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Protein

Thromboxane-A synthase

Gene

Tbxas1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi479 – 4791Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular chloride ion homeostasis Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • prostaglandin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211979. Eicosanoids.
R-RNO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:Tbxas1
Synonyms:Cyp5, Cyp5a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3826. Tbxas1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 7544LumenalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 223127CytoplasmicSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 33591LumenalSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST
Topological domaini357 – 533177CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Thromboxane-A synthasePRO_0000052259Add
BLAST

Proteomic databases

PaxDbiP49430.
PRIDEiP49430.

Expressioni

Gene expression databases

GenevisibleiP49430. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010796.

Chemistry

BindingDBiP49430.

Structurei

3D structure databases

ProteinModelPortaliP49430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP49430.
KOiK01832.
OMAiRMYIVIS.
OrthoDBiEOG744TBS.
PhylomeDBiP49430.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLGLLKFE VSGTVVTVTL SVVLLALLKW YSTSAFSRLR KLGIRHPEPS
60 70 80 90 100
PFVGNLMFFR QGFWESHLEL RERYGPLCGY YLGRRMYIVI SDPDMIKEVL
110 120 130 140 150
VENFSNFSNR MASGLEPKLI ADSVLMLRDR RWEEVRGALM SAFSPEKLNE
160 170 180 190 200
MTPLISQACE LLLSHLKHSA ASGDAFDIQR CYCCFTTNVV ASVAFGIEVN
210 220 230 240 250
SQDAPEDPFV QHCQRVFAFS TPRPLLALIL SFPSIMVPLA RILPNKNRDE
260 270 280 290 300
LNGFFNTLIR NVIALRDKQT AEERRGDFLQ MVLDAQRSMS SVGVEAFDMV
310 320 330 340 350
TEALSSAECM GDPPQRCHPT STAKPLTVDE IAGQAFLFLI AGHEITTNTL
360 370 380 390 400
SFITYLLATH PECQERLLKE VDLFMEKHPA PEYCNLQEGL PYLDMVVAET
410 420 430 440 450
LRMYPPAFRF TREAAQDCEV LGQHIPAGSV LEIAVGALHH DPEHWPNPET
460 470 480 490 500
FDPERFTAEA RLQQKPFTYL PFGAGPRSCL GVRLGLLVVK LTLLQVLHKF
510 520 530
RFEACPETQV PLQLESKSAL CPKNGVYVKI VSR
Length:533
Mass (Da):59,974
Last modified:February 1, 1996 - v1
Checksum:i6661BC5378D4E8C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28773 mRNA. Translation: BAA05962.1.
D31798 mRNA. Translation: BAA22574.1.
PIRiS42404.
RefSeqiNP_036819.1. NM_012687.1.
UniGeneiRn.16283.

Genome annotation databases

EnsembliENSRNOT00000010796; ENSRNOP00000010796; ENSRNOG00000007918.
GeneIDi24886.
KEGGirno:24886.
UCSCiRGD:3826. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28773 mRNA. Translation: BAA05962.1.
D31798 mRNA. Translation: BAA22574.1.
PIRiS42404.
RefSeqiNP_036819.1. NM_012687.1.
UniGeneiRn.16283.

3D structure databases

ProteinModelPortaliP49430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010796.

Chemistry

BindingDBiP49430.
ChEMBLiCHEMBL4028.

Proteomic databases

PaxDbiP49430.
PRIDEiP49430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010796; ENSRNOP00000010796; ENSRNOG00000007918.
GeneIDi24886.
KEGGirno:24886.
UCSCiRGD:3826. rat.

Organism-specific databases

CTDi6916.
RGDi3826. Tbxas1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP49430.
KOiK01832.
OMAiRMYIVIS.
OrthoDBiEOG744TBS.
PhylomeDBiP49430.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiR-RNO-211979. Eicosanoids.
R-RNO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

PROiP49430.

Gene expression databases

GenevisibleiP49430. RN.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Abundant expression of thromboxane synthase in rat macrophages."
    Tone Y., Miyata A., Hara S., Yukawa S., Tanabe T.
    FEBS Lett. 340:241-244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney."
    Tsutsumi E., Takeuchi K., Abe T., Takahashi N., Kato T., Taniyama Y., Ikeda Y., Ito S., Abe K.
    Prostaglandins 53:423-431(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiTHAS_RAT
AccessioniPrimary (citable) accession number: P49430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.