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P49445

- PTN7_RAT

UniProt

P49445 - PTN7_RAT

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Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Inhibited in cells after FCER1A triggering.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei257 – 2571SubstrateBy similarity
Active sitei290 – 2901Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei334 – 3341SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
Alternative name(s):
Hematopoietic protein-tyrosine phosphatase
Short name:
HEPTP
Protein-tyrosine phosphatase LC-PTP
Gene namesi
Name:Ptpn7
Synonyms:Lcptp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi708516. Ptpn7.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cytoplasmic side of plasma membrane Source: Ensembl
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Tyrosine-protein phosphatase non-receptor type 7PRO_0000094763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei66 – 661PhosphothreonineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei290 – 2901Cysteine sulfenic acid (-SOH)1 Publication

Post-translational modificationi

Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

Keywords - PTMi

Oxidation, Phosphoprotein

Proteomic databases

PaxDbiP49445.
PRIDEiP49445.

PTM databases

PhosphoSiteiP49445.

Expressioni

Gene expression databases

GenevestigatoriP49445.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007833.

Structurei

3D structure databases

ProteinModelPortaliP49445.
SMRiP49445. Positions 65-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 349253Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 5114Interaction with MAP kinasesBy similarityAdd
BLAST
Regioni290 – 2967Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiP49445.
KOiK18019.
OMAiGTVEPIC.
OrthoDBiEOG7288QX.
PhylomeDBiP49445.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49445-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQACEGRSR AQLPTLSLGA DMTQPPPAKA PAKKHVRLQE RRGSSVALML
60 70 80 90 100
DVRSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE
110 120 130 140 150
FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AHSQEDSDYI
160 170 180 190 200
NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG
210 220 230 240 250
KEKCVHYWPT EEEAYGPFQI RIQGMKEHPE YTVRHLTIQH QQECRSVKHI
260 270 280 290 300
LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF
310 320 330 340 350
IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA

AQLPPETDP
Length:359
Mass (Da):40,314
Last modified:February 1, 1996 - v1
Checksum:i5B98E196DB633677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28356 mRNA. Translation: AAA84443.1.
RefSeqiNP_663716.1. NM_145683.1.
XP_006249883.1. XM_006249821.2.
UniGeneiRn.10160.

Genome annotation databases

EnsembliENSRNOT00000007833; ENSRNOP00000007833; ENSRNOG00000005807.
GeneIDi246781.
KEGGirno:246781.
UCSCiRGD:708516. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28356 mRNA. Translation: AAA84443.1 .
RefSeqi NP_663716.1. NM_145683.1.
XP_006249883.1. XM_006249821.2.
UniGenei Rn.10160.

3D structure databases

ProteinModelPortali P49445.
SMRi P49445. Positions 65-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007833.

PTM databases

PhosphoSitei P49445.

Proteomic databases

PaxDbi P49445.
PRIDEi P49445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007833 ; ENSRNOP00000007833 ; ENSRNOG00000005807 .
GeneIDi 246781.
KEGGi rno:246781.
UCSCi RGD:708516. rat.

Organism-specific databases

CTDi 5778.
RGDi 708516. Ptpn7.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120452.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi P49445.
KOi K18019.
OMAi GTVEPIC.
OrthoDBi EOG7288QX.
PhylomeDBi P49445.
TreeFami TF331016.

Miscellaneous databases

NextBioi 623877.
PROi P49445.

Gene expression databases

Genevestigatori P49445.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP."
    Swieter M., Berenstein E.H., Swaim W.D., Siraganian R.P.
    J. Biol. Chem. 270:21902-21906(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts."
    Heneberg P., Draberova L., Bambouskova M., Pompach P., Draber P.
    J. Biol. Chem. 285:12787-12802(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, OXIDATION AT CYS-290, ENZYME REGULATION.

Entry informationi

Entry nameiPTN7_RAT
AccessioniPrimary (citable) accession number: P49445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3