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Reviewed, UniProtKB/Swiss-Prot P49407 (ARRB1_HUMAN)

Last modified July 7, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Beta-arrestin-1
Alternative name(s):
    Arrestin beta-1
Gene names
Name: ARRB1
Synonyms: ARR1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.

Sequence similarities

Belongs to the arrestin family.

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Ontologies

Keywords
   Biological processSensory transduction
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processsignal transduction

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Inferred from direct assay. Source: UniProtKB

membrane fraction

Inferred from direct assay. Source: UniProtKB

plasma membrane

Traceable author statement. Source: ProtInc

soluble fraction

Traceable author statement. Source: UniProtKB

   Molecular functionenzyme inhibitor activity

Traceable author statement. Source: ProtInc

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1A (identifier: P49407-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1B (identifier: P49407-2)

The sequence of this isoform differs from the canonical sequence as follows:
     334-341: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Beta-arrestin-1
PRO_0000205194

Amino acid modifications

Modified residue471Phosphotyrosine By similarity
Modified residue4101Phosphothreonine By similarity
Modified residue4121Phosphoserine By similarity

Natural variations

Alternative sequence334 – 3418Missing in isoform 1B.
VSP_000322

Experimental info

Sequence conflict1461V → A in AAA35559. Ref.1
Sequence conflict1461V → A in AAA35558. Ref.1
Sequence conflict1651R → G in AAA35559. Ref.1
Sequence conflict1651R → G in AAA35558. Ref.1
Sequence conflict2291K → E in AAA35559. Ref.1
Sequence conflict2291K → E in AAA35558. Ref.1
Sequence conflict3291V → E in AAC33295. Ref.2
Sequence conflict3291V → E in AAC34123. Ref.2
Sequence conflict4001K → E in AAA35559. Ref.1
Sequence conflict4001K → E in AAA35558. Ref.1
Sequence conflict4141Q → R in AAA35559. Ref.1
Sequence conflict4141Q → R in AAA35558. Ref.1
Sequence conflict4171N → D in AAA35559. Ref.1
Sequence conflict4171N → D in AAA35558. Ref.1

Secondary structure

1 ... 418
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1A [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: 0A3C135092338D10

FASTA41847,066
        10         20         30         40         50         60 
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA 

        70         80         90        100        110        120 
FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP 

       130        140        150        160        170        180 
PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP 

       190        200        210        220        230        240 
QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD 

       250        260        270        280        290        300 
ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL 

       310        320        330        340        350        360 
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP 

       370        380        390        400        410 
PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

« Hide

Isoform 1B.

Checksum: 4FBA2B09E6C2D236
Show »

FASTA41046,309

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References

« Hide 'large scale' references
[1]"Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing."
Parruti G., Peracchia F., Sallese M., Ambrosini G., Masini M., Rotilio D., de Blasi A.
J. Biol. Chem. 268:9753-9761(1993) [PubMed: 8486659] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
Tissue: Peripheral blood.
[2]"Molecular cloning of two isoforms of human beta-arrestin 1."
Yu Q.M., Zhou T.H., Cheng Z.J., Ma L., Pei G.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
Tissue: Brain.
[3]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
Tissue: Uterus.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Web resources

Wikipedia

Arrestin entry

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Cross-references

Sequence databases

L04685 mRNA. Translation: AAA35559.1.
L04685 mRNA. Translation: AAA35558.1.
AF084040 mRNA. Translation: AAC33295.1.
AF084940 mRNA. Translation: AAC34123.1.
DQ314865 Genomic DNA. Translation: ABC40724.1.
BC003636 mRNA. Translation: AAH03636.1.
IPIIPI00293857.
IPI00336017.
PIRB46682.
RefSeqNP_004032.2.
NP_064647.1.
UniGeneHs.503284
Hs.625320

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2IV8X-ray2.80P/Q383-402[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP49407. 189 interactions.

PTM databases

PhosphoSiteP49407.

2-D gel databases

OGPP49407.

Proteomic databases

PRIDEP49407.

Genome annotation databases

EnsemblENSG00000137486. Homo sapiens. [Contig view]
GeneID408.
KEGGhsa:408.
UCSCuc001owe.1. human.
uc001owf.1. human.

Organism-specific databases

GeneCardsGC11M074654.
H-InvDBHIX0009944.
HGNCHGNC:711. ARRB1.
HPACAB003763.
MIM107940. gene.
PharmGKBPA59.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP49407.
HOVERGENP49407.

Enzyme and pathway databases

Pathway_Interaction_DBarf6cyclingpathway. Arf6 signaling events.
ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressP49407.
BgeeP49407.
CleanExHS_ARRB1.
GermOnlineENSG00000137486. Homo sapiens.

Family and domain databases

InterProIPR000698. Arrestin.
IPR011022. Arrestin-like_C.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
[Graphical view]
Gene3DG3DSA:2.60.40.640. Arrestin_C. 1 hit.
G3DSA:2.60.40.840. Arrestin_N. 1 hit.
PANTHERPTHR11792. Arrestin. 1 hit.
PfamPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSPR00309. ARRESTIN.
ProDomPD002099. Arrestin. 2 hits.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio1713.
SOURCESearch...

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Entry information

Entry nameARRB1_HUMAN
AccessionPrimary (citable) accession number: P49407
Secondary accession number(s): O75625 expand/collapse secondary AC list , O75630, Q2PP20, Q9BTK8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 5, 2002
Last modified: July 7, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents