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P49444

- PP2C1_PARTE

UniProt

P49444 - PP2C1_PARTE

Protein

Protein phosphatase 2C 1

Gene

GSPATT00029903001

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Enzyme with a broad specificity.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Manganese 1By similarity
    Metal bindingi57 – 571Manganese 2By similarity
    Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi237 – 2371Manganese 2By similarity
    Metal bindingi289 – 2891Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C 1 (EC:3.1.3.16)
    Short name:
    PP2C 1
    Gene namesi
    ORF Names:GSPATT00029903001
    OrganismiParamecium tetraurelia
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
    ProteomesiUP000000600: Partially assembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Protein phosphatase 2C 1PRO_0000057765Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Structurei

    3D structure databases

    ProteinModelPortaliP49444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    KOiK17499.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49444-1 [UniParc]FASTAAdd to Basket

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    MGPYLSQPKR DKTTTTGQGK SVIFAASEMQ GWRNTMEDAH IHRPDIIQDV    50
    SVFGVFDGHG GREVAQFVEK HFVDELLKNK NFKEQKFEEA LKETFLKMDE 100
    LLLTPEGQKE LNQYKATDTD ESYAGCTANV ALIYKNTLYV ANAGDSRSVL 150
    CRNNTNHDMS VDHKPDNPEE KSRIERAGGF VSDGRVNGNL NLSRALGDLE 200
    YKRDNKLRSN EQLIIALPDV KKTELTPQDK FILMGCDGVF ETLNHQELLK 250
    QVNSTIGQAQ VTEELLKKAA EDLLDQLLAP DTSQGTGCDN MTTILVYLRR 300
    Length:300
    Mass (Da):33,699
    Last modified:October 23, 2007 - v2
    Checksum:iB9EF98B4F78F24EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441P → H in CAA85448. (PubMed:7806499)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36985 mRNA. Translation: CAA85448.1.
    CT868001 Genomic DNA. Translation: CAK59272.1.
    PIRiA55804.
    RefSeqiXP_001426670.1. XM_001426633.1.
    UniGeneiPte.1455.

    Genome annotation databases

    EnsemblProtistsiCAK59272; CAK59272; GSPATT00029903001.
    GeneIDi5012454.
    KEGGiptm:GSPATT00029903001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36985 mRNA. Translation: CAA85448.1 .
    CT868001 Genomic DNA. Translation: CAK59272.1 .
    PIRi A55804.
    RefSeqi XP_001426670.1. XM_001426633.1.
    UniGenei Pte.1455.

    3D structure databases

    ProteinModelPortali P49444.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi CAK59272 ; CAK59272 ; GSPATT00029903001 .
    GeneIDi 5012454.
    KEGGi ptm:GSPATT00029903001.

    Phylogenomic databases

    KOi K17499.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A membrane-bound protein phosphatase type 2C from Paramecium tetraurelia. Purification, characterization, and cloning."
      Klumpp S., Hanke C., Donella-Deana A., Beyer A., Kellner R., Pinna L.A., Schultz J.E.
      J. Biol. Chem. 269:32774-32780(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Stock 51.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Stock d4-2.

    Entry informationi

    Entry nameiPP2C1_PARTE
    AccessioniPrimary (citable) accession number: P49444
    Secondary accession number(s): A0BL55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3