Inositol polyphosphate 1-phosphatase

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P49441 (INPP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Inositol polyphosphate 1-phosphatase
Short name=IPP
Short name=IPPase
EC=3.1.3.57

Gene names

Name:

INPP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	1D-myo-inositol 1,4-bisphosphate + H₂O = 1D-myo-inositol 4-phosphate + phosphate.
Cofactor	Magnesium.
Enzyme regulation	Inhibited by Li⁺.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Subunit structure	Monomer By similarity.
Tissue specificity	Ubiquitously expressed, with highest levels in pancreas and kidney.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement Ref.1. Source: ProtInc
Molecular_function	inositol-1,4-bisphosphate 1-phosphatase activity Traceable author statement Ref.1. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 399

399

Inositol polyphosphate 1-phosphatase

PRO_0000142510

Regions

Region

155 – 158

Substrate binding By similarity

Sites

Metal binding

Magnesium 1 By similarity

Metal binding

153

Magnesium 1 By similarity

Metal binding

153

Magnesium 2 By similarity

Metal binding

155

Magnesium 1; via carbonyl oxygen By similarity

Metal binding

156

Magnesium 2 By similarity

Metal binding

316

Magnesium 2 By similarity

Binding site

119

Substrate By similarity

Binding site

316

Substrate By similarity

Amino acid modifications

Modified residue

317

Phosphoserine Ref.4

Natural variations

Natural variant

228

T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. Ref.6
Corresponds to variant rs7592352 [ dbSNP | Ensembl ].

VAR_019669

Natural variant

355

V → M.
Corresponds to variant rs35616200 [ dbSNP | Ensembl ].

VAR_049599

Sequences

Sequence

Length

Mass (Da)

Tools

P49441 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: AEFD592199A40C6C
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FASTA

399

43,998

        10         20         30         40         50         60 
MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV 

        70         80         90        100        110        120 
IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA 

       130        140        150        160        170        180 
LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ 

       190        200        210        220        230        240 
CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR 

       250        260        270        280        290        300 
NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 

       310        320        330        340        350        360 
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA 

       370        380        390 
AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase." York J.D., Veile R.A., Donis-Keller H., Majerus P.W. Proc. Natl. Acad. Sci. U.S.A. 90:5833-5837(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)." Lovlie R., Gulbrandsen A.-K., Molven A., Steen V.M. Pharmacogenetics 9:517-528(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness." Steen V.M., Lovlie R., Osher Y., Belmaker R.H., Berle J.O., Gulbrandsen A.K. Pharmacogenetics 8:259-268(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ALA-228.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08488 mRNA. Translation: AAA36117.1. AF141325 Genomic DNA. Translation: AAD46766.1. BC015496 mRNA. Translation: AAH15496.1.
IPI	IPI00027139.
RefSeq	NP_001122400.1. NM_001128928.1. NP_002185.1. NM_002194.3.
UniGene	Hs.32309.
3D structure databases
ProteinModelPortal	P49441.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49441. 1 interaction.
MINT	MINT-1429514.
STRING	9606.ENSP00000325423.
PTM databases
PhosphoSite	P49441.
Polymorphism databases
DMDM	1352464.
Proteomic databases
PaxDb	P49441.
PeptideAtlas	P49441.
PRIDE	P49441.
Protocols and materials databases
DNASU	3628.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322522; ENSP00000325423; ENSG00000151689. ENST00000392329; ENSP00000376142; ENSG00000151689. ENST00000541441; ENSP00000440650; ENSG00000151689.
GeneID	3628.
KEGG	hsa:3628.
UCSC	uc002urx.4. human.
Organism-specific databases
CTD	3628.
GeneCards	GC02P191172.
HGNC	HGNC:6071. INPP1.
HPA	HPA036698.
MIM	147263. gene.
neXtProt	NX_P49441.
PharmGKB	PA29880.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG306469.
HOGENOM	HOG000007839.
HOVERGEN	HBG006163.
InParanoid	P49441.
KO	K01107.
OMA	TFKWDSC.
OrthoDB	EOG41C6WB.
PhylomeDB	P49441.
Enzyme and pathway databases
BioCyc	MetaCyc:HS07761-MONOMER.
BRENDA	3.1.3.57. 2681.
Reactome	REACT_111217. Metabolism.
UniPathway	UPA00944.
Gene expression databases
ArrayExpress	P49441.
Bgee	P49441.
CleanEx	HS_INPP1.
Genevestigator	P49441.
GermOnline	ENSG00000151689. Homo sapiens.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. PTHR20854. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	INPP1. human.
DrugBank	DB01356. Lithium.
GenomeRNAi	3628.
NextBio	14197.
SOURCE	Search...

Entry information

Entry name

INPP_HUMAN

Accession

Primary (citable) accession number: P49441

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents