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Protein

Inositol polyphosphate 1-phosphatase

Gene

INPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Magnesium 1By similarity
Binding sitei119 – 1191SubstrateBy similarity
Metal bindingi153 – 1531Magnesium 1By similarity
Metal bindingi153 – 1531Magnesium 2By similarity
Metal bindingi155 – 1551Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi156 – 1561Magnesium 2By similarity
Metal bindingi316 – 3161Magnesium 2By similarity
Binding sitei316 – 3161SubstrateBy similarity

GO - Molecular functioni

  1. inositol-1,3,4-trisphosphate 1-phosphatase activity Source: Reactome
  2. inositol-1,4-bisphosphate 1-phosphatase activity Source: Reactome
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. inositol phosphate metabolic process Source: Reactome
  3. phosphate-containing compound metabolic process Source: ProtInc
  4. phosphatidylinositol phosphorylation Source: InterPro
  5. signal transduction Source: ProtInc
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07761-MONOMER.
BRENDAi3.1.3.57. 2681.
ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00944.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
Gene namesi
Name:INPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6071. INPP1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Inositol polyphosphate 1-phosphatasePRO_0000142510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei317 – 3171Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49441.
PaxDbiP49441.
PeptideAtlasiP49441.
PRIDEiP49441.

PTM databases

DEPODiP49441.
PhosphoSiteiP49441.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in pancreas and kidney.

Gene expression databases

BgeeiP49441.
CleanExiHS_INPP1.
ExpressionAtlasiP49441. baseline and differential.
GenevestigatoriP49441.

Organism-specific databases

HPAiHPA036698.
HPA036699.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi109840. 13 interactions.
IntActiP49441. 2 interactions.
MINTiMINT-1429514.
STRINGi9606.ENSP00000325423.

Structurei

3D structure databases

ProteinModelPortaliP49441.
SMRiP49441. Positions 1-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1584Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiNOG306469.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP49441.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG7G4QG6.
PhylomeDBiP49441.
TreeFamiTF314300.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK
60 70 80 90 100
TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE
110 120 130 140 150
EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI
160 170 180 190 200
WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV
210 220 230 240 250
INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT
260 270 280 290 300
GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG
310 320 330 340 350
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ
360 370 380 390
LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
Length:399
Mass (Da):43,998
Last modified:February 1, 1996 - v1
Checksum:iAEFD592199A40C6C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. 1 Publication
Corresponds to variant rs7592352 [ dbSNP | Ensembl ].
VAR_019669
Natural varianti355 – 3551V → M.
Corresponds to variant rs35616200 [ dbSNP | Ensembl ].
VAR_049599

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08488 mRNA. Translation: AAA36117.1.
AF141325 Genomic DNA. Translation: AAD46766.1.
BC015496 mRNA. Translation: AAH15496.1.
CCDSiCCDS2305.1.
RefSeqiNP_001122400.1. NM_001128928.1.
NP_002185.1. NM_002194.3.
XP_005246589.1. XM_005246532.1.
XP_006712561.1. XM_006712498.1.
UniGeneiHs.32309.

Genome annotation databases

EnsembliENST00000322522; ENSP00000325423; ENSG00000151689.
ENST00000392329; ENSP00000376142; ENSG00000151689.
GeneIDi3628.
KEGGihsa:3628.
UCSCiuc002urx.4. human.

Polymorphism databases

DMDMi1352464.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08488 mRNA. Translation: AAA36117.1.
AF141325 Genomic DNA. Translation: AAD46766.1.
BC015496 mRNA. Translation: AAH15496.1.
CCDSiCCDS2305.1.
RefSeqiNP_001122400.1. NM_001128928.1.
NP_002185.1. NM_002194.3.
XP_005246589.1. XM_005246532.1.
XP_006712561.1. XM_006712498.1.
UniGeneiHs.32309.

3D structure databases

ProteinModelPortaliP49441.
SMRiP49441. Positions 1-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109840. 13 interactions.
IntActiP49441. 2 interactions.
MINTiMINT-1429514.
STRINGi9606.ENSP00000325423.

PTM databases

DEPODiP49441.
PhosphoSiteiP49441.

Polymorphism databases

DMDMi1352464.

Proteomic databases

MaxQBiP49441.
PaxDbiP49441.
PeptideAtlasiP49441.
PRIDEiP49441.

Protocols and materials databases

DNASUi3628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322522; ENSP00000325423; ENSG00000151689.
ENST00000392329; ENSP00000376142; ENSG00000151689.
GeneIDi3628.
KEGGihsa:3628.
UCSCiuc002urx.4. human.

Organism-specific databases

CTDi3628.
GeneCardsiGC02P191172.
HGNCiHGNC:6071. INPP1.
HPAiHPA036698.
HPA036699.
MIMi147263. gene.
neXtProtiNX_P49441.
PharmGKBiPA29880.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG306469.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP49441.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG7G4QG6.
PhylomeDBiP49441.
TreeFamiTF314300.

Enzyme and pathway databases

UniPathwayiUPA00944.
BioCyciMetaCyc:HS07761-MONOMER.
BRENDAi3.1.3.57. 2681.
ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiINPP1. human.
GeneWikiiINPP1.
GenomeRNAii3628.
NextBioi14197.
PROiP49441.
SOURCEiSearch...

Gene expression databases

BgeeiP49441.
CleanExiHS_INPP1.
ExpressionAtlasiP49441. baseline and differential.
GenevestigatoriP49441.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase."
    York J.D., Veile R.A., Donis-Keller H., Majerus P.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:5833-5837(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)."
    Lovlie R., Gulbrandsen A.-K., Molven A., Steen V.M.
    Pharmacogenetics 9:517-528(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness."
    Steen V.M., Lovlie R., Osher Y., Belmaker R.H., Berle J.O., Gulbrandsen A.K.
    Pharmacogenetics 8:259-268(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-228.

Entry informationi

Entry nameiINPP_HUMAN
AccessioniPrimary (citable) accession number: P49441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.