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Protein

Thromboxane-A synthase

Gene

Tbxas1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi479Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular chloride ion homeostasis Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • prostaglandin biosynthetic process Source: UniProtKB-KW
  • response to ethanol Source: RGD
  • response to fatty acid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211979. Eicosanoids.
R-RNO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:Tbxas1
Synonyms:Cyp5, Cyp5a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3826. Tbxas1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 75LumenalSequence analysisAdd BLAST44
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 223CytoplasmicSequence analysisAdd BLAST127
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 335LumenalSequence analysisAdd BLAST91
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 533CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522591 – 533Thromboxane-A synthaseAdd BLAST533

Proteomic databases

PaxDbiP49430.
PRIDEiP49430.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007918.
GenevisibleiP49430. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010796.

Chemistry databases

BindingDBiP49430.

Structurei

3D structure databases

ProteinModelPortaliP49430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP49430.
KOiK01832.
OMAiRMYIVIS.
OrthoDBiEOG091G0JNC.
PhylomeDBiP49430.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLGLLKFE VSGTVVTVTL SVVLLALLKW YSTSAFSRLR KLGIRHPEPS
60 70 80 90 100
PFVGNLMFFR QGFWESHLEL RERYGPLCGY YLGRRMYIVI SDPDMIKEVL
110 120 130 140 150
VENFSNFSNR MASGLEPKLI ADSVLMLRDR RWEEVRGALM SAFSPEKLNE
160 170 180 190 200
MTPLISQACE LLLSHLKHSA ASGDAFDIQR CYCCFTTNVV ASVAFGIEVN
210 220 230 240 250
SQDAPEDPFV QHCQRVFAFS TPRPLLALIL SFPSIMVPLA RILPNKNRDE
260 270 280 290 300
LNGFFNTLIR NVIALRDKQT AEERRGDFLQ MVLDAQRSMS SVGVEAFDMV
310 320 330 340 350
TEALSSAECM GDPPQRCHPT STAKPLTVDE IAGQAFLFLI AGHEITTNTL
360 370 380 390 400
SFITYLLATH PECQERLLKE VDLFMEKHPA PEYCNLQEGL PYLDMVVAET
410 420 430 440 450
LRMYPPAFRF TREAAQDCEV LGQHIPAGSV LEIAVGALHH DPEHWPNPET
460 470 480 490 500
FDPERFTAEA RLQQKPFTYL PFGAGPRSCL GVRLGLLVVK LTLLQVLHKF
510 520 530
RFEACPETQV PLQLESKSAL CPKNGVYVKI VSR
Length:533
Mass (Da):59,974
Last modified:February 1, 1996 - v1
Checksum:i6661BC5378D4E8C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28773 mRNA. Translation: BAA05962.1.
D31798 mRNA. Translation: BAA22574.1.
PIRiS42404.
RefSeqiNP_036819.1. NM_012687.1.
UniGeneiRn.16283.

Genome annotation databases

EnsembliENSRNOT00000010796; ENSRNOP00000010796; ENSRNOG00000007918.
GeneIDi24886.
KEGGirno:24886.
UCSCiRGD:3826. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28773 mRNA. Translation: BAA05962.1.
D31798 mRNA. Translation: BAA22574.1.
PIRiS42404.
RefSeqiNP_036819.1. NM_012687.1.
UniGeneiRn.16283.

3D structure databases

ProteinModelPortaliP49430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010796.

Chemistry databases

BindingDBiP49430.
ChEMBLiCHEMBL4028.

Proteomic databases

PaxDbiP49430.
PRIDEiP49430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010796; ENSRNOP00000010796; ENSRNOG00000007918.
GeneIDi24886.
KEGGirno:24886.
UCSCiRGD:3826. rat.

Organism-specific databases

CTDi6916.
RGDi3826. Tbxas1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP49430.
KOiK01832.
OMAiRMYIVIS.
OrthoDBiEOG091G0JNC.
PhylomeDBiP49430.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiR-RNO-211979. Eicosanoids.
R-RNO-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

PROiP49430.

Gene expression databases

BgeeiENSRNOG00000007918.
GenevisibleiP49430. RN.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAS_RAT
AccessioniPrimary (citable) accession number: P49430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.