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Protein

Syndecan-4

Gene

SDC4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-GGA-2022928. HS-GAG biosynthesis.
R-GGA-2024096. HS-GAG degradation.
R-GGA-3000170. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Gene namesi
Name:SDC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 147ExtracellularSequence analysisAdd BLAST128
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 197CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003351020 – 197Syndecan-4Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi65O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi67O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiP49416.

Expressioni

Gene expression databases

BgeeiENSGALG00000003932.

Interactioni

Subunit structurei

Interacts with SDOS.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006255.

Structurei

3D structure databases

ProteinModelPortaliP49416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP49416.
KOiK16338.
OMAiYLTTMDT.
OrthoDBiEOG091G0OOE.
PhylomeDBiP49416.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPRAAFLL GLLLAAAAAE SVRETETMDA RWLDNVGSGD LPDDEDIGEF
60 70 80 90 100
TPHLTSDEFD IDDTSGSGDY SDYDDAIYLT TVDTPAISDN YIPGDTERKM
110 120 130 140 150
EGEKKNTMLD NEIIPDKASP VEANLSNKIS MASTANSSIF ERTEVLTALI
160 170 180 190
AGGAVGLLFA VFLILLLVYR MKKKDEGSYD LGKKPIYKKA PTNEFYA
Length:197
Mass (Da):21,502
Last modified:February 1, 1996 - v1
Checksum:i88F1C7E188A99848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23940 Unassigned DNA. Translation: AAA16479.1.
PIRiA53126.
RefSeqiNP_001007870.1. NM_001007869.1.
UniGeneiGga.44748.

Genome annotation databases

EnsembliENSGALT00000006265; ENSGALP00000006255; ENSGALG00000003932.
GeneIDi419184.
KEGGigga:419184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23940 Unassigned DNA. Translation: AAA16479.1.
PIRiA53126.
RefSeqiNP_001007870.1. NM_001007869.1.
UniGeneiGga.44748.

3D structure databases

ProteinModelPortaliP49416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006255.

Proteomic databases

PaxDbiP49416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000006265; ENSGALP00000006255; ENSGALG00000003932.
GeneIDi419184.
KEGGigga:419184.

Organism-specific databases

CTDi6385.

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP49416.
KOiK16338.
OMAiYLTTMDT.
OrthoDBiEOG091G0OOE.
PhylomeDBiP49416.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-GGA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-GGA-2022928. HS-GAG biosynthesis.
R-GGA-2024096. HS-GAG degradation.
R-GGA-3000170. Syndecan interactions.

Miscellaneous databases

PROiP49416.

Gene expression databases

BgeeiENSGALG00000003932.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC4_CHICK
AccessioniPrimary (citable) accession number: P49416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.