P49406 (RM19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L19, mitochondrial
Short name=L19mt
Short name=MRP-L19

Alternative name(s):
39S ribosomal protein L15, mitochondrial
Short name=L15mt
Short name=MRP-L15

Gene names

Name:	MRPL19
Synonyms:	KIAA0104, MRPL15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.4 Ref.5.
Sequence similarities	Belongs to the ribosomal protein L19P family.
Sequence caution	The sequence AAY14972.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA03494.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from direct assay PubMed 10942595. Source: UniProtKB ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 292		39S ribosomal protein L19, mitochondrial		PRO_0000030473

Sequences

	Sequence		Length	Mass (Da)
	P49406 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 4056F39694284A9F	FASTA	292	33,535
	10 20 30 40 50 60 MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP 70 80 90 100 110 120 VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML ERRKVLHIPE FYVGSILRVT 130 140 150 160 170 180 TADPYASGKI SQFLGICIQR SGRGLGATFI LRNVIEGQGV EICFELYNPR VQEIQVVKLE 190 200 210 220 230 240 KRLDDSLLYL RDALPEYSTF DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI 250 260 270 280 290 KGIRFDLCLT EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[3]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-292. Tissue: Bone marrow.
[4]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-292, SUBCELLULAR LOCATION.
[5]	"Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle." Graack H.R., Bryant M.L., O'Brien T.W. Biochemistry 38:16569-16577(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN, SUBCELLULAR LOCATION.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005034 Genomic DNA. Translation: AAY14972.1. Different initiation. BC030144 mRNA. Translation: AAH30144.2. D14660 mRNA. Translation: BAA03494.1. Different initiation. AB051621 Genomic DNA. Translation: BAB54949.1.
IPI	IPI00027096.
RefSeq	NP_055578.2. NM_014763.3.
UniGene	Hs.44024.
3D structure databases
ProteinModelPortal	P49406.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49406. 4 interactions.
MINT	MINT-6492165.
STRING	9606.ENSP00000377486.
PTM databases
PhosphoSite	P49406.
Polymorphism databases
DMDM	92090636.
Proteomic databases
PaxDb	P49406.
PRIDE	P49406.
Protocols and materials databases
DNASU	9801.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393909; ENSP00000377486; ENSG00000115364. ENST00000409374; ENSP00000387284; ENSG00000115364.
GeneID	9801.
KEGG	hsa:9801.
UCSC	uc002snl.3. human.
Organism-specific databases
CTD	9801.
GeneCards	GC02P075873.
HGNC	HGNC:14052. MRPL19.
MIM	611832. gene.
neXtProt	NX_P49406.
PharmGKB	PA30948.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0335.
HOGENOM	HOG000020439.
HOVERGEN	HBG023932.
InParanoid	P49406.
KO	K02884.
OMA	KRWERPN.
OrthoDB	EOG4G4GR6.
Gene expression databases
ArrayExpress	P49406.
Bgee	P49406.
CleanEx	HS_MRPL15. HS_MRPL19.
Genevestigator	P49406.
Family and domain databases
InterPro	IPR001857. Ribosomal_L19. IPR008991. Translation_prot_SH3-like. [Graphical view]
PANTHER	PTHR15680. PTHR15680. 1 hit.
Pfam	PF01245. Ribosomal_L19. 1 hit. [Graphical view]
PRINTS	PR00061. RIBOSOMALL19.
SUPFAM	SSF50104. Transl_SH3_like. 1 hit.
PROSITE	PS01015. RIBOSOMAL_L19. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL19. human.
GenomeRNAi	9801.
NextBio	36904.
SOURCE	Search...

Entry information

Entry name

RM19_HUMAN

Accession

Primary (citable) accession number: P49406
Secondary accession number(s): Q53TX9, Q96Q52

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	April 4, 2006
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.