ID   ARR1_HUMAN     STANDARD;      PRT;   418 AA.
AC   P49407; O75625; O75630;
DT   01-FEB-1996 (Rel. 33, Created)
DT   01-FEB-1996 (Rel. 33, Last sequence update)
DT   15-JUL-1999 (Rel. 38, Last annotation update)
DE   BETA-ARRESTIN 1.
GN   ARRB1 OR ARR1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC   Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=PERIPHERAL BLOOD;
RX   MEDLINE; 93252853.
RA   PARRUTI G., PERACCHIA F., SALLESE M., AMBROSINI G., MASINI M.,
RA   ROTILIO D., DE BLASI A.;
RT   "Molecular analysis of human beta-arrestin-1: cloning, tissue
RT   distribution, and regulation of expression. Identification of two
RT   isoforms generated by alternative splicing.";
RL   J. Biol. Chem. 268:9753-9761(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=BRAIN;
RA   YU Q.M., ZHOU T.H., CHENG Z.J., MA L., PEI G.;
RT   "Molecular cloning of two isoforms of human beta-arrestin 1.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: REGULATES BETA-ADRENERGIC RECEPTOR FUNCTION. BETA-
CC       ARRESTINS SEEM TO BIND PHOSPHORYLATED BETA-ADRENERGIC RECEPTORS,
CC       THEREBY CAUSING A SIGNIFICANT IMPAIRMENT OF THEIR CAPACITY TO
CC       ACTIVATE G(S) PROTEINS.
CC   -!- ALTERNATIVE PRODUCTS: TWO ISOFORMS; BETA-ARRESTIN 1A (SHOWN HERE)
CC       AND BETA-ARRESTIN 1B; ARE PRODUCED BY ALTERNATIVE SPLICING.
CC   -!- SIMILARITY: BELONGS TO THE ARRESTIN FAMILY.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L04685; AAA35559.1; -.
DR   EMBL; L04685; AAA35558.1; -.
DR   EMBL; AF084040; AAC33295.1; -.
DR   EMBL; AF084940; AAC34123.1; -.
DR   MIM; 107940; -.
DR   PFAM; PF00339; arrestin; 1.
DR   PROSITE; PS00295; ARRESTINS; 1.
KW   Sensory transduction; Alternative splicing.
FT   VARSPLIC    334    341       MISSING (IN BETA-ARRESTIN 1B).
FT   CONFLICT    146    146       A -> V (IN REF. 2).
FT   CONFLICT    165    165       G -> R (IN REF. 2).
FT   CONFLICT    229    229       E -> K (IN REF. 2).
FT   CONFLICT    329    329       V -> E (IN REF. 2).
FT   CONFLICT    400    400       E -> K (IN REF. 2).
FT   CONFLICT    414    414       R -> Q (IN REF. 2).
FT   CONFLICT    417    417       D -> N (IN REF. 2).
SQ   SEQUENCE   418 AA;  46969 MW;  3EDC1ABB CRC32;
     MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA
     FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP
     PNLPCSVTLQ PGPEDTGKAC GVDYEAKAFC AENLEEKIHK RNSVGLVIRK VQYAPERPGP
     QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVEK IKISVRQYAD
     ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL
     ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP
     PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGME DDKEEEEDGT GSPRLNDR
//