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Protein

Inositol polyphosphate 1-phosphatase

Gene

INPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+.

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Magnesium 1By similarity1
Binding sitei119SubstrateBy similarity1
Metal bindingi153Magnesium 1By similarity1
Metal bindingi153Magnesium 2By similarity1
Metal bindingi155Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi156Magnesium 2By similarity1
Metal bindingi316Magnesium 2By similarity1
Binding sitei316SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate metabolic process Source: Reactome
  • phosphate-containing compound metabolic process Source: ProtInc
  • phosphatidylinositol phosphorylation Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07761-MONOMER
BRENDAi3.1.3.57 2681
ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00944

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
Gene namesi
Name:INPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000151689.12
HGNCiHGNC:6071 INPP1
MIMi147263 gene
neXtProtiNX_P49441

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3628
OpenTargetsiENSG00000151689
PharmGKBiPA29880

Polymorphism and mutation databases

BioMutaiINPP1
DMDMi1352464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425101 – 399Inositol polyphosphate 1-phosphataseAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49441
PaxDbiP49441
PeptideAtlasiP49441
PRIDEiP49441
TopDownProteomicsiP49441

PTM databases

DEPODiP49441
iPTMnetiP49441
PhosphoSitePlusiP49441

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in pancreas and kidney.

Gene expression databases

BgeeiENSG00000151689
CleanExiHS_INPP1
ExpressionAtlasiP49441 baseline and differential
GenevisibleiP49441 HS

Organism-specific databases

HPAiHPA036698
HPA036699

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2Q6FHY53EBI-725432,EBI-16439278

Protein-protein interaction databases

BioGridi10984012 interactors.
IntActiP49441 3 interactors.
MINTiP49441
STRINGi9606.ENSP00000325423

Structurei

3D structure databases

ProteinModelPortaliP49441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 158Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3099 Eukaryota
ENOG410XNMV LUCA
GeneTreeiENSGT00530000063462
HOGENOMiHOG000007839
HOVERGENiHBG006163
InParanoidiP49441
KOiK01107
OMAiAGYKSLC
OrthoDBiEOG091G0LNK
PhylomeDBiP49441
TreeFamiTF314300

Family and domain databases

InterProiView protein in InterPro
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK
60 70 80 90 100
TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE
110 120 130 140 150
EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI
160 170 180 190 200
WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV
210 220 230 240 250
INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT
260 270 280 290 300
GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG
310 320 330 340 350
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ
360 370 380 390
LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT
Length:399
Mass (Da):43,998
Last modified:February 1, 1996 - v1
Checksum:iAEFD592199A40C6C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019669228T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. 1 PublicationCorresponds to variant dbSNP:rs7592352Ensembl.1
Natural variantiVAR_049599355V → M. Corresponds to variant dbSNP:rs35616200Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08488 mRNA Translation: AAA36117.1
AF141325 Genomic DNA Translation: AAD46766.1
BC015496 mRNA Translation: AAH15496.1
CCDSiCCDS2305.1
RefSeqiNP_001122400.1, NM_001128928.1
NP_002185.1, NM_002194.3
XP_005246589.1, XM_005246532.1
UniGeneiHs.32309

Genome annotation databases

EnsembliENST00000322522; ENSP00000325423; ENSG00000151689
ENST00000392329; ENSP00000376142; ENSG00000151689
GeneIDi3628
KEGGihsa:3628

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiINPP_HUMAN
AccessioniPrimary (citable) accession number: P49441
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome