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Protein

39S ribosomal protein L19, mitochondrial

Gene

MRPL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L19, mitochondrial
Short name:
L19mt
Short name:
MRP-L19
Alternative name(s):
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Mitochondrial large ribosomal subunit protein bL19m1 Publication
Gene namesi
Name:MRPL19
Synonyms:KIAA0104, MRPL15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115364.13.
HGNCiHGNC:14052. MRPL19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9801.
OpenTargetsiENSG00000115364.
PharmGKBiPA30948.

Polymorphism and mutation databases

BioMutaiMRPL19.
DMDMi92090636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030473? – 29239S ribosomal protein L19, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49406.
MaxQBiP49406.
PaxDbiP49406.
PeptideAtlasiP49406.
PRIDEiP49406.

PTM databases

iPTMnetiP49406.
PhosphoSitePlusiP49406.

Expressioni

Gene expression databases

BgeeiENSG00000115364.
CleanExiHS_MRPL15.
HS_MRPL19.
ExpressionAtlasiP49406. baseline and differential.
GenevisibleiP49406. HS.

Organism-specific databases

HPAiHPA046805.
HPA056622.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi115142. 61 interactors.
CORUMiP49406.
IntActiP49406. 18 interactors.
MINTiMINT-6492165.
STRINGi9606.ENSP00000377486.

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni78 – 80Combined sources3
Helixi89 – 105Combined sources17
Beta strandi116 – 122Combined sources7
Beta strandi124 – 141Combined sources18
Helixi144 – 146Combined sources3
Beta strandi148 – 155Combined sources8
Beta strandi158 – 165Combined sources8
Beta strandi173 – 178Combined sources6
Beta strandi183 – 185Combined sources3
Helixi188 – 192Combined sources5
Turni236 – 238Combined sources3
Helixi245 – 248Combined sources4
Helixi251 – 258Combined sources8
Turni263 – 267Combined sources5
Turni269 – 271Combined sources3
Helixi276 – 291Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40Q1-292[»]
3J9Melectron microscopy3.50Q1-292[»]
ProteinModelPortaliP49406.
SMRiP49406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1698. Eukaryota.
COG0335. LUCA.
GeneTreeiENSGT00390000009415.
HOGENOMiHOG000020439.
HOVERGENiHBG023932.
InParanoidiP49406.
KOiK02884.
OMAiNIPEFYV.
OrthoDBiEOG091G0O6E.
PhylomeDBiP49406.
TreeFamiTF320270.

Family and domain databases

InterProiView protein in InterPro
IPR001857. Ribosomal_L19.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR15680. PTHR15680. 1 hit.
PfamiView protein in Pfam
PF01245. Ribosomal_L19. 1 hit.
PRINTSiPR00061. RIBOSOMALL19.
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE
60 70 80 90 100
PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML
110 120 130 140 150
ERRKVLHIPE FYVGSILRVT TADPYASGKI SQFLGICIQR SGRGLGATFI
160 170 180 190 200
LRNVIEGQGV EICFELYNPR VQEIQVVKLE KRLDDSLLYL RDALPEYSTF
210 220 230 240 250
DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI KGIRFDLCLT
260 270 280 290
EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS
Length:292
Mass (Da):33,535
Last modified:April 4, 2006 - v2
Checksum:i4056F39694284A9F
GO

Sequence cautioni

The sequence AAY14972 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA03494 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005034 Genomic DNA. Translation: AAY14972.1. Different initiation.
BC030144 mRNA. Translation: AAH30144.2.
D14660 mRNA. Translation: BAA03494.1. Different initiation.
AB051621 Genomic DNA. Translation: BAB54949.1.
CCDSiCCDS1960.2.
RefSeqiNP_055578.2. NM_014763.3.
UniGeneiHs.44024.

Genome annotation databases

EnsembliENST00000393909; ENSP00000377486; ENSG00000115364.
ENST00000409374; ENSP00000387284; ENSG00000115364.
GeneIDi9801.
KEGGihsa:9801.
UCSCiuc002snl.4. human.

Similar proteinsi

Entry informationi

Entry nameiRM19_HUMAN
AccessioniPrimary (citable) accession number: P49406
Secondary accession number(s): Q53TX9, Q96Q52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2006
Last modified: September 27, 2017
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families