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P49441

- INPP_HUMAN

UniProt

P49441 - INPP_HUMAN

Protein

Inositol polyphosphate 1-phosphatase

Gene

INPP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Inhibited by Li+.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Magnesium 1By similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Metal bindingi153 – 1531Magnesium 1By similarity
    Metal bindingi153 – 1531Magnesium 2By similarity
    Metal bindingi155 – 1551Magnesium 1; via carbonyl oxygenBy similarity
    Metal bindingi156 – 1561Magnesium 2By similarity
    Metal bindingi316 – 3161Magnesium 2By similarity
    Binding sitei316 – 3161SubstrateBy similarity

    GO - Molecular functioni

    1. inositol-1,3,4-trisphosphate 1-phosphatase activity Source: Reactome
    2. inositol-1,4-bisphosphate 1-phosphatase activity Source: Reactome
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. inositol phosphate metabolic process Source: Reactome
    3. phosphate-containing compound metabolic process Source: ProtInc
    4. phosphatidylinositol phosphorylation Source: InterPro
    5. signal transduction Source: ProtInc
    6. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Lithium, Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07761-MONOMER.
    BRENDAi3.1.3.57. 2681.
    ReactomeiREACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.
    UniPathwayiUPA00944.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
    Short name:
    IPP
    Short name:
    IPPase
    Gene namesi
    Name:INPP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6071. INPP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29880.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Inositol polyphosphate 1-phosphatasePRO_0000142510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei317 – 3171Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP49441.
    PaxDbiP49441.
    PeptideAtlasiP49441.
    PRIDEiP49441.

    PTM databases

    PhosphoSiteiP49441.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in pancreas and kidney.

    Gene expression databases

    ArrayExpressiP49441.
    BgeeiP49441.
    CleanExiHS_INPP1.
    GenevestigatoriP49441.

    Organism-specific databases

    HPAiHPA036698.
    HPA036699.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi109840. 5 interactions.
    IntActiP49441. 2 interactions.
    MINTiMINT-1429514.
    STRINGi9606.ENSP00000325423.

    Structurei

    3D structure databases

    ProteinModelPortaliP49441.
    SMRiP49441. Positions 1-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1584Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the inositol monophosphatase family.Curated

    Phylogenomic databases

    eggNOGiNOG306469.
    HOGENOMiHOG000007839.
    HOVERGENiHBG006163.
    InParanoidiP49441.
    KOiK01107.
    OMAiAGYKSLC.
    OrthoDBiEOG7G4QG6.
    PhylomeDBiP49441.
    TreeFamiTF314300.

    Family and domain databases

    InterProiIPR020583. Inositol_monoP_metal-BS.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view]
    PANTHERiPTHR20854. PTHR20854. 1 hit.
    PfamiPF00459. Inositol_P. 1 hit.
    [Graphical view]
    PROSITEiPS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK    50
    TLADVLVQEV IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE 100
    EETAELLSKV LNGNKVASEA LARVVHQDVA FTDPTLDSTE INVPQDILGI 150
    WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ CVTILIGVYD IQTGVPLMGV 200
    INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR NGSETHTGNT 250
    GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 300
    LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ 350
    LVYHVENEGA AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT 399
    Length:399
    Mass (Da):43,998
    Last modified:February 1, 1996 - v1
    Checksum:iAEFD592199A40C6C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti228 – 2281T → A Frequency not significantly different between lithium-treated bipolar patients and healthy controls. 1 Publication
    Corresponds to variant rs7592352 [ dbSNP | Ensembl ].
    VAR_019669
    Natural varianti355 – 3551V → M.
    Corresponds to variant rs35616200 [ dbSNP | Ensembl ].
    VAR_049599

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08488 mRNA. Translation: AAA36117.1.
    AF141325 Genomic DNA. Translation: AAD46766.1.
    BC015496 mRNA. Translation: AAH15496.1.
    CCDSiCCDS2305.1.
    RefSeqiNP_001122400.1. NM_001128928.1.
    NP_002185.1. NM_002194.3.
    XP_005246589.1. XM_005246532.1.
    XP_006712561.1. XM_006712498.1.
    UniGeneiHs.32309.

