ID   ARR1_HUMAN     STANDARD;      PRT;   418 AA.
AC   P49407;
DT   01-FEB-1996 (REL. 33, CREATED)
DT   01-FEB-1996 (REL. 33, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   BETA-ARRESTIN 1.
GN   ARRB1 OR ARR1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=PERIPHERAL BLOOD;
RX   MEDLINE; 93252853.
RA   PARRUTI G., PERACCHIA F., AMBROSINI G., ROTILIO D., D BLASI A.;
RL   J. BIOL. CHEM. 268:9753-9761(1993).
CC   -!- FUNCTION: REGULATES BETA-ADRENERGIC RECEPTOR FUNCTION. BETA-
CC       ARRESTINS SEEM TO BIND PHOSPHORYLATED BETA-ADRENERGIC RECEPTORS,
CC       THEREBY CAUSING A SIGNIFICANT IMPAIRMENT OF THEIR CAPACITY TO
CC       ACTIVATE G(S) PROTEINS.
CC   -!- ALTERNATIVE PRODUCTS: TWO FORMS SEEMS TO BE PRODUCED BY
CC       ALTERNATIVE SPLICING OF THE SAME GENE.
CC   -!- SIMILARITY: SIMILARITY IN THE C-TERMINAL WITH ALPHA-TRANSDUCIN
CC       AND OTHER PURINE NUCLEOTIDE-BINDING PROTEINS.
CC   -!- SIMILARITY: BELONGS TO THE ARRESTIN FAMILY.
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DR   EMBL; L04685; G347958; -.
DR   EMBL; L04685; G347957; -.
DR   MIM; 107940; 11TH EDITION.
KW   SENSORY TRANSDUCTION; ALTERNATIVE SPLICING.
FT   VARSPLIC    334    341       MISSING (IN SHORT FORM).
SQ   SEQUENCE   418 AA;  46969 MW;  3EDC1ABB CRC32;
     MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA
     FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP
     PNLPCSVTLQ PGPEDTGKAC GVDYEAKAFC AENLEEKIHK RNSVGLVIRK VQYAPERPGP
     QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVEK IKISVRQYAD
     ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL
     ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP
     PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGME DDKEEEEDGT GSPRLNDR
//