Reviewed, UniProtKB/Swiss-Prot P49442 (INPP_MOUSE)

Names and origin

Protein names

Recommended name:
    Inositol polyphosphate 1-phosphatase
      Short name=IPPase
      Short name=IPP
    EC=3.1.3.57

Gene names

Name:

Inpp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
Cofactor	Magnesium.
Enzyme regulation	Inhibited by Li+ By similarity.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	inositol-1,4-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Inositol polyphosphate 1-phosphatase		PRO_0000142511
Sites
	Metal binding	79	1	Magnesium 1 By similarity
	Metal binding	153	1	Magnesium 1 By similarity
	Metal binding	153	1	Magnesium 2 By similarity
	Metal binding	155	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	156	1	Magnesium 2 By similarity
	Metal binding	313	1	Magnesium 2 By similarity
Amino acid modifications
	Modified residue	314	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	10	1	C → R in AAA97574. Ref.1
	Sequence conflict	276	1	V → A in AAA97574. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P49442-1 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 799D555B153FC975	FASTA	396	43,346
	10 20 30 40 50 60 MSDILLELLC VSEKAANIAR ACRQQETLFQ LLIEEKKGAE KNKKFAADFK TLADVLVQEV 70 80 90 100 110 120 IKQNMENKFP GLGKKVFGEE SNEFTNDLGE KITVELQSTE EETAELLSKV LNGNMPASEA 130 140 150 160 170 180 LAQVVHEDVD LTDPTLESLD ISIPHESLGI WVDPIDSTYQ YIKGSANVKS NQGIFPSGLQ 190 200 210 220 230 240 CVTILIGVYD LQTGLPLMGV INQPFASQNL TTLRWKGQCY WGLSYMGTNI HSLQLAISKS 250 260 270 280 290 300 DSETQTENSD REFSSPFSAV ISTSEKDTIK AALSRVCGGS VFPAAGAGYK SLCVIQGLAD 310 320 330 340 350 360 IYIFSEDTTY KWDSCAAHAI LRAMGGGIVD MKECLERSPD TGLDLPQLLY HVENKGASGV 370 380 390 ELWANKGGLI AYRSRNRLDT FLSRLIQNLG PVKTQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene." Okabe I., Nussbaum R.L. Genomics 30:358-360(1995) [PubMed: 8586440] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U27295 mRNA. Translation: AAA97574.1. AK078382 mRNA. Translation: BAC37245.1. BC025072 mRNA. Translation: AAH25072.1.
IPI	IPI00114801.
RefSeq	NP_032410.2.
UniGene	Mm.917
3D structure databases
HSSP	HSSP built from PDB template 1INP based on UniProtKB P21327.
SMR	P49442. Positions 1-395.
ModBase	Search...
PTM databases
PhosphoSite	P49442.
Genome annotation databases
Ensembl	ENSMUSG00000026102. Mus musculus. [Contig view]
GeneID	16329.
KEGG	mmu:16329.
Organism-specific databases
MGI	MGI:104848. Inpp1.
Phylogenomic databases
HOGENOM	P49442.
HOVERGEN	P49442.
OMA	P49442. FKWDSCA.
Enzyme and pathway databases
BRENDA	3.1.3.57. 244.
Gene expression databases
ArrayExpress	P49442.
Bgee	P49442.
CleanEx	MM_INPP1.
GermOnline	ENSMUSG00000026102. Mus musculus.
Family and domain databases
InterPro	IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	289410.
SOURCE	Search...

Entry information

Entry name

INPP_MOUSE

Accession

Primary (citable) accession number: P49442
Secondary accession number(s): Q8R3L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	August 31, 2004
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)