    Genome annotation databases

    EnsembliENST00000322522; ENSP00000325423; ENSG00000151689.
    ENST00000392329; ENSP00000376142; ENSG00000151689.
    GeneIDi3628.
    KEGGihsa:3628.
    UCSCiuc002urx.4. human.

    Polymorphism databases

    DMDMi1352464.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08488 mRNA. Translation: AAA36117.1 .
    AF141325 Genomic DNA. Translation: AAD46766.1 .
    BC015496 mRNA. Translation: AAH15496.1 .
    CCDSi CCDS2305.1.
    RefSeqi NP_001122400.1. NM_001128928.1.
    NP_002185.1. NM_002194.3.
    XP_005246589.1. XM_005246532.1.
    XP_006712561.1. XM_006712498.1.
    UniGenei Hs.32309.

    3D structure databases

    ProteinModelPortali P49441.
    SMRi P49441. Positions 1-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109840. 5 interactions.
    IntActi P49441. 2 interactions.
    MINTi MINT-1429514.
    STRINGi 9606.ENSP00000325423.

    Chemistry

    DrugBanki DB01356. Lithium.

    PTM databases

    PhosphoSitei P49441.

    Polymorphism databases

    DMDMi 1352464.

    Proteomic databases

    MaxQBi P49441.
    PaxDbi P49441.
    PeptideAtlasi P49441.
    PRIDEi P49441.

    Protocols and materials databases

    DNASUi 3628.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322522 ; ENSP00000325423 ; ENSG00000151689 .
    ENST00000392329 ; ENSP00000376142 ; ENSG00000151689 .
    GeneIDi 3628.
    KEGGi hsa:3628.
    UCSCi uc002urx.4. human.

    Organism-specific databases

    CTDi 3628.
    GeneCardsi GC02P191172.
    HGNCi HGNC:6071. INPP1.
    HPAi HPA036698.
    HPA036699.
    MIMi 147263. gene.
    neXtProti NX_P49441.
    PharmGKBi PA29880.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306469.
    HOGENOMi HOG000007839.
    HOVERGENi HBG006163.
    InParanoidi P49441.
    KOi K01107.
    OMAi AGYKSLC.
    OrthoDBi EOG7G4QG6.
    PhylomeDBi P49441.
    TreeFami TF314300.

    Enzyme and pathway databases

    UniPathwayi UPA00944 .
    BioCyci MetaCyc:HS07761-MONOMER.
    BRENDAi 3.1.3.57. 2681.
    Reactomei REACT_150352. Synthesis of IP2, IP, and Ins in the cytosol.

    Miscellaneous databases

    ChiTaRSi INPP1. human.
    GeneWikii INPP1.
    GenomeRNAii 3628.
    NextBioi 14197.
    PROi P49441.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49441.
    Bgeei P49441.
    CleanExi HS_INPP1.
    Genevestigatori P49441.

    Family and domain databases

    InterProi IPR020583. Inositol_monoP_metal-BS.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view ]
    PANTHERi PTHR20854. PTHR20854. 1 hit.
    Pfami PF00459. Inositol_P. 1 hit.
    [Graphical view ]
    PROSITEi PS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase."
      York J.D., Veile R.A., Donis-Keller H., Majerus P.W.
      Proc. Natl. Acad. Sci. U.S.A. 90:5833-5837(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)."
      Lovlie R., Gulbrandsen A.-K., Molven A., Steen V.M.
      Pharmacogenetics 9:517-528(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness."
      Steen V.M., Lovlie R., Osher Y., Belmaker R.H., Berle J.O., Gulbrandsen A.K.
      Pharmacogenetics 8:259-268(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ALA-228.

    Entry informationi

    Entry nameiINPP_HUMAN
    AccessioniPrimary (citable) accession number: P49441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3