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Protein

Syndecan-4

Gene

SDC4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-GGA-2022928. HS-GAG biosynthesis.
R-GGA-2024096. HS-GAG degradation.
R-GGA-3000170. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Gene namesi
Name:SDC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 147128ExtracellularSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 19729CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 197178Syndecan-4PRO_0000033510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi65 – 651O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi67 – 671O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiP49416.

Interactioni

Subunit structurei

Interacts with SDOS.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006255.

Structurei

3D structure databases

ProteinModelPortaliP49416.
SMRiP49416. Positions 170-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP49416.
KOiK16338.
OMAiYLTTMDT.
OrthoDBiEOG7RV9HS.
PhylomeDBiP49416.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPRAAFLL GLLLAAAAAE SVRETETMDA RWLDNVGSGD LPDDEDIGEF
60 70 80 90 100
TPHLTSDEFD IDDTSGSGDY SDYDDAIYLT TVDTPAISDN YIPGDTERKM
110 120 130 140 150
EGEKKNTMLD NEIIPDKASP VEANLSNKIS MASTANSSIF ERTEVLTALI
160 170 180 190
AGGAVGLLFA VFLILLLVYR MKKKDEGSYD LGKKPIYKKA PTNEFYA
Length:197
Mass (Da):21,502
Last modified:February 1, 1996 - v1
Checksum:i88F1C7E188A99848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23940 Unassigned DNA. Translation: AAA16479.1.
PIRiA53126.
RefSeqiNP_001007870.1. NM_001007869.1.
UniGeneiGga.44748.

Genome annotation databases

EnsembliENSGALT00000006265; ENSGALP00000006255; ENSGALG00000003932.
GeneIDi419184.
KEGGigga:419184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23940 Unassigned DNA. Translation: AAA16479.1.
PIRiA53126.
RefSeqiNP_001007870.1. NM_001007869.1.
UniGeneiGga.44748.

3D structure databases

ProteinModelPortaliP49416.
SMRiP49416. Positions 170-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006255.

Proteomic databases

PaxDbiP49416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000006265; ENSGALP00000006255; ENSGALG00000003932.
GeneIDi419184.
KEGGigga:419184.

Organism-specific databases

CTDi6385.

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP49416.
KOiK16338.
OMAiYLTTMDT.
OrthoDBiEOG7RV9HS.
PhylomeDBiP49416.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-GGA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-GGA-2022928. HS-GAG biosynthesis.
R-GGA-2024096. HS-GAG degradation.
R-GGA-3000170. Syndecan interactions.

Miscellaneous databases

NextBioi20822282.
PROiP49416.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and genomic organization of chicken syndecan-4."
    Baciu P.C., Acaster C., Goetinck P.F.
    J. Biol. Chem. 269:696-703(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization."
    Baciu P.C., Saoncella S., Lee S.H., Denhez F., Leuthardt D., Goetinck P.F.
    J. Cell Sci. 113:315-324(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SDOS.
    Tissue: Embryo.

Entry informationi

Entry nameiSDC4_CHICK
AccessioniPrimary (citable) accession number: P49416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.