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Protein

Protein phosphatase 2C 1

Gene

GSPATT00029903001

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme with a broad specificity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Manganese 1By similarity1
Metal bindingi57Manganese 2By similarity1
Metal bindingi58Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi237Manganese 2By similarity1
Metal bindingi289Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 1 (EC:3.1.3.16)
Short name:
PP2C 1
Gene namesi
ORF Names:GSPATT00029903001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
Proteomesi
  • UP000000600 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577651 – 300Protein phosphatase 2C 1Add BLAST300

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Protein-protein interaction databases

STRINGi412030.XP_001426670.1

Structurei

3D structure databases

ProteinModelPortaliP49444
SMRiP49444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 298PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST276

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
InParanoidiP49444
KOiK17499
OMAiGSMQGYR

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPYLSQPKR DKTTTTGQGK SVIFAASEMQ GWRNTMEDAH IHRPDIIQDV
60 70 80 90 100
SVFGVFDGHG GREVAQFVEK HFVDELLKNK NFKEQKFEEA LKETFLKMDE
110 120 130 140 150
LLLTPEGQKE LNQYKATDTD ESYAGCTANV ALIYKNTLYV ANAGDSRSVL
160 170 180 190 200
CRNNTNHDMS VDHKPDNPEE KSRIERAGGF VSDGRVNGNL NLSRALGDLE
210 220 230 240 250
YKRDNKLRSN EQLIIALPDV KKTELTPQDK FILMGCDGVF ETLNHQELLK
260 270 280 290 300
QVNSTIGQAQ VTEELLKKAA EDLLDQLLAP DTSQGTGCDN MTTILVYLRR
Length:300
Mass (Da):33,699
Last modified:October 23, 2007 - v2
Checksum:iB9EF98B4F78F24EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44P → H in CAA85448 (PubMed:7806499).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36985 mRNA Translation: CAA85448.1
CT868001 Genomic DNA Translation: CAK59272.1
PIRiA55804
RefSeqiXP_001426670.1, XM_001426633.1
UniGeneiPte.1455

Genome annotation databases

EnsemblProtistsiCAK59272; CAK59272; GSPATT00029903001
GeneIDi5012454
KEGGiptm:GSPATT00029903001

Similar proteinsi

Entry informationi

Entry nameiPP2C1_PARTE
AccessioniPrimary (citable) accession number: P49444
Secondary accession number(s): A0BL55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health