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P49406

- RM19_HUMAN

UniProt

P49406 - RM19_HUMAN

Protein

39S ribosomal protein L19, mitochondrial

Gene

MRPL19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L19, mitochondrial
    Short name:
    L19mt
    Short name:
    MRP-L19
    Alternative name(s):
    39S ribosomal protein L15, mitochondrial
    Short name:
    L15mt
    Short name:
    MRP-L15
    Gene namesi
    Name:MRPL19
    Synonyms:KIAA0104, MRPL15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:14052. MRPL19.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. nuclear membrane Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30948.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 29239S ribosomal protein L19, mitochondrialPRO_0000030473
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiP49406.
    PaxDbiP49406.
    PRIDEiP49406.

    PTM databases

    PhosphoSiteiP49406.

    Expressioni

    Gene expression databases

    ArrayExpressiP49406.
    BgeeiP49406.
    CleanExiHS_MRPL15.
    HS_MRPL19.
    GenevestigatoriP49406.

    Organism-specific databases

    HPAiHPA056622.

    Interactioni

    Protein-protein interaction databases

    BioGridi115142. 31 interactions.
    IntActiP49406. 7 interactions.
    MINTiMINT-6492165.
    STRINGi9606.ENSP00000377486.

    Structurei

    3D structure databases

    ProteinModelPortaliP49406.
    SMRiP49406. Positions 87-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L19P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0335.
    HOGENOMiHOG000020439.
    HOVERGENiHBG023932.
    InParanoidiP49406.
    KOiK02884.
    OMAiRWERPNF.
    OrthoDBiEOG7GXPCC.
    PhylomeDBiP49406.
    TreeFamiTF320270.

    Family and domain databases

    InterProiIPR001857. Ribosomal_L19.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR15680. PTHR15680. 1 hit.
    PfamiPF01245. Ribosomal_L19. 1 hit.
    [Graphical view]
    PRINTSiPR00061. RIBOSOMALL19.
    SUPFAMiSSF50104. SSF50104. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE    50
    PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML 100
    ERRKVLHIPE FYVGSILRVT TADPYASGKI SQFLGICIQR SGRGLGATFI 150
    LRNVIEGQGV EICFELYNPR VQEIQVVKLE KRLDDSLLYL RDALPEYSTF 200
    DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI KGIRFDLCLT 250
    EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS 292
    Length:292
    Mass (Da):33,535
    Last modified:April 4, 2006 - v2
    Checksum:i4056F39694284A9F
    GO

    Sequence cautioni

    The sequence AAY14972.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA03494.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005034 Genomic DNA. Translation: AAY14972.1. Different initiation.
    BC030144 mRNA. Translation: AAH30144.2.
    D14660 mRNA. Translation: BAA03494.1. Different initiation.
    AB051621 Genomic DNA. Translation: BAB54949.1.
    CCDSiCCDS1960.2.
    RefSeqiNP_055578.2. NM_014763.3.
    UniGeneiHs.44024.

    Genome annotation databases

    EnsembliENST00000393909; ENSP00000377486; ENSG00000115364.
    ENST00000409374; ENSP00000387284; ENSG00000115364.
    GeneIDi9801.
    KEGGihsa:9801.
    UCSCiuc002snl.3. human.

    Polymorphism databases

    DMDMi92090636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005034 Genomic DNA. Translation: AAY14972.1 . Different initiation.
    BC030144 mRNA. Translation: AAH30144.2 .
    D14660 mRNA. Translation: BAA03494.1 . Different initiation.
    AB051621 Genomic DNA. Translation: BAB54949.1 .
    CCDSi CCDS1960.2.
    RefSeqi NP_055578.2. NM_014763.3.
    UniGenei Hs.44024.

    3D structure databases

    ProteinModelPortali P49406.
    SMRi P49406. Positions 87-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115142. 31 interactions.
    IntActi P49406. 7 interactions.
    MINTi MINT-6492165.
    STRINGi 9606.ENSP00000377486.

    PTM databases

    PhosphoSitei P49406.

    Polymorphism databases

    DMDMi 92090636.

    Proteomic databases

    MaxQBi P49406.
    PaxDbi P49406.
    PRIDEi P49406.

    Protocols and materials databases

    DNASUi 9801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393909 ; ENSP00000377486 ; ENSG00000115364 .
    ENST00000409374 ; ENSP00000387284 ; ENSG00000115364 .
    GeneIDi 9801.
    KEGGi hsa:9801.
    UCSCi uc002snl.3. human.

    Organism-specific databases

    CTDi 9801.
    GeneCardsi GC02P075873.
    HGNCi HGNC:14052. MRPL19.
    HPAi HPA056622.
    MIMi 611832. gene.
    neXtProti NX_P49406.
    PharmGKBi PA30948.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0335.
    HOGENOMi HOG000020439.
    HOVERGENi HBG023932.
    InParanoidi P49406.
    KOi K02884.
    OMAi RWERPNF.
    OrthoDBi EOG7GXPCC.
    PhylomeDBi P49406.
    TreeFami TF320270.

    Miscellaneous databases

    ChiTaRSi MRPL19. human.
    GeneWikii MRPL19.
    GenomeRNAii 9801.
    NextBioi 36904.
    PROi P49406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49406.
    Bgeei P49406.
    CleanExi HS_MRPL15.
    HS_MRPL19.
    Genevestigatori P49406.

    Family and domain databases

    InterProi IPR001857. Ribosomal_L19.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR15680. PTHR15680. 1 hit.
    Pfami PF01245. Ribosomal_L19. 1 hit.
    [Graphical view ]
    PRINTSi PR00061. RIBOSOMALL19.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell.
    3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-292.
      Tissue: Bone marrow.
    4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-292, SUBCELLULAR LOCATION.
    5. "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle."
      Graack H.R., Bryant M.L., O'Brien T.W.
      Biochemistry 38:16569-16577(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM19_HUMAN
    AccessioniPrimary (citable) accession number: P49406
    Secondary accession number(s): Q53TX9, Q96Q52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3