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Protein

Inositol polyphosphate 1-phosphatase

Gene

Inpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Magnesium 1By similarity1
Binding sitei119SubstrateBy similarity1
Metal bindingi153Magnesium 1By similarity1
Metal bindingi153Magnesium 2By similarity1
Metal bindingi155Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi156Magnesium 2By similarity1
Metal bindingi313Magnesium 2By similarity1
Binding sitei313SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.57 3474
ReactomeiR-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00944

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
Gene namesi
Name:Inpp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104848 Inpp1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425111 – 396Inositol polyphosphate 1-phosphataseAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49442
MaxQBiP49442
PaxDbiP49442
PeptideAtlasiP49442
PRIDEiP49442

2D gel databases

UCD-2DPAGEiP49442

PTM databases

iPTMnetiP49442
PhosphoSitePlusiP49442

Expressioni

Gene expression databases

BgeeiENSMUSG00000026102
CleanExiMM_INPP1
ExpressionAtlasiP49442 baseline and differential
GenevisibleiP49442 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi200767, 1 interactor
IntActiP49442, 1 interactor
STRINGi10090.ENSMUSP00000027271

Structurei

3D structure databases

ProteinModelPortaliP49442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 158Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3099 Eukaryota
ENOG410XNMV LUCA
GeneTreeiENSGT00530000063462
HOGENOMiHOG000007839
HOVERGENiHBG006163
InParanoidiP49442
KOiK01107
OMAiAGYKSLC
OrthoDBiEOG091G0LNK
PhylomeDBiP49442
TreeFamiTF314300

Family and domain databases

InterProiView protein in InterPro
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILLELLC VSEKAANIAR ACRQQETLFQ LLIEEKKGAE KNKKFAADFK
60 70 80 90 100
TLADVLVQEV IKQNMENKFP GLGKKVFGEE SNEFTNDLGE KITVELQSTE
110 120 130 140 150
EETAELLSKV LNGNMPASEA LAQVVHEDVD LTDPTLESLD ISIPHESLGI
160 170 180 190 200
WVDPIDSTYQ YIKGSANVKS NQGIFPSGLQ CVTILIGVYD LQTGLPLMGV
210 220 230 240 250
INQPFASQNL TTLRWKGQCY WGLSYMGTNI HSLQLAISKS DSETQTENSD
260 270 280 290 300
REFSSPFSAV ISTSEKDTIK AALSRVCGGS VFPAAGAGYK SLCVIQGLAD
310 320 330 340 350
IYIFSEDTTY KWDSCAAHAI LRAMGGGIVD MKECLERSPD TGLDLPQLLY
360 370 380 390
HVENKGASGV ELWANKGGLI AYRSRNRLDT FLSRLIQNLG PVKTQA
Length:396
Mass (Da):43,346
Last modified:August 31, 2004 - v2
Checksum:i799D555B153FC975
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10C → R in AAA97574 (PubMed:8586440).Curated1
Sequence conflicti276V → A in AAA97574 (PubMed:8586440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27295 mRNA Translation: AAA97574.1
AK078382 mRNA Translation: BAC37245.1
BC025072 mRNA Translation: AAH25072.1
CCDSiCCDS14947.1
RefSeqiNP_032410.2, NM_008384.2
XP_011236743.1, XM_011238441.2
XP_011236744.1, XM_011238442.2
UniGeneiMm.917

Genome annotation databases

EnsembliENSMUST00000027271; ENSMUSP00000027271; ENSMUSG00000026102
GeneIDi16329
KEGGimmu:16329
UCSCiuc007ayo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiINPP_MOUSE
AccessioniPrimary (citable) accession number: P49442
Secondary accession number(s): Q8R3L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 31, 2004
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health