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Protein

Syndecan-4

Gene

SDC4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-GGA-2022928 HS-GAG biosynthesis
R-GGA-2024096 HS-GAG degradation
R-GGA-3000170 Syndecan interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Gene namesi
Name:SDC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 147ExtracellularSequence analysisAdd BLAST128
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 197CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003351020 – 197Syndecan-4Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi65O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi67O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiP49416
PRIDEiP49416

Expressioni

Gene expression databases

BgeeiENSGALG00000003932

Interactioni

Subunit structurei

Interacts with SDOS.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006255

Structurei

3D structure databases

ProteinModelPortaliP49416
SMRiP49416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiP49416
KOiK16338
OMAiQEPDDFE
OrthoDBiEOG091G0OOE
PhylomeDBiP49416
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPRAAFLL GLLLAAAAAE SVRETETMDA RWLDNVGSGD LPDDEDIGEF
60 70 80 90 100
TPHLTSDEFD IDDTSGSGDY SDYDDAIYLT TVDTPAISDN YIPGDTERKM
110 120 130 140 150
EGEKKNTMLD NEIIPDKASP VEANLSNKIS MASTANSSIF ERTEVLTALI
160 170 180 190
AGGAVGLLFA VFLILLLVYR MKKKDEGSYD LGKKPIYKKA PTNEFYA
Length:197
Mass (Da):21,502
Last modified:February 1, 1996 - v1
Checksum:i88F1C7E188A99848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23940 Unassigned DNA Translation: AAA16479.1
PIRiA53126
RefSeqiNP_001007870.1, NM_001007869.1
UniGeneiGga.44748

Genome annotation databases

EnsembliENSGALT00000006265; ENSGALP00000006255; ENSGALG00000003932
GeneIDi419184
KEGGigga:419184

Similar proteinsi

Entry informationi

Entry nameiSDC4_CHICK
AccessioniPrimary (citable) accession number: P49416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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