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P49441 (INPP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol polyphosphate 1-phosphatase

Short name=IPP
Short name=IPPase
EC=3.1.3.57
Gene names
Name:INPP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactor

Magnesium.

Enzyme regulation

Inhibited by Li+.

Pathway

Signal transduction; phosphatidylinositol signaling pathway.

Subunit structure

Monomer By similarity.

Tissue specificity

Ubiquitously expressed, with highest levels in pancreas and kidney.

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Inositol polyphosphate 1-phosphatase
PRO_0000142510

Regions

Region155 – 1584Substrate binding By similarity

Sites

Metal binding791Magnesium 1 By similarity
Metal binding1531Magnesium 1 By similarity
Metal binding1531Magnesium 2 By similarity
Metal binding1551Magnesium 1; via carbonyl oxygen By similarity
Metal binding1561Magnesium 2 By similarity
Metal binding3161Magnesium 2 By similarity
Binding site1191Substrate By similarity
Binding site3161Substrate By similarity

Amino acid modifications

Modified residue3171Phosphoserine Ref.4

Natural variations

Natural variant2281T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. Ref.6
Corresponds to variant rs7592352 [ dbSNP | Ensembl ].
VAR_019669
Natural variant3551V → M.
Corresponds to variant rs35616200 [ dbSNP | Ensembl ].
VAR_049599

Sequences

Sequence LengthMass (Da)Tools
P49441 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: AEFD592199A40C6C

FASTA39943,998
        10         20         30         40         50         60 
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV 

        70         80         90        100        110        120 
IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA 

       130        140        150        160        170        180 
LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ 

       190        200        210        220        230        240 
CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR 

       250        260        270        280        290        300 
NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 

       310        320        330        340        350        360 
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA 

       370        380        390 
AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase."
York J.D., Veile R.A., Donis-Keller H., Majerus P.W.
Proc. Natl. Acad. Sci. U.S.A. 90:5833-5837(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)."
Lovlie R., Gulbrandsen A.-K., Molven A., Steen V.M.
Pharmacogenetics 9:517-528(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness."
Steen V.M., Lovlie R., Osher Y., Belmaker R.H., Berle J.O., Gulbrandsen A.K.
Pharmacogenetics 8:259-268(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ALA-228.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08488 mRNA. Translation: AAA36117.1.
AF141325 Genomic DNA. Translation: AAD46766.1.
BC015496 mRNA. Translation: AAH15496.1.
RefSeqNP_001122400.1. NM_001128928.1.
NP_002185.1. NM_002194.3.
XP_005246589.1. XM_005246532.1.
UniGeneHs.32309.

3D structure databases

ProteinModelPortalP49441.
SMRP49441. Positions 1-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109840. 5 interactions.
IntActP49441. 2 interactions.
MINTMINT-1429514.
STRING9606.ENSP00000325423.

Chemistry

DrugBankDB01356. Lithium.

PTM databases

PhosphoSiteP49441.

Polymorphism databases

DMDM1352464.

Proteomic databases

PaxDbP49441.
PeptideAtlasP49441.
PRIDEP49441.

Protocols and materials databases

DNASU3628.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322522; ENSP00000325423; ENSG00000151689.
ENST00000392329; ENSP00000376142; ENSG00000151689.
ENST00000541441; ENSP00000440650; ENSG00000151689.
GeneID3628.
KEGGhsa:3628.
UCSCuc002urx.4. human.

Organism-specific databases

CTD3628.
GeneCardsGC02P191172.
HGNCHGNC:6071. INPP1.
HPAHPA036698.
HPA036699.
MIM147263. gene.
neXtProtNX_P49441.
PharmGKBPA29880.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG306469.
HOGENOMHOG000007839.
HOVERGENHBG006163.
InParanoidP49441.
KOK01107.
OMAAGAGYKS.
OrthoDBEOG7G4QG6.
PhylomeDBP49441.
TreeFamTF314300.

Enzyme and pathway databases

BioCycMetaCyc:HS07761-MONOMER.
BRENDA3.1.3.57. 2681.
ReactomeREACT_111217. Metabolism.
UniPathwayUPA00944.

Gene expression databases

ArrayExpressP49441.
BgeeP49441.
CleanExHS_INPP1.
GenevestigatorP49441.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. PTHR20854. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSINPP1. human.
GeneWikiINPP1.
GenomeRNAi3628.
NextBio14197.
PROP49441.
SOURCESearch...

Entry information

Entry nameINPP_HUMAN
AccessionPrimary (citable) accession number: P49441
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM