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P49445

- PTN7_RAT

UniProt

P49445 - PTN7_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 7

Gene

Ptpn7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of T and B-lymphocyte development and signal transduction.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited in cells after FCER1A triggering.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei257 – 2571SubstrateBy similarity
    Active sitei290 – 2901Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei334 – 3341SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 7 (EC:3.1.3.48)
    Alternative name(s):
    Hematopoietic protein-tyrosine phosphatase
    Short name:
    HEPTP
    Protein-tyrosine phosphatase LC-PTP
    Gene namesi
    Name:Ptpn7
    Synonyms:Lcptp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi708516. Ptpn7.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasmic side of plasma membrane Source: Ensembl
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Tyrosine-protein phosphatase non-receptor type 7PRO_0000094763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441PhosphoserineBy similarity
    Modified residuei66 – 661PhosphothreonineBy similarity
    Modified residuei93 – 931PhosphoserineBy similarity
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei290 – 2901Cysteine sulfenic acid (-SOH)1 Publication

    Post-translational modificationi

    Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H2O2) or with antigen enhanced oxidation of active site cysteine.1 Publication

    Keywords - PTMi

    Oxidation, Phosphoprotein

    Proteomic databases

    PaxDbiP49445.
    PRIDEiP49445.

    PTM databases

    PhosphoSiteiP49445.

    Expressioni

    Gene expression databases

    GenevestigatoriP49445.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007833.

    Structurei

    3D structure databases

    ProteinModelPortaliP49445.
    SMRiP49445. Positions 65-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 349253Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 5114Interaction with MAP kinasesBy similarityAdd
    BLAST
    Regioni290 – 2967Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117606.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    InParanoidiP49445.
    KOiK18019.
    OMAiGTVEPIC.
    OrthoDBiEOG7288QX.
    PhylomeDBiP49445.
    TreeFamiTF331016.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQACEGRSR AQLPTLSLGA DMTQPPPAKA PAKKHVRLQE RRGSSVALML    50
    DVRSLGTVEP ICSVNTPREV TLHFLRTAGH PLTRWTLQHQ PPSPKQLEEE 100
    FLKIPSNFVN PEDLDIPGHA SKDRYKTILP NPQSRVCLGR AHSQEDSDYI 150
    NANYIRGYDG KEKVYIATQG PMPNTVADFW EMVWQEDVSL IVMLTQLREG 200
    KEKCVHYWPT EEEAYGPFQI RIQGMKEHPE YTVRHLTIQH QQECRSVKHI 250
    LFSAWPDHQT PESAGPLLRL VAEVETPETA ANSGPIVVHC SAGIGRTGCF 300
    IATRIGCQQL KARGEVDILG IVCQLRLDRG GMIQTAEQYQ FLHHTLALYA 350
    AQLPPETDP 359
    Length:359
    Mass (Da):40,314
    Last modified:February 1, 1996 - v1
    Checksum:i5B98E196DB633677
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28356 mRNA. Translation: AAA84443.1.
    RefSeqiNP_663716.1. NM_145683.1.
    XP_006249883.1. XM_006249821.1.
    UniGeneiRn.10160.

    Genome annotation databases

    EnsembliENSRNOT00000007833; ENSRNOP00000007833; ENSRNOG00000005807.
    GeneIDi246781.
    KEGGirno:246781.
    UCSCiRGD:708516. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28356 mRNA. Translation: AAA84443.1 .
    RefSeqi NP_663716.1. NM_145683.1.
    XP_006249883.1. XM_006249821.1.
    UniGenei Rn.10160.

    3D structure databases

    ProteinModelPortali P49445.
    SMRi P49445. Positions 65-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007833.

    PTM databases

    PhosphoSitei P49445.

    Proteomic databases

    PaxDbi P49445.
    PRIDEi P49445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007833 ; ENSRNOP00000007833 ; ENSRNOG00000005807 .
    GeneIDi 246781.
    KEGGi rno:246781.
    UCSCi RGD:708516. rat.

    Organism-specific databases

    CTDi 5778.
    RGDi 708516. Ptpn7.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117606.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    InParanoidi P49445.
    KOi K18019.
    OMAi GTVEPIC.
    OrthoDBi EOG7288QX.
    PhylomeDBi P49445.
    TreeFami TF331016.

    Miscellaneous databases

    NextBioi 623877.
    PROi P49445.

    Gene expression databases

    Genevestigatori P49445.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP."
      Swieter M., Berenstein E.H., Swaim W.D., Siraganian R.P.
      J. Biol. Chem. 270:21902-21906(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts."
      Heneberg P., Draberova L., Bambouskova M., Pompach P., Draber P.
      J. Biol. Chem. 285:12787-12802(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, OXIDATION AT CYS-290, ENZYME REGULATION.

    Entry informationi

    Entry nameiPTN7_RAT
    AccessioniPrimary (citable) accession number: P49445
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3