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P49444

- PP2C1_PARTE

UniProt

P49444 - PP2C1_PARTE

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Protein

Protein phosphatase 2C 1

Gene

GSPATT00029903001

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme with a broad specificity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi237 – 2371Manganese 2By similarity
Metal bindingi289 – 2891Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 1 (EC:3.1.3.16)
Short name:
PP2C 1
Gene namesi
ORF Names:GSPATT00029903001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Protein phosphatase 2C 1PRO_0000057765Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Structurei

3D structure databases

ProteinModelPortaliP49444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

InParanoidiP49444.
KOiK17499.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49444-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPYLSQPKR DKTTTTGQGK SVIFAASEMQ GWRNTMEDAH IHRPDIIQDV
60 70 80 90 100
SVFGVFDGHG GREVAQFVEK HFVDELLKNK NFKEQKFEEA LKETFLKMDE
110 120 130 140 150
LLLTPEGQKE LNQYKATDTD ESYAGCTANV ALIYKNTLYV ANAGDSRSVL
160 170 180 190 200
CRNNTNHDMS VDHKPDNPEE KSRIERAGGF VSDGRVNGNL NLSRALGDLE
210 220 230 240 250
YKRDNKLRSN EQLIIALPDV KKTELTPQDK FILMGCDGVF ETLNHQELLK
260 270 280 290 300
QVNSTIGQAQ VTEELLKKAA EDLLDQLLAP DTSQGTGCDN MTTILVYLRR
Length:300
Mass (Da):33,699
Last modified:October 23, 2007 - v2
Checksum:iB9EF98B4F78F24EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → H in CAA85448. (PubMed:7806499)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36985 mRNA. Translation: CAA85448.1.
CT868001 Genomic DNA. Translation: CAK59272.1.
PIRiA55804.
RefSeqiXP_001426670.1. XM_001426633.1.
UniGeneiPte.1455.

Genome annotation databases

EnsemblProtistsiCAK59272; CAK59272; GSPATT00029903001.
GeneIDi5012454.
KEGGiptm:GSPATT00029903001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36985 mRNA. Translation: CAA85448.1 .
CT868001 Genomic DNA. Translation: CAK59272.1 .
PIRi A55804.
RefSeqi XP_001426670.1. XM_001426633.1.
UniGenei Pte.1455.

3D structure databases

ProteinModelPortali P49444.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi CAK59272 ; CAK59272 ; GSPATT00029903001 .
GeneIDi 5012454.
KEGGi ptm:GSPATT00029903001.

Phylogenomic databases

InParanoidi P49444.
KOi K17499.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A membrane-bound protein phosphatase type 2C from Paramecium tetraurelia. Purification, characterization, and cloning."
    Klumpp S., Hanke C., Donella-Deana A., Beyer A., Kellner R., Pinna L.A., Schultz J.E.
    J. Biol. Chem. 269:32774-32780(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Stock 51.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPP2C1_PARTE
AccessioniPrimary (citable) accession number: P49444
Secondary accession number(s): A0BL55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3