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P49406

- RM19_HUMAN

UniProt

P49406 - RM19_HUMAN

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Protein
39S ribosomal protein L19, mitochondrial
Gene
MRPL19, KIAA0104, MRPL15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L19, mitochondrial
Short name:
L19mt
Short name:
MRP-L19
Alternative name(s):
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Gene namesi
Name:MRPL19
Synonyms:KIAA0104, MRPL15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14052. MRPL19.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. nuclear membrane Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 29239S ribosomal protein L19, mitochondrialPRO_0000030473
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiP49406.
PaxDbiP49406.
PRIDEiP49406.

PTM databases

PhosphoSiteiP49406.

Expressioni

Gene expression databases

ArrayExpressiP49406.
BgeeiP49406.
CleanExiHS_MRPL15.
HS_MRPL19.
GenevestigatoriP49406.

Organism-specific databases

HPAiHPA056622.

Interactioni

Protein-protein interaction databases

BioGridi115142. 31 interactions.
IntActiP49406. 7 interactions.
MINTiMINT-6492165.
STRINGi9606.ENSP00000377486.

Structurei

3D structure databases

ProteinModelPortaliP49406.
SMRiP49406. Positions 87-205.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0335.
HOGENOMiHOG000020439.
HOVERGENiHBG023932.
InParanoidiP49406.
KOiK02884.
OMAiRWERPNF.
OrthoDBiEOG7GXPCC.
PhylomeDBiP49406.
TreeFamiTF320270.

Family and domain databases

InterProiIPR001857. Ribosomal_L19.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR15680. PTHR15680. 1 hit.
PfamiPF01245. Ribosomal_L19. 1 hit.
[Graphical view]
PRINTSiPR00061. RIBOSOMALL19.
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49406-1 [UniParc]FASTAAdd to Basket

« Hide

MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE    50
PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML 100
ERRKVLHIPE FYVGSILRVT TADPYASGKI SQFLGICIQR SGRGLGATFI 150
LRNVIEGQGV EICFELYNPR VQEIQVVKLE KRLDDSLLYL RDALPEYSTF 200
DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI KGIRFDLCLT 250
EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS 292
Length:292
Mass (Da):33,535
Last modified:April 4, 2006 - v2
Checksum:i4056F39694284A9F
GO

Sequence cautioni

The sequence AAY14972.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA03494.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005034 Genomic DNA. Translation: AAY14972.1. Different initiation.
BC030144 mRNA. Translation: AAH30144.2.
D14660 mRNA. Translation: BAA03494.1. Different initiation.
AB051621 Genomic DNA. Translation: BAB54949.1.
CCDSiCCDS1960.2.
RefSeqiNP_055578.2. NM_014763.3.
UniGeneiHs.44024.

Genome annotation databases

EnsembliENST00000393909; ENSP00000377486; ENSG00000115364.
ENST00000409374; ENSP00000387284; ENSG00000115364.
GeneIDi9801.
KEGGihsa:9801.
UCSCiuc002snl.3. human.

Polymorphism databases

DMDMi92090636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005034 Genomic DNA. Translation: AAY14972.1 . Different initiation.
BC030144 mRNA. Translation: AAH30144.2 .
D14660 mRNA. Translation: BAA03494.1 . Different initiation.
AB051621 Genomic DNA. Translation: BAB54949.1 .
CCDSi CCDS1960.2.
RefSeqi NP_055578.2. NM_014763.3.
UniGenei Hs.44024.

3D structure databases

ProteinModelPortali P49406.
SMRi P49406. Positions 87-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115142. 31 interactions.
IntActi P49406. 7 interactions.
MINTi MINT-6492165.
STRINGi 9606.ENSP00000377486.

PTM databases

PhosphoSitei P49406.

Polymorphism databases

DMDMi 92090636.

Proteomic databases

MaxQBi P49406.
PaxDbi P49406.
PRIDEi P49406.

Protocols and materials databases

DNASUi 9801.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393909 ; ENSP00000377486 ; ENSG00000115364 .
ENST00000409374 ; ENSP00000387284 ; ENSG00000115364 .
GeneIDi 9801.
KEGGi hsa:9801.
UCSCi uc002snl.3. human.

Organism-specific databases

CTDi 9801.
GeneCardsi GC02P075873.
HGNCi HGNC:14052. MRPL19.
HPAi HPA056622.
MIMi 611832. gene.
neXtProti NX_P49406.
PharmGKBi PA30948.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0335.
HOGENOMi HOG000020439.
HOVERGENi HBG023932.
InParanoidi P49406.
KOi K02884.
OMAi RWERPNF.
OrthoDBi EOG7GXPCC.
PhylomeDBi P49406.
TreeFami TF320270.

Miscellaneous databases

ChiTaRSi MRPL19. human.
GeneWikii MRPL19.
GenomeRNAii 9801.
NextBioi 36904.
PROi P49406.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49406.
Bgeei P49406.
CleanExi HS_MRPL15.
HS_MRPL19.
Genevestigatori P49406.

Family and domain databases

InterProi IPR001857. Ribosomal_L19.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR15680. PTHR15680. 1 hit.
Pfami PF01245. Ribosomal_L19. 1 hit.
[Graphical view ]
PRINTSi PR00061. RIBOSOMALL19.
SUPFAMi SSF50104. SSF50104. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.
  3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-292.
    Tissue: Bone marrow.
  4. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-292, SUBCELLULAR LOCATION.
  5. "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle."
    Graack H.R., Bryant M.L., O'Brien T.W.
    Biochemistry 38:16569-16577(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM19_HUMAN
AccessioniPrimary (citable) accession number: P49406
Secondary accession number(s): Q53TX9, Q96Q52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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