49447-1]
NP_001317350.1. NM_001330421.1.
NP_001906.3. NM_001915.3.
XP_005257148.1. XM_005257091.1. [P49447-1]
UniGeneiHs.355264.

Genome annotation databases

EnsembliENST00000360793; ENSP00000354028; ENSG00000008283. [P49447-1]
ENST00000392975; ENSP00000376701; ENSG00000008283. [P49447-1]
ENST00000392976; ENSP00000376702; ENSG00000008283. [P49447-1]
ENST00000448884; ENSP00000400350; ENSG00000008283. [P49447-2]
ENST00000581573; ENSP00000462325; ENSG00000008283. [P49447-1]
ENST00000584291; ENSP00000462543; ENSG00000008283. [P49447-1]
GeneIDi1534.
KEGGihsa:1534.
UCSCiuc002jap.4. human. [P49447-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCY561_HUMAN
AccessioniPrimary (citable) accession number: P49447
Secondary accession number(s): B2RE96
, B7Z775, D3DU11, Q5BJG9, Q9BU05, Q9BWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2002
Last modified: August 30, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot