Reviewed, UniProtKB/Swiss-Prot P49441 (INPP_HUMAN)

Names and origin

Protein names

Recommended name:
    Inositol polyphosphate 1-phosphatase
      Short name=IPPase
      Short name=IPP
    EC=3.1.3.57

Gene names

Name:

INPP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
Cofactor	Magnesium.
Enzyme regulation	Inhibited by Li+.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Subunit structure	Monomer By similarity.
Tissue specificity	Ubiquitously expressed, with highest levels in pancreas and kidney.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	phosphate metabolic process Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	inositol-1,4-bisphosphate 1-phosphatase activity Ref.1 Traceable author statement. Source: ProtInc lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Inositol polyphosphate 1-phosphatase		PRO_0000142510
Sites
	Metal binding	79	1	Magnesium 1 By similarity
	Metal binding	153	1	Magnesium 1 By similarity
	Metal binding	153	1	Magnesium 2 By similarity
	Metal binding	155	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	156	1	Magnesium 2 By similarity
	Metal binding	316	1	Magnesium 2 By similarity
Amino acid modifications
	Modified residue	317	1	Phosphoserine Ref.4
Natural variations
	Natural variant	228	1	T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. dbSNP rs7592352. Ref.5		VAR_019669
	Natural variant	355	1	V → M: dbSNP rs35616200.		VAR_049599

Sequences

	Sequence		Length	Mass (Da)
	P49441-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: AEFD592199A40C6C	FASTA	399	43,998
	10 20 30 40 50 60 MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV 70 80 90 100 110 120 IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA 130 140 150 160 170 180 LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ 190 200 210 220 230 240 CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR 250 260 270 280 290 300 NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 310 320 330 340 350 360 LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA 370 380 390 AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase." York J.D., Veile R.A., Donis-Keller H., Majerus P.W. Proc. Natl. Acad. Sci. U.S.A. 90:5833-5837(1993) [PubMed: 8390685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)." Lovlie R., Gulbrandsen A.-K., Molven A., Steen V.M. Pharmacogenetics 9:517-528(1999) [PubMed: 10780272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, MASS SPECTROMETRY.
[5]	"The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness." Steen V.M., Lovlie R., Osher Y., Belmaker R.H., Berle J.O., Gulbrandsen A.K. Pharmacogenetics 8:259-268(1998) [PubMed: 9682271] [Abstract] Cited for: VARIANT ALA-228.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L08488 mRNA. Translation: AAA36117.1. AF141325 Genomic DNA. Translation: AAD46766.1. BC015496 mRNA. Translation: AAH15496.1.
IPI	IPI00027139.
RefSeq	NP_001122400.1. NP_002185.1.
UniGene	Hs.32309
3D structure databases
HSSP	HSSP built from PDB template 1INP based on UniProtKB P21327.
SMR	P49441. Positions 1-399.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49441. 1 interaction.
PTM databases
PhosphoSite	P49441.
Proteomic databases
PeptideAtlas	P49441.
PRIDE	P49441.
Genome annotation databases
Ensembl	ENSG00000151689. Homo sapiens. [Contig view]
GeneID	3628.
KEGG	hsa:3628.
Organism-specific databases
GeneCards	GC02P190916.
H-InvDB	HIX0020648.
HGNC	HGNC:6071. INPP1.
MIM	147263. gene.
PharmGKB	PA29880.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P49441.
HOVERGEN	P49441.
OMA	P49441. FKWDSCA.
Enzyme and pathway databases
BRENDA	3.1.3.57. 247.
Gene expression databases
ArrayExpress	P49441.
Bgee	P49441.
CleanEx	HS_INPP1.
GermOnline	ENSG00000151689. Homo sapiens.
Family and domain databases
InterPro	IPR000760. Inositol_P. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00378. INOSPHPHTASE.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB01356. Lithium.
NextBio	14197.
SOURCE	Search...

Entry information

Entry name

INPP_HUMAN

Accession

Primary (citable) accession number: P49441

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)