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P49406 (RM19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L19, mitochondrial

Short name=L19mt
Short name=MRP-L19
Alternative name(s):
39S ribosomal protein L15, mitochondrial
Short name=L15mt
Short name=MRP-L15
Gene names
Name:MRPL19
Synonyms:KIAA0104, MRPL15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion Ref.4 Ref.5.

Sequence similarities

Belongs to the ribosomal protein L19P family.

Sequence caution

The sequence AAY14972.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA03494.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear membrane

Inferred from direct assay PubMed 10942595. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 10942595. Source: UniProtKB

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 29239S ribosomal protein L19, mitochondrialPRO_0000030473

Sequences

Sequence LengthMass (Da)Tools
P49406 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 4056F39694284A9F

FASTA29233,535
        10         20         30         40         50         60 
MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP 

        70         80         90        100        110        120 
VIVDKHRPVE PERRFLSPEF IPRRGRTDPL KFQIERKDML ERRKVLHIPE FYVGSILRVT 

       130        140        150        160        170        180 
TADPYASGKI SQFLGICIQR SGRGLGATFI LRNVIEGQGV EICFELYNPR VQEIQVVKLE 

       190        200        210        220        230        240 
KRLDDSLLYL RDALPEYSTF DVNMKPVVQE PNQKVPVNEL KVKMKPKPWS KRWERPNFNI 

       250        260        270        280        290 
KGIRFDLCLT EQQMKEAQKW NQPWLEFDMM REYDTSKIEA AIWKEIEASK RS 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell.
[3]"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-292.
Tissue: Bone marrow.
[4]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-292, SUBCELLULAR LOCATION.
[5]"Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle."
Graack H.R., Bryant M.L., O'Brien T.W.
Biochemistry 38:16569-16577(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A RIBOSOMAL PROTEIN, SUBCELLULAR LOCATION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005034 Genomic DNA. Translation: AAY14972.1. Different initiation.
BC030144 mRNA. Translation: AAH30144.2.
D14660 mRNA. Translation: BAA03494.1. Different initiation.
AB051621 Genomic DNA. Translation: BAB54949.1.
RefSeqNP_055578.2. NM_014763.3.
UniGeneHs.44024.

3D structure databases

ProteinModelPortalP49406.
SMRP49406. Positions 108-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115142. 31 interactions.
IntActP49406. 7 interactions.
MINTMINT-6492165.
STRING9606.ENSP00000377486.

PTM databases

PhosphoSiteP49406.

Polymorphism databases

DMDM92090636.

Proteomic databases

PaxDbP49406.
PRIDEP49406.

Protocols and materials databases

DNASU9801.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393909; ENSP00000377486; ENSG00000115364.
ENST00000409374; ENSP00000387284; ENSG00000115364.
GeneID9801.
KEGGhsa:9801.
UCSCuc002snl.3. human.

Organism-specific databases

CTD9801.
GeneCardsGC02P075873.
HGNCHGNC:14052. MRPL19.
HPAHPA056622.
MIM611832. gene.
neXtProtNX_P49406.
PharmGKBPA30948.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0335.
HOGENOMHOG000020439.
HOVERGENHBG023932.
InParanoidP49406.
KOK02884.
OMAKRWERPN.
OrthoDBEOG7GXPCC.
PhylomeDBP49406.
TreeFamTF320270.

Gene expression databases

ArrayExpressP49406.
BgeeP49406.
CleanExHS_MRPL15.
HS_MRPL19.
GenevestigatorP49406.

Family and domain databases

InterProIPR001857. Ribosomal_L19.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR15680. PTHR15680. 1 hit.
PfamPF01245. Ribosomal_L19. 1 hit.
[Graphical view]
PRINTSPR00061. RIBOSOMALL19.
SUPFAMSSF50104. SSF50104. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL19. human.
GeneWikiMRPL19.
GenomeRNAi9801.
NextBio36904.
PROP49406.
SOURCESearch...

Entry information

Entry nameRM19_HUMAN
AccessionPrimary (citable) accession number: P49406
Secondary accession number(s): Q53TX9, Q96Q52
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 4, 2006
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM