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Protein

Inositol polyphosphate 1-phosphatase

Gene

Inpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Magnesium 1By similarity1
Binding sitei119SubstrateBy similarity1
Metal bindingi153Magnesium 1By similarity1
Metal bindingi153Magnesium 2By similarity1
Metal bindingi155Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi156Magnesium 2By similarity1
Metal bindingi313Magnesium 2By similarity1
Binding sitei313SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.57. 3474.
ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00944.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
Gene namesi
Name:Inpp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104848. Inpp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425111 – 396Inositol polyphosphate 1-phosphataseAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49442.
MaxQBiP49442.
PaxDbiP49442.
PeptideAtlasiP49442.
PRIDEiP49442.

2D gel databases

UCD-2DPAGEP49442.

PTM databases

iPTMnetiP49442.
PhosphoSitePlusiP49442.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026102.
CleanExiMM_INPP1.
ExpressionAtlasiP49442. baseline and differential.
GenevisibleiP49442. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi200767. 1 interactor.
IntActiP49442. 1 interactor.
STRINGi10090.ENSMUSP00000027271.

Structurei

3D structure databases

ProteinModelPortaliP49442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 158Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3099. Eukaryota.
ENOG410XNMV. LUCA.
GeneTreeiENSGT00850000132413.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP49442.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG091G0LNK.
PhylomeDBiP49442.
TreeFamiTF314300.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 2 hits.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILLELLC VSEKAANIAR ACRQQETLFQ LLIEEKKGAE KNKKFAADFK
60 70 80 90 100
TLADVLVQEV IKQNMENKFP GLGKKVFGEE SNEFTNDLGE KITVELQSTE
110 120 130 140 150
EETAELLSKV LNGNMPASEA LAQVVHEDVD LTDPTLESLD ISIPHESLGI
160 170 180 190 200
WVDPIDSTYQ YIKGSANVKS NQGIFPSGLQ CVTILIGVYD LQTGLPLMGV
210 220 230 240 250
INQPFASQNL TTLRWKGQCY WGLSYMGTNI HSLQLAISKS DSETQTENSD
260 270 280 290 300
REFSSPFSAV ISTSEKDTIK AALSRVCGGS VFPAAGAGYK SLCVIQGLAD
310 320 330 340 350
IYIFSEDTTY KWDSCAAHAI LRAMGGGIVD MKECLERSPD TGLDLPQLLY
360 370 380 390
HVENKGASGV ELWANKGGLI AYRSRNRLDT FLSRLIQNLG PVKTQA
Length:396
Mass (Da):43,346
Last modified:August 31, 2004 - v2
Checksum:i799D555B153FC975
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10C → R in AAA97574 (PubMed:8586440).Curated1
Sequence conflicti276V → A in AAA97574 (PubMed:8586440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27295 mRNA. Translation: AAA97574.1.
AK078382 mRNA. Translation: BAC37245.1.
BC025072 mRNA. Translation: AAH25072.1.
CCDSiCCDS14947.1.
RefSeqiNP_032410.2. NM_008384.2.
XP_011236743.1. XM_011238441.2.
XP_011236744.1. XM_011238442.2.
UniGeneiMm.917.

Genome annotation databases

EnsembliENSMUST00000027271; ENSMUSP00000027271; ENSMUSG00000026102.
GeneIDi16329.
KEGGimmu:16329.
UCSCiuc007ayo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27295 mRNA. Translation: AAA97574.1.
AK078382 mRNA. Translation: BAC37245.1.
BC025072 mRNA. Translation: AAH25072.1.
CCDSiCCDS14947.1.
RefSeqiNP_032410.2. NM_008384.2.
XP_011236743.1. XM_011238441.2.
XP_011236744.1. XM_011238442.2.
UniGeneiMm.917.

3D structure databases

ProteinModelPortaliP49442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200767. 1 interactor.
IntActiP49442. 1 interactor.
STRINGi10090.ENSMUSP00000027271.

PTM databases

iPTMnetiP49442.
PhosphoSitePlusiP49442.

2D gel databases

UCD-2DPAGEP49442.

Proteomic databases

EPDiP49442.
MaxQBiP49442.
PaxDbiP49442.
PeptideAtlasiP49442.
PRIDEiP49442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027271; ENSMUSP00000027271; ENSMUSG00000026102.
GeneIDi16329.
KEGGimmu:16329.
UCSCiuc007ayo.2. mouse.

Organism-specific databases

CTDi3628.
MGIiMGI:104848. Inpp1.

Phylogenomic databases

eggNOGiKOG3099. Eukaryota.
ENOG410XNMV. LUCA.
GeneTreeiENSGT00850000132413.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP49442.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG091G0LNK.
PhylomeDBiP49442.
TreeFamiTF314300.

Enzyme and pathway databases

UniPathwayiUPA00944.
BRENDAi3.1.3.57. 3474.
ReactomeiR-MMU-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiInpp1. mouse.
PROiP49442.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026102.
CleanExiMM_INPP1.
ExpressionAtlasiP49442. baseline and differential.
GenevisibleiP49442. MM.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 2 hits.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINPP_MOUSE
AccessioniPrimary (citable) accession number: P49442
Secondary accession number(s): Q8R3L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.